Consequences of vitamin B12 deficiency in infants of vegetarian mothers: a review
DOI:
https://doi.org/10.33448/rsd-v11i15.37373Keywords:
Deficiency; Vitamin B12; Infants; Pregnancy.Abstract
Objective: The present study aimed to analyze vitamin B12 deficiency in vegetarian breastfeeding women and its consequences for the mother-child binomial. Methodology: Bibliographic review article, with a search performed in PubMed, Scientifc Electronic Libraly Online and Google Scholar databases from 2013 to 2022. Health Descriptors were used: “Deficiency”, “Vitamin B12”, “Infants”, "Pregnancy". Original articles that were indexed in the selected databases, in the languages: Portuguese, English and Spanish, published in the last ten years (2013 to 2022), original articles, field studies and case reports were included. The exclusion criteria were articles that were not within the selected periodicity, non-original articles and articles that did not address the theme. Initially, 2535 articles were found, which after applying the inclusion and exclusion criteria, at the end of the search, 9 articles remained. Results: In the analyzed studies, it was evidenced that vitamin B12 deficiency can bring serious risks to the health of the mother-child binomial resulting in malformation of the central nervous system, failure in growth, developmental regression, hypotonia, difficulties in feeding, hyperirritability, apathy , weakness, drowsiness, low weight and height gain, which may affect the infant's cognitive development. Conclusion: When adopting a vegetarian diet, care must be taken with their food intake to avoid nutritional deficiencies and, therefore, adequate nutritional monitoring is necessary, so that this style of eating and life does not bring harm to maternal-childish health.
References
Bahadir, A., Reis, P. G. & Erduran, E. (2014). Oral vitamin B12 treatment is effective for children with nutritional vitamin B12 deficiency. Journal of Paediatrics and Child Health, 50(9), 721–725. https://doi.org/10.1111/jpc.12652
Bousselamti, A., El Hasbaoui, B., Echahdi, H. & Krouile, Y. (2018). Psychomotor regression due to vitamin B12 deficiency. Pan African Medical Journal, 30. https://doi.org/10.11604/pamj.2018.30.152.12046
Bravo, J. P., Ibarra, C. J. & Paredes, M. M. (2014). Compromiso neurológico y hematológico por déficit de vitamina B12 en lactante hijo de madre vegetariana: Caso Clínico. Revista Chilena de Pediatría, 85(3), 337–343. https://doi.org/10.4067/S0370-41062014000300010
Demir, N., Koc, A., Üstyol, L., Peker, E. & Abuhandan, M. (2013). Clinical and neurological findings of severe vitamin B12 deficiency in infancy and importance of early diagnosis and treatment. Journal of Paediatrics and Child Health, 49(10), 820–824. https://doi.org/10.1111/jpc.12292
Fall, C. H. D. (2012). Fetal Programming and the Risk of Noncommunicable Disease. The Indian Journal of Pediatrics, 80(S1), 13–20. https://doi.org/10.1007/s12098-012-0834-5
Feraco, P., Incandela, F., Franceschi, R., Gagliardo, C. & Bellizzi, M. (2021). Clinical and Brain Imaging Findings in a Child with Vitamin B12 Deficiency. Pediatric Reports, 13(4), 583–588. https://doi.org/10.3390/pediatric13040069
Goraya, J. S., Kaur, S. & Mehra, B. (2015). Neurology of Nutritional Vitamin B12 Deficiency in Infants. Journal of Child Neurology, 30(13), 1831–1837. https://doi.org/10.1177/0883073815583688
Kalyan, G. B., Mittal, M. & Jain, R. (2020). Compromised Vitamin B12 Status of Indian Infants and Toddlers. Food and Nutrition Bulletin, 037957212095088. https://doi.org/10.1177/0379572120950886
Kocaoglu, C., Akin, F., Caksen, H., Böke, S. B., Arslan, S. & Aygün, S. (2014). Cerebral atrophy in a vitamin B12-deficient infant of a vegetarian mother. Journal of health, population, and nutrition, 32(2), 367–371.
