Evaluation of the effects of photobiomodulation (808 nm) on pain and quality of life of diabetic neuropathy patients
DOI:
https://doi.org/10.33448/rsd-v11i2.25552Keywords:
Diabetes mellitus; Diabetic neuropathies; Pain; Photobiomodulation.Abstract
Diabetic neuropathy (DN) is one of the main complications of diabetes mellitus (DM), responsible for a high morbimortality rate and burdening public health resources. Photobiomodulation has proven to be effective in relieving pain, reducing the inflammation, and improving vascularization. We report an evaluation of the effectiveness of photobiomodulation for the relief of pain and to improve the quality of life in patients with diabetic neuropathy. A total of 30 diabetic volunteers with DN were randomly divided into three groups: control, photobiomodulation (PBM), and placebo (P-PBM). Those in Group control were instructed to take diabetic neuropathy medication for 30 days. The PBM group received laser photobiomodulation treatment with the following protocol: three sessions per week for 30 days, totaling 12 applications (wavelength, 808 nm; energy density, 12 J/cm²). in the of following nerves: tibial medial plantar, own plantar digital, common plantar digital, superficial fibular, deep fibular, sciatic, saphenous, and common fibular. Patients in the P-PBM Group were submitted to the PBM protocol, but with the device switched off. Before and after applying the therapeutic protocols, all volunteers were subjected to pain evaluations. The results showed a statistically significant difference between the groups (p < 0.05). The PBM group confirmed an analgesic effect directly related to the use of the photobiomodulation, whilst the patients in group control and P-PBM, did not present significant results. The study demonstrated that laser photobiomodulation is effective in significantly reducing pain and improving the quality of life of patients with diabetic neuropathy.
References
Almeida, S., Silveira, M., Espírito Santo, P., Pereira, R., & Salomé, G. (2013). Assessment of the quality of life of patients with diabetes mellitus and foot ulcers. Rev. Bras. Cir. Plást, 28(1), 142-146. http://dx.doi.org/10.1590/S1983-51752013000100024.
de Andrade, A. L., Bossini, P. S., & Parizotto, N. A. (2016). Use of low level laser therapy to control neuropathic pain: A systematic review. Journal of photochemistry and photobiology. B, Biology, 164, 36–42. https://doi.org/10.1016/j.jphotobiol.2016.08.025
Aslam, A., Singh, J., & Rajbhandari, S. (2014). Pathogenesis of painful diabetic neuropathy. Pain research and treatment, 2014, 412041. https://doi.org/10.1155/2014/412041
Bashiri H. (2013). Evaluation of low level laser therapy in reducing diabetic polyneuropathy related pain and sensorimotor disorders. Acta medica Iranica, 51(8), 543–547.
Çakici, N., Fakkel, T. M., van Neck, J. W., Verhagen, A. P., & Coert, J. H. (2016). Systematic review of treatments for diabetic peripheral neuropathy. Diabetic medicine : a journal of the British Diabetic Association, 33(11), 1466–1476. https://doi.org/10.1111/dme.13083
Carvalho, A. F., Feitosa, M. C., Coelho, N. P., Rebêlo, V. C., Castro, J. G., Sousa, P. R., Feitosa, V. C., & Arisawa, E. A. (2016). Low-level laser therapy and Calendula officinalis in repairing diabetic foot ulcers. Revista da Escola de Enfermagem da USP, 50(4), 628–634. https://doi.org/10.1590/S0080-623420160000500013
Cidral-Filho, F. J., Martins, D. F., Moré, A. O., Mazzardo-Martins, L., Silva, M. D., Cargnin-Ferreira, E., & Santos, A. R. (2013). Light-emitting diode therapy induces analgesia and decreases spinal cord and sciatic nerve tumour necrosis factor-α levels after sciatic nerve crush in mice. European journal of pain (London, England), 17(8), 1193–1204. https://doi.org/10.1002/j.1532-2149.2012.00280.x
.
Costa, D. R., Costa, D. R., Pessoa, D. R., Masulo, L. J., Arisawa, E., & Nicolau, R. A. (2017). Effect of LED therapy on temporomandibular disorder: a case study. Sci Med, 27(2), ID25872. https://doi.org/10.15448/1980-6108.2017.2.25872.
