Clinical profile of newborns and children who presented COVID-19: scoping review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i10.32337

Keywords:

Child; Infant, Newborn; Coronavirus infections; Pandemics; Review.

Abstract

Objective: to map the clinical profile of newborns and children who had COVID-19. Methods: scoping review, developed based on the method proposed by the Joanna Briggs Institute. The search was carried out in four databases in order to answer the question: What clinical profile of newborns and children who had COVID-19? The extracted data were analyzed in an Excel® spreadsheet. Results: the final sample consisted of 15 studies. There was a predominance of observational cohort studies, published in Asia, Europe and North America, in English and in the year 2020. The most common manifestations were: fever, cough, headache and diarrhea, with mechanical ventilation as the most used device. Ground-glass opacity, lymphopenia, leukopenia and elevated C-reactive protein were the most frequent findings. Most of the population had hospital discharge as an outcome. Conclusion: there is a need to invest in research in this area so that the clinical profile of this population can be more accurately traced in different contexts, so that adequate care can be instituted.

Author Biographies

Isabella Pavarine de Souza, Universidade Federal do Triângulo Mineiro

Enfermeira. Especialista. Mestranda em Atenção à Saúde. 

Giselle Vieira de Souza, Universidade Federal do Triângulo Mineiro

Enfermeira. Especialista. Mestranda em Atenção à Saúde.

Cinthia Lorena Silva Barbosa Teixeira, Universidade Federal do Triângulo Mineiro

Enfermeira. Especialista. Mestre em Atenção à Saúde.

Flávia da Veiga Ued, Universidade Federal do Triângulo Mineiro

Enfermeira. Especialista. Mestre em Atenção à Saúde.

Nylze Helena Guillarducci Rocha, Universidade Federal do Triângulo Mineiro

Enfermeira. Mestre. Doutoranda em Atenção à Saúde. 

Divanice Contim, Universidade Federal do Triângulo Mineiro

Enfermeira. Doutora. Docente no Curso de Enfermagem.

References

Alharbi, M., Kazzaz, Y. M., Hameed, T., Alqanatish, J., Alkhalaf, H., Alsadoon, A., et al (2021). SARS-CoV-2 infection in children, clinical characteristics, diagnostic findings and therapeutic interventions at a tertiary care center in Riyadh, Saudi Arabia. J Infect Public Health. 14(4):446–53. https://doi.org/10.1016/j.jiph.2020.12.034

Anand, P., Yadav, A., Debata, P., Bachani, S., Gupta, N., & Gera, R. (2020). Clinical profile, viral load, management and outcome of neonates born to COVID 19 positive mothers: a tertiary care centre experience from India. Eur J Pediatr. 1-13. https://doi.org/10.1007/s00431-020-03800-7

Ayed, A., Embaireeg, A., Benawadh, A., Al-Fouzan, W., Hammoud, M., Al-Hathal, M., et al (2020). Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait. BMC Pregnancy and Childbirth. 20(1):754. https://doi.org/10.1186/s12884-020-03461-2

Bellino, S., Punzo, O., Rota, M. C., Manso, M. D., Urdiales, A. M., Andrianou, X., et al (2020). COVID-19 Disease Severity Risk Factors for Pediatric Patients in Italy. Pediatrics. 146(4). https://doi.org/10.1542/peds.2020-009399

Bernardino, F. B. S., Alencastro, L. C. da S., Silva, R. A. da, Ribeiro, A. D, do N,, Castilho, G. R. de C., & Gaíva, M. A. M (2021). Perfil epidemiológico de crianças e adolescentes com COVID-19: uma revisão de escopo. Rev Bras Enferm. 74. https://doi.org/10.1590/0034-7167-2020-0624

Blázquez-Gamero, D., Epalza, C., Cadenas, J. A. A., Gero, L. C, Calvo, C., Rodríguez-Molino, P., et al (2021). Fever without source as the first manifestation of SARS-CoV-2 infection in infants less than 90 days old. Eur J Pediatr. 180(7):2099–106. https://doi.org/10.1007/s00431-021-03973-9

Cabrera, S. L., Zamora Torres, A., Guerreiro Núñez, M. C., Alvariño Calderón, D., Suárez Gómez, M., Bello Arcia, J., et al (2021). Caracterización clínico-epidemiológica de 77 niños y adolescentes infectados por el coronavirus SARS-CoV-2. Rev.

