Colorectal Adenocarcinoma with multiple metastasis: case report
Keywords:Intestinal neoplasms; Metastasis; Diagnosis.
Objective: The objective of the presented study was to describe a clinical case of a male patient, 45 years old, diagnosed with colorectal adenocarcinoma, however, in stage IV, with the presence of liver and lung metastases. Methodology: This case was carried out in a retrospective, descriptive and observational manner, by direct collection of patient data through access to medical records, patient interview and results of complementary exams. Case description: Patient, A.A.S.F, 45 years old, complaining about abdominal cramps, rectal tenesmus and ribbon stools who was diagnosed with Metastatic Colorectal Adenocarcinoma in 2011, therefore, with a follow-up of approximately ten years. In this case, several therapies were used and several chemotherapy sessions were performed with the aim of remission of the disease. In addition, imaging tests, for example, PET CT, were of paramount importance for the management of the case, in addition to the measurement of serum levels of the tumor marker CEA. Conclusion: Severe cases like this require different approaches, and early diagnosis is important for more favorable prognoses. The patient, having been diagnosed late, evolves with liver and lung metastases, making treatment difficult, which required a very aggressive therapeutic approach.
Bates, S. E. (1991). Clinicalapplicationsofserum tumor markers. AnnalsofInternal Medicine, 115(8), 623-638.
Biller, L. H; Scharag, D. (2021). DiagnosisandTreatmentofMetastaticColorectalCancer: A Review. JAMA Network, 325(7), 669-685.
Brasileiro, G. B., Fo. (2016) Bogliolo: patologia (9a ed). Rio de Janeiro, RJ: Guanabara Koogan.
Choi, B. W.,Kang, S., Bae, S. U., Jeong, W. K.,Baek, S. K., Song, B. … Kim, H. W. (2021). Prognostic value of metabolic parameters on 18 F-fluorodeoxyglucose positron tomography/computed tomography in classical rectal adenocarcinoma. Scientific Reports, 11(1), 12947.
Faria, S. C., Sagebiel, T., Patnana, M., Cox, V., Viswanathan C., Lall, C. …Bhosale, P. R. (2019). Tumor markers: myths and facts unfolded. Abdominal Radiology, 44(4), 1575-1600.
Feng, Z.,Shi, X., Zhang, Q., Zhang, X., Li, X., Chen, Z. ...Ren, S. (2019). Analysis of clinic pathological features and prognosis of 1315 cases in colorectal cancer located at different anatomical subsites. Pathology – Research and Practice, 215(10), 152560.
Grut, H., Revheim, M. E.,Line, P. D., & Dueland, S.(2018). Importance of 18F-FDG PET/CT to select patients with nonresectable colorectal liver metastases for liver transplantation. Nuclear Medicine Communication, 39(7), 621-627.
Henry, N. L., & Hayes, D. F. (2012). Cancer biomarkers. Molecular oncology, 6(2), 140-146.
Kanth, P., & Inadomi, J. M. (2021). Screening and prevention of colorectal cancer. BMG, 374, 1855.
Kamal, Y., Schmit, S. L., Hoehn, H. J., Amos, C. I., &Frost, H. R. (2019). Transcriptomic differences between primary colorectal adenocarcinomas and distant metastases reveal metastatic colorectal cancer subtypes. Cancer Res, 79(16), 4227-4241.
Ko, H., Baghdadi, Y., Love, C., & Sparano, J. A. (2020). Clinical Utility of 18F-FDG PET/CT in staging localized breast cancer before initiating preoperative systemic therapy. Official Journal of the National Comprehensive Cancer Network, 18(9), 1240-1246.
Kumar, V., Abbas, A. K.,&Aster, J. C. (2018). Robbins: patologia básica (10aed). Rio de Janeiro, RJ: Elsevier.
Li, H., Jing, C., Wu, J.,Ni, J., Sha, H., Xu, X. ... Feng, J. (2019). Circulating tumor DNA detection: A potential tool for colorectal cancer management. Oncology Letters, 17(2), 1409-1416.
Li, C., Tang, D., Ji, J., Zang, B., Chen, C., Zhao, J. (2020). Colorectal adenocarcinoma patients with M1a diseases gain more clinical benefits from palliative primary tumor resection than those with M1b diseases: A propensity score matching analysis. World Journal of Clinical Cases, 8(15), 3230-3239.
Lima, J. F., Macedo, A. B., Panizzon, C. P. N. B., & Perles, J. V. C. M. (2019). Câncer colorretal, diagnóstico e estadiamento: revisão de literatura. Arquivos do MUDI. Maringá, 23(3), 315-329.
