Epidemiological profile and environmental risk factors associated with Motor Neuron Disease in a referral hospital in Belém-PA-Brazil

Authors

DOI:

https://doi.org/10.33448/rsd-v11i7.29285

Keywords:

Motor Neuron Disease; Amyotrophic Lateral Sclerosis; Amazon; Mercury; Risk Factors; Epidemiology.

Abstract

Since the discovery of Amyotrophic Lateral Sclerosis (ALS) there has been a wide search in the world for genetic and environmental elements that may cause it. With the majority of sporadic cases, it draws attention to possible environmental causes for the development and progression of the disease. Several studies on the epidemiological profile and potential risk factors for this disease were carried out in different regions of the world, but there are few data in Latin America and the Amazon, and in view of this need for investigation, this study was developed. To this end, a sample of 31 patients and 29 controls who attended consultations at the Outpatient Clinic of the Neurology Service of Hospital Ophir Pinto de Loyola (HOL) was obtained, and data were collected through questionnaires and notes in medical records. Subsequently, the epidemiological profile of these patients was evaluated, comparing risk factors between patients and controls. As a result, it was found that the patients have a profile similar to the literature, but with a longer average time to diagnosis and an age range of earlier onset of symptoms than usual. There was no statistical significance for exposure to risk factors between cases and controls. It is suggested the need for future prospective studies directed to each risk factor.

References

Al-Chalabi, A., & Hardiman, O. (2013). The epidemiology of ALS: A conspiracy of genes, environment and time. Nature Reviews Neurology, 9(11), 617–628. https://doi.org/10.1038/nrneurol.2013.203

Alonso, A., Logroscino, G., Jick, S. S., & Hernán, M. A. (2009). Incidence and lifetime risk of motor neuron disease in the United Kingdom: A population-based study. European Journal of Neurology, 16(6), 745–751. https://doi.org/10.1111/j.1468-1331.2009.02586.x

Blecher, R., Elliott, M. A., Yilmaz, E., Dettori, J. R., Oskouian, R. J., Patel, A., Clarke, A., Hutton, M., McGuire, R., Dunn, R., DeVine, J., Twaddle, B., & Chapman, J. R. (2019). Contact Sports as a Risk Factor for Amyotrophic Lateral Sclerosis: A Systematic Review. Global Spine Journal, 9(1), 104–118. https://doi.org/10.1177/2192568218813916

Bozzoni, V., & Ceroni, M. (2011). Amyotrophic lateral sclerosis and environmental. 7–19.

Brown, R. H., Phil, D. ., Al-Chalabi, A., & Dip.Stat, F. R. C. P. (2017). Amyotrophic Lateral Sclerosis. N Engl J Med, 377(1), 162–172. https://doi.org/10.1016/B978-0-12-385157-4.00608-4

Carvalho, M. D. E., & Swash, M. (2009). Awaji diagnostic algorithm increases sensitivity of El Escorial criteria for ALS diagnosis. Amyotrophic Lateral Sclerosis, August 2008, 53–57. https://doi.org/10.1080/17482960802521126

Chiò, A., Benzi, G., Dossena, M., Mutani, R., & Mora, G. (2005). Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players. Brain, 128(3), 472–476. https://doi.org/10.1093/brain/awh373

Chiò, A., Logroscino, G., Traynor, B. J., Collins, J., Simeone, J. C., Goldstein, L. A., & White, L. A. (2013). Global epidemiology of amyotrophic lateral sclerosis: A systematic review of the published literature. Neuroepidemiology, 41(2), 118–130. https://doi.org/10.1159/000351153

Costa Junior, J. M. F., da Silva, C. I. M., Lima, A. A. da S., Rodrigues Júnior, D., Silveira, L. C. de L., Souza, G. da S., & Pinheiro, M. da C. N. (2018). Teores de mercúrio em cabelo e consumo de pescado de comunidades ribeirinhas na Amazônia brasileira, região do Tapajós. Ciencia e Saude Coletiva, 23(3), 805–812. https://doi.org/10.1590/1413-81232018233.09492016

Couto, C. M., Queiroz, E. M., Nogueira, R., Küsel, A. P. P. D. & Nascimento, O. J. M. (2021). A Brazilian multicentre study on the clinical and epidemiological profiles of 1116 patients with amyotrophic lateral sclerosis and its phenotypic variants. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. https://doi.org/10.1080/21678421.2021.2007953

