Acute poisoning by organophosphorus pesticides: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i9.31606

Keywords:

Cholinesterases; Cholinesterase inhibitors; Insecticide; Pesticides; Poisoning.

Abstract

Organophosphate pesticides can cause intoxication in exposed individuals. The objective of this work was to carry out an integrative review on acute human intoxication by organophosphate pesticides. The search for scientific articles was carried out in the CAPES Journals Portal and in the Scopus database using the combination of the descriptors “organophosphates”, “cholinesterase” and “acute intoxication” interrelated by the Boolean localizer “AND”. Works in English and Portuguese, published between 2016 and 2021 were considered. 146 articles were identified and after reading the title and abstract, 26 potentially eligible articles were selected, which were read in full, observing if, in fact, they met the criteria settled down. After reading, 19 articles were selected to compose the review. Studies report the importance of measuring cholinesterases in the assessment of acute poisoning by organophosphate pesticides, however, most perform the dosage without the basal value of these enzymes. Although the Ellman method is the most common form of quantification, there are many methodological variations. Thus, it is essential to study new markers for acute intoxication and to optimize existing methodologies. The symptoms that affect individuals are nonspecific and may be related to the specific active ingredient of each organophosphate. Factors such as lifestyle, presence of metabolic alterations, low education, advanced age, low use of PPE and inappropriate use of pesticides are also associated with cases of intoxication. The training and awareness of individuals who handle organophosphates, in addition to actions by the government, are essential to strengthen regulations on the use of these substances, in order to avoid health problems in the population.

Author Biographies

Mariele Abadia Elias, Universidade do Planalto Catarinense

possui gradua??o em Biomedicina pela Universidade do Planalto Catarinense (2017) , especializa??o em Educação a Distância: Gestão e Tutoria pelo Centro Universitário Leonardo da Vinci (2021) , especializa??o em Biotecnologia e Bioprocessos pela Universidade Estadual de Maringá (2019) , curso-tecnico-profissionalizante em Biotecnologia pelo Instituto Federal de Santa Catarina (2012) e ensino-medio-segundo-grau pela EEB Frei Nicodemos (2010) . Atualmente ? Técnica de Laboratório/Área (Biotecnologia) do Instituto Federal de Santa Catarina. Tem experi?ncia na ?rea de Biologia Geral , com ?nfase em Biotecnologia.

Ana Emilia Siegloch, Universidade do Planalto Catarinense

possui graduação em Ciências Biológicas pela Universidade Federal de Santa Maria (2004), mestrado e doutorado em Entomologia pela Universidade de São Paulo - Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (2006 e 2010, respectivamente) e pós-doutorado em Ecologia pela Universidade Federal de Santa Catarina com bolsa oriunda do CNPq/CTHidro entre 2010 e 2011 e pós-doutorado no mesmo programa e instituição com bolsa oriunda do Programa Nacional de Pós-Doutorado - PNPD/ CAPES entre 2011 e 2012. Atualmente é docente da Universidade do Planalto Catarinense - UNIPLAC. Na instituição faz parte do Corpo Docente do Programa de Pós-Graduação em Ambiente e Saúde, onde leciona diversas disciplinas, orienta alunos de mestrado. Entre as áreas de interesse e atuação estão: entomologia e ecologia de comunidades de insetos aquáticos, biodiversidade, educação ambiental, gestão de resíduos e contaminação ambiental.

References

Alves, H. H. F., Silva, A. T., Pavão, J. M. S. J., Matos-Rocha, T. J., Souza, M. A., Costa, J. G., Fonseca, S. A., Pires, L. L. S., Faé, J., & Santos, A. F. (2021). The acetylcholinesterase as indicative of intoxication for pesticide in farmers of conventional and organic cultivation. Brazilian Journal of Biology, 81(3), 632–641. https://doi.org/10.1590/1519-6984.227875

Amin, D. M., Abaza, M. T., Azawy, D. S. El, & Ahmed, A. I. (2018). Morbidity and Mortality Indicators in Acute Organophosphate Poisoning in Zagazig University Hospital, Egypt: Retrospective Study. Occupational Diseases and Environmental Medicine, 06(04), 130–140. https://doi.org/10.4236/odem.2018.64011