Cuba. Pediatr. 93(1). http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S0034-75312021000100009&lng=es&nrm=iso&tlng=es

Cardoso, P. C., Sousa, T. M., Roch, D. S., Menezes, L. R. D., & Santos, L. C (2021). Saúde materno-infantil no contexto da pandemia de COVID-19: evidências, recomendações e desafios. Rev. Bras. Saúde Mater. Infant. 21(Suppl 1):213-20. https://doi.org/10.1590/1806-9304202100S100011

Caro-Dominguez, P., Shelmerdine, S. C., Toso, S., Secinaro, A., Toma, P., Damasio, M. B., et al (2020). Thoracic imaging of coronavirus disease 2019 (COVID-19) in children: a series of 91 cases. Pediatr Radiol. 50(10):1354-68. https://doi.org/10.1007/s00247-020-04747-5

Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., et al (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 395(10223):507–13. https://doi.org/10.1016/S0140-6736(20)30211-7

Dhir, S. K., Kumar, J., Meena, J., & Kumar, P. (2021). Clinical Features and Outcome of SARS-CoV-2 Infection in Neonates: A Systematic Review. J. Trop. Pediatr. 67(3). https://doi.org/10.1093/tropej/fmaa059

Dong, Y., Mo, X., Hu, Y., Qi, X., Jiang, F., Jiang, Z, et al (2020). Epidemiology of COVID-19 Among Children in China. Pediatrics [Internet]. 145(6). https://doi.org/10.1542/peds.2020-0702

Fernández Colomer, B., Sánchez-Luna, M., de Alba Romero, C., Alarcón, A., Baña Souto, A., Camba Longueira, F., et al (2020). Neonatal Infection Due to SARS-CoV-2: An Epidemiological Study in Spain. Front Pediatr. 8:580584. https://doi.org/10.3389/fped.2020.580584

Gale, C., Quigley, M. A., Placzek, A., Knight, M., Ladhani, S., Draper, E. S., et al (2021). Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance. Lancet Child Adolesc. Health. 5(2):113–21. https://doi.org/10.1016/S2352-4642(20)30342-4

Garazzino, S., Lo Vecchio, A., Pierantoni, L., Calò Carducci, F. I., Marchetti, F., Meini, A., et al (2021). Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results From an Italian Multicenter Study. Front Pediatr. 9:649358. https://doi.org/10.3389/fped.2021.649358

Gonzalez Jimenez, D., Velasco Rodríguez-Belvís, M., Ferrer Gonzalez, P., Domínguez Ortega, G., Segarra, O., Medina Benitez, E., et al (2020). COVID-19 Gastrointestinal Manifestations Are Independent Predictors of PICU Admission in Hospitalized Pediatric Patients. Pediatr Infect Dis J. 39(12):e459–62. https://doi.org/10.1097/INF.0000000000002935

Götzinger, F., Santiago-García, B., Noguera-Julián, A., Lanaspa, M., Lancella, L., Carducci, F. I. C., et al (2020). COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study. Lancet Child Adolesc. Health. 4(9):653–61. https://doi.org/10.1016/S2352-4642(20)30177-2

Hassoun, A., Dahan, N., & Kelly, C. (2021). A Case Series of SARS-CoV-RT-PCR-Positive Hospitalized Infants 60 Days of Age or Younger From 2 New York City Pediatric Emergency Departments. Clin Pediatr (Phila). 60(4-5):247-51. https://doi.org/10.1177/00099228211006688

Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., et al (2020). SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 181(2):271-280.e8. https://doi.org/10.1016/j.cell.2020.02.052

Kanburoglu, M. K., Tayman, C., Oncel, M. Y., Akin, I. M., Can EDemir, N., et al (2020). A Multicentered Study on Epidemiologic and Clinical Characteristics of 37 Neonates With Community-acquired COVID-19. Pediatr Infect Dis J. 39(10):e297–302. https://doi.org/10.1097/INF.0000000000002862

Ministério da Saúde (2020). Centro de Operações em Emergências em Saúde Pública. Boletim epidemiológico 03 Doença pelo novo Coronavírus 2019 - COVID-19. Brasília (DF): Secretaria de Vigilância em Saúde. https://portalarquivos2.saude.gov.br/images/pdf/2020/fevereiro/21/2020-02-21-Boletim-Epidemiologico03.pdf

