Diabetes mellitus e sua relação com a COVID-19: um panorama atual proveniente de uma revisão sistemática

Autores

DOI:

https://doi.org/10.33448/rsd-v10i15.22598

Palavras-chave:

Diabetes mellitus; COVID-19; Comorbidade.

Resumo

Introdução: A ocorrência de Diabetes Mellitus (DM), vêm se elevando gradativamente, o que se torna uma preocupação global. Atualmente, esta preocupação se deve ao fato de alguns estudos sugerirem que o diabetes está associado a um maior risco de desenvolver formas graves de COVID-19. Objetivo: Realizar uma revisão sistemática acerca da DM e sua relação com COVID-19. Metodologia: Trata-se de um estudo de revisão sistemática da literatura utilizando as bases de dados PubMed (Biblioteca Nacional de Medicina dos Estados Unidos) e Science Direct com os descritores “Diabetes mellitus”, “covid 19”, “fatores de risco/Diabetes mellitus”, “covid-19”, “comorbidade”. A pesquisa foi limitada com base na data de publicação (no tempo de 2 anos: 2019-2021), espécies (humanos), idiomas disponíveis em (inglês, espanhol e português). Foram excluídos das pesquisas os artigos que não faziam parte da temática “Diabetes Mellitus e sua relação com a COVID-19. Resultados e Discussão: Durante o estudo foi possível observar a forte correlação entre o mal prognóstico de COVID-19 e DM tipo 1 ou 2. Visto que o diabetes imunocompromete o corpo humano, entende-se que uma infecção secundária a COVID-19 seja mais persistente e letal. Conclusão: Conclui-se que pacientes portadores de DM que contraem COVID-19 apresentam um pior prognóstico quando comparados a pacientes não diabéticos. Esses pacientes devem receber uma maior atenção do sistema de saúde, recebendo medidas preventivas como um rigoroso controle glicêmico. Urge também mostrar a essa população a importância da vacinação.

Referências

Abbas, H. M., Nassir, K. F., Al Khames Aga, Q. A., Al‐Gharawi, A. A., Rasheed, J. I., AL‐Obaidy, M. W., & Al Khames Aga, L. A. (2021). Presenting the characteristics, smoking versus diabetes, and outcome among patients hospitalized with COVID‐19. Journal of medical virology, 93(3), 1556-1567.

Akter, F., Mannan, A., Mehedi, H. H., Rob, M. A., Ahmed, S., Salauddin, A., & Hasan, M. M. (2020). Clinical characteristics and short term outcomes after recovery from COVID-19 in patients with and without diabetes in Bangladesh. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 14(6), 2031-2038.

Akbariqomi, M., Hosseini, M. S., Rashidiani, J., Sedighian, H., Biganeh, H., Heidari, R., & Kooshki, H. (2020). Clinical characteristics and outcome of hospitalized COVID-19 patients with diabetes: A single-center, retrospective study in Iran. diabetes research and clinical practice, 169, 108467.

Alam, M. R., Kabir, M. R., & Reza, S. (2021). Comorbidities might be a risk factor for the incidence of COVID-19: Evidence from a web- based survey. Preventive Medicine Reports, 21, 101319.

Al‐Salameh, A., Lanoix, J. P., Bennis, Y., Andrejak, C., Brochot, E., Deschasse, G., & Lalau, J. D. (2021). Characteristics and outcomes of COVID‐19 in hospitalized patients with and without diabetes. Diabetes/metabolism research and reviews, 37(3), e3388.

Alzaid, F., Julla, J. B., Diedisheim, M., Potier, C., Potier, L., Velho, G., & Gautier, J. F. (2020). Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID‐19 in type 2 diabetes. EMBO molecular medicine, 12(10), e13038.

Arango-Guerra, P., Moncayo-Viveros, J. G., Correa-Londoño, N., García-Roncallo, A., Ramírez-Escobar, L., Sánchez-Moreno, A. M., & Moreno-Bedoya, S. (2021). Crisis hiperglucémica concomitante con infección por SARS-CoV-2: una serie de casos. Acta Colombiana de Cuidado Intensivo.

Barron, E., Bakhai, C., Kar, P., Weaver, A., Bradley, D., Ismail, H., & Valabhji, J. (2020). Associations of type 1 and type 2 diabetes with COVID-19- related mortality in England: a whole-population study. The lancet Diabetes & endocrinology, 8(10), 813-822.

