Impacts of nutritional supplementation with turmeric on executive function tests in college students
DOI:
https://doi.org/10.33448/rsd-v11i11.33431Keywords:
Curcumin; Dietary Supplements; Neuropsychological Tests; Plant, Medicinal; Executive function.Abstract
Introduction: Executive functions (EFs) involve three interconnected dimensions: working memory, cognitive flexibility and inhibitory control. Curcumin, present in Curcuma longa rhizomes or turmeric, has been used for its anti-inflammatory, antioxidant, anticancer, and neuroprotective effects, with potential for prevention/treatment of highly prevalent pathologies that burden healthcare systems, such as dementias. Methodology: This paper evaluated whether turmeric consumption by college students impacts their executive performance. University students underwent tests assessing FEs before and after nutritional supplementation with 1g/day of turmeric for 4 weeks. Results: Acute or chronic turmeric consumption had no significant impacts on tests assessing selective attention, working memory, abstract reasoning, cognitive strategy modification and problem solving. Conclusions: The absence of significant effects may be due to the characteristics of the experimental design that analyzed a young population with cognitive integrity. The low absorption/bioavailability of curcumin may also have influenced the results.
References
Ávila, K. N. de. (2007). Modified Wisconsin Card Sorting Test (MCST): Desempenho de idosos com diferentes níveis de escolaridade. Psicologia Hospitalar, 5(2), 21–35.
Blankenship, A. B. (1938). Memory span: A review of the literature. Psychological Bulletin, 35(1), 1–25. https://doi.org/10.1037/h0061086
Baum, L., Lam, C. W., Cheung, S. K., Kwok, T., Lui, V., Tsoh, J., Lam, L., Leung, V., Hui, E., Ng, C., Woo, J., Chiu, H. F., Goggins, W. B., Zee, B. C., Cheng, K. F., Fong, C. Y., Wong, A., Mok, H., Chow, M. S., Ho, P. C., … Mok, V. (2008). Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease. Journal of clinical psychopharmacology, 28(1), 110–113.
Bordoni, P. H. C., Bordoni, L. S., Silva, J. D. M., & Drumond, E. D. F. (2016). Utilização do método de captura-recaptura de casos para a melhoria do registro dos acidentes de trabalho fatais em Belo Horizonte, Minas Gerais, 2011. Epidemiologia e Serviços de Saúde, 25, 85-94.
Borre, Y. E., O'Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014). Microbiota and neurodevelopmental windows: implications for brain disorders. Trends in molecular medicine, 20(9), 509–518.
Brasil, Ministério da Saúde. (2015). Monografia da espécie Curcuma longa L. (Curcuma). Ministério da Saúde e Anvisa 5, 1–150.
Camandola, S., Plick, N., & Mattson, M. P. (2019). Impact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative Disease. Neurochemical research, 44(1), 214–227.
Cheng, A. L., Hsu, C. H., Lin, J. K., Hsu, M. M., Ho, Y. F., Shen, T. S., Ko, J. Y., Lin, J. T., Lin, B. R., Ming-Shiang, W., Yu, H. S., Jee, S. H., Chen, G. S., Chen, T. M., Chen, C. A., Lai, M. K., Pu, Y. S., Pan, M. H., Wang, Y. J., Tsai, C. C., … Hsieh, C. Y. (2001). Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer research, 21(4B), 2895–2900.
Consenza, R. M., Guerra, L. B. (2011). Neurociência e Educação como o cérebro aprende. Artmed.
Corsi, P. M. (n.d.). Human memory and the medial temporal region of the brain. McGill University. Retrieved August 10, 2022, from https://escholarship.mcgill.ca/concern/theses/05741s554
Cox, K. H., Pipingas, A., & Scholey, A. B. (2015). Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. Journal of psychopharmacology (Oxford, England), 29(5), 642–651.
Crous-Bou, M., Molinuevo, J. L., & Sala-Vila, A. (2019). Plant-Rich Dietary Patterns, Plant Foods and Nutrients, and Telomere Length. Advances in nutrition (Bethesda, Md.), 10(Suppl_4), S296–S303.
D'Cunha, N. M., Seddon, N., Mellor, D. D., Georgousopoulou, E. N., McKune, A. J., Panagiotakos, D. B., Kellett, J., & Naumovski, N. (2019). Curcumin for Cognition: Is It Just Hype, Based on Current Data?. Advances in nutrition (Bethesda, Md.), 10(1), 179–181.
