Anthropometric and laboratory characterization of patients tested for SARS-CoV-2 at the Hospital of the Military Policeman of Goiânia-GO

Authors

DOI:

https://doi.org/10.33448/rsd-v11i14.36218

Keywords:

COVID-19; Clinical laboratory techniques; Police.

Abstract

Objective: to find changes between laboratory tests of patients tested for COVID-19. Methodology: An observational analytical study was carried out with military personnel and their family members over 18 years of age who were tested for COVID-19 and were followed up at the Hospital do Policial Militar. A comparative analysis was performed between anthropometric data, age group, sex and the following tests: C-reactive protein (CRP), D-dimer, erythrocyte sedimentation rate (ESR), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (DHL), ferritin, urea, creatinine, creatine kinase (CK) and troponin I. A descriptive analysis was performed, with mean and standard deviation, in addition to the f test and the ANOVA test with a significance level (p < 0.05). Results: Of the total of 4499 patients, 2646 (59%) were male and 3094 (69%) subjects had undetected RT-PCR for SARS-CoV-2. The lowest mean age was female, 28 years (±13.55) and the highest total BMI, 27.81 (±4.45), both in the detected/inconclusive group. Furthermore, the group with detected/inconclusive RT-PCR had significantly higher D-dimer, CRP, AST, ALT, DHL, ferritin and creatinine than the undetected group. Conclusion: It was possible to observe a significant relationship between obesity, COVID-19, male gender and advanced age (above 51 years old) with an increase in laboratory test values (p<0.05).

References

Borges do Nascimento, I. J., Pinto, L. R., Fernandes, V. A., Romero, I. M., Oliveira, J. A. de Q., Marcolino, M. S., & Leite, M. F. (2020). Clinical characteristics and outcomes among Brazilian patients with severe acute respiratory syndrome coronavirus 2 infection: An observational retrospective study. Sao Paulo Medical Journal, 138(6), 490–497.

Bulut, C., & Kato, Y. (2020). Epidemiology of covid-19. Turkish Journal of Medical Sciences, 50(SI-1), 563–570.

Cai, Q., Chen, F., Wang, T., Luo, F., Liu, X., Wu, Q., He, Q., Wang, Z., Liu, Y., Liu, L., Chen, J., & Xu, L. (2020). Obesity and COVID-19 severity in a designated hospital in Shenzhen, China. Diabetes Care, 43(7), 1392–1398.

Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., Xia, J., & Yu, T. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan , China : a descriptive study. The Lancet, 395(10223), 507–513.

Civil, S. de E. da C. (2012). LEI No 17.866, DE 19 DE DEZEMBRO DE 2012. 1–3.

Daly, J. L., Simonetti, B., Klein, K., Chen, K. E., Williamson, M. K., Antón-Plágaro, C., Shoemark, D. K., Simón-Gracia, L., Bauer, M., Hollandi, R., Greber, U. F., Horvath, P., Sessions, R. B., Helenius, A., Hiscox, J. A., Teesalu, T., Matthews, D. A., Davidson, A. D., Collins, B. M., … Yamauchi, Y. (2020). Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science, 370(6518), 861–865.

Dong, L., Tian, J., He, S., Zhu, C., Wang, J., Liu, C., & Yang, J. (2020). Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA, 10(1), 49–61.

Fung, T. S., & Liu, D. X. (2019). Human coronavirus: Host-pathogen interaction. In Annual Review of Microbiology (Vol. 73, Issue 1, pp. 529–557).

Gao, F., Zheng, K. I., Wang, X., Sun, Q., Pan, K., Wang, T., Chen, Y., Targher, G., Byrne, C. D., & George, J. (2020). Obesity Is a Risk Factor for Greater COVID-19 Severity. 43(April), 72–74.

