Profile of primary blood current infections in a neonatal intensive care unit
DOI:
https://doi.org/10.33448/rsd-v11i11.33511Keywords:
Cross infection; Neonatal intensive care unit; Infection control.Abstract
Objective: To evaluate the profile of Primary Bloodstream Infections in a Neonatal Intensive Care Unit. Method: Exploratory and cross-sectional study, carried out in the Neonatal Intensive Care Unit of a reference maternity hospital in Piauí. The sample consisted of all reported cases of primary laboratory bloodstream infection and primary clinical bloodstream infection from January to December 2019. Results: The most frequent healthcare-related infections were primary laboratory bloodstream infection (54.78%) and primary clinical bloodstream infection. At the beginning of the year 2019, there was an increase in the global density (48.5) in relation to the median of 2018 (28), which declined throughout the year, reaching the end of the same with a global density lower than the median (25, 6). The main bacteria isolated in blood cultures were coagulase negative Staphylococcus (229) and klebisiella pneumoniae (52). Regarding the resistance profile, the negative coagulase Staphylococcus showed 75% resistance to Oxacillin. For Staphylococcus aureus, resistance to Oxacillin dropped to almost half of the samples (48.1%). In gram-negative bacteria, the main agents were Klebsiellas, with a resistance profile for Piperacillin-Tazobactam of 28.3%. Conclusion: Primary laboratory bloodstream infections and primary clinical bloodstream infections represent the main topographies of infections in neonatal ICUs, as well as the microbiological profile is similar to the profile of neonatal infections found in the literature.
References
Alvarado-Gamarra, G., Alcalá-Marcos, K., Abarca-Alfaro, D., et al. (2016). Microbiological and therapeutic characteristics of confirmed neonatal sepsis at a hospital in Lima. Peru, Revista Peruana de Medicina Experimental y Salud Publica,33(1):74–82.
Brasil. (1998). Portaria Nº 2.616, de 12 de maio de 1998. https://bvsms.saude.gov.br/bvs/saudelegis/gm/1998/prt2616_12_05_1998.html
Brasil. (2016). Boletim Segurança do Paciente e Qualidade em Serviços de Saúde nº 16. https://www.gov.br/anvisa/pt-br/centraisdeconteudo/publicacoes/servicosdesaude/boletim-seguranca-do-paciente/boletim-seguranca-do-paciente-e-qualidade-em-servicos-de-saude-no-16/view
Brasil. Ministério da Saúde. (2017). Critérios Diagnósticos de Infecções Relacionadas à Assistência à Saúde. Brasília. https://bvsms.saude.gov.br/bvs/publicacoes/criterios_diagnosticos_infeccoes_assistencia_saude.pdf
Cunha, M. L. R. S., Lopes, C. A. M., Rugolo, L. M. S. S., & Chalita, L. V. A.S. (2002). Significância clínica de estafilococos coagulase negativa isolados em recém-nascidos. Jornal de Pediatria, 78 (4), 279-288.
Escobar, A. M. U., Rocha, S. S., Sztajnbok, S., Eisencraft, A. P., & Grisi, S. J. F. E. (1996). Sepse por Klebsiella Pneumoniae – Revisão de 28 casos. Jornal de Pediatria, 72 (4), 230-234.
Eyesus, T.G., Moges, F., Eshetie, S., Yeshitela, B., & Abate, E. (2017). Bacterial etiologic agents causing neonatal sepsis and associated risk factors in Gondar, Northwest Ethiopia. BMC Pediatrics, 17(1), 137.
Freire, I. L. S., Menezes, L. C. C., Sousa, N. M. L., Araújo, R. O., Vasconcelos, Q. L. D. A. Q., & Torres, G. V. (2013). Epidemiologia das infecções relacionadas à assistência à saúde em unidade de terapia intensiva pediátrica. Revista Brasileira de Ciências da Saúde, 11(35), 9-12.