Diamond, A. (2013). Executive Functions. Annual Review of Psychology 64, 135-168.
Dominguez, L. J., & Barbagallo, M. (2018). Nutritional prevention of cognitive decline and dementia. Acta Bio Medica: Atenei Parmensis, 89(2), 276.
Duncan, M. T. (2006). Obtenção de dados normativos para desempenho no teste de Stroop num grupo de estudantes do ensino fundamental em Niterói. Jornal Brasileiro de Psiquiatria, 55, 42-48.
Espirito Santo, H., Lemos, L., Fernandes, D., Cardoso, D., Neves, C., Caldas, L., Marques, M., Guadalupe, S., and Daniel, F. (2015). Teste de Stroop (pp. 114–119).
Gomes, T., Souza, J., Somerlate, L. C., Mendonça, V. A., Lima, N. M., Carli, G. P., Castro, S., de Jesus A S Andrade, T., Dias, J., Oliveira, M., Alves, C., & Carli, A. P. (2021). Miconia albicans and Curcuma longa herbal medicines positively modulate joint pain, function and inflammation in patients with osteoarthritis: a clinical study. Inflammopharmacology, 29(2), 377–391.
Gutierrez, B. A. O., Silva, H. S. D., Guimarães, C., & Campino, A. C. (2014). Impacto econômico da doença de Alzheimer no Brasil: é possível melhorar a assistência e reduzir custos?. Ciência & Saúde Coletiva, 19, 4479-4486.
Guzman-Vilanueva, D., El-Sherbiny, I. M., Herrera-Ruiz, D., & Smyth, H. D. C. (2013). Design and In Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin. BioMed Research International.
Hamaguchi, T., Ono, K., & Yamada, M. (2010). Curcumin and Alzheimer’s Disease. CNS Neurosci Ther 5, 285-297.
He, Y., Yue, Y., Zheng, X., Zhang, K., Chen, S., & Du, Z. (2015). Curcumin, Inflammation, and Chronic Diseases: How Are They Linked? Molecules, Basel 5, 9183-9213.
Klein, M., Adda, C. C., Miotto, E. C., Lucia, M. C. S. de, and Scaff, M. (2010). O paradigma stroop em uma amostra de idosos brasileiros. Psicologia Hospitalar, 8(1), 93–112.
Lopresti, A. L. (2017). Curcumin for neuropsychiatric disorders: a review of in vitro animal and human studies. Journal of Psychopharmacology 3, 287-302.
Louzada, F. M., Macedo, L. d., & Santos, D. D. d. (2016). Funções executivas e desenvolvimento na primeira infância: habilidades necessárias para a autonomia. Comitê Científico do Núcleo Ciência pela Infância.
Mancini, E., Beglinger, C., Drewe, J., & Zanchi, D. (2017). Green tea effects on cognition, mood and human brain function: A systematic review. Phytomedicine 34, 26-37.
Marchi, J. P., Tedesco, L., Melo, A. d. C., Frasson, A. C., França, V. F., Sato, S. W., & Wietzikoski, E. C. (2016). Curcuma longa L., O açafrão da terra, e seus benefícios medicinais. Arquivos de Ciências da Saúde da UNIPAR 3, 189-194.
Marlloy-Diniz, L. F., Fluentes, D., Mattos, P., & Abreu, N. (2016). Neuropsicologia avaliação clínica. Artmed.
Marlloy-Diniz, L. F., Fluentes, D., Mattos, P., & Abreu, N. (2010). Avaliação Neuropsicológica. Artmed.
Marmitt, D. J., Rempel, C., Goettert, M. I., & Silva, A. C. (2015). Plantas Medicinais da RENISUS Com Potencial Anti-Inflamatório: Revisão sistemática em três bases de dados científicas. Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde 9, 129-144.
Martins, M. C., & Rusig, O. (1992). Cúrcuma: um corante natural. Boletim da Sociedade Brasileira de Ciência e Tecnologia de Alimentos 1, 56-65.
Ng, T. P., Chiam, P. C., Lee, T., Chua, H. C., Lim, L., & Kua, E. H. (2006). Curry Consumption and Cognitive Function in the Elderly. American Journal of Epidemiology 9, 898-906.
