Pharmaceutical innovations of dapsone in the treatment of pediatric leprosy: an integrative review
Keywords:Dapsone; Children; Pharmaceutical innovations.
Leprosy is an ancient disease, which is still endemic in developing countries, affecting from childhood to old age. Dapsone is a synthetic sulfone that is an anti-inflammatory and antibiotic agent, which is part of the multidrug regimen suggested by the WHO for the treatment of leprosy. Currently, there are studies of new pharmaceutical forms of dapsone proposed for the treatment of leprosy that are under development, to propose improvement and optimization of this pharmacological therapy. However, the pediatric population still suffers from the lack of specific and adequate treatment. The objective of this article is to describe and report pharmaceutical forms of dapsone, in order to propose a better pharmacological choice, based on research that improves the therapy of pediatric leprosy. As a bibliographic research methodology, the integrative review method was used, in the EBSCO (Business Source Complete), Science Direct, PubMed and Google Scholar databases, using the descriptors ''Leprosy''; ''Pharmaceutical preparations'' and “Dapsone'' and the Boolean operator ''AND'' as a search aid, selecting articles that were between the period 2010 to 2022. The present study resulted in the identification of pharmaceutical innovations of dapsone, demonstrating a high therapeutic potential, helping to improve the drug, such as increasing its solubility, bioavailability, absorption, permeability, dissolution and decreased toxicity. Concluding, therefore, satisfactory results of therapeutic innovations to assist in the adherence of pediatric patients to leprosy. In short, future studies and greater visibility of this population are proposed.
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