Cronin, S. B., Hardiman, O., & Traynor, B. J. (2007). Ethnic variation in the incidence of ALS: A systematic review. Neurology, 68(7), 1002–1007. https://doi.org/10.1212/01.wnl.0000285431.01005.67

Farripas, S. (2010). Aspectos epidemiológicos da exposição ao mercúrio na região do Tapajós, no período de 1994 a 2008 [Universidade Federal do Pará, Núcleo de Medicina Tropical]. https://doi.org/CDD - 22. ed 615.925663

Filippini, T., Tesauro, M., Fiore, M., Malagoli, C., Consonni, M., Violi, F., Iacuzio, L., Arcolin, E., Conti, G. O., Cristaldi, A., Zuccarello, P., Zucchi, E., Mazzini, L., Pisano, F., Gagliardi, I., Patti, F., Mandrioli, J., Ferrante, M., & Vinceti, M. (2020). Environmental and occupational risk factors of amyotrophic lateral sclerosis: A population-based case-control study. International Journal of Environmental Research and Public Health, 17(18), 1–3. https://doi.org/10.3390/ijerph17186492

Kaji, R., Izumi, Y., Adachi, Y., & Kuzuhara, S. (2012). ALS-parkinsonism-dementia complex of kii and other related diseases in Japan. Parkinsonism and Related Disorders, 18(SUPPL. 1), S190–S191. https://doi.org/10.1016/s1353-8020(11)70059-1

Lacorte, E., Ferrigno, L., Leoncini, E., Corbo, M., Boccia, S., & Vanacore, N. (2016). Physical activity, and physical activity related to sports, leisure and occupational activity as risk factors for ALS: A systematic review. Neuroscience and Biobehavioral Reviews, 66, 61–79. https://doi.org/10.1016/j.neubiorev.2016.04.007

Lian, L., Liu, M., Cui, L., Guan, Y., Liu, T., Cui, B., Zhang, K., Tai, H., & Shen, D. (2019). Environmental risk factors and amyotrophic lateral sclerosis (ALS): A case-control study of ALS in China. Journal of Clinical Neuroscience, 66, 12–18. https://doi.org/10.1016/j.jocn.2019.05.036

Lima, N. S. de, Costa, C. C. P. da, Reis, A. A. da S., & Santos, R. da S. (2021). Neurotropismo de SARS-CoV-2: Possíveis impactos da COVID-19 em portadores de Esclerose Lateral Amiotrófica. Research, Society and Development, 10(7), e28310716441. https://doi.org/10.33448/rsd-v10i7.16441

Logroscino, G., Traynor, B. J., Hardiman, O., Chió, A., Mitchell, D., Swingler, R. J., Millul, A., Benn, E., & Beghi, E. (2010). Incidence of amyotrophic lateral sclerosis in Europe. Journal of Neurology, Neurosurgery and Psychiatry, 81(4), 385–390. https://doi.org/10.1136/jnnp.2009.183525

Malek, A. M., Barchowsky, A., Bowser, R., Youk, A., & Talbott, E. O. (2012). Pesticide exposure as a risk factor for amyotrophic lateral sclerosis: A meta-analysis of epidemiological studies. Pesticide exposure as a risk factor for ALS. Environmental Research, 117, 112–119. https://doi.org/10.1016/j.envres.2012.06.007

Newell, M. E., Adhikari, S., & Halden, R. U. (2022). Systematic and state-of the science review of the role of environmental factors in Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig’s Disease. Science of the Total Environment, 817, 152504. https://doi.org/10.1016/j.scitotenv.2021.152504

Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Santa Maria/RS. Ed. UAB/NTE/UFSM

Peters, S., Visser, A. E., D’Ovidio, F., Vlaanderen, J., Portengen, L., Beghi, E., Chio, A., Logroscino, G., Hardiman, O., Pupillo, E., Veldink, J. H., Vermeulen, R., Van Den Berg, L. H., Van Der Kooi, A. J., Raaphorst, J., Calvo, A., Moglia, C., Casale, F., Fuda, G., … Zecca, C. (2020). Effect modification of the association between total cigarette smoking and ALS risk by intensity, duration and time-since-quitting: Euro-MOTOR. Journal of Neurology, Neurosurgery and Psychiatry, 91(1), 33–39. https://doi.org/10.1136/jnnp-2019-320986

