Development of new neuromodulation technologies as an alternative for improvement and insertion in the labor market

Authors

DOI:

https://doi.org/10.33448/rsd-v11i11.33525

Keywords:

Neuromodulation Industry; Entrepreneurship in Scientific Research; Economics of Neurotechnology.

Abstract

Introduction: Neuromodulation devices are already present in many patients' lives, like cardiac pacemaker, spinal cord stimulator for chronic pain treatment, cochlear implant, and even brain stimulation devices used for enhancing performance of athletes, gamers and students. It’s getting even harder to maintain neuromodulation research with high scientific and qualified production in Brazil due to political and economical issues that end leading to student grant cuts. The global market for neurotechnology moves billions in a year, with a growth trend of approximately US$13.3 billion by 2022. This literature review seeks to identify in the Neuromodulation Industry, an opportunity for professional performance, as a self-financing option and as a working field for neuroengineering and neurosciences students. For this, 44 references in English and Portuguese were selected, mainly dating from 2010 to 2020. Research in neurotechnology tends to increase after the creation in 2012, of the Human Brain Project. Neurological disorders affect a large portion of the global population, with a tendency to increase in the next few years, turning this into a profitable market with good future directions. The research into the field of neuromodulation is a marketable product and there are big companies in the business market that are interested in financing the development of new products and technologies, providing opportunities to neuroengineering and neurosciences students entering the formal labor market even before completing a graduate course.

Author Biographies

Luiz da Costa Nepomuceno Filho, Instituto Internacional de Neurociências Edmond e Lily Safra; Instituto Santos Dumont; Universidade Mauricio de Nassau

Mestre em Neuroengenharia no Instituto Santos Dumont. Graduação em Biomedicina com habilitação em Análises Clínica pela Universidade Potiguar (UNP), Especialista em Estética pela Instituto de Ensino Blauro Cardoso de Mattos (FASERRA). Durante o curso de Biomedicina, fiz parte de grupos de estudos. Realizei Iniciação Científica Voluntária no departamento de Ciências Biológicas da UFRN no projeto Avaliação de Biomarcadores em pacientes chagásicos portadores de megacólon e/ou megaesôfago, a partir deste projeto de pesquisa tive a oportunidade de trabalhar no biotério do Departamento de Farmácia da UFRN. No Instituto Internacional de Neurociências Edmond e Lily Safra (IIN-ELS), participei do projeto de biocompatibilidade de microelétrodos medular para avaliação da doença de Parkinson, o trabalho foi apresentado e publicado com o título de: Microglial Activation After Acute Spinal Cord Electrode Implant. Participei também do projeto: Caracterização da Atividade Eletrofisiológica do Circuito Mesolímbico de Camundongos em um Modelo Agudo de Mania, fui bolsista do CNPq neste projeto, construí matrizes de microelétrodos, processei tecidos cerebrais, confecção das lâminas histológicas em coloração Nissl, Imuno-histoquímica e Imunofluorescência.

Catherine Caldas de Mesquita, Instituto Internacional de Neurociências Edmond e Lily Safra; Instituto Santos Dumont

Possui graduação em Biomedicina pela Universidade Potiguar e é mestranda em Neuroengenharia no Instituto Santos Dumont.

Raquel Emanuela de Medeiros, Instituto Internacional de Neurociências Edmond e Lily Safra; Instituto Santos Dumont

Mestranda do Programa de Pós-Graduação em Neuroengenharia do Instituto Internacional de Neurociências Edmond e Lily Safra (IIN-ELS). Graduação em Biomedicina com habilitação em Patologia Clínica pela Universidade Potiguar (UNP) fiz Iniciação científica voluntária no laboratório de Imunoparasitologia no departamento de Ciências Biológicas da UFRN.

References

Abbott. (2022). https://www.abbottbrasil.com.br/carreiras/estudantes.html

Ad Instruments. (2022). https://www.adinstruments.com/company

Alliance for Advancing Bioelectronic Medicine (2020). Building a bioelectronic medicine movement 2019: insights from leaders in industry, academia, and research. Bioelectron Med 6. https://doi.org/10.1186/s42234-020-0037-8

Benabid A. L., Pollak P., Louveau A., Henry S. & de Rougemont J. (1987). Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease. Appl Neurophysiol., 50(1-6):344-346. https://doi.org/10.1159/000100803

Biotronik. (2022). https://www.biotronik.com/pt-br/careers/jobs/career-opportunities/job-search

