Clinical and epidemiological profile of children with congenital toxoplasmosis in a reference institute of perinatology

Authors

DOI:

https://doi.org/10.33448/rsd-v10i17.24524

Keywords:

Congenital Toxoplasmosis; Epidemiology; Maternity.

Abstract

Objective: To analyze congenital toxoplasmosis in children followed at the Social Perinatology Institute of the Dona Evangelina Rosa Maternity Hospital. Methodology: This was a descriptive, quantitative cross-sectional documentary research study. The study included 85 newborns who were exposed to toxoplasmosis during pregnancy, born between January 2018 and December 2021. Data collection was performed using the “Congenital Toxoplasmosis Reporting/Investigation Sheets of the Notifiable Diseases System ”. Results: It was found that most pregnant women were aged between 20 and 29 years at the time of diagnosis. The gestational age at which most mothers were diagnosed was also observed, diagnosis occurred during the range of 37 weeks to 40 weeks and 6 days of gestation. In addition, approximately 56% of the children did not present clinical alterations. Among symptomatic children, the most common alterations were retinochoroiditis, prematurity, jaundice, hydrocephalus and ascites. The results showed that about 53% of the children used the combination of Sulfadiazine + Pyrimethamine + Folinic Acid. Conclusion: It was possible to trace the epidemiological profile of pregnant women diagnosed with toxoplasmosis, as well as the clinical manifestations, treatment and evolution of children with congenital toxoplasmosis were evaluated.

References

Almeida, M. I. D. B. (2017). Associação das manifestações da toxoplasmose congênita em recém-nascidos e lactentes com a história gestacional e tratamento materno. Tese (Doutorado).

Conceição, C. D. S. (2020). Perfil sociodemográfico e obstétrico de gestantes notificadas por toxoplasmose. (Manografia).

de Moura, D. S., Oliveira, R. D. C. M., & Matos-Rocha, T. J. (2018). Toxoplasmose gestacional: perfil epidemiológico e conhecimentos das gestantes atendidas na unidade básica de saúde de um município alagoano/Toxoplasmosis in pregnancy: Epidemiological profile and knowledge of pregnant women assisted in basic units of an Alagoan municipality. Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo, 63(2), 69-76.

Ducournau, C., Moiré, N., Carpentier, R., Cantin, P., Herkt, C., Lantier, I., & Dimier-Poisson, I. (2020). Effective nanoparticle-based nasal vaccine against latent and congenital toxoplasmosis in sheep. Frontiers in Immunology, 11, 2183.

El Bissati, K., Levigne, P., Lykins, J., Adlaoui, E. B., Barkat, A., Berraho, A., & McLeod, R. (2018). Global initiative for congenital toxoplasmosis: an observational and international comparative clinical analysis. Emerging microbes & infections, 7(1), 1-14.

Fonseca, Z. C., Rodrigues, I. M. X., e Melo, N. C., Castro, A. M., & Avelino, M. M. (2016). Importância do teste de avidez IgG na toxoplasmose congênita. Revista de Patologia Tropical/Journal of Tropical Pathology, 45(1), 42-54.

Gómez-Toscano, V., Linares-López, K. A., Arce-Estrada, G. E., Figueroa-Damián, R., Barrios-Bautista, D. M., Hernández-Luengas, L., & Correa, D. (2019). Toxoplasmosis congénita en el valle de México. Resultados de una serie de casos. Acta Pediátrica de México, 39(6), 321-333.

Goncalves, D. D., Silva, B. C., Lopes, L. F., Diegas, P. H., Teixeira, V. S., & Esteves, A. P. V. (2019). Toxoplasmose congênita: Estratégias de controle durante o pré-natal. Cadernos da Medicina-UNIFESO, 2(1).

Hampton, M. M. (2015). Congenital toxoplasmosis: a review. Neonatal Network, 34(5), 274-278.

Hutson, S. L., Wheeler, K. M., McLone, D., Frim, D., Penn, R., Swisher, C. N., & McLeod, R. (2015). Patterns of hydrocephalus caused by congenital Toxoplasma gondii infection associate with parasite genetics. Clinical Infectious Diseases, 61(12), 1831-1834.

Inagaki, A. D. D. M., Cardoso, N. P., Lopes, R. J. P. L., Alves, J. A. B., Mesquita, J. R. F., Araújo, K. C. G. M. D., & Katagiri, S. (2014). Análise espacial da prevalência de toxoplasmose em gestantes de Aracaju, Sergipe, Brasil. Revista Brasileira de Ginecologia e Obstetrícia, 36, 535-540.

Maldonado, Y. A., Read, J. S., Byington, C. L., Barnett, E. D., Davies, H., Edwards, K. M., & COMMITTEE ON INFECTIOUS DISEASES. (2017). Diagnosis, treatment, and prevention of congenital toxoplasmosis in the United States. Pediatrics, 139(2).

Olariu, T. R., Press, C., Talucod, J., Olson, K., & Montoya, J. G. (2019). Congenital toxoplasmosis in the United States: clinical and serologic findings in infants born to mothers treated during pregnancy. Parasite, 26.

Peyron, F., L’ollivier, C., Mandelbrot, L., Wallon, M., Piarroux, R., Kieffer, F., & Garcia–Meric, P. (2019). Maternal and congenital toxoplasmosis: diagnosis and treatment recommendations of a French multidisciplinary working group. Pathogens, 8(1), 24.

Prusa, A. R., Kasper, D. C., Sawers, L., Walter, E., Hayde, M., & Stillwaggon, E. (2017). Congenital toxoplasmosis in Austria: Prenatal screening for prevention is cost-saving. PLoS neglected tropical diseases, 11(7), e0005648.

Sociedade Brasileira de Pediatria. (2020). Toxoplasmose Congênita.

Souza, C. Z., Marchioro, A. A., Rafael, K., Araújo, S. M., & Falavigna-Guilherme, A. L. (2015). Aborto espontâneo e toxoplasmose ocular em um casal infectado com Toxoplasma gondii. Scientia Medica, 25(3), ID21119-ID21119.

Takahashi, A. F. S., Bioni, H. O., de Souza, J. M., Takizawa, M. D. G. M. H., & Paiva, J. E. (2019). Toxoplasmose congênita na cidade de Cascavel/PR no período de 2002-2016. Revista Thêma et Scientia, 9(1), 260-267.

Thakkar, P. A., Shah, A., Javadekar, B. B., & Modasia, S. (2018). Congenital Toxoplasmosis presenting as multiple ring enhancing lesions in brain on neuroimaging. International Journal of Contemporary Pediatrics, 5(5), 2020.

Walcher, D. L., Comparsi, B., & Pedroso, D. (2017). Toxoplasmose gestacional: uma revisão. Brazilian Journal of Clinical Analyses, 49(4), 323-7.

Zahir, F., Abdellaoui, M., Younes, S., Benatiya, I. A., & Tahri, H. (2015). Severe ocular sequelae of congenital toxoplasmosis: huge macular scar. The Pan African Medical Journal, 20.

Published

21/12/2021

How to Cite

FALCÃO, C. de M. M. B. .; SOUSA, A. M. A. de .; MOURA, W. L. de .; BATISTA, L. I. V. . Clinical and epidemiological profile of children with congenital toxoplasmosis in a reference institute of perinatology. Research, Society and Development, [S. l.], v. 10, n. 17, p. e81101724524, 2021. DOI: 10.33448/rsd-v10i17.24524. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/24524. Acesso em: 24 jan. 2022.

Issue

Section

Health Sciences