Use of antimicrobials according to microbial resistance: what is the influence of the restrictive measure implemented in Brazil?
DOI:
https://doi.org/10.33448/rsd-v11i9.31902Keywords:
Anti-Infectious; Microbial Drug Resistance; Use of Medicines.Abstract
Aim: To compare the profile of antimicrobials used, before and after implementation of RDC44/2010, in patients with positive microbial resistance. Method: Cross-sectional analyzes carried out in two phases (Phase I – May to October 2010. Phase II – February to July 2011). Data were collected in reports from the computerized system of the general teaching hospital and analyzed using the statistical software Stata/SE 12.0. Data from 4,786 patients in phase I and 4,261 in phase II were analyzed. Of these, 180 and 115 patients, phases I and II respectively, were identified with results of resistant microorganisms. Results: When analyzing the use of antimicrobials after the identification of resistance, statistical significance (p<0.05) was observed in the greater addition and withdrawal of some drugs in phase II, when compared to I. Conclusion: There was no change in the profile of antimicrobials used before and after the identification of the first strength result when comparing the phases.
References
GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet 2016; 388(10053): 1459-544.
World Health Organization. Antimicrobial resistance: global report on surveillance. Genebra: World Health Organization; 2014. https://apps.who.int/iris/handle/10665/112642.
Brasil. Agência Nacional de Vigilância Sanitária (ANVISA). Plano Nacional para a Prevenção e o Controle da Resistência Microbiana nos Serviços de Saúde. Brasília: ANVISA; 2017. http://portal.anvisa.gov.br/documents/
Brasil. (2017). Agência Nacional de Vigilância Sanitária (ANVISA). Plano Nacional para a Prevenção e o Controle da Resistência Microbiana nos Serviços de Saúde. Brasília: ANVISA. http://portal.anvisa.gov.br/documents/
Lawes, T., Lopez-Lozano, J. M., Nebot, C. A., Macartney, G., Subbarao-Sharma, R., Dare, C. R. et al. (2015). Effects of national antibiotic stewardship and infection control strategies on hospital-associated and community-associated meticillin-resistant Staphylococcus aureus infections across a region of Scotland: a non-linear time-series study. The Lancet Infectious Diseases, 15(12), 1438-1449.
Kardaś-Słoma, L., Boëlle, P. Y., Opatowski, L., Guillemot, D. et al. (2013). Antibiotic reduction campaigns do not necessarily decrease bacterial resistance: the example of methicillin-resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy, 57(9), 4410-4416.
Mattos, K. P., Visacri, M. B., Quintanilha, J. C., Lloret, G. R., Cursino, M. A., Levin, A. S. et al. (2017). Brazil’s resolutions to regulate the sale of antibiotics: impact on consumption and Escherichia coli resistance rates. Journal of global antimicrobial resistance, 10, 195-199.
Costa, J. M. D., Moura, C. S. D., Pádua, C. A. M. D., Vegi, A. S. F., Magalhães, S. M. S., Rodrigues, M. B. et al. (2019). Medida restritiva para comercialização de antimicrobianos no Brasil: resultados alcançados. Revista de Saúde Pública, 53.
Martinez, J. L. (2014). General principles of antibiotic resistance in bacteria. Drug Discovery Today: Technologies, 11, 33-39.
Wacharasint, P., Angsusakun, C., & Jongstapongpun, P. (2016). Impact of Time to Report Positive Hemoculture on Mortality in Surgical Critically Ill Patients with Septicemia. Journal of the Medical Association of Thailand= Chotmaihet Thangphaet, 99, S219-S225.
WHO. (2014). Antimicrobial resistance: global report on surveillance. Genebra: World Health Organization; 2014. https://apps.who.int/iris/handle/10665/112642.
Knoop, S. T., Skrede, S., Langeland, N., & Flaatten, H. K. (2017). Epidemiology and impact on all-cause mortality of sepsis in Norwegian hospitals: a national retrospective study. PLoS One, 12(11), e0187990.
Lim, S. M. S., Abidin, A. Z., Liew, S. M., Roberts, J. A., & Sime, F. B. (2019). The global prevalence of multidrug-resistance among Acinetobacter baumannii causing hospital-acquired and ventilator-associated pneumonia and its associated mortality: A systematic review and meta-analysis. Journal of Infection, 79(6), 593-600.
Kim, B., Kim, Y., Hwang, H., Kim, J., Kim, S. W., Bae, I. G. et al. (2018). Trends and correlation between antibiotic usage and resistance pattern among hospitalized patients at university hospitals in Korea, 2004 to 2012: A nationwide multicenter study. Medicine, 97(51).
Henard, S., Rahib, D., Léon, L., Amadéo, B., Dumartin, C., Cavalié, P., & Coignard, B. (2011). Consommation des antibiotiques rapportée via les bilans standardisés de lutte contre les infections nosocomiales et relation avec l’ICATB. Médecine et maladies infectieuses, 41(4), 197-205.
Cisneros, J. M., Neth, O., Gil‐Navarro, M., Lepe, J. A., Jimenez‐Parrilla, F., Cordero, E. et al. (2014). Global impact of an educational antimicrobial stewardship programme on prescribing practice in a tertiary hospital centre. Clinical Microbiology and Infection, 20(1), 82-88.
Sakeena, M. H. F., Bennett, A. A., & McLachlan, A. J. (2018). Enhancing pharmacists’ role in developing countries to overcome the challenge of antimicrobial resistance: a narrative review. Antimicrobial Resistance & Infection Control, 7(1), 1-11.
Davey, P., Brown, E., Charani, E., Fenelon, L., Gould, I. M., Holmes, A. et al. (2013). Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane database of systematic reviews, (4).
Levin, A. S. S., Kobata, C. H., & Litvoc, M. N. (2014). Princípios do uso de antimicrobianos: perguntas e respostas. Revista de Medicina, 93(2), 63-68.
Pereira A. S. et al. (2018). Metodologia da pesquisa científica. UFSM.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Josiane Moreira da Costa; Cristiane Aparecida Menezes de Pádua; Aline Siqueira Fogal Vegi; Leandro Pinheiro Cintra; Gustavo Chaves de Souza; Bárbara Assumpção Dourado de Aragão; Aline de Cássia Magalhães; Augusto César da Silva; Jessica Soares Malta; Andréia Queiroz Ribeiro
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