Brain Support (2022): http://www.brainsupport.com.br/page/aplicacao/educacao

Brunoni, A. R., Teng, C. T., Correa, C., Imamura, M., Brasil-Neto, J. P., Boechat, R., Rosa, M., Caramelli, P., Cohen, R., Del Porto, J. A., Boggio, P. S. & Fregni, F. (2010). Neuromodulation approaches for the treatment of major depression: challenges and recommendations from a working group meeting. Arquivos de neuro-psiquiatria, 68, 433-451. https://doi.org/10.1590/S0004-282X2010000300021

Campbell, S. R. (2011). Educational Neuroscience: Motivations, methodology, and implications. Educational Philosophy and Theory, 43(1), 7-16. https://doi.org/10.1111/j.1469-5812.2010.00701.x

Cavuoto, J. (2011). Neurotech startups participate at international neuromodulation society congress. Neurotech Reports, 2(14), 400.

Cochlear. (2022). https://www.cochlear.com/br/pt/corporate/careers/cochlear-culture

Costa, E. G. D. & Nebel, L. (2018). O quanto vale a dor? Estudo sobre a saúde mental de estudantes de pós-graduação no Brasil. Polis. Revista Latinoamericana, (50). http://journals.openedition.org/polis/15816

Cota, V. R., Aguiar, C. L., Neto, B. S. & Benegas, M. (2020). Open-source hardware as a model of technological innovation and academic entrepreneurship: The Brazilian landscape. Innovation & Management Review, 17(2), 177;195. https://doi.org/10.1108/INMR-06-2018-0036

Cunha, S. M. & Carrilho, D. M. (2005). O processo de adaptação ao ensino superior e o rendimento acadêmico. Psicologia escolar e educacional, 9, 215-224. https://doi.org/10.1590/S1413-85572005000200004

Deer, T. R., Hagedorn, J. M., Jameson, J. B. & Mekhail, N. (2020). A New Horizon in Neuromodulation. Pain Medicine, 22(4), 2021, 1012–1014. https://doi.org/10.1093/pm/pnaa197

Dubé, E., Vivion, M. & MacDonald, N. (2015). Vaccine hesitancy, vaccine refusal and the anti-vaccine movement: influence, impact and implications. Expert review of vaccines, 14(1), 99-117. https://doi.org/10.1586/14760584.2015.964212

Dudziak, E. A. (2018) Quem financia a pesquisa brasileira? Um estudo InCites sobre o Brasil e a USP. São Paulo: SIBiUSP, 2018. https://www.abcd.usp.br/noticias/quem-financia-a-pesquisa-brasileira-um-estudo-incites-sobre-o-brasil-e-a-usp/#:~:text=O%20financiamento%20da%20pesquisa%20no,Amparo%20a%20Pesquisa%20agrupadas%20no

Feigin, V. L., Vos, T., Nichols, E., Owolabi, M. O., Carroll, W. M., Dichgans, M., Dichgans, M., Deuschl, G., Parmar, P., Brainin, M. & Murray, C. (2019). The global burden of neurological disorders: translating evidence into policy. The Lancet, 19(3), 255-265. https://doi.org/10.1016/S1474-4422(19)30411-9

Forlini, C., Lipworth, W., Carter, A. & Kerridge I. (2019). Beyond Flourishing: Intersecting Uses and Interests in the Neurotechnology Marketplace. AJOB Neurosci. 2019;10(4):178-180. https://doi.org/10.1080/21507740.2019.1665128

Global Burden Disease. (2019) Prevalence of neurological disorders in 2019. Institute for Health Metrics and Evaluation. (Acesso em: agosto/2022) https://vizhub.healthdata.org

Hariz, M. & Amadio, J. P. (2015) The New Era of Neuromodulation. Virtual Mentor, 17(1):74-81. https://doi.org/10.1001/virtualmentor.2015.17.1.oped2-1501.

Kreitmair, K. V. (2019) Response to Open Peer Commentaries on “Ethical Dimensions of Direct-to-Consumer Neurotechnologies”. AJOB Neuroscience, 10(4), W1-W3. https://doi.org/10.1080/21507740.2019.1675798

Kumar, K. &Rizvi, S. (2014) Historical and Present State of Neuromodulation in Chronic Pain. Current Pain and Headache Reports, 18(387). https://doi.org/10.1007/s11916-013-0387-y

Levy, R. M. (2010). The Politics of Neuromodulation in the USA: Spinal Cord Stimulation and the Washington State Department of Labor and Industry. Technology at the Neural Interface, 4(13), 249 - 252. https://doi.org/10.1111/j.1525-1403.2010.00300.x

Luan, S., Williams, I., Nikolic, K. & Constandinou, T. G. (2014) Neuromodulation: present and emerging methods. Frontiers in Neuroengineering, 7(27), 1-9. https://doi.org/10.3389/fneng.2014.00027

Moore, T., Chestek, C., Pooley, D., Chon, A., Hippenmeyer, S. & Anikeeva, P. (2018). Visions for the Future of Neuroscience. Neuron. 2018;98(3):464-465. https://doi.org/10.1016/j.neuron.2018.04.024.

