Persea americana study in the control of Diabetes mellitus: systematic review




Diabetes mellitus; Persea; Hypoglycemia.


Background: Diabetes mellitus (DM) is a prevalent disease that represents one of the great challenges for public health. The use of medicinal plants has been used in the control of diabetes such as Persea americana. Thus, this work aims to collect scientific knowledge about the plant species P. americana in the control of DM through a systematic review. Methods: This is a systematic review of in vivo and in vitro studies, according to the recommendations of the PRISMA protocol, in the following steps: 1) elaboration of the guiding question occurred from the acronym PICO (P - Population and/or Problem, I - Intervention, C - Comparison and O - Outcome/outcomes) with definition of descriptors; 2) sampling (selection of articles) following inclusion/exclusion criteria; 3) search for articles in Scopus, PubMed/MEDLINE and VHL (BIREME) databases; 4) sampling (selection of articles); 5) definition of the information to be extracted from the reviewed works; 6) synthesis of knowledge evidenced in the analyzed articles. Results: Of the 12 articles selected, eight were experimental in vivo studies and 4 were experimental in vitro studies. Diabetic animal models such as Goto-Kakizaki rats and models induced with streptozocin and alloxan were used. The studies showed a reduction in glycemia with the use of P. americana extracts through different pathophysiological pathways. Conclusion: P. americana can contribute to the reduction of DM control and may be a precursor of new substances with pharmacological activity and defined as a great potential for transforming a future antidiabetic drug.


Adeyemi, O. O., Okpo, S. O., & Ogunti, O. O. (2002). Analgesic and anti-inflammatory effects of the aqueous extract of leaves of Persea americana Mill (Lauraceae). Fitoterapia, 73(5), 375–380.

Ajani, A., & Olanrewaju, B. O. (2014). Avocado pear fruits and leaves aqueous extracts inhibit α-amylase, α-glucosidase and snp induced lipid peroxidation–an insight into mechanisms involve in management of type 2 diabetes. Int J Appl Nat Sci, 3, 21–34.

Antia, B. S., Okokon, J. E., & Okon, P. A. (2005). Hypoglycemic activity of aqueous leaf extract of Persea americana Mill. Indian Journal of Pharmacology, 37(5), 325.

Association, A. D. (2019). 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2020. Diabetes Care, 43(Supplement_1), S14–S31.

Baer, D. J., Judd, J. T., Clevidence, B. A., & Tracy, R. P. (2004). Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: a randomized crossover study. The American Journal of Clinical Nutrition, 79(6), 969–973.

Brai, B. I. C., Adisa, R. A., & Odetola, A. A. (2014). Hepatoprotective properties of aqueous leaf extract of Persea Americana, Mill (Lauraceae)‘avocado’against CCL4-induced damage in rats. African Journal of Traditional, Complementary and Alternative Medicines, 11(2), 237–244.

Brai, B. I. C., Odetola, A. A., & Agomo, P. U. (2007). Hypoglycemic and hypocholesterolemic potential of Persea americana leaf extracts. Journal of Medicinal Food, 10(2), 356–360.

Carvajal-Zarrabal, O., Nolasco-Hipolito, C., Aguilar-Uscanga, M., Melo Santiesteban, G., Hayward-Jones, P. M., & Barradas-Dermitz, D. M. (2014). Effect of dietary intake of avocado oil and olive oil on biochemical markers of liver function in sucrose-fed rats. BioMed Research International, 2014.

Dabas, D., M Shegog, R., R Ziegler, G., & D Lambert, J. (2013). Avocado (Persea americana) seed as a source of bioactive phytochemicals. Current Pharmaceutical Design, 19(34), 6133–6140.

Danaei, G., Finucane, M. M., Lu, Y., Singh, G. M., Cowan, M. J., Paciorek, C. J., Lin, J. K., Farzadfar, F., Khang, Y.-H., Stevens, G. A., Rao, M., Ali, M. K., Riley, L. M., Robinson, C. A., & Ezzati, M. (2011). National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants. The Lancet, 378(9785), 31–40.

del Toro-Equihua, M., Velasco-Rodríguez, R., López-Ascencio, R., & Vásquez, C. (2016). Effect of an avocado oil-enhanced diet (Persea americana) on sucrose-induced insulin resistance in Wistar rats. Journal of Food and Drug Analysis, 24(2), 350–357.

