Plantas medicinais e metais pesados: uma revisão bibliométrica
DOI:
https://doi.org/10.33448/rsd-v11i9.32338Palavras-chave:
Plantas medicinais; metais pesados; Segurança alimentar.Resumo
A utilização de plantas medicinais é uma prática muito antiga. De acordo com a Organização Mundial da Saúde, aproximadamente 80% da população utiliza plantas para fins terapêuticos. Plantas medicinais são espécies vegetais com vários princípios ativos, que podem agir no organismo humano e de animais para combater muitas doenças. Apesar de seus efeitos benéficos para a saúde, muitos estudos relatam a contaminação por metais pesados, por fontes naturais e antropogênicas. O objetivo deste artigo foi analisar qualitativamente publicações, realizadas nos últimos 10 anos, sobre contaminação por metais pesados em plantas medicinais, a fim de compreender os mecanismos de tolerância das plantas a presença de metais pesados, conhecer a legislação que norteia o uso de plantas medicinais, e compreender o que ainda precisa ser feito para evitar a contaminação por metais pesados por meio das plantas medicinais. Para a elaboração desta revisão foi realizada uma busca na base Scopus, utilizando os termos “heavy metal” and “medicinal plants”. Após a busca, os trabalhos foram analisados com auxílio do software VOsviewer®. Conclui-se que o interesse pelas plantas nos últimos 10 anos é constante. As plantas possuem diferentes formas para tolerar a presença de metais pesados. Novas regulamentações precisam ser implementadas, a fiscalização de produtos à base de plantas precisa ser mais rigorosa e a população precisa ser melhor informada quanto às propriedades terapêuticas baseadas em trabalhos científicos e sobre as possíveis fontes de contaminação presentes nas plantas.
Referências
Abida, H., Dolch, L. J., Meï, C., Villanova, V., Conte, M., Block, M. A.,& Maréchal, E. (2015). Membrane glycerolipid remodeling triggered by nitrogen and phosphorus starvation in Phaeodactylum tricornutum. Plant Physiology, 167(1), 118–136. https://doi.org/10.1104/pp.114.252395
Alonso-Blázquez, N., García-Gómez, C., & Fernández, M. D. (2015). Influence of Zn-contaminated soils in the antioxidative defence system of wheat (Triticum aestivum) and maize (Zea mays) at different exposure times: potential use as biomarkers. Ecotoxicology, 24(2), 279–291. https://doi.org/10.1007/s10646-014-1376-6
Andrade, D. F., Romanelli, J. P., & Pereira-Filho, E. R. (2019). Past and emerging topics related to electronic waste management: top countries, trends, and perspectives. Environmental Science and Pollution Research, 26(17), 17135–17151. https://doi.org/10.1007/s11356-019-05089-y
ANVISA. (2013) . Agência nacional de vigilância sanitária. RDC Nº 42, de 29 de agosto de 2013. Limites Máximos de Contaminantes Inorgânicos em Alimentos para o Mercosul.. BrasíliA. https://www.gov.br/agricultura/pt-br/assuntos/inspecao/produtos-animal/plano-de-nacional-de-controle-de-residuos-e-contaminantes/documentos-da-pncrc/anvisa-resolucao-rdc-no-42-de-29-de-agosto-de-2013-internaliza-a-resolucao-gmc-res-n-o-12-2011.pdf/view
Asgari Lajayer, B., Ghorbanpour, M., & Nikabadi, S. (2017). Heavy metals in contaminated environment: Destiny of secondary metabolite biosynthesis, oxidative status and phytoextraction in medicinal plants. Ecotoxicology and Environmental Safety. Academic Press. https://doi.org/10.1016/j.ecoenv.2017.07.035
ASTR. (2013) Agency for toxic substances and disease registry . National Toxic Substance Incidents Program (NTSIP) Annual Report, Atlanta, GA: Agency for Toxic Substances and Disease Registry. https://www.atsdr.cdc.gov/ntsip/docs/ATSDR_Annual%20Report_121013_508%20compliant.pdf
Avigan, M. I., Mozersky, R. P., & Seeff, L. B. (2016, March 3). Scientific and regulatory perspectives in herbal and dietary supplement associated hepatotoxicity in the United States. International Journal of Molecular Sciences. MDPI AG. https://doi.org/10.3390/ijms17030331
