Epidemiological and space analysis of cryptococcosis in children in the mesoregions of the state of Pará, Eastern Amazon, from 2000 to 2017

Authors

DOI:

https://doi.org/10.33448/rsd-v11i10.32566

Keywords:

Cryptococcus; Cryptococcosis in children; Georeferencing Pará mesoregions.

Abstract

Cryptococcosis is a fungal disease, which until the year 2020 was not compulsory notification, and until this period there were no exact data on its occurrence in Brazil. Objective: To analyze the clinical, laboratory, and epidemiological characteristics, beyond the spatial distribution and occurrence, of cryptococcosis in children living in the Brazilian Oriental Amazônia from 2000 to 2017. Methodology: This descriptive and transversal study was conducted at the University Hospital João de Barros Barreto (HUJBB), Belém-Pará, through data obtained from records of children aged up to 13 years old who were hospitalized with the diagnosis of cryptococcosis from 2000 to 2017. A descriptive analysis was performed using calculation of frequency, median age, and standard deviation using IBM SPSS 24.05.0. The significance level was set at p=0.05 (α=5%). The data were purified using the Table Win v. XX program. The laboratorial georeferencing of data for the creation of geographic data (BDGeo) was performed using ArcGIS 10.2 and TerraView 4.0. Results: Predominance infections happened in the rural areas, principally from C. gattii. Georeferencing demonstrated heterogenic distribution of the disease in mesoregions of Pará state, having a direct relation with deforested. Conclusion: The largest occurrence was in the northeastern mesoregion of Pará likely due to the environmental impact of deforestation.

References

Brito-Santos, F., Barbosa, G. G., Trilles, L., Nishikawa, M. M., Wanke, B., Meyer, W., Carvalho-Costa, F. A., & Lazéra, M. S. (2015). Environmental isolation of Cryptococcus gattii VGII from indoor dust from typical wooden houses in the deep Amazonas of the Rio Negro basin. Plos One, 10(2), e0115866. https://doi.org/10.1371/journal.pone.0115866

Cagliat, M. C. (2013). Global Molecular Epidemiology of Cryptococcus neoformans and Cryptococcus gatti: Atlas of the Molecular Types. Hindawi Publishing Corporation Scientifica, 1–23. https://doi.org/10.1155/2013/675213

Campana, A. O. (1999). Metodologia da investigação científica aplicada à área biomédica: O método científico. Jornal de Pneumologia, 25 (1), 25-34. https://www.jornaldepneumologia.com.br/details/253/pt-BR/metodologia-da-investigacao-cientifica-aplicada-a-area-biomedica---1--o-metodo-cientifico

Campana, A. O. (1999). Metodologia da investigação científica aplicada à área biomédica: Investigações na área médica. Jornal de Pneumologia, 25 (2), 84-93: https://doi.org/10.1590/S0102-35861999000200005

Carrijo, A. V., Carrijo, B. V., Machado, L. N., Almeida, R. J., & Oliveira, P. P. C. (2021). Análise clínico-epidemiológica de criptococose em indivíduos com hiv: uma revisão sistemática. Brazilian Applied Science Review, 5(2), 802-817. https://doi.org/10.34115/basrv5n2-014

Corrêa, M. P., Oliveira, E. C., Duarte, R. R., Pardal, P. P., Oliveira, F. M., & Severo, L. C. (1999). Cryptococcosis in children in the State of Pará, Brazil. Rev. Soc. Bras. Med. Trop., 32(5), 505–508. https://doi.org/10.1590/S0037-86821999000500006

Costa, S. P. S. E. (2008). Isolamento e caracterização molecular de Cryptococcus neoformans e Cryptococcus gattii de Fontes ambientais na região metropolitana de Belém, Pará (Doctoral dissertation).

Darzé, C., Lucena, R., Gomes, I., & Melo, A. (2000). Características clínicas laboratoriais de 104 casos de meningoencefalite criptocócica. Med. Trop., 33(1), 21–26. https://doi.org/10.1590/S0037-86822000000100003

Escandón, P., de Bedout, C., Lizarazo, J., Agudelo, C. I., Tobón, A., Bello, S., Restrepo, A., Castañeda, E., & Grupo Colombiano para el Estudio de la Criptococosis. (2012). Cryptococcosis in Colombia: results of the national surveillance program for the years 2006-2010. Biomédica, 32(2), 386–398. https://doi.org/10.1590/S0120-41572012000300009

