Characterization of hospitalizations for childhood leukemia in a Brazilian capital

Authors

DOI:

https://doi.org/10.33448/rsd-v11i15.36548

Keywords:

Child hospitalized; Leukemia; Neoplasms; Drug therapy.

Abstract

Introduction: Leukemia is the most common type of cancer in childhood. Among the types of childhood leukemia, acute myeloid and acute lymphoblastic leukemia prevail. Survival has been showing a significant improvement. Patients need several hospital admissions for chemotherapy and treatment of complications. Objective: To analyze hospitalizations for childhood leukemia in a Brazilian capital, 2010 to 2020. Methodology: This is a descriptive and retrospective cross-sectional epidemiological study, with secondary data from the Hospital Admission Authorization (AIH) - Hospital Information System of the Department of Informatics of the Unified Health System of the Ministry of Health. Descriptive statistical analysis was conducted and the results presented in absolute and relative frequency. Results: From 2010 to 2020, there were 425 hospitalizations of patients (under 14 years old) diagnosed with childhood leukemia, an average of 39 hospitalizations per year, and an increasing trend in the period, 2019 and 2020 with more hospitalizations, 69 (16%) and 62 (14 %), respectively. There was a predominance of male hospitalizations (62%), age group from 1 to 5 years old (47%), and mixed race (69.0%). Acute lymphoblastic leukemia (81%) was prevalent. The most performed procedure was the administration of chemotherapy (50%). In the period, 13 patients died during hospitalization. Conclusion: This information can provide evidence for decision-making and the implementation of public health policies, aimed at the diagnosis and treatment of childhood leukemia.

References

Algayer, L. P., Febras, L. L. T., Scheid, B. S., Signori, J. F., & Jantsch, L. B. (2020). Temporal Trend of Hospitalizations for Cancer Diagnosis in Children and Adolescents. Revista Brasileira de Cancerologia, 66(4), 1-8. https://doi.org/10.32635/2176-9745.RBC.2020v66n4.1010

American Cancer Society. Key Statistics for Childhood Cancers. American Cancer Society. Atlanta: 2022.

Bhakta, N., Force, L.M., Allemani, C., Atun, R., Bray, F., Coleman, M. P., Steliarova-Foucher, E., Frazier, A. L., Robinson, L. L., Galindo, C. R., & Fitzmaurice, C. (2019). Childhood cancer burden: a review of global estimates. The Lancet Oncology, 20(1), 42-53. https://doi.org/10.1016/ s1470-2045(18)30761-7

Brasil. Ministério da Saúde. Instituto Nacional do Câncer José de Alencar Gomes da Silva (INCA). (2016). Incidência, mortalidade de morbidade hospitalar por câncer em crianças, adolescentes e adultos jovens no Brasil: Informações dos registros de câncer e do sistema de mortalidade. Rio de Janeiro: INCA.

Brasil. Instituto Nacional de Câncer José Alencar Gomes da Silva. (2017). Incidência, mortalidade e morbidade hospitalar por câncer em crianças, adolescentes e adultos jovens no Brasil: informações dos registros de câncer e do sistema de mortalidade. Rio de Janeiro: INCA.

Brasil. Ministério da Saúde. Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA). Estimativa 2020: Incidência de câncer no Brasil. Rio de Janeiro: INCA.

Brayley, J., Stanton, L. K., Jenner, L., & Paul, S. P. (2019). Recognition and management of leukaemia in children. British Journal of Nursing, (15), 985-92. 10.12968/bjon.2019.28.15.985

Coebergh, J. W. W., Reedij, A. M. J., De Vries, E., Martos, C., Jakab, Z., Steliarova-Foucher E., & Kamps, W. A. (2006). Leukemia incidence and survival in children and adolescents in Europe during 1978-1997. Report from the automated childhood cancer information system project. European Journal of Cancer, 42(13), 2019-36. https://doi.org/10.1016/j.ejca.2006.06.005

Crump, C., Sundquist, J., Sieh, W., Winkleby, M. A., & Sundquist, K. (2014). Perinatal and familial risk factors for acute lymphoblastic leukemia in a Swedish national cohort. Cancer, 121(7), 1040–47. 10.1002/cncr.29172