Dreher, M. L., & Davenport, A. J. (2013). Hass Avocado Composition and Potential Health Effects. Critical Reviews in Food Science and Nutrition, 53(7), 738–750.

Dzeufiet, P. D. D., Mogueo, A., Bilanda, D. C., Aboubakar, B.-F. O., Tédong, L., Dimo, T., & Kamtchouing, P. (2014). Antihypertensive potential of the aqueous extract which combine leaf of Persea americana Mill.(Lauraceae), stems and leaf of Cymbopogon citratus (DC) Stapf.(Poaceae), fruits of Citrus medical L.(Rutaceae) as well as honey in ethanol and sucrose experimental model. BMC Complementary and Alternative Medicine, 14(1), 1–12.

Elya, B., Handayani, R., Sauriasari, R., Hasyyati, U. S., Permana, I. T., & Permatasari, Y. I. (2015). Antidiabetic activity and phytochemical screening of extracts from Indonesian plants by inhibition of alpha amylase, alpha glucosidase and dipeptidyl peptidase IV. Pakistan Journal of Biological Sciences, 18(6), 279.

Ezejiofor, A. N., Okorie, A., & Orisakwe, O. E. (2013). Hypoglycaemic and tissue-protective effects of the aqueous extract of Persea americana seeds on alloxan-induced albino rats. The Malaysian Journal of Medical Sciences: MJMS, 20(5), 31.

Furman, B. L. (2021). Streptozotocin‐induced diabetic models in mice and rats. Current Protocols, 1(4), e78.

Gallagher, A. M., Flatt, P. R., Duffy, G., & Abdel-Wahab, Y. H. A. (2003). The effects of traditional antidiabetic plants on in vitro glucose diffusion. Nutrition Research, 23(3), 413–424.

Galvão, T. F., Pansani, T. de S. A., & Harrad, D. (2015). Principais itens para relatar Revisões sistemáticas e Meta-análises: A recomendação PRISMA. Epidemiologia e Serviços de Saúde, 24, 335–342.

Guest, P. C. (2019). Characterization of the Goto-Kakizaki (GK) rat model of type 2 diabetes. In Pre-Clinical Models (pp. 203–211). Springer.

Health, N. I. of. (2014). National Heart, Lung and Blood Institute. Quality assessment tool for before-after (pre-post) studies with no control group. Health-Pro. Guidelines. Cohort. Bethesda, MD: National Institutes of Health.

Kouamé, N. M., Koffi, C., N’Zoué, K. S., Yao, N., Doukouré, B., & Kamagaté, M. (2019). Comparative antidiabetic activity of aqueous, ethanol, and methanol leaf extracts of Persea americana and their effectiveness in type 2 diabetic rats. Evidence-Based Complementary and Alternative Medicine, 2019.

Lacerda, L. G., da Silva Carvalho Filho, M. A., Bauab, T., Demiate, I. M., Colman, T. A. D., Andrade, M. M. P., & Schnitzler, E. (2015). The effects of heat-moisture treatment on avocado starch granules. Journal of Thermal Analysis and Calorimetry, 120(1), 387–393.

LaMoia, T. E., & Shulman, G. I. (2021). Cellular and Molecular Mechanisms of Metformin Action. Endocrine Reviews, 42(1), 77–96.

Lee, J., Koo, N., & Min, D. B. (2004). Reactive oxygen species, aging, and antioxidative nutraceuticals. Comprehensive Reviews in Food Science and Food Safety, 3(1), 21–33.

Lima, C. R., Vasconcelos, C. F. B., Costa-Silva, J. H., Maranhão, C. A., Costa, J., Batista, T. M., Carneiro, E. M., Soares, L. A. L., Ferreira, F., & Wanderley, A. G. (2012). Anti-diabetic activity of extract from Persea americana Mill. leaf via the activation of protein kinase B (PKB/Akt) in streptozotocin-induced diabetic rats. Journal of Ethnopharmacology, 141(1), 517–525.

