Frequency and specificity of erythrocyte alloimmunization in patients at a reference hospital in Alagoas, Brazil
DOI:
https://doi.org/10.33448/rsd-v11i11.33555Keywords:
Alloimmunization; Antibodies; Antigens; Hematological diseases; Transfusion.Abstract
Objective: To determine the frequency and specificity of erythrocyte alloimmunization in patients treated by hemotherapy at the University Hospital Professor Alberto Antunes - UFAL, Maceió-Alagoas, in the period 2013-2018. Methods: Retrospective analysis all patient records with request for red blood cell concentrate (RBC) with a positive erythrocyte antibody test. Results: The incidence of erythrocyte alloimmunization was higher in women n=144 (80.45%) than in men n=35 (19.55%). We detected 13 antibodies, the most frequent specificities identified were anti-D (35.20%), anti-M (12.30%) and anti-E (7.82%). The combination of antibodies occurred in twenty-six cases with prevalence for combinations of antibodies of the Rh system, anti-D + anti-C (23.08%). The highest incidence of alloantibodies was observed in pregnant women. Conclusion: The population studied had high levels of alloimmunization through the Rh System, greater specificity of alloimmunization in women through anti-D and higher rate of alloimmunization among men over the age of 40. Further studies are necessary for a better understanding of red blood cell alloimmunization for population of Alagoas.
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Copyright (c) 2022 Kledson Lopes Barbosa; Erika Elita Araújo Lessa; Margareth Alves Soares; Walkíria de Araújo Souza; Audemário de Gusmão Lins Filho; Krisley Rodrigues Lima Pereira; Kelly Patrícia Alexandre Chagas; Cinthya Pereira Leite Costa de Araújo; Djana Maria de Lima Brêda; Luciana de Andrade Pereira
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