Kidney complications resulting from SARS-CoV-2 virus infection
DOI:
https://doi.org/10.33448/rsd-v11i8.30276Keywords:
Covid-19; Nephropathies; Acute kidney Injury; Kidney injury; Kidney complications.Abstract
It is known that Covid-19, a pathology discovered at the end of 2019, in the city of Wuhan, China, has spread in several countries, being characterized as a pandemic, has been causing several complications, the main one being the discomfort syndrome. acute respiratory disease (ARDS), but it can cause damage to other organs. Thus, the current study aims to evaluate the kidney injuries caused by Covid-19 and what are the main renal manifestations presented. A narrative literature review was carried out, anchored in the Google Scholar, ScientifEletronic Library Online (SciELO) and PubMED databases, using the descriptors: “covid-19”, “nephropathies”, “acute kidney injury”, “kidney damage”, “renal complications”, published in English and Portuguese during the year 2020 to 2022. 550 scientific productions were collected, 50 productions were selected, 30 of which matched the inclusion criteria after checking the abstracts, but only 20 were used after full reading of the contents. The analyzes suggest that the main kidney injuries caused are electrolyte disturbances, proteinuria, hematuria, metabolic acidosis, which lead to increased creatinine and decreased glomerular filtration rate, this is due to systemic inflammation and hypercytokinemia cascade (IL-6, IL-2, TNF-alpha, and IL-10) that result in systemic endothelial dysfunction and a hypercoagulable state that cause tubular injury in patients with acute renal syndrome.
References
Akalin, E., Azzi, Y., Bartash, R., Seethamraju, H., Parides, M., Hemmige, V., Ross, M., Forest, S., Goldstein, Y. D., Ajaimy, M., Liriano-Ward, L., Pynadath, C., Loarte-Campos, P., Nandigam, P. B., Graham, J., Le, M., Rocca, J., & Kinkhabwala, M. (2020). Covid-19 and Kidney Transplantation. The New England journal of medicine, 382(25), 2475–2477. https://doi.org/10.1056/NEJMc2011117
Argenziano, M. G., Bruce, S. L., Slater, C. L., Tiao, J. R., Baldwin, M. R., Barr, R. G., Chang, B. P., Chau, K. H., Choi, J. J., Gavin, N., Goyal, P., Mills, A. M., Patel, A. A., Romney, M. S., Safford, M. M., Schluger, N. W., Sengupta, S., Sobieszczyk, M. E., Zucker, J. E., Asadourian, P. A., … Chen, R. (2020). Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series. BMJ (Clinical research ed.), 369, m1996. https://doi.org/10.1136/bmj.m1996
Asghar, M. S., Haider Kazmi, S. J., Khan, N. A., Akram, M., Hassan, M., Rasheed, U., & Ahmed Khan, S. (2020). Poor Prognostic Biochemical Markers Predicting Fatalities Caused by COVID-19: A Retrospective Observational Study From a Developing Country. Cureus, 12(8), e9575. https://doi.org/10.7759/cureus.9575.
Bastug, A., Bodur, H., Erdogan, S., Gokcinar, D., Kazancioglu, S., Kosovali, B. D., Ozbay, B. O., Gok, G., Turan, I. O., Yilmaz, G., Gonen, C. C., & Yilmaz, F. M. (2020). Clinical and laboratory features of COVID-19: Predictors of severe prognosis. International immunopharmacology, 88, 106950. https://doi.org/10.1016/j.intimp.2020.106950
Brasil. (2021). Boletim Epidemiológico Especial – Doença pelo Coronavírus COVID-19. Ministério da Saúde – Secretaria de Vigilância em Saúde.
Corrêa, T.D & Ferraz, L.J. (2020). Recomendações de suporte intensivo para pacientes graves com infecção suspeira ou confirmada pela COVID-19. Einstein (São Paulo). V. 18
Diao, B., Wang, C., Wang, R., Feng, Z., Zhang, J., Yang, H., Tan, Y., Wang, H., Wang, C., Liu, L., Liu, Y., Liu, Y., Wang, G., Yuan, Z., Hou, X., Ren, L., Wu, Y., & Chen, Y. (2021). Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection. Nature communications, 12(1), 2506. https://doi.org/10.1038/s41467-021-22781-1
Elshazli, R. M., Toraih, E. A., Elgaml, A., El-Mowafy, M., El-Mesery, M., Amin, M. N., Hussein, M. H., Killackey, M. T., Fawzy, M. S., & Kandil, E. (2020). Diagnostic and prognostic value of hematological and immunological markers in COVID-19 infection: A meta-analysis of 6320 patients. PloS one, 15(8), e0238160. https://doi.org/10.1371/journal.pone.0238160
Ghobadi, H. et al. (2020). COVID-19 and acute kidney injury; a case report. J. Renal Inj Prev. 9(3): e26. https://doi.org/10.34172/jrip.2020.26p
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., Xiao, Y., … Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet (London, England), 395(10223), 497–506. https://doi.org/10.1016/S0140-6736(20)30183-5
Hirsch, J. S., Ng, J. H., Ross, D. W., Sharma, P., Shah, H. H., Barnett, R. L., Hazzan, A. D., Fishbane, S., Jhaveri, K. D., Northwell COVID-19 Research Consortium, & Northwell Nephrology COVID-19 Research Consortium (2020). Acute kidney injury in patients hospitalized with COVID-19. Kidney international, 98(1), 209–218. https://doi.org/10.1016/j.kint.2020.05.006
Jose, R. J., & Manuel, A. (2020). COVID-19 cytokine storm: the interplay between inflammation and coagulation. The Lancet. Respiratory medicine, 8(6), e46–e47. https://doi.org/10.1016/S2213-2600(20)30216-2
Lima, A.A. et al. (2022). Complicações renais decorrentes da infecção por SARS-CoV-2 em pessoas com COVID-19 hospitalizadas: scoping review. Research, Society and Development, v. 11, n.1, e 40811125217
Monte,L.M. (2020). Complicações atípicas e características clínico-epidemiológicas do COVID-19: uma revisão integrativa. Electronic Journal Collection Health Vol.Esp.46. ISSN 2178-2091.
