Passiflora incarnata in the treatment of anxiety and sleep disorder

Authors

DOI:

https://doi.org/10.33448/rsd-v11i15.36724

Keywords:

Passiflora; Anxiety; Anxiety disorder.

Abstract

Popularly known for its flower as "flower of passion", and for its fruit as "passion fruit", Passiflora incarnata L, belonging to the Passifloraceae family, is a species native to South America, Australia and Southeast Asia. According to scientific evidence, Passiflora incarnata has been used in phytotherapy since the mid-nineteenth century in Western Europe, and current studies reaffirm the therapeutic effects under nervous restlessness, attention deficit hyperactivity disorder, preoperative anxiety, and even menopausal symptoms. Thus, through an integrative literature review, the present study aimed to describe, according to the literature, the use of Passiflora incarnata for the treatment of anxiety and sleep disorder. According to the results, it was observed that Passiflora incarnata may be a viable option for the alternative treatment of some patients with anxiety symptoms, provided that the evolution of the disorder and the use or not of psychotropic drugs is considered. Since this species has anxiolytic action acting as an unspecific depressant of the central nervous system. However, although its use in general is efficient and safe, it is still pointed out that when the use is carried out incorrectly there are possibilities of the appearance of toxic principles and generation of serious problems related to its indiscriminate use. It is essential to follow up and guide a pharmaceutical professional.

References

Aman, U., Subhan, F., Shahid, M., Akbar, S., Ahmad, N., Ali, G., ... & Sewell, R. D. (2016). Passiflora incarnata attenuation of neuropathic allodynia and vulvodynia apropos GABA-ergic and opioidergic antinociceptive and behavioural mechanisms. BMC complementary and alternative medicine, 16(1), 1-17.

Anheyer, D., Lauche, R., Schumann, D., Dobos, G., & Cramer, H. (2017). Herbal medicines in children with attention deficit hyperactivity disorder (ADHD): A systematic review. Complementary Therapies in Medicine, 30, 14-23.

Canella, C., Bachmann, C., Wolfensberger, B., & Witt, C. M. (2019). Patients’ experiences attributed to the use of Passiflora incarnata: A qualitative, phenomenological study. Journal of ethnopharmacology, 231, 295-301.

Cardoso, B. S., & Amaral, V. C. S. (2019). O uso da fitoterapia durante a gestação: um panorama global. Ciência & Saúde Coletiva, 24, 1439-1450.

Caruso, S., Cianci, S., Cariola, M., Fava, V., Rapisarda, A. M. C., & Cianci, A. (2017). Effects of nutraceuticals on quality of life and sexual function of perimenopausal women. Journal of endocrinological investigation, 40(1), 27-32.

Dantas, L. P., de Oliveira-Ribeiro, A., de Almeida-Souza, L. M., & Groppo, F. C. (2017). Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Medicina oral, patologia oral y cirugia bucal, 22(1), e95.

Holanda, D. K. R., Wurlitzer, N. J., Dionisio, A. P., Campos, A. R., Moreira, R. A., de Sousa, P. H. M., ... & Costa, A. M. (2020). Garlic passion fruit (Passiflora tenuifila Killip): Assessment of eventual acute toxicity, anxiolytic, sedative, and anticonvulsant effects using in vivo assays. Food Research International, 128, 108813.

Janda, K., Wojtkowska, K., Jakubczyk, K., Antoniewicz, J., & Skonieczna-Żydecka, K. (2020). Passiflora incarnata in Neuropsychiatric Disorders—A Systematic Review. Nutrients, 12(12), 3894.

Jawna‐Zboińska, K., Blecharz‐Klin, K., Joniec‐Maciejak, I., Wawer, A., Pyrzanowska, J., Piechal, A., ... & Widy‐Tyszkiewicz, E. (2016). Passiflora incarnata L. improves spatial memory, reduces stress, and affects neurotransmission in rats. Phytotherapy Research, 30(5), 781-789.

Kim, M., Lim, H. S., Lee, H. H., & Kim, T. H. (2017). Role identification of Passiflora Incarnata Linnaeus: a mini review. Journal of menopausal medicine, 23(3), 156-159.

