Glucose-6-phosphate dehydrogenase deficiency in genetic resistance to malaria: a systematic review and meta-analysis
DOI:
https://doi.org/10.33448/rsd-v11i3.26545Keywords:
Plasmodium; Genetic polymorphism; Disease resistance; Public health.Abstract
Several studies have been conducted aiming to detect the variety of genetic markers associated with malaria resistance. This work aimed to describe the relationship of glucose-6-phosphate dehydrogenase deficiency in host resistance to Plasmodium spp. To this end, a systematic review with meta-analysis was performed, following PRISMA guidelines. The search strategy was done in Medline via Pubmed, Science Direct, Lilacs, Scopus and Google academic. Risk of bias was used to evaluate each selected article using the Joanna Briggs Institute Critical Appraisal Checklist. Subsequently, together, the papers were evaluated using Egger's Test. In total, 638 articles were found. Of these, 26 participated in the qualitative synthesis and 15 in the quantitative. Of the 26 studies, 18 reported a relationship between enzyme deficit and malaria resistance. As for the results of the meta-analysis, it was found that G6PD deficiency may be associated with an individual's resistance to develop malaria, especially in Asians and Africans. Therefore, the results of this article may help in the development of new therapeutic strategies for this disease, benefiting public health worldwide.
References
Adukpo, S., Gyan, B. A., Ofori, M. F., Dodoo, D., Velavan, T. P. & Meyer, C. G. (2016). Triggering receptor expressed on myeloid cells 1 (TREM-1) and cytokine gene variants in complicated and uncomplicated malaria. Trop Med Int Health, 21, 1592-1601.
Allison, A. C., & Clyde, D. F. (1961). Malaria in African children with deficient erythrocyte glucose-6-phosphate dehydrogenase. British medical jornal. 1, 1346-1349.
Arguinano, A. A., Dadé, S., Stathopoulou, M., Ndiaye, N. C., Xie, T. M. C., Gibot, S. & Visvikis-Siet, S. (2017). TREM-1 SNP rs2234246 regulates TREM-1 protein and mRNA levels and is associated with plasma levels of L-selectin. PLoS One, 12, 1-15.
Barravieira, B., Meira, D. A., Machado, P. E. A., & Curi, P. R. (1987). Malária no município de Humaitá, estado do Amazonas. XXI. Prevalência da deficiência de glicose-6-fosfato desidrogenase (G6PD) Em amostra da população e em doentes com malaria causada pelo Plasmodium falciparum. Revista do Instituto de Medicina Tropical. 29.
Bonfim, L. G. S., Magalhães, L. S., Santos-Filho, M. A. A., Peres, N. T. A., Corrêa, C. B., Tanajura, D. M., Silva, A. M., Lipscomb, M. W., Borges, V. M., Jesus, A. R., Almeida, R. P. & Moura, T. R. (2017). Leishmania infantum Induces the Release of sTREM-1 in Visceral Leishmaniasis. Front Microbiol., 8, 1-8.
Eiguelman, B., Alves, F. P., Moura, M. M., & Nunes A. C. (2003). The association of genetic markers and malaria infection in the Brazilian Western Amazonian region. Memórias do Instituto Oswaldo Cruz, 98, 455–460.
Brasil. Ministério da Saúde (2009). Secretaria de Vigilância em Saúde. Manual de diagnóstico laboratorial da malária.
Brasil. Ministério da Saúde. (2015). Diretrizes metodológicas: elaboração de revisão sistemática e metanálise de ensaios clínicos randomizados.
Brasil. Ministério da Saúde (2019). Secretaria de Vigilância em Saúde. Guia de vigilância em saúde.
Brasil. Ministério da Saúde (2020). Boletim de casos de Malária da Região Amazônica. Situação epidemiológica da malária na região Amazônica, 2018 a 2020.
Campino, S., Kwiatkowski, D., & Dessein, A. (2006). Mendelian and complex genetics of susceptibility and resistance to parasitic infections. Seminários em Imunologia. 18, 411-422.
