Medicinal plants and heavy metals: a library review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i9.32338

Keywords:

Medicinal plants; Heavy metals; Food security.

Abstract

The use of medicinal plants is a very old practice. According to the World Health Organization, approximately 80% of the population uses plants for therapeutic purposes. Medicinal plants are plant species with several active principles, which can act in the human and animal body to fight many diseases. Despite its beneficial health effects, many studies report contamination by heavy metals, both from natural and anthropogenic sources. In many countries, medicinal plants are used and marketed with little or no supervision for the presence of heavy metals. The objective of this article was to qualitatively analyze publications, carried out in the last 10 years, on contamination by heavy metals in medicinal plants, in order to understand the mechanisms of tolerance of plants to the presence of heavy metals, to know the legislation that guides the use of medicinal plants and understand what still needs to be done to avoid contamination by heavy metals through medicinal plants. For the elaboration of this review, a search was carried out in the Scopus database, using the terms “heavy metal” and “medicinal plants”. After the search, the works were analyzed using the VOsviewer® software. It is concluded that the interest in plants in the last 10 years is constant. Plants have different ways to tolerate the presence of heavy metals. New regulations need to be implemented, the inspection of herbal products needs to be more rigorous and the population needs to be better informed about the therapeutic properties based on scientific work and about the possible contamination present in plants.

References

Abida, H., Dolch, L. J., Meï, C., Villanova, V., Conte, M., Block, M. A.,& Maréchal, E. (2015). Membrane glycerolipid remodeling triggered by nitrogen and phosphorus starvation in Phaeodactylum tricornutum. Plant Physiology, 167(1), 118–136. https://doi.org/10.1104/pp.114.252395

Alonso-Blázquez, N., García-Gómez, C., & Fernández, M. D. (2015). Influence of Zn-contaminated soils in the antioxidative defence system of wheat (Triticum aestivum) and maize (Zea mays) at different exposure times: potential use as biomarkers. Ecotoxicology, 24(2), 279–291. https://doi.org/10.1007/s10646-014-1376-6

Andrade, D. F., Romanelli, J. P., & Pereira-Filho, E. R. (2019). Past and emerging topics related to electronic waste management: top countries, trends, and perspectives. Environmental Science and Pollution Research, 26(17), 17135–17151. https://doi.org/10.1007/s11356-019-05089-y

ANVISA. (2013) . Agência nacional de vigilância sanitária. RDC Nº 42, de 29 de agosto de 2013. Limites Máximos de Contaminantes Inorgânicos em Alimentos para o Mercosul.. BrasíliA. https://www.gov.br/agricultura/pt-br/assuntos/inspecao/produtos-animal/plano-de-nacional-de-controle-de-residuos-e-contaminantes/documentos-da-pncrc/anvisa-resolucao-rdc-no-42-de-29-de-agosto-de-2013-internaliza-a-resolucao-gmc-res-n-o-12-2011.pdf/view

Asgari Lajayer, B., Ghorbanpour, M., & Nikabadi, S. (2017). Heavy metals in contaminated environment: Destiny of secondary metabolite biosynthesis, oxidative status and phytoextraction in medicinal plants. Ecotoxicology and Environmental Safety. Academic Press. https://doi.org/10.1016/j.ecoenv.2017.07.035

ASTR. (2013) Agency for toxic substances and disease registry . National Toxic Substance Incidents Program (NTSIP) Annual Report, Atlanta, GA: Agency for Toxic Substances and Disease Registry. https://www.atsdr.cdc.gov/ntsip/docs/ATSDR_Annual%20Report_121013_508%20compliant.pdf

Avigan, M. I., Mozersky, R. P., & Seeff, L. B. (2016, March 3). Scientific and regulatory perspectives in herbal and dietary supplement associated hepatotoxicity in the United States. International Journal of Molecular Sciences. MDPI AG. https://doi.org/10.3390/ijms17030331

Balsan, L., Guirra, A. P. M., Barbosa, D. S., Da Silva, N. M., & Filho, A. C. P. (2019). Spatialization of the intrinsic risk of pesticide contamination in water bodies and determination of monitoring points. Anuario Do Instituto de Geociencias, 42(1), 496–513. https://doi.org/10.11137/2019_1_496_513

Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014). Oxidative stress: An essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiological Reviews, 94(2), 329–354. https://doi.org/10.1152/physrev.00040.2012