Archanjo, A. B., Aline, R., Borçoi, A. L. E. M. de, Assis, Camila Vieira Chagas David, C., Cesar Jorden Almança, C. C., Couto, C. V. M. da S., Diego Camuzi, É. A. S., de Freitas, Ester Ribeiro Cunha, F., Vitorino Freitas, G. M. da S., Guanaes, Gabriela Tonini Peterle, G., Assis Robe, Guilherme Colli Valiate, J., Batista Pavesi Simão, J. G., Santos, Julia de Assis Pinheiro, J., Dalbó, Juliana Krüger Arpini, L., Bettcher Brito, L. O. T., Letícia Parmanhani Romão, L. de L., Maia, Marcelo dos Santos, M. V., Moreira Vianna, M. M. de O., Miranda, M. D. de O., & Álvares-da-Silva, M. (2017). Alcoolismo, tabagismo e exposição aos agrotóxicos: avaliação epidemiológica e molecular como auxiliar na prevenção e questões de saúde TT - Alcoholims, smoking and exposure to pesticides: epidemiological and molecular evaluation as support to prevention. Comun. Ciênc. Saúde, 28(1), 40–44. http://bvsms.saude.gov.br/bvs/periodicos/ccs_artigos/alcoolismo_questoes_saude.pdf

Benitez-Medina, A., & Ramírez-Vargas, M. A. (2021). Cholinesterase as a biomarker to identify cases of pesticide poisoning. Mexican Journal of Medical Research ICSA, 9(17), 47–55. https://doi.org/10.29057/mjmr.v9i17.5577

Bento, A. J., Andrade, A. B. A. de, Santos, J. M. dos, Moura, M. A. B. F. de, Goulart, H. F., & Santana, A. E. G. (2020). Exposição ocupacional aos agrotóxicos pelos agricultores da região de Coruripe, Alagoas. Revista Verde de Agroecologia e Desenvolvimento Sustentável, 15(2), 193–201. https://doi.org/10.18378/rvads.v15i2.7642

Bianco, G. E., Suarez, E., Cazon, L., de la Puente, T. B., Ahrendts, M. R. B., & De Luca, J. C. (2017). Prevalence of chromosomal aberrations in Argentinean agricultural workers. Environmental Science and Pollution Research, 24(26), 21146–21152. https://doi.org/10.1007/s11356-017-9664-3

Brasil. Ministério da Saúde. (2021). DATASUS. tabnet. http://tabnet.datasus.gov.br/cgi/tabcgi.exe?sinannet/cnv/Intoxbr.def

Brasil. Ministério da Saúde. (2019). Secretaria de Vigilância em Saúde. Nota Informativa nº 16/2019-CGLAB/DAEVS/SVS/MS. Parâmetros para monitoramento da colinesterase nos agentes de saúde que utilizam inseticidas organofosforados e carbamatos nas atividades de controle vetorial. Brasília. https://central3.to.gov.br/arquivo/481149/

Brasil. Ministério da Economia. (2020). Secretaria Especial de Previdência e Trabalho. Portaria nº 6.734, de 9 de março de 2020. Aprova a nova redação da Norma Regulamentadora nº 07 - Programa de Controle Médico de Saúde Ocupacional - PCMSO. Brasília. https://www.in.gov.br/en/web/dou/-/portaria-n-6.734-de-9-de-marco-de-2020-247886194

CDC - Centros de Controle e Prevenção de Doenças. (2017). Resumo de Biomonitoramento - Inseticidas Organofosforados: Metabólitos de Dialquil Fosfato. Programa Nacional de Biomonitoramento. EUA. https://www.cdc.gov/biomonitoring/OP-DPM_BiomonitoringSummary.html

Çelik, S., Akbaba, M., Nazlıcan, E., Gören, İ. E., Yavuz Güzel, E., & Daglioglu, N. (2021). Association between occupational and environmental pesticide exposure in Cukurova region by hair and blood biomonitoring. Environmental Science and Pollution Research, 28(44), 63191–63201. https://doi.org/10.1007/s11356-021-15227-0

CIATox/SC - Centro de Informação e Assistência Toxicológica de Santa Catarina. (2020). Estatísticas anuais: Ano: 2019. Florianópolis. https://ciatox.sc.gov.br/estatisticas/

