Relationship between pulmonary function, maximum inspiratory pressure, oxygen saturation and exercise capacity in patients with chronic obstructive pulmonary
DOI:
https://doi.org/10.33448/rsd-v11i5.28574Keywords:
COPD; Pulmonary function tests; Respiratory mechanics; Exercise.Abstract
Introduction: Exercise capacity is one of the determining factors in the prognosis of patients with COPD. Assessing exercise capacity and its relationships can contribute to understanding the factors that impact the reduction of physical activity and provide subsidies to mitigate its deleterious effects. Objective: The purpose of this study was to assess the relationship between pulmonary function, respiratory muscle strength, baseline peripheral oxygen saturation and exercise capacity. Methodology: 11 individuals diagnosed with COPD were selected for this study (5 patients in GOLD Stage 3-4; 6 patients in GOLD stage 1-2), of both genders, with a mean age of 70.73±6.19 years. All patients underwent evaluation of the distance covered in the six-minute walk test (6MWD), pulmonary function (FEV1%pred, FVC%pred e %FEV1/FVC), respiratory muscle strength (MIP, MEP) and baseline peripheral oxygen saturation (baseline SpO2). Results: The results showed a positive correlation between baseline SpO2 (p=0.007), FVC%pred (p=0.02) and the 6MWD. Conclusions: The results of this study allow us to infer that there is an association between 6MWD, baseline pulse oxygen saturation, FVC and gender. Thus, this study suggests that the lower oxygenation at rest is correlated with a worsening of lung function and lower tolerance of the individual to physical exercise.
References
Aarli, B. B., Calverley, P. M., Jensen, R. L., Dellaca, R., Eagan, T. M., Bakke, P. S., & Hardie, J. A. (2017). The association of tidal EFL with exercise performance, exacerbations, and death in COPD. International journal of chronic obstructive pulmonary disease, 12, 2179.
Amaral, T. C. N., Dias, A. S., Vilaça, A. F., Guimarães, D. G. G., de Souza Cunha, R. C., Neto, A. H. M., ... & de França, E. É. T. (2020). Evaluation of respiratory muscle strength and endurance, peripheral muscle strength, and functional capacity in patients with COPD. Brazilian Journal of Development, 6(12), 100364-100380.
Bozdemir Ozel, C., Arikan, H., Demirtas, R. N., Saglam, M., Calik-Kutukcu, E., Vardar-Yagli, N., ... & Cakmak, A. (2021). Evaluation of exercise capacity using two field tests in patients with metabolic syndrome. Disability and Rehabilitation, 43(7), 1015-1021
Britto, R. R., Probst, V. S., Andrade, A. F., Samora, G. A., Hernandes, N. A., Marinho, P. E., ... & Parreira, V. F. (2013). Reference equations for the six-minute walk distance based on a Brazilian multicenter study. Brazilian journal of physical therapy, 17, 556-563.
Casaburi R. Skeletal muscle function in COPD. Chest. 2000;117(5 Suppl 1):267S–271S.
Casanova, C., Cote, C., Marin, J. M., Pinto-Plata, V., de Torres, J. P., Aguirre-Jaime, A., ... & Celli, B. R. (2008). Distance and oxygen desaturation during the 6-min walk test as predictors of long-term mortality in patients with COPD. Chest, 134(4), 746-752.
Celli, B., Tetzlaff, K., Criner, G., Polkey, M. I., Sciurba, F., Casaburi, R., ... & Rennard, S. (2016). The 6-minute-walk distance test as a chronic obstructive pulmonary disease stratification tool. Insights from the COPD Biomarker Qualification Consortium. American journal of respiratory and critical care medicine, 194(12), 1483-1493.
Charususin, N., Gosselink, R., Decramer, M., Demeyer, H., McConnell, A., Saey, D., ... & Langer, D. (2018). Randomised controlled trial of adjunctive inspiratory muscle training for patients with COPD. Thorax, 73(10), 942-950.
Cruthirds, C. L., Van der Meij, B. S., Wierzchowska-McNew, A., Deutz, N. E., & Engelen, M. P. (2021). Presence or absence of skeletal muscle dysfunction in chronic obstructive pulmonary disease is associated with distinct phenotypes. Archivos de Bronconeumologia, 57(4), 264-272.
de Souza, Y., Suzana, M. E., Medeiros, S., Macedo, J., & da Costa, C. H. (2022). Respiratory muscle weakness and its association with exercise capacity in patients with chronic obstructive pulmonary disease. The Clinical Respiratory Journal, 16(2), 162-166.
Enright, P. L., & Sherrill, D. L. (1998). Reference equations for the six-minute walk in healthy adults. American journal of respiratory and critical care medicine, 158(5), 1384-1387.
Garcia-Aymerich, J., Lange, P., Benet, M., Schnohr, P., & Antó, J. M. (2006). Regular physical activity reduces hospital admission and mortality in chronic obstructive pulmonary disease: a population based cohort study. Thorax, 61(9), 772-778.
Giua, R., Pedone, C., Scarlata, S., Carrozzo, I., Rossi, F. F., Valiani, V., & Incalzi, R. A. (2014). Relationship between respiratory muscle strength and physical performance in elderly hospitalized patients. Rejuvenation research, 17(4), 366-371.
Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease: 2021 report (Online). https://goldcopd.org. [2021 Feb 25].
