Characterization of children with microcephaly presumed by congenital virus zika syndrome from the west region of Mato Grosso

Authors

DOI:

https://doi.org/10.33448/rsd-v10i16.23438

Keywords:

Zika virus; Congenital malformations; Microcephaly.

Abstract

Objective: To characterize the microcephaly cases in the west region of Mato Grosso presumably by the congenital Zika virus syndrome. Methods: It is a descriptive study, retrospective in longitudinal design. The study included children with microcephaly presumably by the congenital Zika virus syndrome. The selected variables were the epidemiological profile with sociodemographic data, growth monitoring by the cephalic perimeter evolution, length, weight and body mass index. Results: 12 patients were included in the research. Five children were born with congenital microcephaly and six developed the condition after birth. The cephalic perimeter evolved in an inappropriate way only in the first semester of life, with a growth rate of 0.72 cm/month and being the normal rate 1.5cm/month. The most found complications were tetraparetic cerebral paralysis (91,66%), global delay in neuropsychomotor development (91,66%), epilepsy (58,33%) and pyramidal syndrome (50%). Some findings rarely observed in the literature were found in the research like West syndrome, superior sagittal sinus dilation and single lateral ventricles. All of then presented neuroimaging exam alterations. The most found were pachygyria (66,67%), ventriculomegaly (58,34%) and subcortical calcifications (41,66%). Conclusions: The recognition of the onset phenotype in the congenital Zika virus syndrome will help to ensure an appropriate etiological evaluation and an adequate multi-professional continuous monitoring of these affected children.

References

Aguiar, L. R., Frias, P. G. d., Quinino, L. R. d. M., & Miranda-Filho, D. d. B. (2021). Avaliação da implantação da resposta à emergência de saúde pública de microcefalia no Estado de Pernambuco, Brasil. Cadernos de Saúde Pública, 37(8).

Almeida, I. M. L. M. d., Ramos, C. V., Rodrigues, D. C., Sousa, A. C. d., Nascimento, M. d. L. C. A. P. C. d., Silva, M. V. B. d., Batista, F. M. A., Santos, J. P. d., Oliveira, R. S. d., Soares, F. A. d. F., Xavier, S. C. d. C., & Carvalho-Costa, F. A. (2019). Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015–2016. Jornal de Pediatria, 95(4), 466–474.

Barbosa, M. H. d. M., Magalhães-Barbosa, M. C. d., Robaina, J. R., Prata-Barbosa, A., Lima, M. A. d. M. T. d., & Cunha, A. J. L. A. d. (2019). Auditory findings associated with Zika virus infection: an integrative review. Brazilian Journal of Otorhinolaryngology, 85(5), 642–663.

Del Campo, M., Feitosa, I. M. L., Ribeiro, E. M., Horovitz, D. D. G., Pessoa, A. L. S., França, G. V. A., García-Alix, A., Doriqui, M. J. R., Wanderley, H. Y. C., Sanseverino, M. V. T., Neri, J. I. C. F., Pina-Neto, J. M., Santos, E. S., Verçosa, I., Cernach, M. C. S. P., Medeiros, P. F. V., Kerbage, S. C., Silva, A. A., van der Linden, V., … on behalf of Zika Embryopathy Task Force-Brazilian Society of Medical Genetics ZETF-SBGM. (2017). The phenotypic spectrum of congenital Zika syndrome. American Journal of Medical Genetics Part A, 173(4), 841–857.

França, G. V. A., Schuler-Faccini, L., Oliveira, W. K., Henriques, C. M. P., Carmo, E. H., Pedi, V. D., Nunes, M. L., Castro, M. C., Serruya, S., Silveira, M. F., Barros, F. C., & Victora, C. G. (2016). Congenital Zika virus syndrome in Brazil: A case series of the first 1501 livebirths with complete investigation. The Lancet, 388(10047), 891–897.

Garcia, L. P. (2018). Epidemia do vírus Zika e microcefalia no brasil: emergência, evolução e enfrentamento. Instituto de Pesquisa Econômica Aplicada – IPEA. ISSN 1415-4765.

Gómez, L. A., Montoya, G., Rivera, H. M., & Hernández, J. C. (2016). Características de la estructura molecular de las proteínas e del virus Zika y E1 del virus de la rubeola. Posibles implicaciones en el neurotropismo y en las alteraciones del sistema nervioso. Rev Biomédica, 37, 0120-4157.