Pereira Pretto Carlesso, J. (2020). Os desafios da vida acadêmica e o sofrimento psíquico dos estudantes universitários. Research, Society and Development, 9, 82922092. https://doi.org/10.33448/rsd-v9i2.2092
Piper, B. J., Mueller, S. T., Geerken, A. R., Dixon, K. L., Kroliczak, G., Olsen, R. H. J., & Miller, J. K. (2015). Reliability and validity of neurobehavioral function on the Psychology Experimental Building Language test battery in Young adults. PeerJ 3, 1460.
Puig, E. J., Pérez, Y. B., Caro, A. A. H., & Falcón, D. D. (2019). Funciones ejecutivas, cronotipo y rendimiento académico em estudiantes universitários. Revista Cubana de Educación Superior 2.
Polazzi, E., Monti, B. (2010). Microglia and neuroprotection: From in vitro studies to therapeutic applications. Progress in Neurobiology 92, 293-315.
Prasad, S., Gupta, S. C., Tyagi, A. K., & Aggarwal, B. B. (2014). Curcumin, a componente of Golden spice: From bedside to bench and back. Biotechnology Advances 6, 1053-1064.
Rabinovici, G. D., Stephens, M. L., & Possin, K. L. (2015). Executive Dysfunction. Behavioral Neurology and Neuropsychiatry 21, 646-659.
Santos-Parker, J. R., Lubieniecki, K. L., Rossman, M. J., Ark, H. J. V., Bassett, C. J., Strahler, T. R. ... Seals, D. R. (2018). Curcumin supplementation and motor-cognitve function in healthy middle-aged older adults. Nutrition and Healthy Aging 4, 323-333.
Sarker, M. R., Framks, S. F. (2018). Efficacy os curcumin for age-associated cognitive decline: a narrative review of preclinical and clinical studies. GeroScience 40, 73-95.
Serpa, A. L. de O., Timóteo, A. P. P., Querino, E. H. G., and Malloy-Diniz, L. F. (2019). Desenvolvimento do teste de planejamento Torre de Londres – versão brasileira (TOL-BR). Debates em Psiquiatria, 9(4), 10–19. https://doi.org/10.25118/2763-9037.2019.v9.45
Severino, A. J. (2017). Metodologia do trabalho científico. Cortez editora.
Silva, A. W. R. da, and Biegelmeyer, R. (2020). Curcuma longa L. (Zingiberaceae): Desenvolvimento tecnológico para aplicação como agente terapêutico auxiliar no tratamento de pacientes portadores da Doença de Alzheimer. Revista Fitos, 14(2), 249–258. https://doi.org/10.32712/2446-4775.2020.909
Small, G. W., Siddarth, P., Li, Z., Huang, S. C., Heber, D., & Bairro, J. R. (2017). Memory and Brain Amylod and Tau Effects of a Bioavailable Formo f Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial. Issue 3, 266-277.
Tsai, Y. M., Liao, W. L. C., Chien, C. F., Lin, L. C., & Tsai, T. H. (2012). Effects of polymer molecular weight on relative oral bioavailability of curcumin. International Journal of Nanomedicine 7, 2957-2966.
Wang, X., Kim, J. R., Lee, S. B., Kim, Y. J., Jung, M. Y., Kwon, H. W., & Ahn, Y. J. (2014). Effects of curcuminoids identified in rhizomes of Curcuma Longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer’s disease Drosophila models. BMC Complementary & Alternative Medicine 14, 88.
Xu, X. Y., Meng, X., Li, S., Gan, R. Y., Li, Y., & Li, H. B. (2018). Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Curret Progress, Challenges, and Perspectives. Nutrients 10, 1553.
Yu, Z. F., Kong L. D., & Chen, Y. (2002). Antidepressant activity of aqueous extracts of Curcuma longa in mice. Journal of Ethnopharmacology 83, 161-165.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Francyelle Sambüc Lieberenz; Laura Araújo Pereira Santos; Heloiza Pereira Fernandes da Silva; Alisson Hirle Gonçalves; Amanda Pereira dos Anjos; Larissa Kelly Damasceno Costa; Gabriela de Paula Carli; Caio César de Souza Alves; Alessandra de Paula Carli; Ernani Aloysio Amaral
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