Brasil. (2013). Regulamenta as condições para o funcionamento de empresas ao licenciamento sanitário, e o registro, controle e monitoramento, no âmbito da vigilância sanitária, dos produtos de que trata a Lei no 6.360, de 23 de setembro de 1976, e dá outras providências. http://www.planalto.gov.br/ccivil_03/_Ato20112014/2013/Decreto/D8077.htm

Brumbarova, T., Bauer, P., & Ivanov, R. (2015). Molecular mechanisms governing Arabidopsis iron uptake. Trends in Plant Science. Elsevier Ltd. https://doi.org/10.1016/j.tplants.2014.11.004

Cambrollé, J., Mancilla-Leytón, J. M., Muñoz-Vallés, S., Luque, T., & Figueroa, M. E. (2012). Zinc tolerance and accumulation in the salt-marsh shrub Halimione portulacoides. Chemosphere, 86(9), 867–874. https://doi.org/10.1016/j.chemosphere.2011.10.039

Campos, S. A. B., Dal-Magro, J., & de Souza-Franco, G. M. (2018). Metals in fish of different trophic levels in the area of influence of the AHE Foz do Chapecó reservoir, Brazil. Environmental Science and Pollution Research, 25(26), 26330–26340. https://doi.org/10.1007/s11356-018-2522-0

Cuypers, A., Karen, S., Jos, R., Kelly, O., Els, K., Tony, R., … Jaco, V. (2011). The cellular redox state as a modulator in cadmium and copper responses in Arabidopsis thaliana seedlings. Journal of Plant Physiology, 168(4), 309–316. https://doi.org/10.1016/j.jplph.2010.07.010

De Lurdes Dinis, M., & Fiúza, A. (2011). Exposure Assessment to Heavy Metals in the Environment: Measures to Eliminate or Reduce the Exposure to Critical Receptors. NATO Science for Peace and Security Series C: Environmental Security. https://doi.org/10.1007/978-94-007-0253-0_2

Denholm J. (2010). Complementary Medicine And Heavy Metal Toxicity In Australia. Webmed central toxicology ;(9):WMC00535

Dogan, I., Ozyigit, I. I., & Demir, G. (2014). Influence of aluminum on mineral nutrient uptake and accumulation in urtica pilulifera l. Journal of Plant Nutrition, 37(3), 469–481. https://doi.org/10.1080/01904167.2013.864306

Dong, Q., Xu, P. X., & Wang, Z. L. (2017). Differential cadmium distribution and translocation in roots and shoots related to hyper-tolerance between tall fescue and Kentucky bluegrass. Frontiers in Plant Science, 8(FEBRUARY). https://doi.org/10.3389/fpls.2017.00113

Efferth, T., & Kaina, B. (2011). Toxicities by Herbal Medicines with Emphasis to Traditional Chinese Medicine. Current Drug Metabolism, 12(10), 989–996. https://doi.org/10.2174/138920011798062328

Efferth, T., & Kaina, B. (2011). Toxicities by Herbal Medicines with Emphasis to Traditional Chinese Medicine. Current Drug Metabolism, 12(10), 989–996. https://doi.org/10.2174/138920011798062328

Efferth, T., & Koch, E. (2011). Complex Interactions between Phytochemicals. The Multi-Target Therapeutic Concept of Phytotherapy. Current Drug Targets, 12(1), 122–132. https://doi.org/10.2174/138945011793591626

FAO, & OECD. (2015). Agricultural Outlook 2015. OECD-FAO Agricultural Outlook, 145. Retrieved from http://www.oecd-ilibrary.org/agriculture-and-food/oecd-fao-agricultural-outlook-2015_agr_outlook-2015-en

Gallego, S. M., Pena, L. B., Barcia, R. A., Azpilicueta, C. E., Iannone, M. F., Rosales, E. P.& Benavides, M. P. (2012). Unravelling cadmium toxicity and tolerance in plants: Insight into regulatory mechanisms. Environmental and Experimental Botany. https://doi.org/10.1016/j.envexpbot.2012.04.006

Genuis, S. J., Schwalfenberg, G., Siy, A. K. J., & Rodushkin, I. (2012). Toxic Element Contamination of Natural Health Products and Pharmaceutical Preparations. PLoS ONE, 7(11). https://doi.org/10.1371/journal.pone.0049676

