Use of liposomes in the diagnosis and treatment of non-melanoma skin cancer: an integrative review
DOI:
https://doi.org/10.33448/rsd-v11i10.32984Keywords:
Basal cell carcinoma; Squamous cell carcinoma; Nanotechnology.Abstract
Non-melanoma skin cancer (NMSC) is the type of cancer with the highest incidence and has been classified into: basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The aim of the present study was to evaluate, through an integrative literature review, the use of liposomes in the diagnosis and treatment of NMSC. The search strategy for scientific articles was carried out through an investigation in the Scopus, Pubmed and Web Of Science databases, accessing through the Capes Periodicals Portal, using the English descriptors "Liposomes" AND "non-melanoma" AND "skin" AND “cancer” AND “(treatment OR diagnosis)”. To assist the process of analyzing the articles, the Rayyan platform was used. After analysis, 7 publications were selected to compose this review, identifying: titles, authors, objectives, main results, conclusions and topics addressed in the studies. It was observed that most of the thematic axes addressed the use of liposomal systems for the potentiation of drugs with antitumor capacity. The other articles discussed the use in the detection and diagnosis of lesions associated with Non-Melanoma Skin Cancer and also the application of nanocarriers in anticancer therapies, especially in photodynamic therapy. Based on this, it was concluded that liposomes have a versatile application in NMSC, ranging from treatment to diagnosis, however, research on the application focused on this topic is scarce and recent. Thus, this review is extremely relevant so that we can direct the elaboration of new studies that aim to improve the aforementioned techniques and develop new research on the subject.
References
Apalla, Z. et al. (2017) Epidemiological trends in skin cancer. Dermatology practical & conceptual, 7(2), 1.
Bäumler, W., Abels, C., & Szeimies, R. M. (2003). Fluorescence diagnosis and photodynamic therapy in dermatology. Medical Laser Application, 18(1), p. 47-56.
Chen, W., Goldys, E. M., & Deng, W. (2020). Light-induced liposomes for cancer therapeutics. Progress in lipid research, 79, p. 101052.
Christiansen, K., Bjerring, P., & Troilius, A. (2007). 5‐ALA for photodynamic photorejuvenation—optimization of treatment regime based on normal‐skin fluorescence measurements. Lasers in Surgery and Medicine: The Official Journal of the American Society for Laser Medicine and Surgery, 39(4). 302-310.
Cives, M. et al. (2020). Non-melanoma skin cancers: Biological and clinical features. International Journal of Molecular Sciences, 21(15), 5394.
Ciążyńska, M. et al. (2021). The incidence and clinical analysis of non-melanoma skin cancer. Scientific reports, 11(1), 1-10.
Cosco, D. et al. (2015). Ultradeformable liposomes as multidrug carrier of resveratrol and 5-fluorouracil for their topical delivery. International journal of pharmaceutics, 489(1-2), 1-10.
De Leeuw, J. et al. (2009) Fluorescence detection and diagnosis of non‐melanoma skin cancer at an early stage. Lasers in Surgery and Medicine: The Official Journal of the American Society for Laser Medicine and Surgery, 41(2), 96-103.
Fakayode, O. J. et al. (2018) Applications of functionalized nanomaterials in photodynamic therapy. Biophysical Reviews, 10(1), 49-67.
Fang, Y. P. et al. (2008). Comparison of 5-aminolevulinic acid-encapsulated liposome versus ethosome for skin delivery for photodynamic therapy. International Journal of Pharmaceutics, 356(1-2), 144-152.
Ferrari, G. et al. (2022). Effective Penetration of a Liposomal Formulation of Bleomycin through Ex-Vivo Skin Explants from Two Different Species. Cancers, 14(4), 1083.
Fogel, A. L., Sarin, K. Y., & Teng, J. (2017). Genetic diseases associated with an increased risk of skin cancer development in childhood. Current Opinion in Pediatrics, 29(4), 426-433.
Frézard, F. et al. (2005). Lipossomas: propriedades físico-químicas e farmacológicas, aplicações na quimioterapia à base de antimônio. Química Nova, 28, 511-518.
Hampras, S. S. et al. (2018). Prevalência de infecções virais cutâneas em carcinoma epidermóide cutâneo incidente detectado em pacientes com leucemia linfocítica crônica e transplante de células-tronco hematopoéticas. Leucemia & linfoma, 59(4), 911-917.
Hiesse, C. et al. (1997). Malignancy after renal transplantation: analysis of incidence and risk factors in 1700 patients followed during a 25-year period. In: Transplantation proceedings. Elsevier. p. 831-833.
INCA. Instituto Nacional de Câncer. (2022). Câncer de pele não melanoma. https://www.inca.gov.br/tipos-de-cancer/cancer-de-pele-nao-melanoma.