Garzillo, C., Bagattine, M., Bogdanovic, L., Popolo, D. A., Lula, V. D., Catania, M. R., Raimond, F., Triassi, M., & Zarrilli, R. (2017). Risk factors for Candida parapsilosis bloodstream infection in a neonatal intensive care unit: a case-control study Ital. Journal of Pediatrics, 43(1), 10.
Gil, A. C. (2002). Como elaborar projetos de pesquisa. 4ª ed. São Paulo.
Leoncio, J. M., Almeida, V. F., Ferrari, R. A. P., Capobiango, J. D., Kerbauy, G., & Tada, M. T. G. M. (2019). Impacto das infecções relacionadas à assistência à saúde nos custos da hospitalização de crianças. Revista da Escola de Enfermagem da USP, 53.
Liu, L.(2016). Níveis e causas de mortalidade em menores de cinco anos. Saúde reprodutiva, materna, neonatal e infantil, 1 (3), 74.
Mahallei, M., Rezaee, M. A., Mehramuz, B., et al. (2018). Clinical symptoms, laboratory, and microbial patterns of suspected neonatal sepsis cases in a children’s referral hospital in northwestern Iran. Medicine (Baltimore), 97(25), 106–30.
Marwah, P., Chawla, Deepak., Chander, J., Guglani, V., & Marwah, A. (2015). Perfil bacteriológico da sepse neonatal em um hospital terciário do norte da Índia. Indian Pediatrics, 52, 158-159.
Medeiros, K., Hermes, T. C., Campos, C. G. P., Cabral, L. P. A., & Bordin, D.(2019). Perfil, sintomas e tratamento realizado em neonatos diagnosticados com sepse. Revista de epidemiologia e controle de infecção, 9(3), 220-226.
Moura, M. E. B., Campelo, S. M. A., Brito, F. C. P., Batista, O. M.A., Araújo, O. M. E., & Oliveira, A. D. S. (2007). Infecção hospitalar: estudo de prevalência em um hospital público de ensino. Revista Brasileira de Enfermagem, 60(4), 416-421.
Oza, S. (2015). Estimativas de causa de morte neonatal para os períodos neonatais precoce e tardio para 194 países: 2000–2013. Bulletin of the World Health Organization, 93 (1), 19–28.
Pokhrel, B., Koirala, T., Shah, G., Joshi, S., & Bral, P. (2018). Bacteriological profile and antibiotic susceptibility of neonatal sepsis in neonatal intensive care unit of a tertiary hospital in Nepal. BMC Pediatrics, 18(1), 208.
Srivastavaa, S. & Shetty, N. (2007). Healthcare-associated infections in neonatal units: lessons from contrasting worlds. Journal of Hospital Infection, 65, 292-306.
Stuchi, R. A. G., Oliveira, C. H. A. S., Soares, B. M., & Arreguy-Sena, C. (2013). Contaminação bacteriana e fúngica dos telefones celulares da equipe de saúde num hospital em Minas Gerais. Ciência, Cuidado e Saúde, 12(4), 760-767.
Thakur, S., Thakur K., Sood, A., & Chaudhary, S. (2016). Bacteriological profile and antibiotic sensitivity pattern of neonatal septicaemia in a rural tertiary care hospital in North India. Journal of Medical Microbiology, 34(1), 67-71.
Yadav, N. S., Sharma, S., Chaudhary, D. K., Panthi, P., Pokhrel, P., Shrestha, A., & Mandal, P. K. (2018). Bacteriological profile of neonatal sepsis and antibiotic susceptibility pattern of isolates admitted at Kanti Children's Hospital, Kathmandu, Nepal. BMC Research Notes, 11(1), 301.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Sara Machado Miranda Leal Barbosa ; Josilene Ribeiro de Sousa Machado; Nayana da Silva Oliveira de Melo; Amanda Carvalho de Sousa; Lílian Machado Vilarinho de Moraes; Paula Lima da Silva; Izane Luiza Xavier Carvalho Andrade ; Larissa Nunes de Alencar; Lucas Manoel Oliveira Costa
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