Ghori, N. H., Ghori, T., Hayat, M. Q., Imadi, S. R., Gul, A., Altay, V., & Ozturk, M. (2019, March 14). Heavy metal stress and responses in plants. International Journal of Environmental Science and Technology. Center for Environmental and Energy Research and Studies. https://doi.org/10.1007/s13762-019-02215-8

Halim, M. A., Majumder, R. K., & Zaman, M. N. (2015). Paddy soil heavy metal contamination and uptake in rice plants from the adjacent area of Barapukuria coal mine, northwest Bangladesh. Arabian Journal of Geosciences, 8(6), 3391–3401. https://doi.org/10.1007/s12517-014-1480-1

Harris, E. S. J., Cao, S., Littlefield, B. A., Craycroft, J. A., Scholten, R., Kaptchuk, T.,& Eisenberg, D. M. (2011). Heavy metal and pesticide content in commonly prescribed individual raw Chinese Herbal Medicines. Science of the Total Environment, 409(20), 4297–4305. https://doi.org/10.1016/j.scitotenv.2011.07.032

Hatami, M., & Ghorbanpour, M. (2016). Changes in phytochemicals in response to rhizospheric microorganism infection. In Microbial-Mediated Induced Systemic Resistance in Plants (pp. 1–14). Springer Singapore. https://doi.org/10.1007/978-981-10-0388-2_1

Hussain, S., Rengel, Z., Qaswar, M., Amir, M., & Zafar-ul-Hye, M. (2019). Arsenic and Heavy Metal (Cadmium, Lead, Mercury and Nickel) Contamination in Plant-Based Foods. In Plant and Human Health, Volume 2 (pp. 447–490). Springer International Publishing. https://doi.org/10.1007/978-3-030-03344-6_20

Hussein, H. M. (2016). Analysis of trace heavy metals and volatile chemical compounds of Lepidium sativum using atomic absorption spectroscopy, gas chromatography-mass spectrometric and fourier-transform infrared spectroscopy. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7(4), 2529–2555.

Khan, A., Khan, S., Khan, M. A., Qamar, Z., & Waqas, M. (2015). The uptake and bioaccumulation of heavy metals by food plants, their effects on plants nutrients, and associated health risk: a review. Environmental Science and Pollution Research, 22(18), 13772–13799. https://doi.org/10.1007/s11356-015-4881-0

Kishan, P.S., Bhattacharya, S., Sharma, P. (2014) Assessment of heavy metal contents of some Indian medicinal plants. American-Eurasian. J Agric Environ Sci 14(10):1125–1129

Klebis, D. (2018). China é o país que produz mais artigos científicos no mundo. Brasil é o 12º. Science NSF. https://www.ufrgs.br/bibliotecacentral/china-e-o-pais-que-produz-mais-artigos-cientificos-no-mundo-brasil-e-o-12o

Koganti, D.K. (2021), A produção total de grãos alimentícios no país é estimada em um recorde de 308,65 milhões de toneladas, 11,15 milhões de toneladas a mais do que em 2019-20. INVEST INDIA, 2020. https://www.investindia.gov.in/pt-br/sector/agriculture-forestry

Kohzadi, S., Shahmoradi, B., Ghaderi, E., Loqmani, H., & Maleki, A. (2019). Concentration, Source, and Potential Human Health Risk of Heavy Metals in the Commonly Consumed Medicinal Plants. Biological Trace Element Research, 187(1), 41–50. https://doi.org/10.1007/s12011-018-1357-3

Kumar, D., Bharti, S. K., Anand, S., & Kumar, N. (2018). Bioaccumulation and biochemical responses of Vetiveria zizanioides grown under Cadmium and Copper stresses. Environmental Sustainability, 1(2), 133–139. https://doi.org/10.1007/s42398-018-0009-z

Lamhamdi, M., Bakrim, A., Aarab, A., Lafont, R., & Sayah, F. (2011). Lead phytotoxicity on wheat (Triticum aestivum L.) seed germination and seedlings growth. Comptes Rendus - Biologies, 334(2), 118–126. https://doi.org/10.1016/j.crvi.2010.12.006

Lanini, J., Duarte-Almeida, J. M., Nappo, S. A., & Carlini, E. A. (2011). Are medicinal herbs safe? the opinion of plant vendors from Diadema (São Paulo, southeastern Brazil). Revista Brasileira de Farmacognosia, 22(1), 21–28. https://doi.org/10.1590/S0102-695X2011005000188