Balsan, L., Guirra, A. P. M., Barbosa, D. S., Da Silva, N. M., & Filho, A. C. P. (2019). Spatialization of the intrinsic risk of pesticide contamination in water bodies and determination of monitoring points. Anuario Do Instituto de Geociencias, 42(1), 496–513. https://doi.org/10.11137/2019_1_496_513
Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014). Oxidative stress: An essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiological Reviews, 94(2), 329–354. https://doi.org/10.1152/physrev.00040.2012
Brasil. (2013). Regulamenta as condições para o funcionamento de empresas ao licenciamento sanitário, e o registro, controle e monitoramento, no âmbito da vigilância sanitária, dos produtos de que trata a Lei no 6.360, de 23 de setembro de 1976, e dá outras providências. http://www.planalto.gov.br/ccivil_03/_Ato20112014/2013/Decreto/D8077.htm
Brumbarova, T., Bauer, P., & Ivanov, R. (2015). Molecular mechanisms governing Arabidopsis iron uptake. Trends in Plant Science. Elsevier Ltd. https://doi.org/10.1016/j.tplants.2014.11.004
Cambrollé, J., Mancilla-Leytón, J. M., Muñoz-Vallés, S., Luque, T., & Figueroa, M. E. (2012). Zinc tolerance and accumulation in the salt-marsh shrub Halimione portulacoides. Chemosphere, 86(9), 867–874. https://doi.org/10.1016/j.chemosphere.2011.10.039
Campos, S. A. B., Dal-Magro, J., & de Souza-Franco, G. M. (2018). Metals in fish of different trophic levels in the area of influence of the AHE Foz do Chapecó reservoir, Brazil. Environmental Science and Pollution Research, 25(26), 26330–26340. https://doi.org/10.1007/s11356-018-2522-0
Cuypers, A., Karen, S., Jos, R., Kelly, O., Els, K., Tony, R., … Jaco, V. (2011). The cellular redox state as a modulator in cadmium and copper responses in Arabidopsis thaliana seedlings. Journal of Plant Physiology, 168(4), 309–316. https://doi.org/10.1016/j.jplph.2010.07.010
De Lurdes Dinis, M., & Fiúza, A. (2011). Exposure Assessment to Heavy Metals in the Environment: Measures to Eliminate or Reduce the Exposure to Critical Receptors. NATO Science for Peace and Security Series C: Environmental Security. https://doi.org/10.1007/978-94-007-0253-0_2
Denholm J. (2010). Complementary Medicine And Heavy Metal Toxicity In Australia. Webmed central toxicology ;(9):WMC00535
Dogan, I., Ozyigit, I. I., & Demir, G. (2014). Influence of aluminum on mineral nutrient uptake and accumulation in urtica pilulifera l. Journal of Plant Nutrition, 37(3), 469–481. https://doi.org/10.1080/01904167.2013.864306
Dong, Q., Xu, P. X., & Wang, Z. L. (2017). Differential cadmium distribution and translocation in roots and shoots related to hyper-tolerance between tall fescue and Kentucky bluegrass. Frontiers in Plant Science, 8(FEBRUARY). https://doi.org/10.3389/fpls.2017.00113
Efferth, T., & Kaina, B. (2011). Toxicities by Herbal Medicines with Emphasis to Traditional Chinese Medicine. Current Drug Metabolism, 12(10), 989–996. https://doi.org/10.2174/138920011798062328
Efferth, T., & Kaina, B. (2011). Toxicities by Herbal Medicines with Emphasis to Traditional Chinese Medicine. Current Drug Metabolism, 12(10), 989–996. https://doi.org/10.2174/138920011798062328
Efferth, T., & Koch, E. (2011). Complex Interactions between Phytochemicals. The Multi-Target Therapeutic Concept of Phytotherapy. Current Drug Targets, 12(1), 122–132. https://doi.org/10.2174/138945011793591626
FAO, & OECD. (2015). Agricultural Outlook 2015. OECD-FAO Agricultural Outlook, 145. Retrieved from http://www.oecd-ilibrary.org/agriculture-and-food/oecd-fao-agricultural-outlook-2015_agr_outlook-2015-en
Gallego, S. M., Pena, L. B., Barcia, R. A., Azpilicueta, C. E., Iannone, M. F., Rosales, E. P.& Benavides, M. P. (2012). Unravelling cadmium toxicity and tolerance in plants: Insight into regulatory mechanisms. Environmental and Experimental Botany. https://doi.org/10.1016/j.envexpbot.2012.04.006