Chuang, C. Sen, Yang, K. W., Yen, C. M., Lin, C. L., & Kao, C. H. (2019). Risk of seizures in patients with organophosphate poisoning: A nationwide population-based study. International Journal of Environmental Research and Public Health, 16(17), 1–9. https://doi.org/10.3390/ijerph16173147

Corcino, C. O., De Andrade Teles, R. B., Da Silva Almeida, J. R. G., Da Silva Lirani, L., Araújo, C. R. M., De Assis Gonsalves, A., & De Azevedo Maia, G. L. (2019). Avaliação do efeito do uso de agrotóxicos sobre a saúde de trabalhadores rurais da fruticultura irrigada. Ciencia e Saude Coletiva, 24(8), 3117–3128. https://doi.org/10.1590/1413-81232018248.14422017

Darwish, R. T., Megahed, H. M., Ayad, M. W., & Barakat, A. A. A. (2016). Study of acyl-peptide hydrolase as a probable marker of severity in cases of acute poisoning by cholinesterase enzyme inhibitor insecticides. Tanta Medical Journal, 44, 4–11. https://doi.org/10.4103/1110-1415.180542

Dhananjayan, V., Ravichandran, B., Panjakumar, K., Kalaiselvi, K., Rajasekar, K., Mala, A., Avinash, G., Shridhar, K., Manju, A., & Wilson, R. (2019). Assessment of genotoxicity and cholinesterase activity among women workers occupationally exposed to pesticides in tea garden. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 841(March), 1–7. https://doi.org/10.1016/j.mrgentox.2019.03.002

Esparza-Olalla, J. E., Forero-Lugo, F. C., & Mardones-Montanares, M. A. (2020). Uso de organofosforados por agricultores de la comunidad de Guaslán- Ecuador y los cambios hematológicos. Ciencia y Agricultura, 17(1), 31–50. https://doi.org/10.19053/01228420.v17.n1.2020.10603

Faria, N. M. X., Fassa, A. G., & Facchini, L. A. (2007). Intoxicação por agrotóxicos no Brasil: Os sistemas oficiais de informação e desafios para realização de estudos epidemiológicos. Ciencia e Saude Coletiva, 12(1), 25–38. https://doi.org/10.1590/S1413-81232007000100008

Faria, N. M. X., Rosa, J. A. R. da, & Facchini, L. A. (2009). Intoxicações por agrotóxicos entre trabalhadores rurais de fruticultura, Bento Gonçalves, RS. TT - [Poisoning by pesticides among family fruit farmers, Bento Gonçalves, Southern Brazil]. Rev Saude Publica, 43(2), 335–344. http://www.scielo.br/scielo.php?script=sci_arttext&nrm=iso&lng=pt&tlng=pt&pid=S0034-89102009000200015%0Ahttp://www.scielosp.org/scielo.php?script=sci_arttext&nrm=iso&lng=pt&tlng=pt&pid=S0034-89102009000200015

FAO - Food and Agriculture Organization of the United Nations - Organização das Nações Unidas para Alimentação e Agricultura (2019). Estatística da FAO. Indicadores de pesticidas. https://www.fao.org/faostat/en/#data/EP/visualize.

Figueiredo, T. H., Apland, J. P., Braga, M. F. M., & Marini, A. M. (2018). Acute and long-term consequences of exposure to organophosphate nerve agents in humans. Epilepsia, 59(August), 92–99. https://doi.org/10.1111/epi.14500

Joshi, A. K. R., & Sukumaran, B. O. (2019). Metabolic dyshomeostasis by organophosphate insecticides: Insights from experimental and human studies. EXCLI Journal, 18, 479–484. https://doi.org/10.17179/excli2019-1492

Kadakol, N. S., Biradar, S. S., Smitha, M., & Biradar, M. K. (2017). A study of organo-phosphorous compound poisoning with reference to blood sugar and pseudocholinesterase levels. Indian Journal of Public Health Research and Development, 8(4), 33–36. https://doi.org/10.5958/0976-5506.2017.00308.4