Lee, J., Jung, H. Y., Lee, S. I., Choi, J. H., & Kim, S. G. (2020). Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study. International clinical psychopharmacology, 35(1), 29-35.

Lopes, M. W., Tiyo, R. & Arantes, V. P. (2017). Utilização de passiflora incarnata no tratamento da ansiedade. Uningá Review, 29(2)

Madaus, G. (1938). Pflanzenstudien I. Ein Beitrag zur Frage der Wirkungssteigerung der Heilpflanzen. DMW-Deutsche Medizinische Wochenschrift, 64(26), 925-928.

Mendes, K. D. S., Silveira, R. C. D. C. P., & Galvão, C. M. (2019). Uso de gerenciador de referências bibliográficas na seleção dos estudos primários em revisão integrativa. Texto & Contexto-Enfermagem, 28.

Ministério da Saúde (BR). (2006). Política nacional de práticas integrativas e complementares no SUS - PNPIC-SUS. Secretaria de Atenção à Saúde. Departamento de Atenção Básica, (1), 92p.

Oliveira, L. M., Menezes Filho, A. C. P., & Porfiro, C. A. (2020). Uso da Passiflora incarnata L. no tratamento alternativo do transtorno de ansiedade generalizada. Research, Society and Development, 9(11), e2349119487-e2349119487.

Organização Mundial de Saúde (OMS). (1979). Fundo das Nações Unidas para Infância (UNICEF). Conferência internacional sobre cuidados primários de saúde, Alma-Ata-URSS, 6-12 de setembro de 1978: relatório final. Brasília: OMS-UNICEF.

Ozturk, Z., & Kalayci, C. C. (2018). Pregnancy outcomes in psychiatric patients treated with passiflora incarnata. Complementary Therapies in Medicine, 36, 30-32.

Rodrigues, F. G., de Oliveira Stroparo, J. L., & Manzini, F. (2022). O uso das plantas medicinais no tratamento de situações odontológicas comuns na atenção primária à saúde. Research, Society and Development, 11(8), e7311830425-e7311830425.

Sakalem, M. E., Tabach, R., de Oliveira, M., & Carlini, E. A. (2022). Behavioral Pharmacology of Five Uncommon Passiflora Species Indicates Sedative and Anxiolytic-like Potential. Central Nervous System Agents in Medicinal Chemistry.

Santos, A. P. M., Galindo, A. S., & de Souza Queiroz, E. (2020). Propriedades neuropsicofarmacológicas, compostos quimicamente ativos e uso medicinal da passiflora incarnata. Brazilian Journal of Development, 6(12), 94823-94836.

Sarto, D. A. Q. S., Siqueira, A. H. D., Magalhaes, F. M. D. A., Caproni, K. D. P., Martins, Â. M., Santos, G. B., ... & Garcia, J. A. D. (2018). Dry extract of passiflora incarnata L. leaves as a cardiac and hepatic oxidative stress protector in LDLr-/-mice fed high-fat diet. Brazilian Archives of Biology and Technology, 61.

Soto-Vásquez, M. R., Alvarado-García, A., & Rosales-Cerquin, L. (2019). Phytotherapy based on the fluid extract of passiflora ligulain the treatment of test anxiety.

Villet, S., Vacher, V., Colas, A., Danno, K., Masson, J. L., Marijnen, P., & Bordet, M. F. (2016). Open-label observational study of the homeopathic medicine Passiflora Compose for anxiety and sleep disorders. Homeopathy, 105(01), 84-91.

Published

08/11/2022

How to Cite

SILVA, L. de A. M. .; SANTOS, L. S. M. .; SIQUEIRA, L. da P. . Passiflora incarnata in the treatment of anxiety and sleep disorder. Research, Society and Development, [S. l.], v. 11, n. 15, p. e07111536724, 2022. DOI: 10.33448/rsd-v11i15.36724. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/36724. Acesso em: 26 apr. 2024.

Issue

Section

Health Sciences