Ketogenic diet: an efficient strategy in body weight control?

Authors

DOI:

https://doi.org/10.33448/rsd-v11i2.25303

Keywords:

Low carbohydrate; Ketogenic; Weight loss.

Abstract

Obesity is a worldwide public health problem that favors chronic noncommunicable diseases that affect the quality of life and the risk of death. Therefore, it’s necessary to combat this epidemic through loss of body weight. Carbohydrate restricted diets are the subject of questions about efficacy, mechanism of action and adverse effects. Under this definition there is a dietary protocol that has a severe restriction on carbohydrates, the ketogenic diet, which was originally indicated for the  non-pharmacological treatment in epilepsy, has currently been indicated for weight loss without a consensus in the literature . The objective of this work was to carry out a narrative  review of literature on the ketogenic diet as to its efficiency in weight loss, metabolic repercussions, sports performance and side effects. Twenty-six scientific articles published in the last fourteen years available in the portals PubMed, Scielo, Google Academic, BioMed was selected. In 24 studies there was participation of control group. In 18 articles the participants were submitted to protocols without caloric restrictions. In all the studies, weight reduction of the participants was verified. After the review, it’s considered that the ketogenic diet is effective in weight loss, improves certain biochemical parameters, but when the calories are controlled the results in weight loss tend to be similar to a control diet, although there are differences in serum biochemistry.

References

ABESO, Diretrizes (2016). https://abeso.org.br/diretrizes/

Atkins, R. C. (2002). Dr. Atkins’ New Diet Revolution. Government Institutes. .

Bazzano, L. A., Hu, T., Reynolds, K., Yao, L., Bunol, C., Liu, Y., … He, J. (2014). Effects of Low-Carbohydrate and Low-Fat Diets. Annals of Internal Medicine, 161(5), 309.

Brasil. (2020). Secretaria de Vigilância em Saúde. Vigitel Brasil 2019 : vigilância de fatores de risco e proteção para doenças crônicas por inquérito telefônico : estimativas sobre frequência e distribuição sociodemográfica de fatores de risco e proteção para doenças crônicas nas capitais dos 26 estados brasileiros e no Distrito Federal em 2019. Secretaria de Vigilância em Saúde. – Brasília: Ministério da Saúde, 2020

Brinkworth, G. D., Noakes, M., Clifton, P. M., & Buckley, J. D. (2009). Effects of a Low Carbohydrate Weight Loss Diet on Exercise Capacity and Tolerance in Obese Subjects. Obesity, 17(10), 1916–1923. ‌

Brinkworth, G. D., Noakes, M., Buckley, J. D., Keogh, J. B., & Clifton, P. M. (2009). Long-term effects of a very-low-carbohydrate weight loss diet compared with an isocaloric low-fat diet after 12 mo. The American Journal of Clinical Nutrition, 90(1), 23–32. ‌

Brinkworth, G. D., Wycherley, T. P., Noakes, M., Buckley, J. D., & Clifton, P. M. (2016). Long-term effects of a very-low-carbohydrate weight-loss diet and an isocaloric low-fat diet on bone health in obese adults. Nutrition, 32(9), 1033–1036.

Brinkworth, G. D., Buckley, J. D., Noakes, M., & Clifton, P. M. (2010). Renal Function Following Long-Term Weight Loss in Individuals with Abdominal Obesity on a Very-Low-Carbohydrate Diet vs High-Carbohydrate Diet. Journal of the American Dietetic Association, 110(4), 633–638.

Carneiro, G., Faria, A. N., Ribeiro Filho, F. F., Guimarães, A., Lerário, D., Ferreira, S. R. G., & Zanella, M. T. (2003). Influência da distribuição da gordura corporal sobre a prevalência de hipertensão arterial e outros fatores de risco cardiovascular em indivíduos obesos. Revista da Associação Médica Brasileira, 49(3), 306-311.

D’Andrea Meira, I., Romão, T. T., Pires do Prado, H. J., Krüger, L. T., Pires, M. E. P., & da Conceição, P. O. (2019). Ketogenic Diet and Epilepsy: What We Know So Far. Frontiers in Neuroscience, 13

Dehghan, M., Mente, A., Zhang, X., Swaminathan, S., Li, W., Mohan, V., … Mohammadifard, N. (2017). Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study. The Lancet, 390(10107), 2050–2062.

Enes, C. C. & Slater, B. (2010). Obesidade na adolescência e seus principais fatores determinantes. Revista Brasileira de Epidemiologia, 13(1), 163-171.

Faustino, B. E.; Braga de Azevedo; E., De Castro Silva, P. M., Sales, S. & Barros, W. P. de S. (2011). Diabetes mellitus: busca ativa em portadores de obesidade. Cogitare Enfermagem, 16(1).

