Polymorphisms in the glucose transporter gene (GLUT4) associated with the development of type 1 Diabetes mellitus
DOI:
https://doi.org/10.33448/rsd-v11i13.35549Keywords:
Pathophysiology; Type 1 diabetes mellitus; Genetic polymorphism; GLUT4 gene.Abstract
Diabetes Mellitus (DM) is part of the group of chronic and multifactorial diseases, and exogenous and endogenous factors are responsible for the development of this disease. DM is considered a public health problem in the world due to the high number of people affected by this pathology. Type 1 diabetes mellitus (DM1) is characterized by the autoimmune process that causes the destruction of pancreatic β cells, which is responsible for the production of insulin. The genetic factor is a component that favors the development of autoimmunity present in this disease. The aim of this study is to describe the various factors associated with the development of DM1, with emphasis on the pathophysiological description of the disease and to report the main polymorphisms associated with the Glut4 gene. This work is a literature review developed through the search of publications obtained in the databases: Google academic, SciELO and Pubmed. The descriptors type 1 diabetes mellitus, GLUT4, polymorphisms and pathophysiology were used. Through the analysis of the survey of all the material, it was possible to demonstrate the presence of three mutations (C/C; C/T; T/T). However, the statistical analysis did not indicate significance regarding the relationship of these mutations with the development of DM1. It is concluded that it is necessary to carry out more studies on the GLUT4 gene, as well as to seek evidence on the association of polymorphisms with individuals with DM1.
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