Pavone, P., Sullo, F., Falsaperla, R., Greco, F., Crespo, A., Calvo, A. & Caraballo, R. (2021). Vitamin B12 Deficiency and West Syndrome: An Uncommon but Preventable Cause of Neurological Disorder. Report on Three Cases, One of Them with Late Onset during Vitamin B12 Treatment. Neuropediatrics, 52(04), 333–336. https://doi.org/10.1055/s-0041-1725013
Pawlak, R., Lester, S. E. & Babatunde, T. (2014). The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: a review of literature. European Journal of Clinical Nutrition, 68(5), 541–548. https://doi.org/10.1038/ejcn.2014.46
Scolamiero, E., Villani, G. R. D., Ingenito, L., Pecce, R., Albano, L., Caterino, M., di Girolamo, M. G., Di Stefano, C., Franzese, I., Gallo, G. & Ruoppolo, M. (2014). Maternal vitamin B12 deficiency detected in expanded newborn screening. Clinical Biochemistry, 47(18), 312–317. https://doi.org/10.1016/j.clinbiochem.2014.08.020
Sebastiani, G., Herranz Barbero, A., Borrás-Novell, C., Alsina Casanova, M., Aldecoa-Bilbao, V., Andreu-Fernández, V., Pascual Tutusaus, M., Ferrero Martínez, S., Gómez Roig, M. & García-Algar, O. (2019). The Effects of Vegetarian and Vegan Diet during Pregnancy on the Health of Mothers and Offspring. Nutrients, 11(3), 557. https://doi.org/10.3390/nu11030557
Silva, C. D., Figueiredo, B. Q. de, Souto, B. O. V., Araújo, A. P. F., Coury, B. F., Bomfim, K. C. N., Sousa, K. K. de, Miranda, L. D., Gaia, M. G. G., Fernandes, S. R. & Oliveira, R. C. (2021). O risco de dietas veganas em idade gestacional e pediátrica: hipóteses, evidências e recomendações. Research, Society and Development, 10(10), e442101019105. https://doi.org/10.33448/rsd-v10i10.19105
Souza, M. T. D., Silva, M. D. D. & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8, 102-106.
Srinivasan, K., Thomas, T., Kapanee, A. R. M., Ramthal, A., Bellinger, D. C., Bosch, R. J., Kurpad, A. V. & Duggan, C. (2016). Effects of maternal vitamin B12 supplementation on early infant neurocognitive outcomes: a randomized controlled clinical trial. Maternal & Child Nutrition, 13(2), e12325. https://doi.org/10.1111/mcn.12325
Světnička, M., Sigal, A., Selinger, E., Heniková, M., El-Lababidi, E. & Gojda, J. (2022). Cross-Sectional Study of the Prevalence of Cobalamin Deficiency and Vitamin B12 Supplementation Habits among Vegetarian and Vegan Children in the Czech Republic. Nutrients, 14(3), 535. https://doi.org/10.3390/nu14030535
Venkatramanan, S., Armata, I. E., Strupp, B. J. & Finkelstein, J. L. (2016). Vitamin B-12 and Cognition in Children. Advances in Nutrition, 7(5), 879–888. https://doi.org/10.3945/an.115.012021
Viana, A. da S. T., Santos, L. S. dos, Pasqualotto, M. F., Ferreira, T. R. L. & Placido, G. R. (2022). Você sabia que a falta de vitamina B12 pode desencadear doenças neurológicas? Research, Society and Development, 11(3), e43311326712–e43311326712. https://doi.org/10.33448/rsd-v11i3.26712
Zanella, P. B. & Garzone, E. O. C. (2021). A Importância da vitamina B12 para a função neurológica e cognitiva: da gestação à infância. Revista de Atenção à Saúde, 19(69). https://doi.org/10.13037/ras.vol19n69.7841
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Nadiely Viana Freitas; Daniela Fortes Neves Ibiapina; Keila Cristiane Batista Bezerra
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