Kapeleka, J. A., Sauli, E., & Ndakidemi, P. A. (2019). Pesticide exposure and genotoxic effects as measured by DNA damage and human monitoring biomarkers. International Journal of Environmental Health Research, 00(00), 1–18. https://doi.org/10.1080/09603123.2019.1690132

Kapeleka, J. A., Sauli, E., Sadik, O., & Ndakidemi, P. A. (2019). Biomonitoring of Acetylcholinesterase (AChE) Activity among Smallholder Horticultural Farmers Occupationally Exposed to Mixtures of Pesticides in Tanzania. Journal of Environmental and Public Health, 2019, 1–11. https://doi.org/10.1155/2019/3084501

Klein, B., Staudt, K., Missio, R., Peruzzi Hammad, M., & Almeida Alves, I. (2018). Análise do impacto do uso de organofosforados e carbamatos em trabalhadores rurais de um município da região noroeste do estado do Rio Grande do Sul. Acta Toxicológica Argentina, 26(3), 104–112.

Kofod, D. H., Jørs, E., Varma, A., Bhatta, S., & Thomsen, J. F. (2016). The use of self-reported symptoms as a proxy for acute organophosphate poisoning after exposure to chlorpyrifos 50% plus cypermethrin 5% among Nepali farmers: a randomized, double-blind, placebo-controlled, crossover study. Environmental Health: A Global Access Science Source, 15(1), 1–10. https://doi.org/10.1186/s12940-016-0205-1

Lee, Y. H., Oh, Y. T., Lee, W. W., Ahn, H. C., Sohn, Y. D., Ahn, J. Y., Min, Y. H., Kim, H., Lim, S. W., Lee, K. J., Shin, D. H., Park, S. O., & Park, S. M. (2017). The association of alcohol consumption with patient survival after organophosphate poisoning: a multicenter retrospective study. Internal and Emergency Medicine, 12(4), 519–526. https://doi.org/10.1007/s11739-016-1484-9

Lorenzatto, L. B., Da Silva, M. I. G., Roman Junior, W. A., Rodrigues Junior, S. A., De Sá, C. A., & Corralo, V. (2020). Exposição De Trabalhadores Rurais a Organofosforados E Carbamatos. Revista Brasileira de Ciências Ambientais (Online), 55(1), 19–31. https://doi.org/10.5327/z2176-947820200528

Mohapatra, S., & Panda, U. K. (2016). Neuropsychiatric manifestations following acute organophosphate poisoning. Medical Journal of Dr. D.Y. Patil University, 9(5), 654–656. https://doi.org/10.4103/0975-2870.192163

Mulyana, Sugiarta, I., Fuk, L. J., Yunia, P. D., Fitrianti, Y., Adi, N. P., & Soemarko, D. S. (2020). Biomonitoring of Acetylcholinesterase (AChE) Inhibitor and the Association with Hypertension among Farmers in Bandung, Indonesia. Indonesian Biomedical Journal, 12(4), 325–332. https://doi.org/10.18585/INABJ.V12I4.1220

Muñoz-Quezada, M. T., Lucero, B., Iglesias, V., Levy, K., Muñoz, M. P., Achú, E., Cornejo, C., Concha, C., Brito, A. M., & Villalobos, M. (2017). Exposure to organophosphate (OP) pesticides and health conditions in agricultural and non-agricultural workers from Maule, Chile. International Journal of Environmental Health Research, 27(1), 82–93. https://doi.org/10.1080/09603123.2016.1268679

Naughton, S. X., & Terry, A. V. (2018). Neurotoxicity in acute and repeated organophosphate exposure. Toxicology, 408, 101–112. https://doi.org/10.1016/j.tox.2018.08.011

Neupane, D., Jørs, E., & Brandt, L. P. A. (2017). Plasma Cholinesterase Levels of Nepalese Farmers Following Exposure to Organophosphate Pesticides. Environmental Health Insights, 11, 117863021771926. https://doi.org/10.1177/1178630217719269

Patel, S., & Sangeeta, S. (2019). Pesticides as the drivers of neuropsychotic diseases, cancers, and teratogenicity among agro-workers as well as general public. Environmental Science and Pollution Research, 26(1), 91–100. https://doi.org/10.1007/s11356-018-3642-2