Caroline, L. L. C., Graham, B., John, A. H., Stephen, R., & Philippe, B. (2013). Monocytes and macrophages in malaria: protection or pathology?. Trends Parasitology. 29, 26-34
Cavasini, C. E., Mattos, L. C., Couto, A. A., Couto, V. S., & Gollino, Y. (2007). Duffy blood group gene polymorphisms among malaria vivax patients in four areas of the Brazilian Amazon region. Malaria Journal. 6, 1-8.
Coban, C., Lee, M. S. J. & Ishii, K. J. (2018). Tissue-specific immunopathology during malária infection. Nature Reviews, 18, 266-278.
Chu; C. S., Bancone, G., Moore, K. A., Win, H. H., Thitipanawan, N., Po, C., & White, N. J. (2017). Haemolysis in G6PD Heterozygous Females Treated with Primaquine for Plasmodium vivax Malaria: A Nested Cohort in a Trial of Radical Curative Regimens. PLoS Medicine. 4.
Dombrowski, J. G., Souza, R. M., Curry, J., Hinton, L., Silva, N. R. M., Grignard, L., Gonçalves, L. A., Gomes, A. R., Epiphanio, S., Drakeley, C., Huggett, J., Clark, T. G., Campino, S., & Marinho, C. R. F. (2017). G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon. Malar Journal, 16.
Duarte, E.C., Pang, L., & Fontes, C.J.F. (2003). Validade interna de ensaios terapêuticos em malária: análise de estudos de avaliação da emergência de resistência in vivo do Plasmodium vivax a doses padronizadas de primaquina. Revista da Sociedade Brasileira de Medicina Tropical. 36, 383-386.
Guindo, A. Fairhurst, R. M., Doumbo, O. K., Wellems, T. E., & Diallo, D. A. (2007). deficiency protects hemizygous males but not heterozygous females against severe malaria. PLoS Medicine. 4.
Júnior et al. (2021). TREM1 rs2234237 (Thr25Ser) polymorphism in patientes with cutaneous leishmaniasis caused by Leishmania guyanensis: A case-control study in the State of Amazonas, Brazil. Pathogens, 10(498), 1-11.
Khim, N., Benedet, C., Kim, S., Kheng, S., Siv, S., & Leang, R. (2013). G6PD deficiency in Plasmodium falciparum and Plasmodium vivax malaria-infected Cambodian patients. Malar Journal. 12.
Kotepui, M., Uthaisar, K., Phunphuech, B., & Phiwklam, N. (2016). Prevalence and hematological indicators of G6PD deficiency in malaria-infected patients. Infectious Diseases of Poverty. 5.
Kruatrachue, M., Charoenlarp, P., Chongsuphajaisiddhi, T., & Harinasuta, C. (1962). Erythrocyte glucose-6-phosphate dehydrogenase and malaria in Thailand. Lancet.2, 1183-1186.
Kruatrachue, M., Bhaibulaya, M., Clongkamnaukorn, K., Harinasuta, C. (1966). Re-examination of the relationship of erythrocyte Glucose-6-Phosphate Dehydrogenase and malaria in Thailand. World Health Organization,
Liang, X. Y., Chen, J. T., Ma, Y., Huang, H., Xie, D., Monte- Nguba, S., Ehapo, C. S., Eyi, U. M., Zheng, Y., & Liu, X. (2019). Evidence of positively selected G6PD A- allele reduces risk of Plasmodium falciparum infection in African population on Bioko Island. Molecular Genetics Genomic Medicine.8, 1-11.
Longo, L., Vanegas, O. C., Patel, M., Rosti, V., Li, H., & Waka, J. (2002). Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal. EMBO Journal, 21, 4229-4239.
Manjurano, A., Sepulveda, N., Nadjm, B., Mtove, G., Wangai, H., Maxwell, C., Olomi, R., Reyburn, H., Riley, E. M., Drakeley, C. J. & Clark, T. G. (2017). African glucose-6-phosphate dehydrogenase alleles associated with protection from severe malaria in heterozygous females in Tanzania. PLoS Genet, 11.