Costa, D. R., Pessoa, D. R., Seefeldt, V. B., Costa, D. R., Maia, D., Dos Santos Maciel, T., Mota, B., Delpasso, C. A., Ribeiro, C., & Nicolau, R. A. (2021). Orofacial evaluation of individuals with temporomandibular disorder after LED therapy associated or not of occlusal splint: a randomized double-blind controlled clinical study. Lasers in medical science, 36(8), 1681–1689. https://doi.org/10.1007/s10103-021-03269-2
Costa, DR., Delpasso, CA, Ribeiro, LAP., Maciel, T. dos S.., & Costa, DR. (2021 B). Fotobiomodulação utilizada no tratamento e / ou prevenção da fadiga muscular em humanos: Direcção para a empregabilidade clínica. Research, Society and Development, 10 (4), e24410414126. https://doi.org/10.33448/rsd-v10i4.14126
Davies, M., Brophy, S., Williams, R., & Taylor, A. (2006). The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes care, 29(7), 1518–1522. https://doi.org/10.2337/dc05-2228
da Silva Leal, M. V., Lima, M. O., Nicolau, R. A., de Carvallho, T., Abreu, J., Pessoa, D. R., & Arisawa, E. (2020). Effect of Modified Laser Transcutaneous Irradiation on Pain and Quality of Life in Patients with Diabetic Neuropathy. Photobiomodulation, photomedicine, and laser surgery, 38(3), 138–144. https://doi.org/10.1089/photob.2019.4714
de Abreu, A. M., & de Oliveira, B. G. (2015). A study of the Unna Boot compared with the elastic bandage in venous ulcers: a randomized clinical trial. Revista latino-americana de enfermagem, 23(4), 571–577. https://doi.org/10.1590/0104-1169.0373.2590
de Freitas, L. F., & Hamblin, M. R. (2016). Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy. IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society, 22(3), 7000417. https://doi.org/10.1109/JSTQE.2016.2561201
de Andrade, A., Bossini, P. S., do Canto De Souza, A., Sanchez, A. D., & Parizotto, N. A. (2017). Effect of photobiomodulation therapy (808 nm) in the control of neuropathic pain in mice. Lasers in medical science, 32(4), 865–872. https://doi.org/10.1007/s10103-017-2186-x
Duncan, B. B., França, E. B., Passos, V., Cousin, E., Ishitani, L. H., Malta, D. C., Naghavi, M., Mooney, M., & Schmidt, M. I. (2017). The burden of diabetes and hyperglycemia in Brazil and its states: findings from the Global Burden of Disease Study 2015. Revista brasileira de epidemiologia = Brazilian journal of epidemiology, 20Suppl 01(Suppl 01), 90–101. https://doi.org/10.1590/1980-5497201700050008
Dworkin, R. H., O'Connor, A. B., Backonja, M., Farrar, J. T., Finnerup, N. B., Jensen, T. S., Kalso, E. A., Loeser, J. D., Miaskowski, C., Nurmikko, T. J., Portenoy, R. K., Rice, A., Stacey, B. R., Treede, R. D., Turk, D. C., & Wallace, M. S. (2007). Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain, 132(3), 237–251. https://doi.org/10.1016/j.pain.2007.08.033
Faria, H. T., Veras, V. S., Xavier, A. T., Teixeira, C. R., Zanetti, M. L., & Santos, M. A. (2013). Qualidade de vida de pacientes com diabetes mellitus antes e após participação em programa educativo [Quality of life in patients with diabetes mellitus before and after their participation in an educational program]. Revista da Escola de Enfermagem da USP, 47(2), 348–354. https://doi.org/10.1590/s0080-62342013000200011
Feitosa, M. C. P., Carvalho, A. F. M., Feitosa, V. C., de Oliveira, R. A., Coelho, N. P. M. F., Rebêlo, V. C. N., & Arisawa, E. (2017). Pain and Quality of life of diabetic patients with ulcers, before and after treatment with low intensity laser therapy and Hellantus Annus oil. O Mundo da Saúde, 41(1), 18-29. http://dx.doi.org/10.15343/0104-7809.201741011829
Gonçalves, R. B., Marques, J. C., Monte-Raso, V., Zamarioli, A., Carvalho, L., & Fazan, V. P. S. (2010). Efeito da aplicação do laser de baixa potência na regeneração do nervo isquiático de ratos. Fisioter e Pesqui,7(1),34-9. http://dx.doi.org/10.1590/S1809-29502010000100007.
Head, K. A. (2006). Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev,11(4), 294-329.
