Influence of seasonality on the incidence of cleft lip and palate in a reference center in western Paraná

Authors

DOI:

https://doi.org/10.33448/rsd-v11i2.25577

Keywords:

Cleft Lip; Cleft Palate; Seasons; Craniofacial abnormalities.

Abstract

Purpose: The aim of this study was to verify, based on the date of conception, if there is an influence of seasonality with the increased risk of developing orofacial clefts, relating it to gender. Methodology: A retrospective documental study conducted by compiling secondary data of patients seen between the years 2013 and 2019, in a referral center. Only patients with isolated cleft lip and/or palate were included. The X² test of adherence and the X² test of independence followed, when necessary, by the post-test of adjusted residuals, were used to analyze the statistical difference and the association between the variables. The groups were ordered considering gender and seasonality, divided according to the seasons of the year: fall, winter, spring and summer. Results: 181 patients met the inclusion criteria. The mean gestational age was 38.4 weeks. Family history was negative in 114 (63%) cases. Of the total, 51 conceptions (28.18%) occurred in spring, 46 (25.41%) in winter, 42 (23.20%) in fall, and 42 (23.20%) in summer. There was no significant difference in the incidence of orofacial clefts among the 4 seasons of the year, nor when the seasonal distribution was related to gender. Conclusion: No association was found between seasonality and the development of orofacial clefts, considering the date of conception. No significant difference was found when relating seasonal distribution to gender.

References

Altoé, R. S. et al (2020). Influence of parental exposure to risk factors in the occurrence of oral clefts. J. Dent., v.21, n.2, p.119- 126.

Borges, A. R.; Mariano, L.; Sá, J.; Medrado, A. P.; Veiga, P. C.; Reis, S. R. A. (2014). Fissuras labiais e/ou palatinas não sindrômicas: determinantes ambientais e genéticos. Revista Bahiana de Odontologia. 5(1):48-58.

Cooper, M. E., Ratay, J. S., Marazita, M. L. (2006). Asian oral-facial cleft birth prevalence. Cleft Palate Craniofac J. 43(5):580-9.

Costa, R. R.; Takeshita, W. M.; Farah, G. J (2013). Levantamento epidemiológico de fissuras labiopalatais no município de Maringá e região. Rev. Assoc. Paul. Cir. Dent., 67(1): 40-44.

Aquino, S. N.; Machado, R. A.; Paranaíba, L. M. R.; Martelli, D. R.; Popoff, D. A. V.; Swerts, M. S. O. et al. (2017). A review of seasonality of cleft births - The Brazil experience. J Oral Biol Craniofac Res.7(1):2-6.

Dixon, M. J.; Marazita, M.; Beaty, T. H.; Murray, J. C. (2011). Cleft lip and palate: understanding genetic and environmental influences. Nat Rev Genet.,12(3):167-78.

Dodge, Y. (2006). The Oxford Dictionary of Statistical Terms. Oxford: Oxford University Press.

Elliott, R. F.; Jovic, G.; Beveridge, M. (2008). Seasonal variation and regional distribution of cleft lip and palate in Zambia. Cleft Palate Craniofac J. 45(5):533-8.

Fraser, F. C. & Gwyn, A. (1998). Seasonal variation in birth date of children with cleft lip. Teratology. 57(2):93-5.

Governo do Brasil, 2017. Um em cada 650 bebês nasce com fissura labiopalatal no país. http://www.brasil.gov.br/noticias/saude/2016/11/um-em-cada-650-bebes-nasce-com-fissuralabiopalatal- no-pais.

Hao, Y.; Zhuang, D.; Jiao, X. (2021). Seasonal Variation of Nonsyndromic Orofacial Clefts in Northern Chinese Population, Journal of Craniofacial Surgery.

Krapels, I. P.; Vermeij-Keers, C.; Müller, M.; de Klein, A.; Steegers-Theunissen, R. P. (2006). Nutrition and genes in the development of orofacial clefting. Nutr Rev.64(6):280-8.

Krost, B. & Schubert, J. (2006). Influence of season on prevalence of cleft lip and palate. Int J Oral Maxillofac Surg. 35(3):215-8.

Maia, C. S.; Junior, J. R. A. Q.; Medeiros, J. P.; Tenório, F. C. A. M. et al. (2020). Metabolismo do ácido fólico e suas ações na embriogênese. Braz. J. of Develop.,Curitiba, v.6, n.8,p. 57002-57009

Sakran, K. A.; Mashrah, M. A.; Al-Rokhami, R. K.; Hsieh, T.; Huang, H.; Alkebsi, K.; et al. (2021) Nonsyndromic Oral clefts and associated risk factors in Gansu Province, Northwestof China. J Oral Maxillofac Surg Med Pathol. 33(5): 494-499

Santos, L. M. P. & Pereira, M. Z. (2007). Efeito da fortificação com ácido fólico na redução dos defeitos do tubo neural. Cadernos de Saúde Pública. 23(1):17-24.

Schoenwolf, G. C. et al. (2016). Larsen embriologia humana. 5. ed. ‑ Rio de Janeiro : Elsevier, 178 – 698.

Silva, C. M., Pereira, M. C., Queiroz, T. B., & Neves, L. T. (2018). O papel do ácido fólico na prevenção das fissuras labiopalatinas não sindrômicas: uma revisão integrative. Braz. Ap. Sci. Rev., Curitiba, v. 3, n. 1, p. 641-658.

Souza, J. & Raskin, S. (2013). Clinical and epidemiological study of orofacial clefts. J. Pediatr. 89(2):137-144.

Spina, V.; Psillakis, J. M.; Lapa, F.S. (1972). Classificação das fissuras lábio-palatinas: sugestão de modificação. Rev. Hosp Clin Fac Med São Paulo. 27:5-6.

Van der Lek, L .M.; Pool, S. M. W.; de Jong, K.; Vermeij-Keers, C.; Mouës-Vink, C. M. (2021). Seasonal Influence on the Numbers of Gender-Related Orofacial Cleft Conceptions in the Netherlands. Cleft Palate Craniofac J.

Wehby, G. L.; Félix, T. M.; Goco, N.; Richieri-Costa, A.; Chakraborty, H.; Souza, J.; et al. (2013). High dosage folic acid supplementation, oral cleft recurrence, and fetal growth. Int J Environ Res Public Health. 10(2):590-605.

Published

23/01/2022

How to Cite

LUIZ, A. F.; RODRIGUES, L. P. G. d’Arce; DEMARCO, N. R. . Influence of seasonality on the incidence of cleft lip and palate in a reference center in western Paraná. Research, Society and Development, [S. l.], v. 11, n. 2, p. e20111225577, 2022. DOI: 10.33448/rsd-v11i2.25577. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/25577. Acesso em: 22 dec. 2024.

Issue

Section

Health Sciences