Ge, X. Y., Li, J. L., Yang, X. Lou, Chmura, A. A., Zhu, G., Epstein, J. H., Mazet, J. K., Hu, B., Zhang, W., Peng, C., Zhang, Y. J., Luo, C. M., Tan, B., Wang, N., Zhu, Y., Crameri, G., Zhang, S. Y., Wang, L. F., Daszak, P., & Shi, Z. L. (2013). Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature, 503(7477), 535–538.

Heininger, U. (2020). Severe acute respiratory syndrome coronavirus 2 vaccines: Setting expectations appropriately. Pediatric Infectious Disease Journal, January, 123-14.

Henry, B. M., De Oliveira, M. H. S., Benoit, S., Plebani, M., & Lippi, G. (2020). Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): A meta-analysis. In Clinical Chemistry and Laboratory Medicine (Vol. 58, Issue 7, pp. 1021–1028).

Jaillon, S., Berthenet, K., & Garlanda, C. (2019). Sexual Dimorphism in Innate Immunity. Clinical Reviews in Allergy & Immunology, 56(3), 308–321.

Jakhmola, S., Baral, B., & Jha, H. C. (2021). A comparative analysis of COVID-19 outbreak on age groups and both the sexes of population from India and other countries. Journal of Infection in Developing Countries, 15(3), 333–341.

Jin, Y., Yang, H., Ji, W., Wu, W., Chen, S., Zhang, W., & Duan, G. (2020). Virology, epidemiology, pathogenesis, and control of covid-19. In Viruses, 12,1-17.

Kass, D. A., Duggal, P., & Cingolani, O. (2020). Obesity could shift severe COVID-19 disease to younger ages. The Lancet, 395(10236), 1544–1545.

Li, H., Xiang, X., Ren, H., Xu, L., Zhao, L., Chen, X., Long, H., Wang, Q., & Wu, Q. (2020). Serum Amyloid A is a biomarker of severe Coronavirus Disease and poor prognosis. Journal of Infection, 80(6), 646–655.

Li, X., Geng, M., Peng, Y., Meng, L., & Lu, S. (2020). Molecular immune pathogenesis and diagnosis of COVID-19. In Journal of Pharmaceutical Analysis (Vol. 10, Issue 2, pp. 102–108). Elsevier Ltd.

Liang, W., Liang, H., Ou, L., & Al, E. (2020). Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19. 180(8), 1081–1089.

Lippi, G., & Plebani, M. (2020). Laboratory abnormalities in patients with COVID-2019 infection. 58(7), 1131–1134.

Maria Falci Vieira, L., Emery, E., & Andriolo, A. (n.d.). COVID-19-Diagnóstico Laboratorial para Médicos. 1–19.

Mayi, B. S., Leibowitz, J. A., Woods, A. T., Ammon, K. A., Liu, A. E., & Raja, A. (2021). The role of Neuropilin-1 in COVID-19. PLoS Pathogens, 17(1), 1–8.

Peckham, H., de Gruijter, N. M., Raine, C., Radziszewska, A., Ciurtin, C., Wedderburn, L. R., Rosser, E. C., Webb, K., & Deakin, C. T. (2020). Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission. Nature Communications, 11(1), 1–10.

Ritchie, H., Mathieu, E., Rodés-Guirao, L., Appel, C., Giattino, C., Ortiz-Ospina, E., Hasell, J., Macdonald, B., Beltekian, D., & Roser, M. (2020). Coronavirus Pandemic (COVID-19). Our World in Data.

Shi, H., Han, X., Jiang, N., Cao, Y., Alwalid, O., Gu, J., Fan, Y., & Zheng, C. (2020). Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. The Lancet Infectious Diseases, 20(4), 425–434.

Sinha, N., & Balayla, G. (2020). Sequential battery of COVID-19 testing to maximize negative predictive value before surgeries. In Revista do Colegio Brasileiro de Cirurgioes (Vol. 47, pp. 1–14).