Li, F. S., & Weng, J. K. (2017). Demystifying traditional herbal medicine with modern approaches. Nature Plants. Palgrave Macmillan Ltd. https://doi.org/10.1038/nplants.2017.109

Liu, S. H., Chuang, W. C., Lam, W., Jiang, Z., & Cheng, Y. C. (2015). Safety Surveillance of Traditional Chinese Medicine: Current and Future. Drug Safety, 38(2), 117–128. https://doi.org/10.1007/s40264-014-0250-z

Liu, X., Xu, W., Pan, Y., & Du, E. (2015). Liu et al. suspect that Zhu et al. (2015) may have underestimated dissolved organic nitrogen (N) but overestimated total particulate N in wet deposition in China. Science of the Total Environment. Elsevier. https://doi.org/10.1016/j.scitotenv.2015.03.004

Mahmood, A., Mahmood, A., & Malik, R. N. (2012). Indigenous knowledge of medicinal plants from Leepa valley, Azad Jammu and Kashmir, Pakistan. Journal of Ethnopharmacology, 143(1), 338–346. https://doi.org/10.1016/j.jep.2012.06.046

Mahmood, A., Mahmood, A., & Tabassum, A. (2011). ETHNOMEDICINAL SURVY OF PLANTS FROM DISTRICT SIALKOT, PAKISTAN. Journal of Applied Pharmacy, 3, 212–220. https://doi.org/10.21065/19204159.3.212

Malar, S., Manikandan, R., Favas, P. J. C., Vikram Sahi, S., & Venkatachalam, P. (2014). Effect of lead on phytotoxicity, growth, biochemical alterations and its role on genomic template stability in Sesbania grandiflora: A potential plant for phytoremediation. Ecotoxicology and Environmental Safety, 108, 249–257. https://doi.org/10.1016/j.ecoenv.2014.05.018

Maleki, M., Ghorbanpour, M., & Kariman, K. (2017). Physiological and antioxidative responses of medicinal plants exposed to heavy metals stress. Plant Gene, 11, 247–254. https://doi.org/10.1016/j.plgene.2017.04.006

Mazid, M., Khan, T. A., & Mohammad, F. (2011). Role of secondary metabolites in defense mechanisms of plants. Biology and Medicine. AstonJournals.. . 10. n.1. 2178-0722. https://doi.org/10.5281/zenodo.5203222

Mishra, K., Boynton, L., & Mishra, A. (2014). Driving Employee Engagement : The Expanded Role of Internal Communications. International Journal of Business Communication, 51(2), 183–202. https://doi.org/10.1177/2329488414525399

Mziray, P., & Kimirei, I. A. (2016). Bioaccumulation of heavy metals in marine fishes (Siganus sutor, Lethrinus harak, and Rastrelliger kanagurta) from Dar es Salaam Tanzania. Regional Studies in Marine Science, 7, 72–80. https://doi.org/10.1016/j.rsma.2016.05.014

Nafiu, M. O., Hamid, A. A., Muritala, H. F., & Adeyemi, S. B. (2017). Preparation, Standardization, and Quality Control of Medicinal Plants in Africa. In Medicinal Spices and Vegetables from Africa: Therapeutic Potential Against Metabolic, Inflammatory, Infectious and Systemic Diseases (pp. 171–204). Elsevier Inc. https://doi.org/10.1016/B978-0-12-809286-6.00007-8

Nicoletti, D., Casandruc, E., Laplace, Y., Khanna, V., Hunt, C. R., Kaiser, S., … Cavalleri, A. (2014). Optically induced superconductivity in striped La 2 − x Ba x CuO 4 by polarization-selective. Physical Review B, 90(10), 100503. Retrieved from http://link.aps.org/doi/10.1103/PhysRevB.90.100503

Oliveira, M. C., & Schoffen, J. P. F. (2010). Oxidative stress action in cellular aging. Brazilian Archives of Biology and Technology, 53(6), 1333–1342. https://doi.org/10.1590/S1516-89132010000600009

Oliveira, V. M., Caldeira, A. J. R., Ayres, F. M & Santo, C. A. F. E. (2020). Uso de plantas medicinais por idosos. https://doi.org/10.5281/zenodo.5203222. Revista Anópolis, v

OPAS - Organização Pan-Americana de Saúde. (2002). Consenso Brasileiro de Atenção Farmacêutica: proposta. Brasília: Organização Pan-Americana Da Saúde, 24.