Naicker, S., Yang, C. W., Hwang, S. J., Liu, B. C., Chen, J. H., & Jha, V. (2020). The Novel Coronavirus 2019 epidemic and kidneys. Kidney international, 97(5), 824–828. https://doi.org/10.1016/j.kint.2020.03.001
Nogueira, S., Oliveira, S., Carvalho, A., Neves, J., Silva, L., Silva Junior, G., & Nobre, M. (2020). Renal changes and acute kidney injury in covid-19: a systematic review. Revista da Associacao Medica Brasileira (1992), 66Suppl 2(Suppl 2), 112–117. https://doi.org/10.1590/1806-9282.66.S2.112
Pecly, I.M et al. (2021). Uma revisão da Covid-19 e lesão renal aguda: da fisiopatologia aos resultados clínicos. Braz. J. Nephrol. v. 43, n. 4 [Acessado 1 Junho 2022] , pp. 551-571. Disponível em: <https://doi.org/10.1590/2175-8239-JBN-2020-0204>. Epub 28 Maio 2021. ISSN 2175-8239. https://doi.org/10.1590/2175-8239-JBN-2020-0204.
Pereira, A. S. et al. (2018). Metodologia da pesquisa cientifica. [free e-book]. Santa Maria: UAB/NTE/UFSM. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1.
Petrilli, C. M., Jones, S. A., Yang, J., Rajagopalan, H., O'Donnell, L., Chernyak, Y., Tobin, K. A., Cerfolio, R. J., Francois, F., & Horwitz, L. I. (2020). Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ (Clinical research ed.), 369, m1966. https://doi.org/10.1136/bmj.m1966
Qian, J. Y., Wang, B., Lv, L. L., & Liu, B. C. (2021). Pathogenesis of Acute Kidney Injury in Coronavirus Disease 2019. Frontiers in physiology, 12, 586589. https://doi.org/10.3389/fphys.2021.586589
Ramirez-Sandoval, J. C., Gaytan-Arocha, J. E., Xolalpa-Chávez, P., Mejia-Vilet, J. M., Arvizu-Hernandez, M., Rivero-Sigarroa, E., Torruco-Sotelo, C., Correa-Rotter, R., & Vega-Vega, O. (2021). Prolonged Intermittent Renal Replacement Therapy for Acute Kidney Injury in COVID-19 Patients with Acute Respiratory Distress Syndrome. Blood purification, 50(3), 355–363. https://doi.org/10.1159/000510996
Richardson, S., Hirsch, J. S., Narasimhan, M., Crawford, J. M., McGinn, T., Davidson, K. W., the Northwell COVID-19 Research Consortium, Barnaby, D. P., Becker, L. B., Chelico, J. D., Cohen, S. L., Cookingham, J., Coppa, K., Diefenbach, M. A., Dominello, A. J., Duer-Hefele, J., Falzon, L., Gitlin, J., Hajizadeh, N., Harvin, T. G., … Zanos, T. P. (2020). Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA, 323(20), 2052–2059. https://doi.org/10.1001/jama.2020.6775
Ronco, C., & Reis, T. (2020). Kidney involvement in COVID-19 and rationale for extracorporeal therapies. Nature reviews. Nephrology, 16(6), 308–310. https://doi.org/10.1038/s41581-020-0284-7
Sang, L., Chen, S., Zheng, X., Guan, W., Zhang, Z., Liang, W., Zhong, M., Jiang, L., Pan, C., Zhang, W., Xia, J., Chen, N., Wu, W., Wu, H., Xu, Y., Liu, X., Liu, X., He, J., Li, S., Zhang, D., … Li, Y. (2020). The incidence, risk factors and prognosis of acute kidney injury in severe and critically ill patients with COVID-19 in mainland China: a retrospective study. BMC pulmonary medicine, 20(1), 290. https://doi.org/10.1186/s12890-020-01305-5
Naicker, S., Yang, C. W., Hwang, S. J., Liu, B. C., Chen, J. H., & Jha, V. (2020). The Novel Coronavirus 2019 epidemic and kidneys. Kidney international, 97(5), 824–828. https://doi.org/10.1016/j.kint.2020.03.001
Li, R., Pei, S., Chen, B., Song, Y., Zhang, T., Yang, W., & Shaman, J. (2020). Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2). Science (New York, N.Y.), 368(6490), 489–493. https://doi.org/10.1126/science.abb3221
Yang, F. et al. (2020). Analysis of 92 deceased patients with COVID‐19. J. Med. Virol., 92:2511–2515. https://doi.org/10.1002/jmv.25891.
Zhen L, et al. (2020). Caution on Kidney Dysfunctions of COVID-19 Patients. MedRxiv, v.1 pg 1-25
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Copyright (c) 2022 Emillene de Holanda Colli; Silvio Rodrigo Arevalos Davalos; Diego Francisco Degiovanni Benítez; Fernando Araújo de Oliveira; Camila Borges Siqueira Campos; Maria Eugênia de Lima Pinheiro; Marco Antônio de Souza Borges Tavares; Tauanne Fernanda dos Santos
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