Genuis, S. J., Schwalfenberg, G., Siy, A. K. J., & Rodushkin, I. (2012). Toxic Element Contamination of Natural Health Products and Pharmaceutical Preparations. PLoS ONE, 7(11). https://doi.org/10.1371/journal.pone.0049676
Ghori, N. H., Ghori, T., Hayat, M. Q., Imadi, S. R., Gul, A., Altay, V., & Ozturk, M. (2019, March 14). Heavy metal stress and responses in plants. International Journal of Environmental Science and Technology. Center for Environmental and Energy Research and Studies. https://doi.org/10.1007/s13762-019-02215-8
Halim, M. A., Majumder, R. K., & Zaman, M. N. (2015). Paddy soil heavy metal contamination and uptake in rice plants from the adjacent area of Barapukuria coal mine, northwest Bangladesh. Arabian Journal of Geosciences, 8(6), 3391–3401. https://doi.org/10.1007/s12517-014-1480-1
Harris, E. S. J., Cao, S., Littlefield, B. A., Craycroft, J. A., Scholten, R., Kaptchuk, T.,& Eisenberg, D. M. (2011). Heavy metal and pesticide content in commonly prescribed individual raw Chinese Herbal Medicines. Science of the Total Environment, 409(20), 4297–4305. https://doi.org/10.1016/j.scitotenv.2011.07.032
Hatami, M., & Ghorbanpour, M. (2016). Changes in phytochemicals in response to rhizospheric microorganism infection. In Microbial-Mediated Induced Systemic Resistance in Plants (pp. 1–14). Springer Singapore. https://doi.org/10.1007/978-981-10-0388-2_1
Hussain, S., Rengel, Z., Qaswar, M., Amir, M., & Zafar-ul-Hye, M. (2019). Arsenic and Heavy Metal (Cadmium, Lead, Mercury and Nickel) Contamination in Plant-Based Foods. In Plant and Human Health, Volume 2 (pp. 447–490). Springer International Publishing. https://doi.org/10.1007/978-3-030-03344-6_20
Hussein, H. M. (2016). Analysis of trace heavy metals and volatile chemical compounds of Lepidium sativum using atomic absorption spectroscopy, gas chromatography-mass spectrometric and fourier-transform infrared spectroscopy. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7(4), 2529–2555.
Khan, A., Khan, S., Khan, M. A., Qamar, Z., & Waqas, M. (2015). The uptake and bioaccumulation of heavy metals by food plants, their effects on plants nutrients, and associated health risk: a review. Environmental Science and Pollution Research, 22(18), 13772–13799. https://doi.org/10.1007/s11356-015-4881-0
Kishan, P.S., Bhattacharya, S., Sharma, P. (2014) Assessment of heavy metal contents of some Indian medicinal plants. American-Eurasian. J Agric Environ Sci 14(10):1125–1129
Klebis, D. (2018). China é o país que produz mais artigos científicos no mundo. Brasil é o 12º. Science NSF. https://www.ufrgs.br/bibliotecacentral/china-e-o-pais-que-produz-mais-artigos-cientificos-no-mundo-brasil-e-o-12o
Koganti, D.K. (2021), A produção total de grãos alimentícios no país é estimada em um recorde de 308,65 milhões de toneladas, 11,15 milhões de toneladas a mais do que em 2019-20. INVEST INDIA, 2020. https://www.investindia.gov.in/pt-br/sector/agriculture-forestry
Kohzadi, S., Shahmoradi, B., Ghaderi, E., Loqmani, H., & Maleki, A. (2019). Concentration, Source, and Potential Human Health Risk of Heavy Metals in the Commonly Consumed Medicinal Plants. Biological Trace Element Research, 187(1), 41–50. https://doi.org/10.1007/s12011-018-1357-3
Kumar, D., Bharti, S. K., Anand, S., & Kumar, N. (2018). Bioaccumulation and biochemical responses of Vetiveria zizanioides grown under Cadmium and Copper stresses. Environmental Sustainability, 1(2), 133–139. https://doi.org/10.1007/s42398-018-0009-z
Lamhamdi, M., Bakrim, A., Aarab, A., Lafont, R., & Sayah, F. (2011). Lead phytotoxicity on wheat (Triticum aestivum L.) seed germination and seedlings growth. Comptes Rendus - Biologies, 334(2), 118–126. https://doi.org/10.1016/j.crvi.2010.12.006