Nanavati, R., Mascarenhas, D., Goyal, M., Haribalakrishna, A., & Nataraj, G. (2021). A single-center observational study on clinical features and outcomes of 21 SARS-CoV-2-infected neonates from India. Eur J Pediatr. 180(6):1895–906. https://doi.org/10.1007/s00431-021-03967-7

Oncel, M. Y., Akın, I. M., Kanburoglu, M. K., Tayman, C., Coskun, S., Narter, F., et al (2021). A multicenter study on epidemiological and clinical characteristics of 125 newborns born to women infected with COVID-19 by Turkish Neonatal Society. Eur J Pediatr. 180(3):733–42. https://doi.org/10.1007/s00431-020-03767-5

Papapanou, M., Papaioannou, M., Petta, A., Routsi, E., Farmaki, M.,Vlahos, N., et al (2021). Maternal and Neonatal Characteristics and Outcomes of COVID-19 in Pregnancy: An Overview of Systematic Reviews. Int J Environ Res Public Health. 18(2):E596. https://doi.org/10.3390/ijerph18020596.

Poline, J., Gaschignard, J., Leblanc, C., Madhi, F., Foucaud, E., Nattes, E., et al (2020). Systematic Severe Acute Respiratory Syndrome Coronavirus 2 Screening at Hospital Admission in Children: A French Prospective Multicenter Study. Clin Infect Dis. 72(15):2215-7. https://doi.org/10.1093/cid/ciaa1044

Rao, S., Gavali, V., Prabhu, S. S., Mathur, R., Dabre, L. R., Prabhu, S. B., et al (2021). Outcome of Children Admitted With SARS-CoV-2 Infection: Experiences From a Pediatric Public Hospital. Indian Pediatr. 358–62. https://doi.org/10.1007/s13312-021-2196-4

Ronchi, A., Pietrasanta, C., Zavattoni, M., Saruggia, M., Schena, F., Sinelli, M. T., et al (2021). Evaluation of Rooming-in Practice for Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Italy. JAMA Pediatrics. 175(3):260–6. https://doi.org/doi:10.1001/jamapediatrics.2020.5086

Society of Pediatrics, Chinese Medical Association, Editorial Board & Chinese Journal of Pediatrics (2020). Recommendations for the diagnosis, prevention and control of the 2019 novel coronavirus infection in children (first interim edition). Chin J Pediatr. 58(0):e004. https://dx.doi.org/10.3760/cma.j.issn.0578-1310.2020.0004

Vardhelli, V., Pandita, A., Pillai, A., & Badatya, S. K. (2021). Perinatal COVID-19: review of current evidence and practical approach towards prevention and management. Eur J Pediatr. 180(4):1009-31. https://doi.org/10.1007/s00431-020-03866-3

Vivanti, A. J., Vauloup-Fellous, C., Prevot, S., Zupan, V., Suffee, C., Do Cao, J., et al (2020). Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 11(1):3572. https://doi.org/10.1038/s41467-020-17436-6

Wang, D., Ju, X. L., Xie, F., Lu, Y., Li, F. Y., Huang, H. H., et al (2020). Clinical analysis of 31 cases of 2019 novel coronavirus infection in children from six provinces (autonomous region) of northern China. Zhonghua Er Ke Za Zhi. 58(4):269–74. https://doi.org/10.3760/cma.j.cn112140-20200225-00138

World Health Organization (2020). Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Interim guidance. Pediatr Med Rodz. 16(1):9-. 26https://apps.who.int/iris/handle/10665/331446

World Health Organization (2021). WHO Coronavirus (COVID-19) Dashboard. https://who.sprinklr.com/

Wu, C., Chen, X., Cai, Y., Xia, J., Zhou, X-barra., Xu, S., et al (2020). Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Internal Medicine.180(7):934–43. https://doi.org/10.1001/jamainternmed.2020.0994

Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., et al (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 395(10229):1054–62. https://doi.org/10.1016/S0140-6736(20)30566-3

Published

21/07/2022

How to Cite

SILVA, M. P. C.; SOUZA, I. P. de .; SOUZA, G. V. de .; TEIXEIRA, C. L. S. B. .; UED, F. da V. . .; ROCHA, N. H. G. .; CONTIM, D. . Clinical profile of newborns and children who presented COVID-19: scoping review. Research, Society and Development, [S. l.], v. 11, n. 10, p. e30111032337, 2022. DOI: 10.33448/rsd-v11i10.32337. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/32337. Acesso em: 30 nov. 2022.

Issue

Section

Review Article