Osma, E., Ozyigit, I. I., Demir, G., & Yasar, U. (2014). Assesment of some heavy metals in wild type and cultivated purslane (portulaca oleracea L.) and soils in Istanbul, Turkey. Fresenius Environmental Bulletin, 23(9), 2181–2189.

Ozturk, A., Yarci, C., & Ozyigit, I. I. (2017). Assessment of heavy metal pollution in Istanbul using plant (Celtis australis L.) and soil assays. Biotechnology and Biotechnological Equipment, 31(5), 948–954. https://doi.org/10.1080/13102818.2017.1353922

Ramakrishna, A., & Ravishankar, G. A. (2011) Influence of abiotic stress signals on secondary metabolites in plants. Plant Signaling and Behavior. https://doi.org/10.4161/psb.6.11.17613

Revathi, P., Parimelazhagan,T., & Manian, S. (2013). Ethnomedicinal plants and novel formulations used by Hooralis tribe in Sathyamangalam forests, Western Ghats of Tamil Nadu, India. Journal of Medicinal Plants Research, 7(28), 2083–2097. https://doi.org/10.5897/jmpr2013.5074

Rocha, L. S., Arakaki, D. G., Bogo, D., Melo, E. S. P., Lima, N. V., Souza, I. D. D., & Nascimento, V. A. (2019). Evaluation of level of essential elements and toxic metal in the medicinal plant hymenaea martiana Hayne (Jatobá) used by mid-west population of Brazil. Scientific World Journal, 2019. https://doi.org/10.1155/2019/4806068

Rodriguez-Hernandez, M. C., Bonifas, I., Alfaro-De la Torre, M. C., Flores-Flores, J. L., Bañuelos-Hernández, B., & Patiño-Rodríguez, O. (2015). Increased accumulation of cadmium and lead under Ca and Fe deficiency in Typha latifolia: A study of two pore channel (TPC1) gene responses. Environmental and Experimental Botany, 115, 38–48. https://doi.org/10.1016/j.envexpbot.2015.02.009

Rosa, C. da, Câmara, S. G., & Béria, J. U. (2011). Representações e intenção de uso da fitoterapia na atenção básica à saúde. Ciência & Saúde Coletiva, 16(1), 311–318. https://doi.org/10.1590/s1413-81232011000100033

Schreck, E., Foucault, Y., Sarret, G., Sobanska, S., Cécillon, L., Castrec-Rouelle, M. & Dumat, C. (2012). Metal and metalloid foliar uptake by various plant species exposed to atmospheric industrial fallout: Mechanisms involved for lead. Science of the Total Environment, 427–428, 253–262. https://doi.org/10.1016/j.scitotenv.2012.03.051

Shahid, M., Dumat, C., Khalid, S., Schreck, E., Xiong, T., & Niazi, N. K. (2017, March 5). Foliar heavy metal uptake, toxicity and detoxification in plants: A comparison of foliar and root metal uptake. Journal of Hazardous Materials. Elsevier B.V. https://doi.org/10.1016/j.jhazmat.2016.11.063

Singh, V. P., Srivastava, P. K., & Prasad, S. M. (2013). Nitric oxide alleviates arsenic-induced toxic effects in ridged Luffa seedlings. Plant Physiology and Biochemistry, 71, 155–163. https://doi.org/10.1016/j.plaphy.2013.07.003

Soriano-Disla, J. M., Gómez, I., Navarro-Pedreño, J., & Jordán, M. M. (2014). The transfer of heavy metals to barley plants from soils amended with sewage sludge with different heavy metal burdens. Journal of Soils and Sediments, 14(4), 687–696. https://doi.org/10.1007/s11368-013-0773-4

Souza, V. L., De Almeida, A. A. F., Lima, S. G. C., Júlio, J. C., Da C. Silva, D., Mangabeira, P. A. O., & Gomes, F. P. (2011). Morphophysiological responses and programmed cell death induced by cadmium in Genipa americana L. (Rubiaceae). BioMetals, 24(1), 59–71. https://doi.org/10.1007/s10534-010-9374-5

Street, R. A. (2012). Heavy metals in medicinal plant products - An African perspective. South African Journal of Botany, 82, 67–74. https://doi.org/10.1016/j.sajb.2012.07.013