Griffin, D. E. (2017). Why are neurons susceptible to Zika virus? Rev Science, 357(6346), 33–34.

Krenn, V., Bosone, C., Burkard, T. R., Spanier, J., Kalinke, U., Calistri, A., Salata, C., Rilo Christoff, R., Pestana Garcez, P., Mirazimi, A., & Knoblich, J. A. (2021). Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly. Cell Stem Cell, 28(8), 1362–1379.e7.

Larrandaburu, M., Vianna, F. S., Anjos-daSilva, A., Sanseverino, M. T., & Schuler-Faccini, L. (2017). Zika virus infection and congenital anomalies in the Americas: Opportunities for regional action. Rev Panamericana de Salud Pública, 1–8.

Marinho, F., Araújo, V. E. M. d., Porto, D. L., Ferreira, H. L., Coelho, M. R. S., Lecca, R. C. R., Oliveira, H. d., Poncioni, I. P. d. A., Maranhão, M. H. N., Mendes, Y. M. M. B. e., Fernandes, R. M., Lima, R. B. d., Rabello, D. d. L., Marinho, F., Araújo, V. E. M. d., Porto, D. L., Ferreira, H. L., Coelho, M. R. S., Lecca, R. C. R., … Rabello, D. d. L. (2016). Microcefalia no Brasil: prevalência e caracterização dos casos a partir do Sistema de Informações sobre Nascidos Vivos (Sinasc), 2000-2015. Rev Epidemiologia e Serviços de Saúde, 25(4), 701–712.

Melo, A. S. de O., Aguiar, R. S., Amorim, M. M. R., Arruda, M. B., Melo, F. de O., Ribeiro, S. T. C., Batista, A. G. M., Ferreira, T., dos Santos, M. P., Sampaio, V. V., Moura, S. R. M., Rabello, L. P., Gonzaga, C. E., Malinger, G., Ximenes, R., de Oliveira-Szejnfeld, P. S., Tovar-Moll, F., Chimelli, L., Silveira, P. P., Tanuri, A. (2016). Congenital Zika Virus Infection: Beyond Neonatal Microcephaly. JAMA Neurology, 73(12), 1407.

Ministério da Saúde; Secretaria de Vigilância em Saúde (2017). Vírus Zika no Brasil – A resposta do SUS. 1. ed. Brasília: Editora MS – OS 2017/0227. 135 p. ISBN 978-85-334-2482-1.

Mitsikas, D., Gabrani, C., Giannakou, K., & Lamnisos, D. (2021). Intrauterine exposure to Zika virus and hearing loss within the first few years of life: A systematic literature review. International Journal of Pediatric Otorhinolaryngology, 147, 110801.

Moore, C. A., Staples, J. E., Dobyns, W. B., Pessoa, A., Ventura, C. V., Fonseca, E. B. da, Ribeiro, E. M., Ventura, L. O., Neto, N. N., Arena, J. F., & Rasmussen, S. A. (2017). Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians. JAMA Pediatrics, 171(3), 288–295.

Musso, D., & Gubler, D. J. (2016). Zika Virus. Clinical Microbiology Reviews, 29(3), 487–524.

Papageorghiou, A. T., Kennedy, S. H., Salomon, L. J., Altman, D. G., Ohuma, E. O., Stones, W., Gravett, M. G., Barros, F. C., Victora, C., Purwar, M., Jaffer, Y., Noble, J. A., Bertino, E., Pang, R., Cheikh Ismail, L., Lambert, A., Bhutta, Z. A., & Villar, J. (2018). The INTERGROWTH-21 st fetal growth standards: Toward the global integration of pregnancy and pediatric care. American Journal of Obstetrics and Gynecology, 218(2), S630–S640.

Parra-Saavedra, M., Reefhuis, J., Piraquive, J. P., Gilboa, S. M., Badell, M. L., Moore, C. A., Mercado, M., Valencia, D., Jamieson, D. J., Beltran, M., Sanz-Cortes, M., Rivera-Casas, A. M., Yepez, M., Parra, G., Ospina Martinez, M., & Honein, M. A. (2017). Serial Head and Brain Imaging of 17 Fetuses With Confirmed Zika Virus Infection in Colombia, South America. Obstetrics & Gynecology, 130(1), 207–212.

