Impact of psychobiotics on anxiety disorder

Authors

DOI:

https://doi.org/10.33448/rsd-v11i15.37400

Keywords:

Anxiety; Probiotics; Psychobiotics; Gut-brain axis.

Abstract

Objective: The objective of this study was to carry out a search for scientific evidence to analyze the impact of psychobiotics in the treatment of anxiety disorder symptoms. Methodology: This is a narrative literature review carried out through a bibliographic search of Portuguese and English articles, available in the Scielo and PubMed/MEDLINE databases. Articles available in full and from the period between 2013 and 2022 were included. The descriptors used were: “Probiotics”, “Anxiety”, “Probiotics” and “Anxiety”. Results: The brain and gut form a two-way communication axis, and information can be generated both at the gut and brain level, popularly known as the microbiota-gut-brain axis, which can be directly or indirectly related to certain psychological disorders such as anxiety. Indicators indicate that therapies capable of modulating the microbiota can alleviate symptoms of anxiety, with an inadequate diet and poor in nutrients being a risk factor for this pathology. Thus, studies have shown that supplementation with probiotics (psychobiotics), especially Lactobacillus and Bifidobacterium species, combined with a balanced diet, has shown positive results. Final considerations: It is concluded that the psychobiotics of the Lactobacillus and Bifidobacterium classes have a positive impact on the treatment of anxiety symptoms. In this way, psychobiotic supplementation is presented as a complement to the treatment of anxiety and the importance of a balanced diet in conjunction with probiotic supplementation for physical and psychological health is evident.

References

Alves, T. C. D. T. F. (2014). Depressão e ansiedade entre estudantes da área de saúde. Revista de Medicina, 93(3), 101-105.

Arneth, B. M. Gut–brain axis biochemical signaling from the gastrointestinal tract to the central nervous system: gut dysbiosis and altered brain function. Postgrad. Med. J., Oxford, v. 94, n. 1114, p. 446-452,218

Bandelow, B., Michaelis, S., & Wedekind, D. (2022). Treatment of anxiety disorders. Dialogues in clinical neuroscience.

Bastiaanssen, T. F., Cussotto, S., Claesson, M. J., Clarke, G., Dinan, T. G., & Cryan, J. F. (2020). Gutted! Unraveling the role of the microbiome in major depressive disorder. Harvard Review of Psychiatry, 28(1), 26.

Bharwani, A., Mian, M. F., Surette, M. G., Bienenstock, J., & Forsythe, P. (2017). Oral treatment with Lactobacillus rhamnosus attenuates behavioural deficits and immune changes in chronic social stress. BMC medicine, 15(1), 1-14.

Bouter, K. E., van Raalte, D. H., Groen, A. K., & Nieuwdorp, M. (2017). Role of the gut microbiome in the pathogenesis of obesity and obesity-related metabolic dysfunction. Gastroenterology, 152(7), 1671-1678.

Claudino, J., & Cordeiro, R. (2016). Níveis de ansiedade e depressão nos alunos do curso de licenciatura em enfermagem. O caso particular dos alunos da Escola Superior de Saúde de Portalegre. Millenium-Journal of Education, Technologies, and Health, (32), 197-210.

Costa, B. C., dos Santos Azevedo, G. S., Ferreira, P. H. A., & Almeida, L. M. R. (2020). Probióticos na redução de sintomas de ansiedade e depressão: uma revisão integrativa. Revista Ciências em Saúde, 10(4), 97-108.

da Silva, K. C. J., de Brito, M. G. J. P., de Lima, A. A., & Viana, M. D. M. (2021). Psicobióticos: potenciais alternativas aos ansiolíticos convencionais?. Research, Society and Development, 10(4), e40810414102-e40810414102.

de Carvalho Furtado, C., da Silva, A. L. B., & Walfall, A. M. (2018). Psicobióticos: uma ferramenta para o tratamento no transtorno da ansiedade e depressão?. UNILUS Ensino e Pesquisa, 15(40), 137-151.

Dhaliwal, J., Singh, D. P., Singh, S., Pinnaka, A. K., Boparai, R. K., Bishnoi, M., ... & Chopra, K. (2018). Lactobacillus plantarum MTCC 9510 supplementation protects from chronic unpredictable and sleep deprivation‐induced behaviour, biochemical and selected gut microbial aberrations in mice. Journal of applied microbiology, 125(1), 257-269.

De Punder, K., & Pruimboom, L. (2015). Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability. Frontiers in immunology, 6, 223.