Crump, C., Sundquist, J., Sieh, W., Winkleby, M. A., & Sundquist, K. (2015). Perinatal risk factors for acute myeloid leukemia. European. Journal of Epidemiology, 30(12), 1277–85. 10.1007/s10654-015-0063-0

Ferreira, D. F. L. G., Pereira, S. L. F., Carvalho, C. O. M., Silva Junior, R. F., Rocha F. C., Evangelista C. B., Fernandes, T. F., & Ribeiro, K. S. M. A. (2019). Morbidity and deaths due to leucemia in patients under 14 years. Journal of Nursing UFPE on line, 13:e237584. https://doi.org/10.5205/1981- 8963.2019.237584

Fujita, T. C., Sousa-Pereira, N., Amarante, M. K., & Watanabe, M. A. E. (2021). Acute lymphoid leukemia etiopathogenesis. Molecular Biology Reports, 48, 817-22. https://doi.org/10.1007/s11033-020-06073-3

Hospitalregional.org [Internet]. Brasil: Hospital Regional de Mato Grosso do Sul. Disponível em: https://www.hospitalregional.ms.gov.br

Koche, J. C. (2011). Fundamentos de metodologia científica. Petrópolis. Vozes.

Lima, P. A., Queiroz, W. R., Rocha, F. C., Cruz, I. B., Dias, J. L. C., Neto, G. R. A., & Ferreira, T. N. (2020). Hospitalizations for childhood cancer in the north of Minas Gerais state, Brazil, between 2008 and 2015 based on the DATASUS. Revista Unimontes Científica. https://www.periodicos.unimontes.br/index.php/unicientifica/article/view/1048

Maia, R. R. P., & Filho, V. W. (2013). Infection and childhood leukemia: review of evidence. Revista de Saúde Pública, 47(6), 1172-85. https://doi.org/10.1590/S0034-8910.2013047004753

Malard, F., & Mohty, M. (2020). Acute lymphoblastic leukaemia. Lancet, 395, 1146-62. https://doi.org/10.1016/S0140-6736(19)33018-1

Marcotte, E. L., Thomopoulos, T. P., Infante-Rivard, C., Clavel, J., Petridou, E. T., Schuz, J., Ezzat, S., Dockerty, J. D., Metayer, C., Magnani, C., Scheurer, M. E., Mueller, B. A., Mora, A. M., Wesseling, C., Skalkidou, A., Rashed, W. M., Francisco, S. S., Ajrouche, R., Erdmann, F., Orsi, L., & Spector, L. G. (2016). Caesarean delivery and risk of childhood leukaemia: a pooled analysis from the Childhood Leukemia International Consortium (CLIC). The Lancet Haematology, 3(4), 176–185. 10.1016/S2352-3026(16)00002-8

Medronho, R. A. (2015). Epidemiologia. Editora Atheneu.

Miranda-Filho, A., Piñeros, M., Ferlay, J., Soerjomataram, I., Monnereau, A., & Bray, F. (2018). Epidemiological patterns of leukaemia in 184 countries: a population-basead study. The Lancet Haematology, 5(1), 14-24. 10.1016/S2352-3026(17)30232-6

Morettin, P. A. (2018). Análise de Séries Temporais. Editora Blucher.

Muñoz-Aguirre, P., Zapata-Tarrés, M., Espinosa-Tamez, P., Sánchez-Blas, H., Brochier, M., & Lamadrid-Figueroa, H. (2022). Childhood acute lymphoblastic leukemia in Mexico: mortality trend analysis, 1998-2018. Salud Publica de México, 64(1), 26-34. https://doi.org/10.21149/13210

Namayandeh, S. M., Khazaei, Z., Najafi, L. M., Goodarzi, E., & Moslem, A. (2020). GLOBAL Leukemia in Children 0-14 Statistics 2018, Incidence and Mortality and Human Development Index (HDI): GLOBOCAN Sources and Methods. Asian Pacific Journal of Cancer Prevention, 21(5), 1487–94. 10.31557/APJCP.2020.21.5.1487

Nickhill, B., Force, L. M., Allemani, C., Atun, R., Bray, F., Coleman, M. P., Steliarova-Foucher, E., Frazier, A. L., Robinson, L. L., Galindo, C. R., & Fitzmaurice, C. (2019). Childhood cancer burden: a review of global. The Lancet Oncology, 20(1), 42–53. https://doi.org/10.1016/ s1470-2045(18)30761-7