Lanini, J., Duarte-Almeida, J. M., Nappo, S. A., & Carlini, E. A. (2011). Are medicinal herbs safe? the opinion of plant vendors from Diadema (São Paulo, southeastern Brazil). Revista Brasileira de Farmacognosia, 22(1), 21–28. https://doi.org/10.1590/S0102-695X2011005000188
Li, F. S., & Weng, J. K. (2017). Demystifying traditional herbal medicine with modern approaches. Nature Plants. Palgrave Macmillan Ltd. https://doi.org/10.1038/nplants.2017.109
Liu, S. H., Chuang, W. C., Lam, W., Jiang, Z., & Cheng, Y. C. (2015). Safety Surveillance of Traditional Chinese Medicine: Current and Future. Drug Safety, 38(2), 117–128. https://doi.org/10.1007/s40264-014-0250-z
Liu, X., Xu, W., Pan, Y., & Du, E. (2015). Liu et al. suspect that Zhu et al. (2015) may have underestimated dissolved organic nitrogen (N) but overestimated total particulate N in wet deposition in China. Science of the Total Environment. Elsevier. https://doi.org/10.1016/j.scitotenv.2015.03.004
Mahmood, A., Mahmood, A., & Malik, R. N. (2012). Indigenous knowledge of medicinal plants from Leepa valley, Azad Jammu and Kashmir, Pakistan. Journal of Ethnopharmacology, 143(1), 338–346. https://doi.org/10.1016/j.jep.2012.06.046
Mahmood, A., Mahmood, A., & Tabassum, A. (2011). ETHNOMEDICINAL SURVY OF PLANTS FROM DISTRICT SIALKOT, PAKISTAN. Journal of Applied Pharmacy, 3, 212–220. https://doi.org/10.21065/19204159.3.212
Malar, S., Manikandan, R., Favas, P. J. C., Vikram Sahi, S., & Venkatachalam, P. (2014). Effect of lead on phytotoxicity, growth, biochemical alterations and its role on genomic template stability in Sesbania grandiflora: A potential plant for phytoremediation. Ecotoxicology and Environmental Safety, 108, 249–257. https://doi.org/10.1016/j.ecoenv.2014.05.018
Maleki, M., Ghorbanpour, M., & Kariman, K. (2017). Physiological and antioxidative responses of medicinal plants exposed to heavy metals stress. Plant Gene, 11, 247–254. https://doi.org/10.1016/j.plgene.2017.04.006
Mazid, M., Khan, T. A., & Mohammad, F. (2011). Role of secondary metabolites in defense mechanisms of plants. Biology and Medicine. AstonJournals.. . 10. n.1. 2178-0722. https://doi.org/10.5281/zenodo.5203222
Mishra, K., Boynton, L., & Mishra, A. (2014). Driving Employee Engagement : The Expanded Role of Internal Communications. International Journal of Business Communication, 51(2), 183–202. https://doi.org/10.1177/2329488414525399
Mziray, P., & Kimirei, I. A. (2016). Bioaccumulation of heavy metals in marine fishes (Siganus sutor, Lethrinus harak, and Rastrelliger kanagurta) from Dar es Salaam Tanzania. Regional Studies in Marine Science, 7, 72–80. https://doi.org/10.1016/j.rsma.2016.05.014
Nafiu, M. O., Hamid, A. A., Muritala, H. F., & Adeyemi, S. B. (2017). Preparation, Standardization, and Quality Control of Medicinal Plants in Africa. In Medicinal Spices and Vegetables from Africa: Therapeutic Potential Against Metabolic, Inflammatory, Infectious and Systemic Diseases (pp. 171–204). Elsevier Inc. https://doi.org/10.1016/B978-0-12-809286-6.00007-8
Nicoletti, D., Casandruc, E., Laplace, Y., Khanna, V., Hunt, C. R., Kaiser, S., … Cavalleri, A. (2014). Optically induced superconductivity in striped La 2 − x Ba x CuO 4 by polarization-selective. Physical Review B, 90(10), 100503. Retrieved from http://link.aps.org/doi/10.1103/PhysRevB.90.100503
Oliveira, M. C., & Schoffen, J. P. F. (2010). Oxidative stress action in cellular aging. Brazilian Archives of Biology and Technology, 53(6), 1333–1342. https://doi.org/10.1590/S1516-89132010000600009
Oliveira, V. M., Caldeira, A. J. R., Ayres, F. M & Santo, C. A. F. E. (2020). Uso de plantas medicinais por idosos. https://doi.org/10.5281/zenodo.5203222. Revista Anópolis, v
OPAS - Organização Pan-Americana de Saúde. (2002). Consenso Brasileiro de Atenção Farmacêutica: proposta. Brasília: Organização Pan-Americana Da Saúde, 24.