Pothu, U., Thammisetty, A., & Nelakuditi, L. (2019). Evaluation of cholinesterase and lipid profile levels in chronic pesticide exposed persons. Journal of Family Medicine and Primary Care, 8(6), 2073. https://doi.org/10.4103/jfmpc.jfmpc_239_19

Ramírez-Santana, M., Farías-Gómez, C., Zúñiga-Venegas, L., Sandoval, R., Roeleveld, N., Van der Velden, K., Scheepers, P. T. J., & Pancetti, F. (2018). Biomonitoring of blood cholinesterases and acylpeptide hydrolase activities in rural inhabitants exposed to pesticides in the Coquimbo Region of Chile. PLoS ONE, 13(5), 1–19. https://doi.org/10.1371/journal.pone.0196084

Ramírez-santana, M., Zúñiga-venegas, L., Corral, S., Roeleveld, N., Groenewoud, H., Velden, K. Van Der, Scheepers, P. T. J., & Pancetti, F. (2020). Reduced neurobehavioral functioning in agricultural workers and rural inhabitants exposed to pesticides in northern Chile and its association with blood biomarkers inhibition. Environmental Health, 6, 1–13. https://doi.org/10.1186/s12940-020-00634-6

Salvi, R. M., Lara, D. R., Ghisolfi, E. S., Portela, L. V., Dias, R. D., & Souza, D. O. (2003). Neuropsychiatric evaluation in subjects chronically exposed to organophosphate pesticides. Toxicological Sciences, 72(2), 267–271. https://doi.org/10.1093/toxsci/kfg034

Shabka, O. (2017). Characteristics of Organophosphate Poisoned Patients Admitted to Emergency Hospital. Mansoura Journal of Forensic Medicine and Clinical Toxicology, 25(2), 25–32. https://doi.org/10.21608/mjfmct.2018.47243

Shentema, M. G., Kumie, A., Bråtveit, M., Deressa, W., Ngowi, A. V., & Moen, B. E. (2020). Pesticide use and serum acetylcholinesterase levels among flower farm workers in Ethiopia—a cross-sectional study. International Journal of Environmental Research and Public Health, 17(3). https://doi.org/10.3390/ijerph17030964

Sine, H., Grafel, K. El, Alkhammal, S., Achbani, A., & Filali, K. (2019). Serum cholinesterase biomarker study in farmers–Souss Massa region-, Morocco: case–control study. Biomarkers, 24(8), 771–775. https://doi.org/10.1080/1354750X.2019.1684564

Souza, M. T. de, Silva, M. D. da, & Carvalho, R. de. (2010). Integrative review: what is it? How to do it? Einstein (São Paulo), 8(1), 102–106. https://doi.org/10.1590/s1679-45082010rw1134

Terziev, V., & Petkova-Georgieva, S. (2020). Human Health Problems and Classification of the Most Toxic Pesticides. SSRN Electronic Journal, V(15). https://doi.org/10.2139/ssrn.3513837

Thundiyil, J. G., Stober, J., Besbelli, N., & Pronczuk, J. (2008). Acute pesticide poisoning: a proposed classification tool. Bulletin of the World Health Organization, 86(3), 205–209. https://doi.org/10.2471/blt.08.041814

Todd, S. W., Lumsden, E. W., Aracava, Y., Mamczarz, J., Albuquerque, E. X., & Pereira, E. F. R. (2020). Gestational exposures to organophosphorus insecticides: From acute poisoning to developmental neurotoxicity. Neuropharmacology, 180, 108271. https://doi.org/10.1016/j.neuropharm.2020.108271

Tsai, Y.-H., & Lein, P. J. (2021). Mechanisms of organophosphate neurotoxicity. Current Opinion in Toxicology, 26, 49–60. https://doi.org/10.1016/j.cotox.2021.04.002

Published

04/07/2022

How to Cite

ELIAS, M. A. .; SIEGLOCH, A. E.; AGOSTINETTO, L. Acute poisoning by organophosphorus pesticides: an integrative review. Research, Society and Development, [S. l.], v. 11, n. 9, p. e11611931606, 2022. DOI: 10.33448/rsd-v11i9.31606. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/31606. Acesso em: 19 aug. 2022.

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Section

Review Article