Pathological and historical association between Guillain-Barré Syndrome (SGB) and Zika Virus infection




Zika virus infection; Arbovirus infections; Guillain-Barré Syndrome.


Introduction: The origin of GBS is still unknown, however, it is often preceded by an infection, with reports of its relationship with Zika Virus infection. Objective: to investigate the relationship between Zika virus infection and Guillain-Barré Syndrome (GBS). Method: An integrative literature review carried out through databases indexed in the Virtual Health Library (VHL), using the descriptors: “Zika Virus Infection”, “Arbovirus Infections” and “Guillain-Barré Syndrome”. Six studies were selected. Results: The underlying pathophysiological mechanisms of GBS linked to Zika virus are unknown, although the immunological reactions described with other pathogenic microbes could have the same putative role. Furthermore, there is no valid explanation for the emergence of this complication that was not previously related to the Zika virus; one theory is that the virus has genetically evolved to a more pathogenic genotype. Final Considerations: An association between GBS and Zika virus infection is reported, and there are some hypotheses and studies carried out that aim to investigate the pathophysiology involved in this association. Despite recent studies, further studies are needed to deepen the full understanding of the mechanisms involved.

Author Biography

João Felipe Tinto Silva, Universidade Estácio de Sá

Enfermeiro. Pós graduando em Enfermagem em Unidade de Terapia Intensiva pela Universidade Estácio de Sá (UNESA).


Acosta-Ampudia, Y. et al. (2018). Autoimmune neurological conditions associated with Zika virus infection. Frontiers in molecular neuroscience, 11, 116.

Araújo, A. Q. C., Silva, M. T. T., & Araújo, A. P. Q. C. (2016). Zika virus-associated neurological disorders: a review. Brain, 139(8), 2122-2130.

Chimelli, L. et al. (1990). Dengue: Neuropathological findings in 5 fatal cases from Brazil. Clinical Neuropathology, 9(3), 157–162.

Donalisio, M. R., Freitas, A. R. R., & Von Zuben, A. P. B. (2017). Arboviroses emergentes no Brasil: desafios para a clínica e implicações para a saúde pública. Revista de Saúde Pública, 10(51), 30.

Duffy, M. R. et al. (2009). Zika virus outbreak on Yap Island, Federated States of Micronesia. The New England of Journal Medicine, 360(24), 2536-43.

Eldar, A. H., & Chapman, J. (2014). Guillain Barré syndrome and other immune mediated neuropathies: diagnosis and classification. Autoimmunity Reviews, 13(4-5), 525-30.

Enfissi, A. et al. (2016). Zika virus genome from the Americas. Lancet., 387, 227-8.

Fokam, E. B. et al. (2010). Silent circulation of arboviruses in Cameroon. East African Medical Journal, 87(6), 262-8.

Kankirawatana, P. et al. (2000). Dengue infection presenting with central nervoussystem manifestation. Journal of Child Neurology, 15(8), 544–547.

Li, M. I. et al. (2012). Oral susceptibility of Singapore Aedes (Stegomyia) aegypti (Linnaeus) to Zika virus. Plos Neglected Tropical Diseases, 6(8), e1792.

Lopes, N., Nozawa, C., & Linhares, R. E. C. (2014). Características gerais e epidemiologia dos arbovírus emergentes no Brasil. Revista Pan-Amazônica de Saude, 5(3), 55-64.

Luchesse, G., & Kanduc, D. (2016). Zika virus and autoimmunity: from microcephaly to Guillain-Barré syndrome, and beyond. Autoimmunity reviews, 15(8), 801-808.

Malta, J. M. A. S. et al. (2017). Síndrome de Guillain-Barré e outras manifestações neurológicas possivelmente relacionadas à infecção pelo vírus Zika em municípios da Bahia, 2015. Epidemiologia e Serviços de Saúde, 26, 9-18.

Nóbrega, M. E. B. et al. (2018). Surto de síndrome de Guillain-Barré possivelmente relacionado à infecção prévia pelo vírus Zika, Região Metropolitana do Recife, Pernambuco, Brasil, 2015. Epidemiologia e servicos de saude: revista do Sistema Unico de Saude do Brasil. 26(2), e2017039.

Olson, J. G., Ksiazek, T. G., & Suhandiman, T. (1981). Zika virus, a cause of fever in Central Java, Indonesia. Transactions of the Royal Society of Tropical Medicine and Hygiene. 75(3), 389-93.

Oehler, E. et al. (2014). Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013. Euro Surveillance, 19(9), 20720.

Pereira, A. S. (2018). Metodologia da pesquisa científica. UFSM.

Pinto-Díaz, C. A. et al. (2017). Autoimmunity in Guillain-Barré syndrome associated with Zika virus infection and beyond. Autoimmunity reviews, 16(4), 327-334.

Rivera-Correa, J. et al. (2019). Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barré Syndrome in Brazil. PLoS Neglected Tropical Diseases, 13(9), e0007695.

Row, D., Weinstein, P., & Murray-Smith, S. (1996). Dengue fever with encephalopathy in Australia. American Journal of Tropical Medicine Hygiene, 54(3), 253–255.

Van Den Berg, B. et al. (2014). Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis. Nature Reviews Neurology, 10(8), 469-82.

Wielanek, A. C. et al. (2007). Guillain-Barré syndrome complicating a Chikungunya virus infection. Neurology, 69(22), 2105-2107.

World Health Organization. Situation Report Zika Virus Microcephaly Guillain-Barré Syndrome 20 January, 2017.

World Health Organization. Zika causality statement, 2016.>.

Wu, P. et al. (2019) Arbovirus lifecycle in mosquito: acquisition, propagation and transmission. Expert Reviews in Molecular Medicine, 21.



How to Cite

SILVA, J. F. T. .; MEDEIROS, F. L. de; MELLO, E. C. de A.; SOUSA, E. O. de; OLIVEIRA, I. M. M. de; ARAÚJO, E. L. C.; SOARES, G. H. dos S.; LIMA, T. B. dos S.; SOUZA, T. F. M.; LEAL, E. C. P. de S.; LEITÃO, D. T.; ANDRADE, K. H. M. de. Pathological and historical association between Guillain-Barré Syndrome (SGB) and Zika Virus infection. Research, Society and Development, [S. l.], v. 11, n. 9, p. e54211932412, 2022. DOI: 10.33448/rsd-v11i9.32412. Disponível em: Acesso em: 25 sep. 2022.



Review Article