Gardner, C. D., Kiazand, A., Alhassan, S., Kim, S., Stafford, R. S., Balise, R. R., … King, A. C. (2007). Comparison of the Atkins, Zone, Ornish, and LEARN Diets for Change in Weight and Related Risk Factors Among Overweight Premenopausal Women. JAMA, 297(9), 969.

Gregory, R. M. (2016). A Low-Carbohydrate Ketogenic Diet Combined with 6-Weeks of Crossfit Training Improves Body Composition and Performance.

Hall, K. D., Guo, J., Courville, A. B., Boring, J., Brychta, R., Chen, K. Y., … Walter, M. (2021). Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake. Nature Medicine, 27(2), 344–353.

Halyburton, A. K., Brinkworth, G. D., Wilson, C. J., Noakes, M., Buckley, J. D., Keogh, J. B., & Clifton, P. M. (2007). Low- and high-carbohydrate weight-loss diets have similar effects on mood but not cognitive performance. The American Journal of Clinical Nutrition, 86(3), 580–587.‌

Hashimoto, Y., Fukuda, T., Oyabu, C., Tanaka, M., Asano, M., Yamazaki., & Fukui, M. (2016). Impact of low-carbohydrate diet on body composition: meta-analysis of randomized controlled studies. Obesity Reviews, 17(6), 499-509.

Hu, T., Yao, L., Reynolds, K., Niu, T., Li, S., Whelton, P. K., … Bazzano, L. A. (2016). Adherence to low‐carbohydrate and low‐fat diets in relation to weight loss and cardiovascular risk factors. Obesity Science & Practice, 2(1), 24–31.

Jabekk, P. T., Moe, I. A., Meen, H. D., Tomten, S. E., & Høstmark, A. T. (2010). Resistance training in overweight women on a ketogenic diet conserved lean body mass while reducing body fat. Nutrition & Metabolism, 7(1), 17.

Johnstone, A. M., Horgan, G. W., Murison, S. D., Bremner, D. M., & Lobley, G. E. (2008). Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum. The American Journal of Clinical Nutrition, 87(1), 44–55.

Johnstone, A. M., Lobley, G. E., Horgan, G. W., Bremner, D. M., Fyfe, C. L., Morrice, P. C., & Duthie, G. G. (2011). Effects of a high-protein, low-carbohydrate v. high-protein, moderate-carbohydrate weight-loss diet on antioxidant status, endothelial markers and plasma indices of the cardiometabolic profile. British Journal of Nutrition, 106(2), 282–291. ‌

Kirk, S., Brehm, B., Saelens, B. E., Woo, J. G., Kissel, E., D’Alessio, D., … Daniels, S. R. (2012). Role of Carbohydrate Modification in Weight Management among Obese Children: A Randomized Clinical Trial. The Journal of Pediatrics, 161(2), 320-327.e1.

Krebs, N. F., Gao, D., Gralla, J., Collins, J. S., & Johnson, S. L. (2010). Efficacy and Safety of a High Protein, Low Carbohydrate Diet for Weight Loss in Severely Obese Adolescents. The Journal of Pediatrics, 157(2), 252–258.

Leith, W. (1961). Experiences with the Pennington diet in the management of obesity. Canadian Medical Association Journal, 84(25), 1411-1414.

Liu, X., Zhang, G., Ye, X., Li, H., Chen, X., Tang, L., … Lin, X. (2013). Effects of a low-carbohydrate diet on weight loss and cardiometabolic profile in Chinese women: a randomised controlled feeding trial. British Journal of Nutrition, 110(8), 1444–1453.

Marchioni, D. M. L., Slater, B., & Fisberg, R. M. (2004). Aplicação das Dietary Reference Intakes na avaliação da ingestão de nutrientes para indivíduos. Revista de Nutrição, 17(2), 207-216.

Mohorko, N., Černelič-Bizjak, M., Poklar-Vatovec, T., Grom, G., Kenig, S., Petelin, A., & Jenko-Pražnikar, Z. (2019). Weight loss, improved physical performance, cognitive function, eating behavior, and metabolic profile in a 12-week ketogenic diet in obese adults. Nutrition Research, 62, 64–77.

National Academies of Sciences, Engineering, and Medicine (2019). Dietary Reference Intakes.

Noakes, T. D., & Windt, J. (2017). Evidence that supports the prescription of low-carbohydrate high-fat diets: a narrative review. British Journal of Sports Medicine, 51(2), 133-139.

Paoli, A., Grimaldi, K., D’Agostino, D., Cenci, L., Moro, T., Bianco, A., & Palma, A. (2012). International Society of Sports Nutrition, 9(1).

Paoli, A, Rubini, A., Volek, J. S., & Grimaldi, K. A. (2013). Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. European Journal of Clinical Nutrition, 67(8), 789-796.

