Disparities in access to reperfusion therapies among patients with STEMI of the non-metropolitan and metropolitan region of Aracaju
DOI:
https://doi.org/10.33448/rsd-v11i3.26505Keywords:
Myocardial infarction; Myocardial reperfusion; Disparities in health care.Abstract
Aim: To compare the celerity of hospital access with percutaneous coronary intervention (PCI), use of primary PCI and 30-day mortality among patients with STEMI who initiated symptoms in the non-metropolitan region with those who started in the metropolitan region of the state of Aracaju. Method: A quantitative cohort study using data from the VICTIM registry from December 2014 to October 2017. A significance level of 5% was adopted (p<0,05). Findings: 878 patients participated in the study, of which 382 started the symptoms in the metropolitan region and 496 in the non-metropolitan region. The latter region traveled more distances (104 ± 58.4km vs. 16 ± 49.3km, p <0.001), passed more than 1 institution (96% vs. 73%, p <0.001), presented greater delay to the hospital (11h [7-26] vs. 7h [3-17], p <0.001) and therefore performed less primary PCI (45% vs. 59%, p <0.001). It was also observed that those from the non-metropolitan region had a higher chance of death at 30 days (OR 1.84, 95% CI, 1.12 to 3.04, p = 0.016). Conclusion: Disparities in access, use of primary PCI, and 30-day mortality rates observed among the groups analyzed. These findings may help to better delineate the logistics of access to reperfusion therapies in Sergipe.
References
Agresti, A. (2009). Categorical data analysis. 2. ed. New York: John Wiley & Sons.
Ayad, M., Hyun, K., D'Souza, M., Redfern, J., Gullick, J., Ryan, M., & Brieger DB. (2021). Factors that influence whether patients with acute coronary syndromes undergo cardiac catheterisation. Med J Aust, 214(7), 310-317. DOI: 10.5694/mja2.50997.
Balamurugan, A., Phillips, M., Selig, J.P., Felix, H., & Ryan, K. (2018). Association Between System Factors and Acute Myocardial Infarction Mortality. South Med J, 111(9), 556-564. DOI: 10.14423/SMJ.0000000000000853.
Balen, F., Lhermusier, T., Grolleau, S., Pélissier, F., Dehours, E., Charpentier, S., … & Lamy, S; RESCAMIP investigators. (2019). Identifying key factors leading to the optimal care pathway for patients with ST-segment elevation myocardial infarction: Results from the RESCAMIP registry. Arch Cardiovasc Dis, 112(6-7), 374-380. DOI: 10.1016/j.acvd.2019.01.004.
Bennin, C.K., Ibrahim, S., Al-Saffar, F., Box, L.C., & Strom, J.A. (2016). Achieving timely percutaneous reperfusion for rural ST-elevation myocardial infarction patients by direct transport to an urban PCI-hospital. J Geriatr Cardiol, 13(10), 840-845. DOI: 10.11909/j.issn.1671-5411.2016.10.012.
Bugiardini, R., Ricci, B., Cenko, E., Vasiljevic, Z., Kedev, S., Davidovic, G., ... & Badimon, L. (2017). Delayed Care and Mortality Among Women and Men With Myocardial Infarction. J Am Heart Assoc, 6(8), e005968. DOI: 10.1161/JAHA.117.005968.
Conover, W.J. (1999). Practical nonparametric statistics. 3.ed. New York, Estados Unidos: John Wiley & Sons.
Doll, J.A., Roe, M.T. (2015). Time to treatment as a quality metric for acute STEMI care. Lancet, 385(9973), 1056-7. DOI: 10.1016/S0140-6736(14)62051-1.
Dreyer, R.P., Wang, Y., Strait, K.M., Lorenze, N.P., D'Onofrio, G., Bueno, H., …& Krumholz, H.M. (2015). Gender differences in the trajectory of recovery in health status among young patients with acute myocardial infarction: results from the variation in recovery: role of gender on outcomes of young AMI patients (VIRGO) study. Circulation, 131(22), 1971-80. DOI: 10.1161/CIRCULATIONAHA.114.014503.
Hosmer, D.W., Lemeshow, S., & May, S. (2008). Applied survival analysis: regression modeling of time-to-event data. 2.ed. New Jersey, Estados Unidos: Wiley-Interscience.
Hsia, R.Y., Krumholz, H., Shen, Y. (2020). Evaluation of STEMI Regionalization on Access, Treatment, and Outcomes Among Adults Living in Nonminority and Minority Communities. JAMA Netw Open, 3(11), e2025874. DOI:10.1001/jamanetworkopen.2020.25874.
Huguenin, F.M., Pinheiro, R.S., Almeida, R.M., & Infantosi, A.F. (2016). Characterization of the variation of health care taking into account the costs of hospital admissions for acute myocardial infarction in Brazilian Unified Health System. Rev Bras Epidemiol, 19(2), 229-42. DOI: 10.1590/1980-5497201600020002.
Jang, W.M., Lee, J., Eun, S.J., Yim, J., Kim, Y., & Kwak, M.Y. (2021). Travel time to emergency care not by geographic time, but by optimal time: A nationwide cross-sectional study for establishing optimal hospital access time to emergency medical care in South Korea. PLoS One, 16(5), e0251116. DOI: 10.1371/journal.pone.0251116.