Bhatti, R., Khamis, A. H., Khatib, S., Shiraz, S., & Matfin, G. (2020). Clinical Characteristics and Outcomes of Patients With Diabetes Admitted for COVID- 19 Treatment in Dubai: Single-Centre Cross-Sectional Study. JMIR public health and surveillance, 6(4), e22471.

Chan, K. H., Thimmareddygari, D., Ramahi, A., Atallah, L., Baranetsky, N. G., & Slim, J. (2020). Clinical characteristics and outcome in patients with combined diabetic ketoacidosis and hyperosmolar hyperglycemic state associated with COVID- 19: a retrospective, hospital-based observational case series. Diabetes research and clinical practice, 166, 108279.

Chen, Q., Zheng, Z., Zhang, C., Zhang, X., Wu, H., Wang, J., & Zheng, C. (2020). Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China. Infection, 48(4), 543-551.

Cheng, Y., Yue, L., Wang, Z., Zhang, J., & Xiang, G. (2021). Hyperglycemia associated with lymphopenia and disease severity of COVID-19 in type 2 diabetes mellitus. Journal of Diabetes and its Complications, 35(2), 107809.

Dyusupova, A., Faizova, R., Yurkovskaya, O., Belyaeva, T., Terekhova, T., Khismetova, A., & Glushkova, N. (2021). Clinical characteristics and risk factors for disease severity and mortality of COVID-19 patients with diabetes mellitus in Kazakhstan: A nationwide study. Heliyon, 7(3), e06561.

Ebinger, J. E., Achamallah, N., Ji, H., Claggett, B. L., Sun, N., Botting, P., & Cheng, S. (2020). Pre-existing traits associated with Covid- 19 illness severity. PloS one, 15(7), e0236240.

Escobedo-de la Peña, J., Pacheco, R. A. R., de Jesús Ascencio-Montiel, I., González-Figueroa, E., Fernández-Gárate, J. E., Medina-Gómez, O. S., & Borja- Aburto, V. H. (2020). Hypertension, diabetes and obesity, major risk factors for death in patients with COVID-19 in Mexico. Archives of Medical Research.

Fadini, G. P., Morieri, M. L., Boscari, F., Fioretto, P., Maran, A., Busetto, L., & Vettor, R. (2020). Newly- diagnosed diabetes and admission hyperglycemia predict COVID-19 severity by aggravating respiratory deterioration. Diabetes research and clinical practice, 168, 108374.

Fox, T., Ruddiman, K., Lo, K. B., Peterson, E., DeJoy, R., Salacup, G., & Patarroyo-Aponte, G. (2021). The relationship between diabetes and clinical outcomes in COVID-19: a single-center retrospective analysis. Acta Diabetologica, 58(1), 33-38.

Kim, M. K., Jeon, J. H., Kim, S. W., Moon, J. S., Cho, N. H., Han, E., & Lee, J. H. (2020). The clinical characteristics and outcomes of patients with moderate- to-severe coronavirus disease 2019 infection and diabetes in Daegu, South Korea. Diabetes & metabolism journal, 44(4), 602.

Lampasona, V., Secchi, M., Scavini, M., Bazzigaluppi, E., Brigatti, C., Marzinotto, I., & Piemonti, L. (2020). Antibody response to multiple antigens of SARS-CoV-2 in patients with diabetes: an observational cohort study. Diabetologia, 63(12), 2548-2558.

Liang, J. J., Liu, J., Chen, Y., Ye, B., Li, N., Wang, X., & Shao, J. (2020). Characteristics of laboratory findings of COVID-19 patients with comorbid diabetes mellitus. Diabetes research and clinical practice, 167, 108351.

Liu, Y., Lu, R., Wang, J., Cheng, Q., Zhang, R., Zhang, S., & Hong, T. (2021). Diabetes, even newly defined by HbA1c testing, is associated with an increased risk of in-hospital death in adults with COVID- 19. BMC Endocrine Disorders, 21(1), 1-10.

Liu, Z., Li, J., Huang, J., Guo, L., Gao, R., Luo, K., & Wu, X. (2020). Association Between Diabetes and COVID-19: A Retrospective Observational Study With a Large Sample of 1,880 Cases in Leishenshan Hospital, Wuhan. Frontiers in endocrinology, 11, 478.

McGurnaghan, S. J., Weir, A., Bishop, J., Kennedy, S., Blackbourn, L. A., McAllister, D. A., & Health Protection Study Group. (2021). Risks of and risk factors for COVID-19 disease in people with diabetes: a cohort study of the total population of Scotland. The Lancet Diabetes & Endocrinology, 9(2), 82-93.