Paoli, A., Bianco, A., & Grimaldi, K. A. (2015). The Ketogenic Diet and Sport. Exercise and Sport Sciences Reviews, 43(3), 153–162.

Partsalaki, , I., Karvela, A., & Spiliotis, B. E. (2012). Metabolic impact of a ketogenic diet compared to a hypocaloric diet in obese children and adolescents. Journal of Pediatric Endocrinology and Metabolism, 25(7-8).

Penna, P. M.; Saron, M. L. G. & Hermsdorff, H. H. M. (2020). O papel de adipocinas a relação entre obesidade e resistência à insulina: uma revisão integrativa. Cadernos UniFOA, 15(42).

Pereira, L. O, Francischi, R. P. de, & Lancha Jr., A. H. (2003). Obesidade: hábitos nutricionais, sedentarismo e resistência à insulina. Arquivos Brasileiros de Endocrinologia & Metabologia, 47(2), 111-127.

Philippi, S. T., (2015). Pirâmide dos alimentos: fundamentos básicos da nutrição. Editora Manole.

Pogozelski, W., Arpaia, N., & Priore, S. (2005). The metabolic effects of low-carbohydrate diets and incorporation into a biochemistry course. Biochemistry and Molecular Biology Education, 33(2), 91-100.

Rhyu, H., & Cho, S.-Y. (2014). The effect of weight loss by ketogenic diet on the body composition, performance-related physical fitness factors and cytokines of Taekwondo athletes. Journal of Exercise Rehabilitation, 10(5), 326–331.

Robergs, S. O. & Roberts, R. A. (2002). Princípios fundamentais de fisiologia do exercício para aptidão, desempenho e saúde. Phorte.

Ruth, M. R., Port, A. M., Shah, M., Bourland, A. C., Istfan, N. W., Nelson, K. P., … Apovian, C. M. (2013). Consuming a hypocaloric high fat low carbohydrate diet for 12weeks lowers C-reactive protein, and raises serum adiponectin and high density lipoprotein-cholesterol in obese subjects. Metabolism, 62(12), 1779–1787.

Urbain, P., Strom, L., Morawski, L., Wehrle, A., Deibert, P., & Bertz, H. (2017). Impact of a 6-week non-energy-restricted ketogenic diet on physical fitness, body composition and biochemical parameters in healthy adults. Nutrition & Metabolism, 14(1).

Vargas, S., Romance, R., Petro, J. L., Bonilla, D. A., Galancho, I., Espinar, S., … Benítez-Porres, J. (2018). Efficacy of ketogenic diet on body composition during resistance training in trained men: a randomized controlled trial. Journal of the International Society of Sports Nutrition, 15(1).

Yancy, W. S., Westman, E. C., McDuffie, J. R., Grambow, S. C., Jeffreys, A. S., Bolton, J., … Oddone, E. Z. (2010). A Randomized Trial of a Low-Carbohydrate Diet vs Orlistat Plus a Low-Fat Diet for Weight Loss. Archives of Internal Medicine, 170(2), 136.

Weber, D. D., Aminzadeh-Gohari, S., Tulipan, J., Catalano, L., Feichtinger, R. G., & Kofler, B. (2020). Ketogenic diet in the treatment of cancer- Where do we stand? Molecular Metabolism, 33, 102-121.

Wilson, J., Lowery, R., (2017). The Ketogenic Bible.

World Health Organization: WHO. (2020). Obesity. https://www.who.int/health-topics/obesity#tab=tab_3

Zajac, A., Poprzecki, S., Maszczyk, A., Czuba, M., Michalczyk, M., & Zydek, G. (2014). The Effects of a Ketogenic Diet on Exercise Metabolism and Physical Performance in Off-Road Cyclists. Nutrients, 6(7), 2493–2508.

Zinn, C., Wood, M., Williden, M., Chatterton, S., & Maunder, E. (2017). Ketogenic diet benefits body composition and well-being but not performance in a pilot case study of New Zealand endurance athletes. Journal of the International Society of Sports Nutrition, 14(1). ‌

Published

18/01/2022

How to Cite

SILVA JUNIOR, A. P. da; FREITAS, F. de O.; BRANDÃO , V. C. S.; QUEIROZ, S. G. .; ALCÂNTARA, A. M. de; XAVIER, W. de S.; AMBRÓSIO, C. L. B.; SANTANA, R. A. de. Ketogenic diet: an efficient strategy in body weight control?. Research, Society and Development, [S. l.], v. 11, n. 2, p. e3911225303, 2022. DOI: 10.33448/rsd-v11i2.25303. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/25303. Acesso em: 19 apr. 2024.

Issue

Section

Health Sciences