The importance of early diagnosis of Chagas disease congenital
DOI:
https://doi.org/10.33448/rsd-v11i4.27077Keywords:
Chagas disease; Congenital Chagas disease; Vertical transmission.Abstract
Introduction: Chagas disease (CD) or American trypanosomiasis is a neglected and multisystemic anthropozoonosis that can affect the cardiovascular, digestive, and central nervous systems. The congenital transmission of Trypanosoma cruzi is considered one of the main sources of infection of the disease worldwide, this type of infection happens vertically, that is, during pregnancy. The objective of this work is to highlight the importance of early diagnosis of Congenital Chagas disease. Methodology: This is systematic bibliographic research, of a descriptive nature, with a qualitative approach. For the construction of the study, the following databases were used: Scientific Electronic Library Online – SciELO, U.S Library of Medicine – PubMed, and the Virtual Health Library (BVS). Results: The results obtained present the main methods of laboratory diagnosis of congenital Chagas disease, highlighting the high number of women of childbearing age infected by T. cruzi, enabling vertical transmission and its complications. Conclusion: The need to create new strategies to optimize the control and prevention of congenital Chagas disease, in addition to the development of new screening protocols.
References
Alarcón, A., Morgan, M., Montgomery, S. P., Scavo, L., Wong, E. C. C., Hahn, A., & Jantausch, B. (2016). Diagnosis and Treatment of Congenital Chagas Disease in a Premature Infant. Journal of the Pediatric Infectious Diseases Society, 5(4), e28–e31.
Amorín, B., & Pérez, L. (2016). Chagas congénito de segunda generación en Uruguay: Primer caso sintomático descrito en el país. Archivos de Pediatría Del Uruguay, 87(3), 245–252.
Andrade, J. P. de, Marin Neto, J. A., Paola, A. A. V. de, Vilas-Boas, F., Oliveira, G. M. M., Bacal, F., Bocchi, E. A., Almeida, D. R., Fragata Filho, A. A., Moreira, M. da C. V., Xavier, S. S., Oliveira Junior, W. A. de, & Dias, J. C. P. (2011). I Latin American Guidelines for the diagnosis and treatment of Chagas’ heart disease: executive summary. Arquivos Brasileiros de Cardiologia, 96(6), 434–442.
Bardin, L., (2016). Análise de Conteúdo. São Paulo: Edições 70.
Bermudez, J., Davies, C., Simonazzi, A., Pablo Real, J., & Palma, S. (2016). Current drug therapy and pharmaceutical challenges for Chagas disease. Acta Tropica, 156, 1–16.
BRASIL. Ministério da Saúde Secretária de Ciência, Tecnologia e Insumos Estratégicos. Portaria nº57. (2018). http://conitec.gov.br/images/PCDT_Doenca_de_Chagas.pdf
BRASIL. Guia de Vigilância em Saúde. Brasília: Ministério da Saúde Secretaria de Vigilância em Saúde Coordenação-Geral de Desenvolvimento da Epidemiologia em Serviços. (2019). https://bvsms.saude.gov.br/bvs/publicacoes/guia_vigilancia_saude_3ed.pdf
BRASIL. Ministério da Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Protocolo Clínico e Diretrizes terapêuticas da doença de Chagas. (2018). http://conitec.gov.br/images/PCDT_Doenca_de_Chagas.pdf.
BRASIL. Ministério da Saúde. Secretaria de Vigilância em Saúde Coordenação-Geral de Desenvolvimento da Epidemiologia em Serviços. Guia de Vigilância em Saúde. (2017). https://portalarquivos2.saude.gov.br/images/PDF/2017/outubro/16/Volume-Unico-2017.pdf
Bustos, P. L., Milduberger, N., Volta, B. J., Perrone, A. E., Laucella, S. A., & Bua, J. (2019). Trypanosoma cruzi Infection at the Maternal-Fetal Interface: Implications of Parasite Load in the Congenital Transmission and Challenges in the Diagnosis of Infected Newborns. Frontiers in Microbiology, 10, 1250.
Cevallos, A. M., & Hernández, R. (2014). Chagas’ Disease: Pregnancy and Congenital Transmission. BioMed Research International, 2014, 1–10.
Chain, C. Y., Pires Souto, D. E., Sbaraglini, M. L., Labriola, C. A., Daza Millone, M. A., Ramirez, E. A., Cisneros, J. S., Lopez-Albizu, C., Scollo, K., Kubota, L. T., Ruiz, A. M., & Vela, M. E. (2019). Trypanosoma cruziVirulence Factors for the Diagnosis of Chagas’ Disease. ACS Infectious Diseases, 5(11), 1813–1819.
Corrêa, V. R., Barbosa, F. G., Melo Junior, C. A. de, D’Albuquerque e Castro, L. F., Andrade Junior, H. F. de, & Nascimento, N. (2014). Uneventful benznidazole treatment of acute Chagas disease during pregnancy: a case report. Revista Da Sociedade Brasileira de Medicina Tropical, 47(3), 397–400.
Denegri C, M., Oyarce F, A., Larraguibel C, P., Ramírez V, I., Rivas B, E., Arellano P, G., Báez M, A., & Maulén L, N. P. (2020). [Screening and congenital transmission of Chagas Disease in the user population of the Dr. Félix Bulnes Cerda Hospital and Primary Health Care Services of the Metropolitan Health Service West of Santiago, Chile]. Revista Chilena de Infectologia: Organo Oficial de La Sociedad Chilena de Infectologia, 37(2), 129–137.
