Celiac disease and its oral manifestations: a literature review
Keywords:Celiac disease; Dental abnormalities; Dental enamel; Oral manifestations.
Aim: The present study aims to highlight the current understanding and literature evidence about the oral presentations of celiac disease. Methodology: The search was conducted in PubMed/MedLine and gray literature (Scholar Google) databases in September 2021. Medical Subject Headings (MeSH - Pubmed) was used to define the descriptors, in English and Portuguese, and the search strategy retrieved only studies with human beings. The descriptors applied were: "celiac disease", "dental abnormalities", "enamel defects", and "oral manifestations". Articles published in the last ten years were screened. Results: A total of 23 articles were found, of which 14 were chosen for the review. The study had a sample composed of 2323 patients. Conclusion: Recognition of the oral manifestations of celiac disease plays a key role in the early diagnosis of this condition. This study highlighted a significant association between enamel development defects, aphthous stomatitis and xerostomia as signs suggestive of celiac disease manifestation.
Acar, S., Yetkıner, A. A., Ersın, N., Oncag, O., Aydogdu, S., & Arıkan, C. (2012). Oral findings and salivary parameters in children with celiac disease: a preliminary study. Medical Principles and Practice, 21(2), 129-133.
Ahmed, A., Singh, A., Kajal, S., Chauhan, A., Rajput, M. S., Banyal, V., ... & Makharia, G. K. (2021). Dental enamel defects and oral cavity manifestations in Asian patients with celiac disease. Indian Journal of Gastroenterology, 40(4), 402-409.
Aine, L. (1986). Dental enamel defects and dental maturity in children and adolescents with coeliac disease. Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia, 82, 1-71.
Aine, L., Mäki, M., Collin, P., & Keyriläinen, O. (1990). Dental enamel defects in celiac disease. Journal of Oral Pathology & Medicine, 19(6), 241-245.
Amir, R. M., Abdelwahab, M., & Abdelaziz, A. (2021). Systematic Review: The Impact of Coeliac Disease On the Oral Cavity. Educational Research (IJMCER), 3(3), 268-272.
Cantekin, K., Arslan, D., & Delikan, E. (2015). Presence and distribution of dental enamel defects, recurrent aphthous lesions and dental caries in children with celiac disease. Pakistan journal of medical sciences, 31(3), 606.
Cervino, G., Fiorillo, L., Laino, L., Herford, A. S., Lauritano, F., Giudice, G. L., ... & Cicciù, M. (2018). Oral health impact profile in celiac patients: analysis of recent findings in a literature review. Gastroenterology Research and Practice, 2018.
Cruz, I. T., Fraiz, F. C., Celli, A., Amenabar, J. M., & Assunção, L. R. (2018). Dental and oral manifestations of celiac disease. Medicina oral, patologia oral y cirugia bucal, 23(6), e639–e645. https://doi.org/10.4317/medoral.22506.
Dababneh, R. H., & Hijazeen, R. (2014). Periodontal treatment needs and oral ulceration in children and adolescents with celiac disease. Journal of Advances in Medicine and Medical Research, 1772-1782.
de Carvalho, F. K., de Queiroz, A. M., da Silva, R. A. B., Sawamura, R., Bachmann, L., da Silva, L. A. B., & Nelson-Filho, P. (2015). Oral aspects in celiac disease children: clinical and dental enamel chemical evaluation. Oral surgery, oral medicine, oral pathology and oral radiology, 119(6), 636-643.
de Queiroz, A. M., Arid, J., de Carvalho, F. K., da Silva, R. A. B., Küchler, E. C., Sawamura, R., ... & Nelson‐Filho, P. (2017). Assessing the proposed association between DED and gluten‐free diet introduction in celiac children. Special Care in Dentistry, 37(4), 194-198.
Ertekin, V., SÜMBÜLLÜ, M. A., Tosun, M. S., SELİMOĞLU, M. A., Kara, M., & Kilic, N. (2012). Oral findings in children with celiac disease. Turkish Journal of Medical Sciences, 42(4), 613-617.
Hall, S. W., Shaoul, R., & Day, A. S. (2020). The Contribution of Non-Food-Based Exposure to Gluten on the Management of Coeliac Disease. Gastrointestinal Disorders, 2(2), 140-143.
Jajam, M., Bozzolo, P., & Niklander, S. (2017). Oral manifestations of gastrointestinal disorders. Journal of clinical and experimental dentistry, 9(10), e1242.
Kreutz, J. M., Adriaanse, M., van der Ploeg, E., & Vreugdenhil, A. (2020). Narrative Review: Nutrient Deficiencies in Adults and Children with Treated and Untreated Celiac Disease. Nutrients, 12(2), 500. https://doi.org/10.3390/nu12020500
Lebwohl, B., & Rubio-Tapia, A. (2021). Epidemiology, presentation, and diagnosis of celiac disease. Gastroenterology, 160(1), 63-75.
Lebwohl, B., Sanders, D. S., & Green, P. H. (2018). Coeliac disease. The Lancet, 391(10115), 70-81.