Frota, E. F., & Figueiredo, E. F. G. (2021). Criptococose: consequência da infecção por Cryptococcus neoformans em pacientes com AIDS no Brasil. Research, Society and Development, 10(15), e150101522591. https://doi.org/10.33448/rsd-v10i15.22591

Goldman, D. L., Khine, H., Abadi, J., Lindenberg, D. J., Pirofski, La, Niang, R., & Casadevall, A. (2001). Serologic evidence for Cryptococcus neoformans infection in early childhood. Pediatrics, 107(5), E66. https://doi.org/10.1542/peds.107.5.e66

Guo, J., Zhou, J., Zhang, S., Zhang, X., Li, J., Sun, Y., & Qi, S. (2012). A case-control study of risk factors for HIV-negative children with cryptococcal meningitis in Shi Jiazhuang, China. BMC Infect. Dis., 12(376). doi: https://doi.org/10.1186/1471-2334-12-376

Guo, L. Y., Liu, L. L., Liu, Y., Chen, T. M., Li, S. Y., Yang, Y. H., & Liu, G. (2016). Characteristics and outcomes of cryptococcal meningitis in HIV seronegative children in Beijing, China, 2002-2013. BMC Infect. Dis., 16(635). https://doi.org/10.1186/s12879-016-1964-6

Huang, K. Y., Huang, Y. C., Hung, I. J., & Lin, T. Y. (2010). Cryptococcosis in nonhuman immunodeficiency virus-infected children. Pediatr. Neurol., 42(4), 267–270. https://doi.org/10.1016/j.pediatrneurol.2009.10.015

Instituto Brasileiro de Geografia e Estatística. (2010). Censo demográfico 2010. https://censo2010.ibge.gov.br. (Accessed 13 abr 2019).

Instituto Nacional de Pesquisas Espaciais. (2018). INPE Estima 7 km2 de desmatamento por corte raso na Amazônia em 2018. http://www.obt.inpe.br/OBT/noticias/inpe-estima-7-900-km2-de-desmatamento-por-corte-raso-na-amazonia-em-2018.

Jongwutiwes, U., Sungkanuparph, S., & Kiertiburanakul, S. (2008). Comparison of clinical features and survival between Cryptococcosis in human immunodeficiency vírus (HIV)-positive and HIV-negative patients. Jpn. J. Infect. Dis., 61(2), 111–115. https://www.researchgate.net/publication/5490760_Comparison_of_clinical_features_and_survival_between_cryptococcosis_in_human_immunodeficiency_virus_HIV-positive_and_HIV-negative_patients

Joshi, N. S., Fisher, B. T., Prasad, P. A., & Zaoutis, T. E. (2010). Epidemiology of cryptococcal infection in hospitalized children. Pediatr. Infect. Dis. J., 29(1), e91–e95. https://doi.org/10.1097/INF.0b013e3181fbc83d

Junior, V. L. P., et al. (2010) Cryptococcus gattii molecular type VGII as agent of meningitis in a healthy child in Rio de Janeiro, Brazil: report of an autochthonous case. Rev. Soc. Bras. Med. Trop., 43(6), 746-748. https://doi.org/10.1590/s0037-86822010000600032

Lizarazo, J., Escandón, P., Agudelo, C. I., & Castañeda, E. (2014). Cryptococcosis in Colombian children and literature review. Mem. Inst. Oswaldo Cruz, 109(6), 797–804. https://doi.org/10.1590/0074-0276130537

Lizarazo, J., Linares, M., de Bedout, C., Restrepo, A., Agudelo, C. I., & Castañeda, E., Grupo Colombiano para el Estudio de la Criptococosis. (2007). Results of nine years of the clinical and epidemiological SURVEY on cryptococcosis in Colombia, 1997–2005. Biomedica, 27(1), 94–109. https://doi.org/10.7705/biomedica.v27i1.236.

Lopes, M. V. O., & Lima, J. R. C. (2018). Análise de Dados Epidemiológicos. In M. Z. Rouquayrol & M. G. C. da Silva (Ed.), Epidemiologia & Saúde (pp. 314-349). Rio de Janeiro, RJ: Medbook.

Lopes, M. V. O. (2018). Desenho de Pesquisa em Epidemiologia. In M. Z. Rouquayrol & M. G. C. da Silva (Ed.), Epidemiologia & Saúde (pp. 285-313). Rio de Janeiro, RJ: Medbook.