Gosselink, R. I. K., Troosters, T., & Decramer, M. (1996). Peripheral muscle weakness contributes to exercise limitation in COPD. American journal of respiratory and critical care medicine, 153(3), 976-980.
Holland, A. E., Spruit, M. A., Troosters, T., Puhan, M. A., Pepin, V., Saey, D., ... & Singh, S. J. (2014). An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease. European Respiratory Journal, 44(6), 1428-1446.
Hulya, S., Ilknur, N., & Gulru, P. (2020). Effect of exercise capacity on perception of dyspnea, psychological symptoms and quality of life in patients with chronic obstructive pulmonary disease. Heart & Lung, 49(6), 753-757.
Kim, H. C., Mofarrahi, M., & Hussain, S. N. (2008). Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease. International journal of chronic obstructive pulmonary disease, 3(4), 637.
Klein, S. R., Gulart, A. A., Venâncio, R. S., Munari, A. B., Gavenda, S. G., Martins, A. C. B., & Mayer, A. F. (2021). Performance difference on the six-minute walk test on tracks of 20 and 30 meters for patients with chronic obstructive pulmonary disease: validity and reliability. Brazilian Journal of Physical Therapy, 25(1), 40-47.
Kofod, L. M., Hage, T., Christiansen, L. H., Skalkam, K., Martinez, G., Godtfredsen, N. S., & Molsted, S. (2020). Inspiratory muscle strength and walking capacity in patients with COPD. European clinical respiratory journal, 7(1), 1700086.
Kyomoto, Y., Asai, K., Yamada, K., Okamoto, A., Watanabe, T., Hirata, K., & Kawaguchi, T. (2019). Handgrip strength measurement in patients with chronic obstructive pulmonary disease: Possible predictor of exercise capacity. Respiratory investigation, 57(5), 499-505.
Laveneziana, P., Albuquerque, A., Aliverti, A., Babb, T., Barreiro, E., Dres, M., ... & Verges, S. (2019). ERS statement on respiratory muscle testing at rest and during exercise. European Respiratory Journal, 53(6).
Li, N., Li, P., Lu, Y., Wang, Z., Li, J., Liu, X., & Wu, W. (2020). Effects of resistance training on exercise capacity in elderly patients with chronic obstructive pulmonary disease: A meta-analysis and systematic review. Aging Clinical and Experimental Research, 32(10), 1911-1922.
Loiseau A, Dubreuil C, Loiseau P, Puiet JC, Georges R, Saumon G. Exercise tolerance in chronic pulmonary disease; importance of active and passive components of the ventilatory system. Eur Respir J 1989;2:522-7.
Mansour, K. M. K., Goulart, C. D. L., Carvalho-Junior, L. C. S. D., Trimer, R., Borghi-Silva, A., & Silva, A. L. G. D. (2019). Pulmonary function and functional capacity cut-off point to establish sarcopenia and dynapenia in patients with COPD. Jornal Brasileiro de Pneumologia, 45.
Neder, J. A., Andreoni, S., Lerario, M. C., & Nery, L. E. (1999). Reference values for lung function tests: II. Maximal respiratory pressures and voluntary ventilation. Brazilian journal of medical and biological research, 32(6), 719-727.
Perez, T., Deslée, G., Burgel, P. R., Caillaud, D., Le Rouzic, O., Zysman, M., ... & Initiatives BPCO Scientific Committee. (2019). Predictors in routine practice of 6-min walking distance and oxygen desaturation in patients with COPD: impact of comorbidities. International journal of chronic obstructive pulmonary disease, 14, 1399.
Singh, S. J., Puhan, M. A., Andrianopoulos, V., Hernandes, N. A., Mitchell, K. E., Hill, C. J., ... & Holland, A. E. (2014). An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease. European Respiratory Journal, 44(6), 1447-1478.
Souza, R. B., & Sociedade Brasileira de Pneumologia e Tisiologia. (2002). Diretrizes para testes de função pulmonar. J Pneumol, 28(3), 155-65.
Vaes, A. W., Sillen, M. J., Goertz, Y. M., Machado, F. V. C., Van Herck, M., Burtin, C., ... & Spruit, M. A. (2021). The correlation between quadriceps muscle strength and endurance and exercise performance in patients with COPD. Journal of Applied Physiology, 131(2), 589-600.
Vinod K, Prashanth K, Rao KNM, Chandran RR, Thirthashree K. Study to assess exercise capacity in patients with copd on pulmonary rehabilitation through six minute walk test. Indian J Immunol Respir Med. 2019;4(3):181-4.
Watz, H., Pitta, F., Rochester, C. L., Garcia-Aymerich, J., ZuWallack, R., Troosters, T., ... & Spruit, M. A. (2014). An official European Respiratory Society statement on physical activity in COPD.
Wijkstra, P. J., TenVergert, E. M., Van Der Mark, T., Postma, D. S., Van Altena, R., Kraan, J., & Koëter, G. H. (1994). Relation of lung function, maximal inspiratory pressure, dyspnoea, and quality of life with exercise capacity in patients with chronic obstructive pulmonary disease. Thorax, 49(5), 468-472. 1994;49:468-472.
Zeng, Y., Jiang, F., Chen, Y., Chen, P., & Cai, S. (2018). Exercise assessments and trainings of pulmonary rehabilitation in COPD: a literature review. International journal of chronic obstructive pulmonary disease, 13, 2013.
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