Udugama, B., Kadhiresan, P., Kozlowski, H. N., Malekjahani, A., Osborne, M., Li, V. Y. C., Chen, H., Mubareka, S., Gubbay, J. B., & Chan, W. C. W. (2020). Diagnosing COVID-19: The Disease and Tools for Detection. ACS Nano, 14(4), 3822–3835.

van Doremalen, N., Bushmaker, T., Morris, D. H., Holbrook, M. G., Gamble, A., Williamson, B. N., Tamin, A., Harcourt, J. L., Thornburg, N. J., Gerber, S. I., Lloyd-Smith, J. O., de Wit, E., & Munster, V. J. (2020). Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. New England Journal of Medicine, 382(16), 1564–1567.

Wang, B., Li, R., Lu, Z., & Huang, Y. (2020). Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis. Aging, 12(7), 6049–6057.

Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., Zhao, Y., Li, Y., Wang, X., & Peng, Z. (2020). Detection of SARS-CoV-2 in Different Types of Clinical Specimens. JAMA - Journal of the American Medical Association, 323(11), 1061–1069.

Woloshin, S., Patel, N., & Kesselheim, A. S. (2020). False Negative Tests for SARS-CoV-2 Infection — Challenges and Implications. New England Journal of Medicine, 383(6), e38.

Wu, F., Zhao, S., Yu, B., Chen, Y.-M., Wang, W., Hu, Y., Song, Z.-G., Tao, Z.-W., Tian, J.-H., Pei, Y.-Y., Yuan, M.-L., Zhang, Y.-L., Dai, F.-H., Liu, Y., Wang, Q.-M., Zheng, J.-J., Xu, L., Holmes, E., & Zhang, Y.-Z. (2020). Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China. 1-32.

Yang, S., Stanzione, N., Uslan, D. Z., Garner, O. B., & De St Maurice, A. (2021). Clinical and Epidemiologic Evaluation of Inconclusive COVID-19 PCR Results Using a Quantitative Algorithm. American Journal of Clinical Pathology, 155(3), 376–380.

Yuan, X., Huang, W., Ye, B., Chen, C., Huang, R., Wu, F., Wei, Q., Zhang, W., & Hu, J. (2020). Changes of hematological and immunological parameters in COVID-19 patients. International Journal of Hematology, 112(4):553-559.

Zhao, J., Yuan, Q., Wang, H., Liu, W., Liao, X., Su, Y., Wang, X., Yuan, J., Li, T., Li, J., Qian, S., Hong, C., Wang, F., Liu, Y., Wang, Z., He, Q., Li, Z., He, B., Zhang, T., … Zhang, Z. (2020). Antibody Responses to SARS-CoV-2 in Patients with Novel Coronavirus Disease 2019. Clinical Infectious Diseases, 71(16), 2027–2034.

Zheng, Z., Peng, F., Xu, B., Zhao, J., Liu, H., Peng, J., Li, Q., Jiang, C., Zhou, Y., Liu, S., Ye, C., Zhang, P., Xing, Y., Guo, H., & Tang, W. (2020). Risk factors of critical & mortal COVID-19 cases: a systematic literature review and meta-analysis. Journal of Infection, 81(2), e16–e25.

Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., Guan, L., Wei, Y., Li, H., Wu, X., Xu, J., Tu, S., Zhang, Y., Chen, H., & Cao, B. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet, 395(10229), 1054–1062.

Zou, X., Chen, K., Zou, J., Han, P., Hao, J., & Han, Z. (2020). Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Frontiers of Medicine, 14(2), 185–192.

Published

26/10/2022

How to Cite

ALCÂNTARA, R. Q. .; ARANTES, B. de O. .; GOMES, C. M. .; COSTA, S. H. N. . Anthropometric and laboratory characterization of patients tested for SARS-CoV-2 at the Hospital of the Military Policeman of Goiânia-GO. Research, Society and Development, [S. l.], v. 11, n. 14, p. e269111436218, 2022. DOI: 10.33448/rsd-v11i14.36218. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/36218. Acesso em: 25 nov. 2024.

Issue

Section

Health Sciences