Maffione, A. M., Montesi, G., Caroli, P., Colletti, P. M., Rubello, D., Matteucci, F. (2020). Is it to introduce PET/CT in Rectal Cancer Guidelines? Clinical Nuclear Medicine, 45(8), 611-617.
Milardovic, R., Beslic, N., Sadija, A., Ceric, A., Bukvic, M., Dzananovic, L. (2020). Role of 18F-FDG PET/CT in the follow-up of colorectal cancer. Acta Informatica Medica, 28(2), 119-123.
INCA - Instituto Nacional Do Câncer José Alencar Gomes Da Silva (2019). Estimativa 2020: Incidência de Câncer no Brasil. https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document//estimativa-2020-incidencia-de-cancer-no-brasil.pdf
INCA - Instituto Nacional Do Câncer José Alencar Gomes Da Silva (2004). Classificação de Tumores Malignos, 2004. https://bvsms.saude.gov.br/bvs/publicacoes/inca/tnm2.pdf.
Montalban-Arques A. & Scharl M. (2019). Intestinal microbiota and colorectal carcinoma: Implications for pathogenesis, diagnosis, and therapy. 2019 Oct 17. EBioMedicine, 48, 648-655.
Mullangi S, & Lekkala M.R. (2021). Adenocarcinoma. In: Stat Pearls [Internet]. Treasure Island (FL): Stat Pearls Publishing.
Naoum, P. C., & Naoum, F. A. (2018). Marcadores Tumorais - Uma Revisão até 2018. Academia de Ciência e Tecnologia.
Oh, H. H. & Joo, Y. E. (2020). Novel biomarkers for the diagnosis and prognosis of colorectal cancer. Intestinal Research, 18(2), 168-183.
Pazmiño, A., Lorena, M., Maldonado, P., Rocío, L., Fabián, L., ... Pilar, M. (2021). Utilidaddel antígeno carcinoembrionarioem el diagnóstico y pronóstico del câncer colorrectal. ArchivosVenezolanos de Farmacologia y Terapéutica, 40(6), 633-637.
Pereira, A. S. et al. (2018). Metodologia da pesquisa científica. UFSM.
Sawicki, T., Ruszkowska, M., Danielewicz, A., Niedźwiedzka, E. ,Arłukowicz, T., ... Przybyłowicz, K. E. (2021). A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis. Cancers, 13(2025), 1-23.
Simonetti, A. C., Melo, J. H. L., Andrade, E. C. B., & Vasconcelos, V. S. (2018). Variações dos valores séricos do CEA, bilirrubinas e aminotransferases em indivíduos oncológicos. Revista Brasileira de Análises Clínicas, 50(1), 44-49.
Soltani, G., Poursheikhani, A., Yassi, M., Hayatbakhsh, A., Kerachian, M., &Kerachian, M. A. (2019). Obesity, diabetes and the risk of colorectal adenoma and cancer. BMC Endocrine Disorders, 19(1), 113.
Testa, U.,Pelosi, E., & Castelli, G. (2018). Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells. Medical Science, 6(31), 1-113.
Todate, Y., Honda, M., Takada, T., Saginoya, T., Yamaguchi, H., ... Hashimoto, K. (2021). The additionaldiagnosticimpactofpositronemissiontomography-computedtomography for lymph node metastasis from colorectal cancer: A prospective lymph node level analysis. Journal of Surgical Oncology, 124(7), 1085-1090.
Zaterka, S., &Eisig, J. N. (2016). Tratado de gastroenterologia: da graduação à pós-graduação (2aed). São Paulo, SP: Atheneu.
Zajac, M. L., &Mroczko, B. (2021). Circulatingbiomarkersofcolorectalcancer (CRC)—theirutility in diagnosisandprognosis. JournalofClinical Medicine, 10(2391), 1- 15.
Zhang, X. C., Zhang, J. H., Wang, R. F., Fan, Y., Fu, Z. L., ...Bai, Y. X. (2019,). Diagnostic value of 18 F-FDG PET/CT and tumor markers (CEA, CA19-9, CA24-2) in recurrenceandmetastasisofpostoperativecolorectalmoderatelydifferentiated adenocarcinoma. Journal of Peking University, 51(6), 1071-1077.
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Copyright (c) 2022 Gutierry Moraes Sobral; Márcio Silva da Cruz Júnior; Severino Correia do Prado Neto; Érica Rezende Pereira ; Leana Ferreira Crispim
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