Macdonald Ighodaro, O., Mohammed Adeosun, A., & Adeboye Akinloye, O. (2017). Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies. Medicina, 53(6), 365–374.

Marrero-Faz, E., Sanchez-Calero, J., Young, L., & Harvey, A. (2014). Inhibitory effect of Persea americana Mill leaf aqueous extract and its fractions on PTP1B as therapeutic target for type 2 diabetes. Boletín Latinoamericano y Del Caribe de Plantas Medicinales y Aromáticas, 13(2), 144–151.

Mata, R., Cristians, S., Escandon-Rivera, S., Juarez-Reyes, K., & Rivero-Cruz, I. (2013). Mexican antidiabetic herbs: valuable sources of inhibitors of α-glucosidases. Journal of Natural Products, 76(3), 468–483.

Moini, J. (2019). Epidemiology of diabetes. Elsevier.

Musabayane, C. T., Moodley, K., Gondwe, M. M., Kamadyaapa, D. R., & Ojewole, J. A. O. (2007). Cardiovascular effects of Persea americana Mill (Lauraceae) (avocado) aqueous leaf extract in experimental animals: cardiovascular topic. Cardiovascular Journal of South Africa, 18(2), 69–76.

Nagaraj, M., Sandhya, V., Supriya, G., Manju, R., Pranitha, K., Shivaji, B., Lalitha, V., & Kiran, B. (2010). Antioxidant and antibacterial activity of avocado (Persea gratissima Gaertner.) seed extract. World Applied Sciences Journal, 9(6), 695–698.

Njateng, G. S. S., Zaib, S., Chimi, L. Y., Feudjio, C., Mouokeu, R. S., Gatsing, D., Kuiate, J.-R., Adewole, E., & Iqbal, J. (2018). Antidiabetic potential of methanol extracts from leaves of Piper umbellatum L. and Persea americana Mill. Asian Pacific Journal of Tropical Biomedicine, 8(3), 160.

Oboh, G., Temitope Isaac, A., Jacobson Akinyemi, A., & Ajani, R. A. (2014). Inhibition of Key Enzymes Linked to Type 2 Diabetes and Sodium Nitroprusside Induced Lipid Peroxidation in Rats’ Pancreas by Phenolic Extracts of Avocado Pear Leaves and Fruit Anti-diAbetic potentiAl of Persea americana. Int J Biomed Sci Www.Ijbs.Org 208 InternatIonal Journal of BIomedIcal ScIence Int J Biomed Sci, 10(3).

Ortiz-Avila, O., Figueroa-García, M. del C., García-Berumen, C. I., Calderón-Cortés, E., Mejía-Barajas, J. A., Rodriguez-Orozco, A. R., Mejía-Zepeda, R., Saavedra-Molina, A., & Cortés-Rojo, C. (2017). Avocado oil induces long-term alleviation of oxidative damage in kidney mitochondria from type 2 diabetic rats by improving glutathione status. Journal of Bioenergetics and Biomembranes, 49(2), 205–214.

Ortiz-Avila, O., Gallegos-Corona, M. A., Sánchez-Briones, L. A., Calderón-Cortés, E., Montoya-Pérez, R., Rodriguez-Orozco, A. R., Campos-García, J., Saavedra-Molina, A., Mejía-Zepeda, R., & Cortés-Rojo, C. (2015). Protective effects of dietary avocado oil on impaired electron transport chain function and exacerbated oxidative stress in liver mitochondria from diabetic rats. Journal of Bioenergetics and Biomembranes, 47(4), 337–353.

Ortiz-Avila, O., Sámano-García, C. A., Calderón-Cortés, E., Pérez-Hernández, I. H., Mejía-Zepeda, R., Rodríguez-Orozco, A. R., Saavedra-Molina, A., & Cortés-Rojo, C. (2013). Dietary avocado oil supplementation attenuates the alterations induced by type I diabetes and oxidative stress in electron transfer at the complex II-complex III segment of the electron transport chain in rat kidney mitochondria. Journal of Bioenergetics and Biomembranes, 45(3), 271–287.