Onyije, F. M., Olsson, A., Baaken, D., Erdmann, F., Stanulla, M., Wollschlager, D., & Schuz, J. (2022). Environmental Risk Factors for Childhood Acute Lymphoblastic Leukemia: An Umbrella Review. Câncer, 14(2), 2–25. 10.3390/câncer 14020382

Paltiel, O., Lemeshow, S., Phillips, G. S., Tikellis, G., Linet, M. S., Ponsonby, A., Magnus, P., Haberg, E. S., Olsen, S. F., Granstrom, M. K., Goldin, J., Herceg, Z., Ghantous, A., Hirst, J. E., Borkhardt, A., Maria, A., Soegaard, H. S., & Dwyer, T. (2019). The association between birth order and childhood leukemia may be modified by paternal age and birth weight. Pooled results from the International Childhood Cancer Cohort Consortium (I4C). International Journal of Cancer, 144, 26–33. 10.1002/ijc.31635

Pereira, M. G. (2017). Epidemiologia: teoria e prática. Editora Guanabara Koogan.

Q, AN., Fan, C. H., & Xu, S. M. (2017). Recent perspectives of pediatric leukemia – an update. Eur Rev Med Pharmacol Sci, 21(4), 31-6.

Rodrigues, J. V. C., Sanches, A. M., Oliveira, A. T. D., Ribeiro, L. A., Paraíso, R. M. R., & França, D. S. (2019). Leucemia e gastos hospitalares: uma análise do impacto econômico para o sistema público de saúde de Montes Claros, MG. Revista de Atenção à Saúde, 17(59), 33-38. 10.13037/ras.vol17n59.5753

Sadigurschi, G., Frigotto, K. G., Garcia, G. S.B., Riscarolli, E.B., Apolinario, L. E. V., Tiago, C. F. D. S., Santos, T. L. D., & Valviesse, V. R. A. (2021). Perfil epidemiológico dos pacientes internados por leucemia no município do Rio de Janeiro. Hematology, Transfusion and Cell Therapy, 43(1), 171. https://doi.org/10.1016/j.htct.2021.10.291

Silva, F. F., Zandonade, E., & Zouain-Figueiredo, G. P. (2014). Analysis of childhood leukemia mortality trends in Brazil, from 1980 to 2010. The Journal of Pediatrics, 90(6), 587-92. http://dx.doi.org/10.1016/j.jped.2013.12.013

Silva, F. F., & Latorre, M. R. D.O. (2020). Sobrevida das leucemias linfoides agudas em crianças no Município de São Paulo, Brasil. Cadernos de Saúde Pública, 36(3), 1-9. 10.1590/0102-311X00008019

Valcarcel, B., Murillo, F., & Torres-Roman, J. S. (2021). Association of healthcare system factors with childhood leukemia mortality in Peru, 2017–2019: A population-based analysis. Journal of Cancer Policy, 29, 1-6. https://doi.org/10.1016/j.jcpo.2021.100288

Wen, Y., Jin, R., & Chen, H. (2019). Interactions between gut microbiota and cute childhood leucemia. Frontiers in Microbiology, 10(1300), 1-7. https://doi.org/10.3389/fmicb.2019.01300

Winter, M. L., Tosi, M. C., Lara, L. L. P., Soares, L. A., Rodrigues, F. G., & Rocha, L. L. V. (2022). Análise do perfil epidemiológico de leucemias e a sua evolução no Brasil durante o período de 2010 a 2020. Brazilian Journal of Health Review, 5(2), 4211-25. 10.34119/bjhrv5n2-017

Published

14/11/2022

How to Cite

HERKERT, C. M. M. .; PINTO , A. M. A. C.; CARDOSO, A. I. de Q. . Characterization of hospitalizations for childhood leukemia in a Brazilian capital. Research, Society and Development, [S. l.], v. 11, n. 15, p. e194111536548, 2022. DOI: 10.33448/rsd-v11i15.36548. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/36548. Acesso em: 14 nov. 2024.

Issue

Section

Health Sciences