Johansson, A. et al. (2007). Fluorescence and absorption assessment of a lipid mTHPC formulation following topical application in a non-melanotic skin tumor model. Journal of biomedical optics, 12(3), 034026.
Karagas, M. R. et al. (2007). Squamous cell and basal cell carcinoma of the skin in relation to radiation therapy and potential modification of risk by sun exposure. Epidemiology, p. 776-784.
Leiter, U.; Eigentler, T. & Garbe, C. (2014). Epidemiology of skin cancer. Sunlight, vitamin D and skin cancer, p. 120-140.
Lucas, R. et al. (2006). Solar ultraviolet radiation: global burden of disease from solar ultraviolet radiation. World Health Organization.
Martinez, J. C. & Otley, C. C. (2001). The management of melanoma and nonmelanoma skin cancer: a review for the primary care physician. In: Mayo Clinic Proceedings. Elsevier, p. 1253-1265.
Meirelles, I. O. et al. (2020). Terapia Fotodinâmica para lesões de pele não melanoma. Ministério da Saúde.
Mendes, K. D. S.; Silveira, R. C. C. P. & Galvão, C. M (2008). Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto contexto - enferm, 17(4).
Miranda, K. W. R. et al. (2020). Aplicações de Nanocarreadores Baseados em Células Animais na Terapia Fotodinâmica em Oncologia. Revista Internacional de Ciências, 10(2), 43-54.
Moan, J., Ma, L. W., & Iani, V. (2001). On the pharmacokinetics of topically applied 5‐aminolevulinic acid and two of its esters. International journal of cancer, 92(1), 139-143.
Nikolaou, V., Stratigos, A. J., & Tsao, H. (2012). Hereditary nonmelanoma skin cancer. In: Seminars in cutaneous medicine and surgery. NIH Public Access. p. 204.
Olson, A. L. et al. (2008). The impact of an appearance-based educational intervention on adolescent intention to use sunscreen. Health education research, 23(5), 763-769.
Paolino, D. et al. (2008). Innovative bola-surfactant niosomes as topical delivery systems of 5-fluorouracil for the treatment of skin cancer. International journal of Pharmaceutics, 353(1-2), 233-242.
Patel, A. S. et al. (2008). Exposure profiles and human papillomavirus infection in skin cancer: an analysis of 25 genus β-types in a population-based study. Journal of investigative dermatology, 128(12), 2888-2893.
Penn, I. (2000). Post-transplant malignancy: the role of immunosuppression. Drug safety, 23, 101-113.
Samarasinghe, V. & Madan, Vl. (2012). Nonmelanoma skin cancer. Journal of cutaneous and aesthetic surgery, 5(1), 3.
Souto, E. B. et al. (2022). Non-melanoma skin cancers: physio-pathology and role of lipid delivery systems in new chemotherapeutic treatments. Neoplasia, 30, 100810.
Svaasand, L. O. et al. (1996). Dosimetry model for photodynamic therapy with topically administered photosensitizers. Lasers in Surgery and Medicine: The Official Journal of the American Society for Laser Medicine and Surgery, 18(2), 139-149.
Thomas, S. M. et al. (2021). Interpretable deep learning systems for multi-class segmentation and classification of non-melanoma skin cancer. Medical Image Analysis, 68, 101915.
Ulrich, M. et al (2007). Noninvasive diagnostic tools for nonmelanoma skin cancer. British Journal of Dermatology, 157, 56-58.
Umar, A. K. et al (2022). Liposome-polymer complex for drug delivery system and vaccine stabilization. Heliyon, p. e08934.
Van Der Beek, N. et al. (2012). PpIX fluorescence combined with auto‐fluorescence is more accurate than PpIX fluorescence alone in fluorescence detection of non‐melanoma skin cancer: an intra‐patient direct comparison study. Lasers in Surgery and Medicine, 44(4), 271-276.
Weinstock, M. A. et al (2007). Melanoma early detection with thorough skin self-examination: the “Check It Out” randomized trial. American journal of preventive medicine, 32(6), 517-524.
Woźniak, M. et al (2021). The comparison of in vitro photosensitizing efficacy of curcumin-loaded liposomes following photodynamic therapy on melanoma MUG-Mel2, squamous cell carcinoma SCC-25, and normal keratinocyte HaCaT cells. Pharmaceuticals, 14(4), 374.
Xia, H. et al (2015). Retinoic acid liposome-hydrogel: preparation, penetration through mouse skin and induction of F9 mouse teratocarcinoma stem cells differentiation. Brazilian Journal of Pharmaceutical Sciences, 51, 541-549.
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