Osma, E., Ozyigit, I. I., Demir, G., & Yasar, U. (2014). Assesment of some heavy metals in wild type and cultivated purslane (portulaca oleracea L.) and soils in Istanbul, Turkey. Fresenius Environmental Bulletin, 23(9), 2181–2189.
Ozturk, A., Yarci, C., & Ozyigit, I. I. (2017). Assessment of heavy metal pollution in Istanbul using plant (Celtis australis L.) and soil assays. Biotechnology and Biotechnological Equipment, 31(5), 948–954. https://doi.org/10.1080/13102818.2017.1353922
Ramakrishna, A., & Ravishankar, G. A. (2011) Influence of abiotic stress signals on secondary metabolites in plants. Plant Signaling and Behavior. https://doi.org/10.4161/psb.6.11.17613
Revathi, P., Parimelazhagan,T., & Manian, S. (2013). Ethnomedicinal plants and novel formulations used by Hooralis tribe in Sathyamangalam forests, Western Ghats of Tamil Nadu, India. Journal of Medicinal Plants Research, 7(28), 2083–2097. https://doi.org/10.5897/jmpr2013.5074
Rocha, L. S., Arakaki, D. G., Bogo, D., Melo, E. S. P., Lima, N. V., Souza, I. D. D., & Nascimento, V. A. (2019). Evaluation of level of essential elements and toxic metal in the medicinal plant hymenaea martiana Hayne (Jatobá) used by mid-west population of Brazil. Scientific World Journal, 2019. https://doi.org/10.1155/2019/4806068
Rodriguez-Hernandez, M. C., Bonifas, I., Alfaro-De la Torre, M. C., Flores-Flores, J. L., Bañuelos-Hernández, B., & Patiño-Rodríguez, O. (2015). Increased accumulation of cadmium and lead under Ca and Fe deficiency in Typha latifolia: A study of two pore channel (TPC1) gene responses. Environmental and Experimental Botany, 115, 38–48. https://doi.org/10.1016/j.envexpbot.2015.02.009
Rosa, C. da, Câmara, S. G., & Béria, J. U. (2011). Representações e intenção de uso da fitoterapia na atenção básica à saúde. Ciência & Saúde Coletiva, 16(1), 311–318. https://doi.org/10.1590/s1413-81232011000100033
Schreck, E., Foucault, Y., Sarret, G., Sobanska, S., Cécillon, L., Castrec-Rouelle, M. & Dumat, C. (2012). Metal and metalloid foliar uptake by various plant species exposed to atmospheric industrial fallout: Mechanisms involved for lead. Science of the Total Environment, 427–428, 253–262. https://doi.org/10.1016/j.scitotenv.2012.03.051
Shahid, M., Dumat, C., Khalid, S., Schreck, E., Xiong, T., & Niazi, N. K. (2017, March 5). Foliar heavy metal uptake, toxicity and detoxification in plants: A comparison of foliar and root metal uptake. Journal of Hazardous Materials. Elsevier B.V. https://doi.org/10.1016/j.jhazmat.2016.11.063
Singh, V. P., Srivastava, P. K., & Prasad, S. M. (2013). Nitric oxide alleviates arsenic-induced toxic effects in ridged Luffa seedlings. Plant Physiology and Biochemistry, 71, 155–163. https://doi.org/10.1016/j.plaphy.2013.07.003
Soriano-Disla, J. M., Gómez, I., Navarro-Pedreño, J., & Jordán, M. M. (2014). The transfer of heavy metals to barley plants from soils amended with sewage sludge with different heavy metal burdens. Journal of Soils and Sediments, 14(4), 687–696. https://doi.org/10.1007/s11368-013-0773-4
Souza, V. L., De Almeida, A. A. F., Lima, S. G. C., Júlio, J. C., Da C. Silva, D., Mangabeira, P. A. O., & Gomes, F. P. (2011). Morphophysiological responses and programmed cell death induced by cadmium in Genipa americana L. (Rubiaceae). BioMetals, 24(1), 59–71. https://doi.org/10.1007/s10534-010-9374-5