Huang, Y. Y., Chen, A. C., Carroll, J. D., & Hamblin MR. (2009). Biphasic dose response in low level light therapy. Dose Response, 7(4), 358-83. http://dx.doi.org/10.2203/dose-response.09-027.
Moreira, M. M. R., da Silva, A. F., Blanes, L., Gragnani Filho, A., & Masako, F. L. (2016). Qualidade de vida e capacidade funcional em pacientes com úlcera arterial. Av.enferm, 34(2), 170-180. http://dx.doi.org/10.15446/av.enferm.v34n2.61617.
Pessoa, D. R., Costa, D. R., Costa, D. R., Delpasso, C. A., & Arisawa, E. (2017). Effects of Low-level laser therapy in an experimental model of tendinopathy in Rats: Literature Review. Revista Univap, 23(43), 102-112.
Pessoa, D. R., Costa, D. R., Prianti, B. M., Costa, D. R., Delpasso, C. A., Arisawa, E., & Nicolau, R. A. (2018). Association of facial massage, dry needling, and laser therapy in Temporomandibular Disorder: case report. CoDAS, 30(6), e20170265. https://doi.org/10.1590/2317-1782/20182017265
Sehlo, M. G., Alzahrani, O. H., & Alzahrani, H. A. (2016). Illness invalidation from spouse and family is associated with depression in diabetic patients with first superficial diabetic foot ulcers. International journal of psychiatry in medicine, 51(1), 16–30. https://doi.org/10.1177/0091217415621032
Telo, G. H., Cureau, F. V., de Souza, M. S., Andrade, T. S., Copês, F., & Schaan, B. D. (2016). Prevalence of diabetes in Brazil over time: a systematic review with meta-analysis. Diabetology & metabolic syndrome, 8(1), 65. https://doi.org/10.1186/s13098-016-0181-1
Tesfaye, S., & Selvarajah, D. (2012). Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy. Diabetes/metabolism research and reviews, 28 Suppl 1, 8–14. https://doi.org/10.1002/dmrr.2239
Volchegorskii I. A. (2017). Systematic review of treatments for diabetic peripheral neuropathy: lost in translation. Diabetic medicine : a journal of the British Diabetic Association, 34(6), 866–867. https://doi.org/10.1111/dme.13339
Wang, X., Reddy, D. D., Nalawade, S. S., Pal, S., Gonzalez-Lima, F., & Liu, H. (2018). Impact of heat on metabolic and hemodynamic changes in transcranial infrared laser stimulation measured by broadband near-infrared spectroscopy. Neurophotonics, 5(1), 011004. https://doi.org/10.1117/1.NPh.5.1.011004
Wang, X., Tian, F., Soni, S. S., Gonzalez-Lima, F., & Liu, H. (2016). Interplay between up-regulation of cytochrome-c-oxidase and hemoglobin oxygenation induced by near-infrared laser. Scientific reports, 6, 30540. https://doi.org/10.1038/srep30540
Wróbel, M. P., Szymborska-Kajanek, A., Wystrychowski, G., Biniszkiewicz, T., Sieroń-Stołtny, K., Sieroń, A., Pierzchała, K., Grzeszczak, W., & Strojek, K. (2008). Impact of low frequency pulsed magnetic fields on pain intensity, quality of life and sleep disturbances in patients with painful diabetic polyneuropathy. Diabetes & metabolism, 34(4 Pt 1), 349–354. https://doi.org/10.1016/j.diabet.2008.02.003
Yekta, Z., Pourali, R., & Ghasemi-Rad, M. (2011). Comparison of demographic and clinical characteristics influencing health-related quality of life in patients with diabetic foot ulcers and those without foot ulcers. Diabetes, metabolic syndrome and obesity : targets and therapy, 4, 393–399. https://doi.org/10.2147/DMSO.S27050
Yoo, M., Sharma, N., Pasnoor, M., & Kluding, P. M. (2013). Painful Diabetic Peripheral Neuropathy: Presentations, Mechanisms, and Exercise Therapy. Journal of diabetes & metabolism, 10, 005. https://doi.org/10.4172/2155-6156.S10-005
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Milena Valdinéia da Silva Leal; Mário Oliveira Lima; Davidson Ribeiro Costa; Renata Amadei Nicolau; Luana Aparecida Pilato Ribeiro; David Ribeiro Costa; Teresa Marly Teles de Carvallho; Kelson Nonato Gomes da Silva; Diego Rodrigues Pessoa; Emilia Angela Lo Schiavo Arisawa
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