Teschke, R., Sarris, J., & Lebot, V. (2013). Contaminant hepatotoxins as culprits for kava hepatotoxicity - Fact or fiction? Phytotherapy Research, 27(3), 472–474. https://doi.org/10.1002/ptr.4729

Wani, A. L., Ara, A., & Usmani, J. A. (2015). Lead toxicity: A review. Interdisciplinary Toxicology. Slovak Toxicology Society. https://doi.org/10.1515/intox-2015-0009

WHO. (2015). World Health Organization. WHO Estimates of the Global Burden of Foodborne Diseases: Foodborne Disease Burden Epidemiology Reference Group 2007-2015. Encyclopedia of Parasitology, 1–265. Retrieved from https://apps.who.int/iris/bitstream/handle/10665/199350/?sequence=1

WHO.(1998). WHA 51.23 Amendments to articles 24 and 25 of the Constitution. Genebra: WHO. https://treaties.un.org/pages/ViewDetails.aspx?src=TREATY&mtdsg_no=IX-1-h&chapter=9&clang=_en

Woszezenki, C. R., & Gonçalves, A. L. (2013). Biomedical text mining: A bibliometrics review. Perspectivas Em Ciencia Da Informacao, 18(3), 24–44. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887901111&doi=10.1590%2FS1413-99362013000300003&partnerID=40&md5=56f0e02f9f30d69e8d483fdac1d16eb6

Wyszkowska, J., Boros-Lajszner, E., Borowik, A., Baćmaga, M., Kucharski, J., & Tomkiel, M. (2016). Implication of zinc excess on soil health. Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes, 51(5), 261–270. https://doi.org/10.1080/10934529.2015.1128726

Yasar, U., Ozyigit, I. I., Yalcin, I. E., Dogan, I., & Demir, G. (2012). Determination of some heavy metals and mineral nutrients of bay tree (Laurus nobilis L.) in Bartin city, Turkey. Pakistan Journal of Botany, 44(SPL.ISS.1), 81–89.

Yuan, X., Chapman, R. L., & Wu, Z. (2011). Analytical methods for heavy metals in herbal medicines. Phytochemical Analysis, 22(3), 189–198. https://doi.org/10.1002/pca.1287

Zhao, Q., Wang, Y., Cao, Y., Chen, A., Ren, M., Ge, Y., & Li, L. (2014). Potential health risks of heavy metals in cultivated topsoil and grain, including correlations with human primary liver, lung and gastric cancer, in Anhui province, Eastern China. Science of the Total Environment, 470–471, 340–347. https://doi.org/10.1016/j.scitotenv.2013.09.086

Zhao, Q., Wang, Y., Cao, Y., Chen, A., Ren, M., Ge, Y., … Li, L. (2014). Potential health risks of heavy metals in cultivated topsoil and grain, including correlations with human primary liver, lung and gastric cancer, in Anhui province, Eastern China. Science of the Total Environment, 470–471, 340–347. https://doi.org/10.1016/j.scitotenv.2013.09.086

Zheng, E. X., & Navarro, V. J. (2015). Liver injury from herbal, dietary, and weight loss supplements: A review. Journal of Clinical and Translational Hepatology. Xia and He Publishing Inc. https://doi.org/10.14218/JCTH.2015.00006

Zheng, S., Wang, Q., Yuan, Y., & Sun, W. (2020). Human health risk assessment of heavy metals in soil and food crops in the Pearl River Delta urban agglomeration of China. Food Chemistry, 316. https://doi.org/10.1016/j.foodchem.2020.126213

Zhou, H., Yang, W. T., Zhou, X., Liu, L., Gu, J. F., Wang, W. L., … Liao, B. H. (2016). Accumulation of heavy metals in vegetable species planted in contaminated soils and the health risk assessment. International Journal of Environmental Research and Public Health, 13(3). https://doi.org/10.3390/ijerph13030289

Published

19/07/2022

How to Cite

GALVAN, N. da S.; CAMPOS, M. L.; MIQUELLUTI, D. J. .; ESTEVES, M. E. S. .; DORS, P. . Medicinal plants and heavy metals: a library review. Research, Society and Development, [S. l.], v. 11, n. 9, p. e57911932338, 2022. DOI: 10.33448/rsd-v11i9.32338. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/32338. Acesso em: 19 apr. 2024.

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Section

Agrarian and Biological Sciences