Echeverría, L. E., Marcus, R., Novick, G., Sosa-Estani, S., Ralston, K., Zaidel, E. J., Forsyth, C., Ribeiro, A. L. P., Mendoza, I., Falconi, M. L., Mitelman, J., Morillo, C. A., Pereiro, A. C., Pinazo, M. J., Salvatella, R., Martinez, F., Perel, P., Liprandi, Á. S., Piñeiro, D. J., & Molina, G. R. (2020). WHF IASC Roadmap on Chagas Disease. Global Heart, 15(1), 26.
Edwards, M. S., Abanyie, F. A., & Montgomery, S. P. (2018). Survey of Pediatric Infectious Diseases Society Members About Congenital Chagas Disease. The Pediatric Infectious Disease Journal, 37(1), e24–e27.
Gebrekristos, H. T., & Buekens, P. (2014). Mother-to-Child Transmission of Trypanosoma cruzi. Journal of the Pediatric Infectious Diseases Society, 3 Suppl 1, S36-40.
Gomes, Y., M., (2017). Diagnóstico laboratorial – situação atual. http://chagas.fiocruz.br/doenca/diagnostico/
Dias, J. C. P., Ramos, A. N. Jr., Gontijo, E. D., Luquetti, A., Shikanai-Yasuda, M. A., Coura, J. R., ... Alves, R. V. II Consenso Brasileiro em Doença de Chagas, 2015. Epidemiol. Serv. Saúde 25. http://scielo.iec.gov.br/scielo.php?script=sci_arttext&pid=S1679-49742016000500007
Sales Junior, P. A., Molina, I., Fonseca Murta, S. M., Sánchez-Montalvá, A., Salvador, F., Corrêa-Oliveira, R., & Carneiro, C. M. (2017). Experimental and Clinical Treatment of Chagas Disease: A Review. The American Journal of Tropical Medicine and Hygiene, 97(5), 1289–1303.
Lima, R. de S., Teixeira, A. B., & Lima, V. L. da S. (2019). Doença de chagas: uma atualização bibliográfica. Rev. Bras. Anal. Clin, 103–106.
Messenger, L. A., & Bern, C. (2018). Congenital Chagas disease. Current Opinion in Infectious Diseases, 31(5), 415–421.
Moscatelli, G., Moroni, S., García-Bournissen, F., Ballering, G., Bisio, M., Freilij, H., & Altcheh, J. (2015). Prevention of congenital Chagas through treatment of girls and women of childbearing age. Memorias Do Instituto Oswaldo Cruz, 110(4), 507–509.
Nobre, T., Fonseca, S., Medeiros, R., Hecht, M., Hagström, L., Fernandes, M. R., & Nitz, N. (2021). Seroprevalence of Trypanosoma cruzi in pregnant women in Midwest Brazil: an evaluation of congenital transmission. Revista Do Instituto de Medicina Tropical de Sao Paulo, 63, e8.
Norman, F. F., & López-Vélez, R. (2014). Mother-to-child transmission of Trypanosoma cruzi infection (Chagas disease): a neglected problem. Transactions of the Royal Society of Tropical Medicine and Hygiene, 108(7), 388–390.
Oliveira, M. G., (2018). Análise espacial e epidemiológica da Doença de Chagas: distribuição e incidência no Brasil. Paraíba, Brasil. [Internet]. http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/8139
Pearson, R. D., (2019). Doença de Chagas (Tripanossomíase americana). https://www.msdmanuals.com/pt/profissional/doen%C3%A7as-infecciosas/protozo%C3%A1rios-extraintestinais/doen%C3%A7a-de-chagas?query=doen%C3%A7a%20de%20chagas
Pérez-Molina, J. A., & Molina, I. (2018). Chagas disease. The Lancet, 391(10115), 82–94.
Rios, L., Campos, E. E., Menon, R., Zago, M. P., & Garg, N. J. (2020). Epidemiology and pathogenesis of maternal-fetal transmission of Trypanosoma cruzi and a case for vaccine development against congenital Chagas disease. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1866(3), 165591.
Romero, L., Arita, I., Martínez, A., & Alas, C. (2019). Enfermedad de Chagas Congénito: Presentación de caso clínico. Acta Pediátrica Hondureña, 10(1), 1006–1010.
Sociedade Brasileira de Medicina Tropical, (2018). Apesar de estar em constante ascensão, Chagas congênita continua negligenciada. [Internet] https://www.sbmt.org.br/portal/despite-being-in-constant-rise-congenital-chagas-disease-is-still-neglected/
Stillwaggon, E., Perez-Zetune, V., Bialek, S. R., & Montgomery, S. P. (2018). Congenital Chagas Disease in the United States: Cost Savings through Maternal Screening. The American Journal of Tropical Medicine and Hygiene, 98(6), 1733–1742.
World Health Organization. Chagas disease (American trypanosomiasis), (2019). https://www.who.int/en/news-room/fact-sheets/detail/chagas-disease-(american-trypanosomiasis)
World Health Organization. Expert Committee on the Control of Chagas Disease (2000: Brasilia, B., & Organization, W. H. (2002). Control of Chagas disease: second report of the WHO expert committee. http://www.who.int/iris/handle/10665/42443.
World Health Organization. Weekly epidemiological record Relevé épidémiologique hebdomadaire (2015). 6, 33–44. https://www.who.int/wer/2015/wer9006.pdf?ua=1
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Tiago Patricio de Almeida Carvalho; Leonardo Mendes Araujo da Silva; Márcio Cerqueira de Almeida; José Eduardo Teles de Andrade
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.