Maulén, N. P., & Cifuentes O. L. (2018). Polimorfismos genéticos asociados a la inmunidad innata y la susceptibilidad genética a la tuberculosis. Revista chilena de enfermedades respiratorias, 34(4), 226-235.
Monteiro, W. M., Val, F. F., Siqueira, A. M., Franca, G. P., Sampaio, V. S., & Melo, G. C. (2014). G6PD deficiency in Latin America: systematic review on prevalence and variants. Institute Oswaldo Cruz. 109, 553-568.
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). The PRISMA Group. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Medicine. 6.
Nahrevanian, H. (2006). Immune effector mechanisms of the nitric oxide pathway in malaria: cytotoxicity versus cytoprotection. Revista Brasileira de Doenças Infecciosas. 10, 283-292
Notaro, R., Afolayan, A., & Luzzatto, L. (2000). Human mutations in glucose 6-phosphate dehydrogenase reflect evolutionary history. FASEB Journal, 14,485-494.
Ohanna, C. L. B. (2019). Polimorfismos selecionados por patógenos em genes do metabolismo energético e associação com doenças micobacterianas. Tese de doutorado – Instituto Oswaldo Cruz, Pós-Graduação em Bilogia Celular e Molecular, 223.
Pereira, M. G., & Galvão, T. F. (2014). Heterogeneidade e viés de publicação em revisões sistemáticas. Epidemiologia e Serviços de Saúde. 23, 775–778.
Plewes, K., Soontarawira, I., Ghose, A., Bancone, G., Kingston, H. W., Herdman, M. T., Leopold, S. J., Ishioka, H., Faiz, M., Anstey, N., Day, N., Hossain, M., Imwong, M., Dondorp, A., & Woodrow, C. (2017). Genotypic and phenotypic characterization of G6PD deficiency in bengali adults with severe and uncomplicated malaria. Malar Journal. 16.
Reich, D. E., Reich, D.E., Cargill, M., Cargill, M. & Bolk, S. (2001). Linkage disequilibrium in the human genome. Nature, 411, 199-204.
Rocha, A. P., Magalhães, P. K. R., Maia, A. L., & Maciel, L. M. Z. (2007). Polimorfismos genéticos: implicações na patogênese do carcinoma medular de tireóide. Arquivo brasileiro de endocrinologia e metabologia, 51(5), 723-731.
Ruwende, C., Khoo, S.C., Snow, R. W., Yates, S., Kwiatkowski, D., Gupta, S., Warn P., Allsopp, C., Gilbert, S., Peschu, N., Newbold, C., Greenwood, B., Marsh, K., & Hill, A. (1995). Natural selection of hemy and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria. Nature. 376, 246-249.
Smith, T. G., Ayi, K., Serghides, L., Mcallister, C. D., & Kain, K. C. (2002). Innate immunity to malaria caused by Plasmodium falciparum. Jornal Oficial da Sociedade Canadense de Investigação Clínica. 25, 262-272.
Joanna Briggs Institute. (2020). Critical Appraisal Tools Checklist. https://jbi.global/critical-appraisal-tools
Tishkoff, S. A. & Williams, S. M. (2002). Genetic analysis of African populations: Human evolution and complex disease. Nature Reviews Genetics, 3, 611-621.
Veronesi, R., & Focaccia, R. (1999). Imunologia e imunopatologia da malária. Tratado de infectologia.
World Health Organization (WHO). (2019). World Malaria Report. 232.
Yi, H (2019). The glucose-6-phosphate dehydrogenase Mahidol variant protects against uncomplicated Plasmodium vivax infection and reduces disease severity in a Kachin population from northeast Myanmar. Infection. Genetics and Evolution. 75, 1-7.
Yuthavong, Y., & Wilairat, P. (1993). Protection against malaria by thalassaemia and haemoglobin variants. Parasitol Today. 9, 241–245.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Marcelo Cerilo Santos-Filho; Maria Tairla Viana Gonçalves; Karolayne Silva Souza; Myrela Conceição Santos de Jesus; Luciane Moreno Storti-Melo; Erika dos Santos Nunes; Katia Cilene da Silva Felix
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