Street, R. A. (2012). Heavy metals in medicinal plant products - An African perspective. South African Journal of Botany, 82, 67–74. https://doi.org/10.1016/j.sajb.2012.07.013
Teschke, R., Sarris, J., & Lebot, V. (2013). Contaminant hepatotoxins as culprits for kava hepatotoxicity - Fact or fiction? Phytotherapy Research, 27(3), 472–474. https://doi.org/10.1002/ptr.4729
Wani, A. L., Ara, A., & Usmani, J. A. (2015). Lead toxicity: A review. Interdisciplinary Toxicology. Slovak Toxicology Society. https://doi.org/10.1515/intox-2015-0009
WHO. (2015). World Health Organization. WHO Estimates of the Global Burden of Foodborne Diseases: Foodborne Disease Burden Epidemiology Reference Group 2007-2015. Encyclopedia of Parasitology, 1–265. Retrieved from https://apps.who.int/iris/bitstream/handle/10665/199350/?sequence=1
WHO.(1998). WHA 51.23 Amendments to articles 24 and 25 of the Constitution. Genebra: WHO. https://treaties.un.org/pages/ViewDetails.aspx?src=TREATY&mtdsg_no=IX-1-h&chapter=9&clang=_en
Woszezenki, C. R., & Gonçalves, A. L. (2013). Biomedical text mining: A bibliometrics review. Perspectivas Em Ciencia Da Informacao, 18(3), 24–44. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887901111&doi=10.1590%2FS1413-99362013000300003&partnerID=40&md5=56f0e02f9f30d69e8d483fdac1d16eb6
Wyszkowska, J., Boros-Lajszner, E., Borowik, A., Baćmaga, M., Kucharski, J., & Tomkiel, M. (2016). Implication of zinc excess on soil health. Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes, 51(5), 261–270. https://doi.org/10.1080/10934529.2015.1128726
Yasar, U., Ozyigit, I. I., Yalcin, I. E., Dogan, I., & Demir, G. (2012). Determination of some heavy metals and mineral nutrients of bay tree (Laurus nobilis L.) in Bartin city, Turkey. Pakistan Journal of Botany, 44(SPL.ISS.1), 81–89.
Yuan, X., Chapman, R. L., & Wu, Z. (2011). Analytical methods for heavy metals in herbal medicines. Phytochemical Analysis, 22(3), 189–198. https://doi.org/10.1002/pca.1287
Zhao, Q., Wang, Y., Cao, Y., Chen, A., Ren, M., Ge, Y., & Li, L. (2014). Potential health risks of heavy metals in cultivated topsoil and grain, including correlations with human primary liver, lung and gastric cancer, in Anhui province, Eastern China. Science of the Total Environment, 470–471, 340–347. https://doi.org/10.1016/j.scitotenv.2013.09.086
Zhao, Q., Wang, Y., Cao, Y., Chen, A., Ren, M., Ge, Y., … Li, L. (2014). Potential health risks of heavy metals in cultivated topsoil and grain, including correlations with human primary liver, lung and gastric cancer, in Anhui province, Eastern China. Science of the Total Environment, 470–471, 340–347. https://doi.org/10.1016/j.scitotenv.2013.09.086
Zheng, E. X., & Navarro, V. J. (2015). Liver injury from herbal, dietary, and weight loss supplements: A review. Journal of Clinical and Translational Hepatology. Xia and He Publishing Inc. https://doi.org/10.14218/JCTH.2015.00006
Zheng, S., Wang, Q., Yuan, Y., & Sun, W. (2020). Human health risk assessment of heavy metals in soil and food crops in the Pearl River Delta urban agglomeration of China. Food Chemistry, 316. https://doi.org/10.1016/j.foodchem.2020.126213
Zhou, H., Yang, W. T., Zhou, X., Liu, L., Gu, J. F., Wang, W. L., … Liao, B. H. (2016). Accumulation of heavy metals in vegetable species planted in contaminated soils and the health risk assessment. International Journal of Environmental Research and Public Health, 13(3). https://doi.org/10.3390/ijerph13030289
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