Peters, S., Visser, A. E., Ovidio, F. D., Beghi, E., Chiò, A., Logroscino, G., Kromhout, H., Huss, A., Veldink, J., Vermeulen, R., & Berg, L. H. Van Den. (2019). Electric Shock and Extremely Low-Frequency Magnetic Field Exposure and the Risk of ALS: Euro-MOTOR. American Journal of Epidemiology, 188(4), 796–805. https://doi.org/10.1093/aje/kwy287

Phukan, J., Pender, N. P., & Hardiman, O. (2007). Cognitive impairment in amyotrophic lateral sclerosis. Lancet, 6(11), 994–1003.

Prado, L. D. G. R., Bicalho, I. C. S., Vidigal-Lopes, M., Ferreira, C. J. A., Mageste Barbosa, L. S., Gomez, R. S., De Souza, L. C., & Teixeira, A. L. (2016). Amyotrophic lateral sclerosis in Brazil: Case series and review of the Brazilian literature. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 17(3–4), 282–288. https://doi.org/10.3109/21678421.2016.1143011

Riancho, J., Gonzalo, I., Ruiz-Soto, M., & Berciano, J. (2015). Why do motor neurons degenerate? Actualization in the pathogenesis of amyotrophic lateral sclerosis. Neurologia, 34(1), 27–37. https://doi.org/10.1016/j.nrl.2015.12.001

Roberts, A. L., Johnson, N. J., Chen, J. T., Cudkowicz, M. E., & Weisskopf, M. G. (2016). Race/ethnicity, socioeconomic status, and ALS mortality in the United States. Neurology, 87(22), 2300–2308. https://doi.org/10.2307/4591378

Strickland, D., Smith, S. A., Goldman, L., & Roelofs, R. I. (1996). Amyotrophic Occupational. Archives of Gerontology and Geriatrics, 53, 730–7333.

Trojsi, F., Monsurrò, M. R., & Tedeschi, G. (2013). Exposure to environmental toxicants and pathogenesis of amyotrophic lateral sclerosis: State of the art and research perspectives. International Journal of Molecular Sciences, 14(8), 15286–15311. https://doi.org/10.3390/ijms140815286

van Es, M. A., Hardiman, O., Chio, A., Al-Chalabi, A., Pasterkamp, R. J., Veldink, J. H., & van den Berg, L. H. (2017). Amyotrophic lateral sclerosis. The Lancet, 390(10107), 2084–2098. https://doi.org/10.1016/S0140-6736(17)31287-4

Wang, M. D., Little, J., Gomes, J., Cashman, N. R., & Krewski, D. (2017). Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis. NeuroToxicology, 61, 101–130. https://doi.org/10.1016/j.neuro.2016.06.015

Wong, C., Stavrou, M., Elliott, E., Gregory, J. M., Leigh, N., Pinto, A. A., Williams, T. L., Chataway, J., Swingler, R., Parmar, M. K. B., Stallard, N., Weir, C. J., Parker, R. A., Chaouch, A., Hamdalla, H., Ealing, J., Gorrie, G., Morrison, I., Duncan, C., … Chandra, S. (2021). Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective. Brain Communications, 3(4), fcab242. https://doi.org/10.1093/braincomms/fcab242

Zapata-Zapata, C. H., Franco-Dáger, E., Solano-Atehortúa, J. M., & Ahunca-Velásquez, L. F. (2016). Esclerosis lateral amiotrófica: actualización. Iatreia, 29(2), 194–205. https://doi.org/10.17533/udea.iatreia.v29n2a08.194

Published

21/05/2022

How to Cite

FERREIRA, N. B. .; SANTOS-LOBATO , B. L. dos .; PINHEIRO , M. da C. N. . Epidemiological profile and environmental risk factors associated with Motor Neuron Disease in a referral hospital in Belém-PA-Brazil. Research, Society and Development, [S. l.], v. 11, n. 7, p. e21811729285, 2022. DOI: 10.33448/rsd-v11i7.29285. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/29285. Acesso em: 7 jul. 2022.

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Section

Health Sciences