Luo, F. L., Tao, Y. H., Wang, Y. M., & Li, H. (2015). Clinical study of 23 pediatric patients with cryptococcosis. Eur. Rev. Med. Pharmacol. Sci., 19(20), 3801–3810.

Miglia, K. J., Govender, N. P., Rossouw, J., Meiring, S., & Mitchell, T. G., & Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa. (2011). Analyses of pediatric isolates of Cryptococcus neoformans from South Africa. J. Clin. Microbiol., 49(1), 307–314. https://doi.org/10.1128/JCM.01277-10

Ministério da Saúde. (2020). Portaria nº 264, de 17 de fevereiro de 2020. (Publicação Diário Oficial da União, seção 1, 35, 97). Brasília, DF, Brasil: Ministério da Saúde. https://www.in.gov.br/en/web/dou/-/portaria-n-264-de-17-de-fevereiro-de-2020-244043656

Ministério da Saúde. (2021a). Criptococose. https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/c/criptococose

Ministério da Saúde. (2021b). Relatório de Recomendação: Produto Teste diagnóstico, point of care, de Cryptococcal Antigen Lateral Flow Assay (CRAG-LFA) para detecção de infecção por Cryptococcus e diagnóstico de meningite criptocócica em pessoas vivendo com o vírus da imunodeficiência humana (PVHIV). Brasília, DF, Brasil: Ministério da Saúde.

Pará, Sistema Único de Saúde, Secretaria de Saúde Pública. (2012). Plano Estadual de Saúde, 2012–2015.

Pará, Sistema Único de Saúde, Secretaria de Saúde Pública. (2016). Plano Estadual de Saúde 2016–2019.

Pereira, T., & Barros, R. (2012). Cryptococcus neoformans e Cryptococcus gatti. Perspectivas sobre a ecoepidemiologia e novos nichos ecológicos. Facider. Ver. Cient., 1(1), 1–21.

Rajasingham, R., Smith, R. M., Park, B. J., Jarvis, J. N., Govender, N. P., Chiller, T. M., Denning, D. W., Loyse, A., & Boulware, D. R. (2017). Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis. The Lancet. Infectious diseases, 17(8), 873–881. https://doi.org/10.1016/S1473-3099(17)30243-8

Reichert-Lima, F., Busso-Lopes, A.F., Lyra, L., Peron, I. H., Taguchi, H., Mikami, Y., Kamei, K., Moretti, M. L., & Schreiber, A. Z. (2016). Evaluation of antifungal combination against Cryptococcus spp. Mycoses, 59(9), 585–593. https://doi.org/10.1111/myc.12510

Santos, W. R. A., Meyer, W., Wanke, B., Costa, S. P., Trilles, L., Nascimento, J. L., Medeiros, R., Morales, B. P., Bezerra, C. C., Macêdo, R. C., Ferreira, S. O., Barbosa, G. G., Perez, M. A., Nishikawa, M. M., & Lazéra, M. S. (2008). Primary endemic Cryptococcosis gattii by molecular type VGII in the state of Pará, Brazil. Mem. Inst. Oswaldo Cruz, 103(8), 813–818. https://doi.org/10.1590/s0074-02762008000800012

Severo, C. B., et al. (2009). Cryptococcosis in children. Paediatr. Respir. Rev., 10(4), 166–171. https://doi.org/10.1016/j.prrv.2009.06.009

uma revisão sistemática. Brazilian Applied Science Review, 5(2), 802-817. https://doi.org/10.34115/basrv5n2-014

World Health Organization. (2018). Guidelines for the Diagnosis, Prevention and Management of Cryptococcal Disease in HIV-Infected Adults, Adolescents and Children. https://www.who.int/publications/i/item/9789241550277

Yuanjie, Z., Jianghan, C., Nan, X., Xiaojun, W., Hai, W., Wanqing, L., & Julin, G. (2012). Cryptococcal meningitis in immunocompetent children. Mycoses, 55(2), 168–171. https://doi.org/10.1111/j.1439-0507.2011.02063.x

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Published

27/07/2022

How to Cite

PINHEIRO, M. C.; GONÇALVES, N. V.; BRITO, M. T. F. M. de; QUARESMA, J. A. S. . Epidemiological and space analysis of cryptococcosis in children in the mesoregions of the state of Pará, Eastern Amazon, from 2000 to 2017. Research, Society and Development, [S. l.], v. 11, n. 10, p. e194111032566, 2022. DOI: 10.33448/rsd-v11i10.32566. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/32566. Acesso em: 4 oct. 2022.

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Health Sciences