Mishra, Y., Pathak, B. K., Mohakuda, S. S., Tilak, T. V. S. V. G. K., Sen, S., Harikrishnan, P., & Singh, A. R. (2020). Relation of D-dimer levels of COVID- 19 patients with diabetes mellitus. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 14(6), 1927-1930.

Mithal, A., Jevalikar, G., Sharma, R., Singh, A., Farooqui, K. J., Mahendru, S., & Budhiraja, S. (2021). High prevalence of diabetes and other comorbidities in hospitalized patients with COVID-19 in Delhi, India, and their association with outcomes. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 15(1), 169-175.

Mondal, S., DasGupta, R., Lodh, M., Gorai, R., Choudhury, B., Hazra, A. K., & Ganguly, A. (2021). Predictors of new- onset diabetic ketoacidosis in patients with moderate to severe COVID-19 receiving parenteral glucocorticoids: A prospective single- centre study among Indian type 2 diabetes patients. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 15(3), 795-801.

Odriozola, A., Ortega, L., Martinez, L., Odriozola, S., Torrens, A., Corroleu, D., & Malik, R. A. (2021). Widespread sensory neuropathy in diabetic patients hospitalized with severe COVID-19 infection. Diabetes research and clinical practice, 172, 108631.

O’Malley, G., Ebekozien, O., Desimone, M., Pinnaro, C. T., Roberts, A., Polsky, S., & Levy, C. J. (2021). COVID-19 Hospitalization in Adults with Type 1 Diabetes: Results from the T1D Exchange Multicenter Surveillance Study. The Journal of Clinical Endocrinology & Metabolism, 106(2), e936-e942.

Satman, I., Demirci, I., Haymana, C., Tasci, I., Salman, S., Ata, N., & Sonmez, A. (2021). Unexpectedly lower mortality rates in COVID- 19 patients with and without type 2 diabetes in Istanbul. Diabetes Research and Clinical Practice, 174, 108753.

Schlömmer, C., Dünser, M. W., Antlanger, M., Paar, C., Winkler, M., Meier, J., & Salzer, H. J. (2020). Fatal case of COVID-19 in a 27-year- old woman with diabetes mellitus. Wiener klinische Wochenschrift, 132(21), 695-696.

Shang, J., Wang, Q., Zhang, H., Wang, X., Wan, J., Yan, Y., & Lin, J. (2021). The relationship between diabetes mellitus and COVID-19 prognosis: a retrospective cohort study in Wuhan, China. The American journal of medicine, 134(1), e6-e14.

Sun, Y., Guan, X., Jia, L., Xing, N., Cheng, L., Liu, B., & He, K. (2021). Independent and combined effects of hypertension and diabetes on clinical outcomes in patients with COVID‐19: A retrospective cohort study of Huoshen Mountain Hospital and Guanggu Fangcang Shelter Hospital. The Journal of Clinical Hypertension, 23(2), 218-231.

Ushigome, E., Yamazaki, M., Hamaguchi, M., Ito, T., Matsubara, S., Tsuchido, Y., & Fukui, M. (2021). Usefulness and safety of remote continuous glucose monitoring for a severe COVID-19 patient with diabetes. DiabetesTechnology & Therapeutics, 23(1), 78-80.

Yan, Y., Yang, Y., Wang, F., Ren, H., Zhang, S., Shi, X., & Dong, K. (2020). Clinical characteristics and outcomes of patients with severe covid- 19 with diabetes. BMJ open diabetes research and care, 8(1), e001343.

Zhang, N., Wang, C., Zhu, F., Mao, H., Bai, P., Chen, L. L., & Zhou, M. (2020). Risk factors for poor outcomes of diabetes patients with COVID-19: a single- center, retrospective study in early outbreak in China. Frontiers in endocrinology, 11.

Zhang, Q., Wei, Y., Chen, M., Wan, Q., & Chen, X. (2020). Clinical analysis of risk factors for severe COVID-19 patients with type 2 diabetes. Journal of Diabetes and its Complications, 34(10)

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Publicado

28/11/2021

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LIMA, B. S. .; FROTA, M. C. M. .; RAMOS, S. P. .; PEREIRA JÚNIOR, J. L. .; NÓBREGA NETO , A. de P. R. . Diabetes mellitus e sua relação com a COVID-19: um panorama atual proveniente de uma revisão sistemática. Research, Society and Development, [S. l.], v. 10, n. 15, p. e384101522598, 2021. DOI: 10.33448/rsd-v10i15.22598. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/22598. Acesso em: 25 nov. 2024.

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