Pathological and historical association between Guillain-Barré Syndrome (SGB) and Zika Virus infection
Keywords:Zika virus infection; Arbovirus infections; Guillain-Barré Syndrome.
Introduction: The origin of GBS is still unknown, however, it is often preceded by an infection, with reports of its relationship with Zika Virus infection. Objective: to investigate the relationship between Zika virus infection and Guillain-Barré Syndrome (GBS). Method: An integrative literature review carried out through databases indexed in the Virtual Health Library (VHL), using the descriptors: “Zika Virus Infection”, “Arbovirus Infections” and “Guillain-Barré Syndrome”. Six studies were selected. Results: The underlying pathophysiological mechanisms of GBS linked to Zika virus are unknown, although the immunological reactions described with other pathogenic microbes could have the same putative role. Furthermore, there is no valid explanation for the emergence of this complication that was not previously related to the Zika virus; one theory is that the virus has genetically evolved to a more pathogenic genotype. Final Considerations: An association between GBS and Zika virus infection is reported, and there are some hypotheses and studies carried out that aim to investigate the pathophysiology involved in this association. Despite recent studies, further studies are needed to deepen the full understanding of the mechanisms involved.
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Copyright (c) 2022 João Felipe Tinto Silva; Felipe Lima de Medeiros; Emmanuella Costa de Azevedo Mello; Emanuel Osvaldo de Sousa; Ingrid Mikaela Moreira de Oliveira; Emanueli Larice Costa Araújo; Gustavo Henrique dos Santos Soares; Tuanny Beatriz dos Santos Lima; Thaís Ferreira Modesto Souza; Elayne Cristina Pereira de Souza Leal; Darlly Tavares Leitão; Katia Helena Marinho de Andrade
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