Pastrana, A., Albarracín, M., Hoffmann, M., Delturco, G., López, R., Gil, R., Guzmán, A., Del Barco, M., & Espeche, A. (2019). Síndrome de Zika congénito en la Argentina: Presentación de dos casos clínicos. Arch Argent Pediatr, 117(6), e635–e639.

Petribu, N. C. de L., Aragao, M. de F. V., van der Linden, V., Parizel, P., Jungmann, P., Araújo, L., Abath, M., Fernandes, A., Brainer-Lima, A., Holanda, A., Mello, R., Sarteschi, C., & Duarte, M. do C. M. B. (2017). Follow-up brain imaging of 37 children with congenital Zika syndrome: Case series study. BMJ, j4188.

Pierson, T. C., & Diamond, M. S. (2018). The emergence of Zika virus and its new clinical syndromes. Nature, 560(7720), 573–581.

Pinto e Sá, L. M. S. d. M. (2013). Intervenção Precoce e Microcefalia: Estratégias de Intervenção Eficazes [Dissertação de mestrado, Escola Superior de Educação João de Deus].

Prata-Barbosa, A., Martins, M. M., Guastavino, A. B., & Cunha, A. J. L. A. da. (2019). Effects of Zika infection on growth. Jornal de Pediatria, 95, 30–41.

Reveiz, L., Haby, M. M., Martínez-Vega, R., Pinzón-Flores, C. E., Elias, V., Smith, E., Pinart, M., Broutet, N., Becerra-Posada, F., Aldighieri, S., & Van Kerkhove, M. D. (2017). Risk of bias and confounding of observational studies of Zika virus infection: A scoping review of research protocols. Plos one, 12(7), 0180-220.

Ribeiro, I. G., Andrade, M. R. de, Silva, J. de M., Silva, Z. M., Costa, M. A. de O., Vieira, M. A. da C. e S., Batista, F. M. de A., Guimarães, H., Wada, M. Y., & Saad, E. (2018). Microcefalia no Piauí, Brasil: Estudo descritivo durante a epidemia do vírus Zika, 2015-2016. Rev Epidemiologia e Serviços de Saúde, 27(1).

Soares de Oliveira-Szejnfeld, P., Levine, D., Melo, A. S. de O., Amorim, M. M. R., Batista, A. G. M., Chimelli, L., Tanuri, A., Aguiar, R. S., Malinger, G., Ximenes, R., Robertson, R., Szejnfeld, J., & Tovar-Moll, F. (2016). Congenital Brain Abnormalities and Zika Virus: What the Radiologist Can Expect to See Prenatally and Postnatally. Radiology, 281(1), 203–218.

Linden, V. V. D., Filho, E. L. R., Lins, O. G., van der Linden, A., Aragão, M. de F. V. V., Brainer-Lima, A. M., Cruz, D. D. C. S., Rocha, M. A. W., Sobral da Silva, P. F., Carvalho, M. D. C. G., do Amaral, F. J., Gomes, J. A., Ribeiro de Medeiros, I. C., Ventura, C. V., & Ramos, R. C. (2016). Congenital Zika syndrome with arthrogryposis: Retrospective case series study. BMJ, 3899.

Vanessa, V. D. L., Epitacio, L. R. F., & Ana, V. D. L. (2017). Congenital Zika Syndrome: Clinical Aspects. Springer International Publishing, Zika Focus, First, 33–45.

Zorrilla, C. D., García García, I., García Fragoso, L., & De La Vega, A. (2017). Zika Virus Infection in Pregnancy: Maternal, Fetal, and Neonatal Considerations. The Journal of Infectious Diseases, 216(10), S891–S896.

Published

05/12/2021

How to Cite

LOPES, E. B. N. .; BRAGATO, S. G. R. .; RAMSDORF, F. B. M. .; BERLANGA, J. F. U. . Characterization of children with microcephaly presumed by congenital virus zika syndrome from the west region of Mato Grosso . Research, Society and Development, [S. l.], v. 10, n. 16, p. e42101623438, 2021. DOI: 10.33448/rsd-v10i16.23438. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/23438. Acesso em: 14 nov. 2024.

Issue

Section

Health Sciences