Mouly et al. (2018). Market and Technology Report: Market Expectations and Technology Trends - Update. Technologies to Market, 01(01), 40.

Mouly, J., Villien, M., Le Greneur, C. & Sagot, B. (2019). Neurotechnologies and brain computer interface: How are neurotechnologies unraveling the mystery of our brain and opening new business opportunities?. Technologies to Market, 01(01), 40. https://s3.i-micronews.com/uploads/2019/01/yole_Neurotechnologies_and_Brain_Computer_Interface_flyer.pdf

Nicola, M., Alsafi, Z., Sohrabi, C., Kerwan, A., Al-Jabir, A., Iosifidis, C., Agha, M. & Aghaf, R. (2020). The socio-economic implications of the coronavirus pandemic (COVID-19): A review. International journal of surgery, 78, 185-193. https://doi.org/10.1016/j.ijsu.2020.04.018

Nicolelis, M. A. (2001). Actions from thoughts. Nature, 409(6818), 403-407. https://doi.org/10.1038/35053191

Nunes, A. (2020, 01 de abril). Bolsas de mestrado e doutorado são cortadas e alunos ficam sem renda. A Gazeta.

Penido, A. (2019, 04 setembro). Cresce 18% número de casos de sarampo no Brasil. Ministério da Saúde.

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica. UFSM. https://repositorio.ufsm.r/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica. Pdf

Pinheiro, C. (2020). A pandemia atrapalha a vacinação e pode deixar 80 milhões de bebês em risco. Veja Saúde. A

Proetti, S. (2018). As pesquisas qualitativa e quantitativa como métodos de investigação científica: Um estudo comparativo e objetivo. Revista Lumen ISSN: 2447-8717, 2 (4). https://doi.org/10.32459/revistalumen.v2i4.60

Puerta, M. (2020). The Market for Neurotechnology: 2020-2024. Neurotech Reports, 1(01), 254.

Rizzolatti G, Fabbri-Destro M, Caruana F & Avanzini P.(1997). System neuroscience: Past, present, and future. CNS Neurosci Ther., 24(8):685-693. http://dx.doi.org/10.1111/cns.12997.

Ruffini, G. Maiques, A. & Casas, Y. (2020). Neuroelectrics.

Saldaña, P. (2020, 17 de fevereiro). O impacto de cortes de bolsas da Capes foi maior no Nordeste. Folha de São Paulo. Acesso em: 5 de julho de 2020.

Schmälzle, R., & Meshi, D. (2020). Communication neuroscience: Theory, methodology and experimental approaches. Communication methods and measures, 14(2), 105-124. https://doi.org/10.1080/19312458.2019.1708283

Silva, A. I. A., Siqueira, J. G. de, & Siqueira, C. G. de. (2022). Vacinas: história, negacionismo, ‘fake news’ e a Covid-19 no Brasil hoje. Brazilian Journal of Development, 8(5), 35200–35217. https://doi.org/10.34117/bjdv8n5-165.

Slavin, K. V. (2011). History of peripheral nerve stimulation. Peripheral nerve stimulation, 24, 1-15. https://doi.org/10.1159/000323002

Wexler, A., & Reiner, P. B. (2019). Oversight of direct-to-consumer neurotechnologies. Science, 363(6424), 234–235. https://doi.org/10.1126/science.aav0223.

Wiest, M. C., & Nicolelis, M. A. (2003). Behavioral detection of tactile stimuli during 7–12 Hz cortical oscillations in awake rats. Nature neuroscience, 6(9), 913-914. https://doi.org/10.1038/nn1107

World Health Organization. (2006). Neurological disorders: public health challenges. WHO Library Cataloguing-in-Publication Data. https://www.who.int/publications/i/item/9789241563369

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Published

23/08/2022

How to Cite

NEPOMUCENO FILHO, L. da C.; MESQUITA, C. C. de .; MEDEIROS, R. E. de . Development of new neuromodulation technologies as an alternative for improvement and insertion in the labor market. Research, Society and Development, [S. l.], v. 11, n. 11, p. e294111133525, 2022. DOI: 10.33448/rsd-v11i11.33525. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/33525. Acesso em: 14 nov. 2024.

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Vol. 11 No. 11

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Review Article

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Copyright (c) 2022 Luiz da Costa Nepomuceno Filho; Catherine Caldas de Mesquita; Raquel Emanuela de Medeiros

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