Li, X., Murugiah, M., Li, J., Masoudi, F.A., Chan, P.S., Hu, S., … & Jiang, L. (2017). Urban–Rural Comparisons in Hospital Admission, Treatments, and Outcomes for ST-Segment–Elevation Myocardial Infarction in China From 2001 to 2011. Circ Cardiovasc Qual Outcomes, 10(11), 1-47. DOI: 10.1161/CIRCOUTCOMES.117.003905
Mathew, A., Abdullakutty, J., Sebastian, P., Viswanathan, S., Mathew, C., Nair, V., … & George Koshy, A. (2017). Population access to reperfusion services for ST-segment elevation myocardial infarction in Kerala, India. Indian Heart J, 69 (Suppl 1), S51-S56. DOI: 10.1016/j.ihj.2017.02.014.
Mendes, A.S., Reis, V.R., Menezes, T.M., Santos, C.A., & Mussi, F.C. (2014). Acesso de usuários com infarto do miocárdio a hospitais referência em cardiologia. Acta Paul Enferm, 27(6), 505-12. DOI: https://doi.org/10.1590/1982-0194201400083.
Ministério da Saúde. Datasus. (01 fev 2018). Mortalidade geral. Disponível em: http://tabnet.datasus.gov.br/cgi/deftohtm.exe?sim/cnv/obt10uf.def.
Nicolau, J.C., Franken, M., Lotufo, P.A., Carvalho, A.C., Neto, J.A.M., Lima, F.G., ... & Stefanini, E. (2012). Utilização de terapêuticas comprovadamente úteis no tratamento da coronariopatia aguda: comparação entre diferentes regiões brasileiras. Análise do Registro Brasileiro de Síndromes Coronarianas Agudas (BRACE - Brazilian Registry on Acute Coronary Syndromes). Arq Bras Cardiol, 98(4), 282-9. DOI: 10.1590/S0066-782X2012000400001.
Oliveira, J.C., Almeida-Santos, M.A., Cunha-Oliveira, J., Oliveira, L.C.S., de Carvalho Barreto, I.D., Clair RemacreMunareto Lima, T., ... & Barreto-Filho, J.A; VICTIM Register Investigators. (2019). Disparities in Access and Mortality of Patients With ST-Segment-Elevation Myocardial Infarction Using the Brazilian Public Healthcare System: VICTIM Register. J Am Heart Assoc, 8(20), e013057. DOI: 10.1161/JAHA.119.013057.
Oliveira, J.C., Barros, M.P.S., Barreto, I.D.C., Silva Filho, R.C., Andrade, V.A., Oliveira, A.M., ... & Barreto Filho, J.A.S. (2021a). Access to Reperfusion Therapy and Mortality in Women with ST-Segment-Elevation Myocardial Infarction: VICTIM Register. Arq Bras Cardiol, 116(4), 695-703. DOI: 10.36660/abc.20190468.
Oliveira, J.C., de Jesus, N.C., Oliveira, J.C., Munareto Lima, T.C.R., Carvalho Barreto, I.D.D., ... & Barreto Filho, J.A.S. (2021c). Hospital Pharmacological Treatment of Acute Myocardial Infarction with st Supra: Sus x Private. J Clinical Cardiology and Cardiovascular Interventions, 4(16). DOI:10.31579/2641-0419/205.
Oliveira, J.C., Ferreira, G.J.S., Oliveira, J.C., Lima, T.C.R.M., Barreto, I.D.C., Oliveira, L.C.S., ... & Barreto Filho, J.A.S. (2021b). Influência da Localização Geográfica no Acesso às Terapias de Reperfusão e Mortalidade de Pacientes com IAMcSST em Sergipe: Registro VICTIM. Arq Bras Cardiol, 117(1), 120-9. DOI: 10.36660/abc.20200015.
Piegas, L.S., Timerman, A., Feitosa, G.S., Nicolau, J.C., Mattos, L.A.P., Andrade, M.D., ... & Mathias Junior, W. (2015, 19 jan 2016 ). V Diretriz da Sociedade Brasileira de Cardiologia sobre tratamento do Infarto Agudo do Miocárdio com Supradesnível do Segmento ST. Arq Bras Cardiol, 105(2), 1-105. http://publicacoes.cardiol.br/2014/diretrizes/2015/02_TRATAMENTO%20DO%20IAM%20COM%20SUPRADESNIVEL%20DO%20SEGMENTO%20ST.pdf.
R Core Team. (2014, 19 jan 2016). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. http://www.R-project.org/.
Scheffer, M., Cassenote, A., Guilloux, A.G,A., Biancarelli, A., Miotto, B.A., & Mainardi, G.M. (2018). Demografia Médica no Brasil 2018. Departamento de Medicina Preventiva, Faculdade de Medicina da USP. Conselho Regional de Medicina do Estado de São Paulo. Conselho Federal de Medicina, 1-286.
Sergipe. (20003). Lei complementar nº 86, de 25 de agosto de 2003. Dá nova redação à Lei Complementar nº 25, de 29 de dezembro de 1995.
World Health Organization (WHO). (2021, 11 jun 2021). Cardiovascular diseases (CVDs). https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds).
Yin, X., He, Y., Zhang, J., Song, F., Liu, J., Sun, G., …& Tian, M. (2020). Patient-level and system-level barriers associated with treatment delays for ST elevation myocardial infarction in China. Heart, 106(19), 1477-1482. DOI: 10.1136/heartjnl-2020-316621.
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Copyright (c) 2022 Larissa Andreline Maia Arcelino; Jussiely Cunha Oliveira; Ticiane Clair Remacre Munareto Lima; Jeferson Cunha Oliveira; Íkaro Daniel de Carvalho Barreto; Laís Costa Souza Oliveira; Maria Júlia Oliveira Ramos; José Augusto Barreto-Filho
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