Macho, V. M. P., Coelho, A. S., e Silva, D. M. V., & de Andrade, D. J. C. (2017). Oral manifestations in pediatric patients with coeliac disease–a review article. The open dentistry journal, 11, 539.
Macho, V. M. P., de Barros Menéres, M. C. A., e Silva, D. M. V., & de Andrade, D. J. C. (2020). The difference in symmetry of the enamel defects in celiac disease versus non-celiac pediatric population. Journal of Dental Sciences, 15(3), 345-350.
Nieri, M., Tofani, E., Defraia, E., Giuntini, V., & Franchi, L. (2017). Enamel defects and aphthous stomatitis in celiac and healthy subjects: Systematic review and meta-analysis of controlled studies. Journal of dentistry, 65, 1-10.
Nota, A., Abati, S., Bosco, F., Rota, I., Polizzi, E., & Tecco, S. (2020). General Health, Systemic Diseases and Oral Status in Adult Patients with Coeliac Disease. Nutrients, 12(12), 3836. https://doi.org/10.3390/nu12123836.
Petronijevic, S., Stig, S., & Halstensen, T. S. (2021). Epitope mapping of anti‐amelogenin IgG in untreated celiac children. European Journal of Oral Sciences, 129(2), e12770.
Rashid, M., Zarkadas, M., Anca, A., & Limeback, H. (2011). Oral manifestations of celiac disease: a clinical guide for dentists. J Can Dent Assoc, 77(b39), 1-6.
Rauen, M. S., Back, J. C. D. V., & Moreira, E. A. M. (2005). Doença celíaca: sua relação com a saúde bucal. Revista de Nutrição, 18(2), 271-276.
Riznik, P., De Leo, L., Dolinsek, J., Gyimesi, J., Klemenak, M., Koletzko, B., ... & Dolinsek, J. (2021). The knowledge about celiac disease among healthcare professionals and patients in Central Europe. Journal of Pediatric Gastroenterology and Nutrition, 72(4), 552-557.
Rondanelli, M., Faliva, M. A., Gasparri, C., Peroni, G., Naso, M., Picciotto, G., Riva, A., Nichetti, M., Infantino, V., Alalwan, T. A., & Perna, S. (2019). Micronutrients Dietary Supplementation Advices for Celiac Patients on Long-Term Gluten-Free Diet with Good Compliance: A Review. Medicina (Kaunas, Lithuania), 55(7), 337. https://doi.org/10.3390/medicina55070337.
Shahraki, T., Omrani Mehr, S., Hill, I. D., & Shahraki, M. (2019). A Comparison of the Prevalence of Dental Enamel Defects and Other Oral Findings in Children with and without Celiac Disease. Iranian Journal of Pediatrics, 29(1).
Shteyer, E., Berson, T., Lachmanovitz, O., Hidas, A., Wilschanski, M., Menachem, M., ... & Moskovitz, M. (2013). Oral health status and salivary properties in relation to gluten-free diet in children with celiac disease. Journal of pediatric gastroenterology and nutrition, 57(1), 49-52.
Souto-Souza, D., da Consolação Soares, M. E., Rezende, V. S., de Lacerda Dantas, P. C., Galvão, E. L., & Falci, S. G. M. (2018). Association between developmental defects of enamel and celiac disease: a meta-analysis. Archives of oral biology, 87, 180-190.
Sóñora, C., Arbildi, P., Rodríguez‐Camejo, C., Beovide, V., Marco, A., & Hernández, A. (2016). Enamel organ proteins as targets for antibodies in celiac disease: implications for oral health. European journal of oral sciences, 124(1), 11-16.
Therrien, A., Kelly, C. P., & Silvester, J. A. (2020). Celiac disease: extraintestinal manifestations and associated conditions. Journal of clinical gastroenterology, 54(1), 8.
Tye-Din, J. A., Galipeau, H. J., & Agardh, D. (2018). Celiac disease: a review of current concepts in pathogenesis, prevention, and novel therapies. Frontiers in pediatrics, 6, 350.
van Gils, T., Bouma, G., Bontkes, H. J., Mulder, C. J., & Brand, H. S. (2017). Self-reported oral health and xerostomia in adult patients with celiac disease versus a comparison group. Oral surgery, oral medicine, oral pathology and oral radiology, 124(2), 152-156.
Zoumpoulakis , M. (2017). Oral Manifestations in Celiac Disease Patients (thesis). Aristotle University Of Thessaloniki, Thessaloniki.
Zoumpoulakis, M., Fotoulaki, M., Topitsoglou, V., Lazidou, P., Zouloumis, L., & Kotsanos, N. (2019). Prevalence of dental enamel defects, aphthous-like ulcers and other oral manifestations in celiac children and adolescents: a comparative study. Journal of Clinical Pediatric Dentistry, 43(4), 274-280.
How to Cite
Copyright (c) 2022 Luiz Gustavo de Sousa Duda Júnior; Marília Fernanda de Andrade Silva Correia; Letícia Andréa da Silva; Gabriella Pirro Lacerda; Maysa Swellen Valentim de Oliveira; Verônica Maria de Sá Rodrigues
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.