Padilla-Camberos, E., Martínez-Velázquez, M., Flores-Fernández, J. M., & Villanueva-Rodríguez, S. (2013). Acute toxicity and genotoxic activity of avocado seed extract (Persea americana Mill., cv Hass). The Scientific World Journal, 2013.

Rao, U. S. M., & Adinew, B. (2011). Remnant B-cell-stimulative and anti-oxidant effects of Persea americana fruit extract studied in rats introduced into streptzotocin-induced hyperglycaemic state. African Journal of Traditional, Complementary and Alternative Medicines, 8(3).

Rocca, A. S., LaGreca, J., Kalitsky, J., & Brubaker, P. L. (2001). Monounsaturated fatty acid diets improve glycemic tolerance through increased secretion of glucagon-like peptide-1. Endocrinology, 142(3), 1148–1155.

Salgado, J. M., Danieli, F., Regitano-D’arce, M. A. B., Frias, A., & Mansi, D. N. (2008). O óleo de abacate (Persea americana Mill) como matéria-prima para a indústria alimentícia. Ciência e Tecnologia de Alimentos, 28, 20–26.

Santos, C. M. da C., Pimenta, C. A. de M., & Nobre, M. R. C. (2007). The PICO strategy for the research question construction and evidence search. Revista Latino-Americana de Enfermagem, 15(3), 508–511.

Santos, W. M. dos, Secoli, S. R., & Püschel, V. A. de A. (2018). The Joanna Briggs Institute approach for systematic reviews. Revista Latino-Americana de Enfermagem, 26.

Serafini, M., Peluso, I., & Raguzzini, A. (2010). Flavonoids as anti-inflammatory agents. Proceedings of the Nutrition Society, 69(3), 273–278.

Stokes, A., & Preston, S. H. (2017). Deaths Attributable to Diabetes in the United States: Comparison of Data Sources and Estimation Approaches. PLOS ONE, 12(1), e0170219-.

Stoner, L., Lucero, A. A., Palmer, B. R., Jones, L. M., Young, J. M., & Faulkner, J. (2013). Inflammatory biomarkers for predicting cardiovascular disease. Clinical Biochemistry, 46(15), 1353–1371.

Sun, H., Saeedi, P., Karuranga, S., Pinkepank, M., Ogurtsova, K., Duncan, B. B., Stein, C., Basit, A., Chan, J. C. N., & Mbanya, J. C. (2022). IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Research and Clinical Practice, 183, 109119.

Tabeshpour, J., Razavi, B. M., & Hosseinzadeh, H. (2017). Effects of avocado (Persea americana) on metabolic syndrome: A comprehensive systematic review. Phytotherapy Research, 31(6), 819–837.

Tahrani, A. A., Barnett, A. H., & Bailey, C. J. (2016). Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus. Nature Reviews Endocrinology, 12(10), 566–592.

Tirosh, A., Potashnik, R., Bashan, N., & Rudich, A. (1999). Oxidative Stress Disrupts Insulin-induced Cellular Redistribution of Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes: a putative cellular mechanism for impaired protein kinase b activation and glut4 translocation*. Journal of Biological Chemistry, 274(15), 10595–10602.

Wang, M., Zheng, Y., Khuong, T., & Lovatt, C. J. (2012). Effect of harvest date on the nutritional quality and antioxidant capacity in ‘Hass’ avocado during storage. Food Chemistry, 135(2), 694–698.



How to Cite

SILVA, V. B. .; OLIVEIRA NETO, C. P. de .; BRAGANÇA, M. L. B. M. .; LIMA, S. S. B. .; FERNANDES, D. R. .; MOREIRA, M. A. P. .; MARTINS, S.; CARTÁGENES, M. do S. de S. .; FARIA, M. dos S. .; LOPES, F. F. . Persea americana study in the control of Diabetes mellitus: systematic review. Research, Society and Development, [S. l.], v. 11, n. 6, p. e24811629068, 2022. DOI: 10.33448/rsd-v11i6.29068. Disponível em: Acesso em: 29 may. 2022.



Review Article