Dinan, T. G., Stanton, C., & Cryan, J. F. (2013). Psychobiotics: a novel class of psychotropic. Biological psychiatry, 74(10), 720-726.

Eskandarzadeh, S., Effatpanah, M., Khosravi-Darani, K., Askari, R., Hosseini, A. F., Reisian, M., & Jazayeri, S. (2021). Efficacy of a multispecies probiotic as adjunctive therapy in generalized anxiety disorder: a double blind, randomized, placebo-controlled trial. Nutritional Neuroscience, 24(2), 102-108.

Ferreira, A. S., Bicalho, B. P., Neves, L. F. G., Menezes, M. T., Silva, T. A., Faier, T. A., & Machado, R. M. (2016). Prevalência de ansiedade e depressão em pacientes oncológicos e identificação de variáveis predisponentes. Revista Brasileira de Cancerologia, 62(4), 321-328.

Furtado, C; da Silva, A. L. B; Walfall, A. (2018). M. PSICOBIÓTICOS: Uma ferramenta para o tratamento no transtorno da ansiedade e depressão?. UNILUS Ensino e Pesquisa, v. 15, n. 40, p. 137-151.

Gacias, M., Gaspari, S., Santos, P. M. G., Tamburini, S., Andrade, M., Zhang, F., ... & Casaccia, P. (2016). Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior. elife, 5, e13442.

Galley, J. D., Nelson, M. C., Yu, Z., Dowd, S. E., Walter, J., Kumar, P. S., ... & Bailey, M. T. (2014). Exposure to a social stressor disrupts the community structure of the colonic mucosa-associated microbiota. BMC microbiology, 14(1), 1-13.

Gualtieri, P., Marchetti, M., Cioccoloni, G., De Lorenzo, A., Romano, L., Cammarano, A., ... & Di Renzo, L. (2020). Psychobiotics regulate the anxiety symptoms in carriers of allele A of IL-1β gene: a randomized, placebo-controlled clinical trial. Mediators of inflammation, 2020.

Huang, T. T., Lai, J. B., Du, Y. L., Xu, Y., Ruan, L. M., & Hu, S. H. (2019). Current understanding of gut microbiota in mood disorders: an update of human studies. Frontiers in genetics, 10, 98.

Karbownik, M. S., Kręczyńska, J., Kwarta, P., Cybula, M., Wiktorowska-Owczarek, A., Kowalczyk, E., Pietras, T., & Szemraj, J. (2020). Effect of Supplementation with Saccharomyces Boulardii on Academic Examination Performance and Related Stress in Healthy Medical Students: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients, 12(5), 1469.

Kazemi, A., Noorbala, A. A., Azam, K., Eskandari, M. H., & Djafarian, K. (2019). Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial. Clinical Nutrition, 38(2), 522-528.

Lassale, C., Batty, G. D., Baghdadli, A., Jacka, F., Sánchez-Villegas, A., Kivimäki, M., & Akbaraly, T. (2019). Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies. Molecular psychiatry, 24(7), 965-986.

Lew, L.-C., Hor, Y.-Y., Yusoff, N. A. A., Choi, S.-B., Yusoff, M. S. B., Roslan, N. S., Ahmad, A., Mohammad, J. A. M., Abdullah, M. F. I. L., Zakaria, N., Wahid, N., Sun, Z., Kwok, L.-Y., Zhang, H., & Liong, M.-T. (2019). Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: A randomised, double-blind, placebo-controlled study. Clinical Nutrition (Edinburgh, Scotland), 38(5), 2053–2064.

Li, Y., Lv, M. R., Wei, Y. J., Sun, L., Zhang, J. X., Zhang, H. G., & Li, B. (2017). Dietary patterns and depression risk: A meta-analysis. Psychiatry research, 253, 373-382.

Liang, S., Wang, T., Hu, X., Luo, J., Li, W., Wu, X., ... & Jin, F. (2015). Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress. Neuroscience, 310, 561-577.

LIN, L., & ZHANG, J. (2017). Papel da microbiota intestinal e metabólitos na homeostase intestinal e doenças humanas. Imunologia BMC.

Łuc, M., Misiak, B., Pawłowski, M., Stańczykiewicz, B., Zabłocka, A., Szcześniak, D., ... & Rymaszewska, J. (2021). Gut microbiota in dementia. Critical review of novel findings and their potential application. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 104, 110039.

Marin, I. A., Goertz, J. E., Ren, T., Rich, S. S., Onengut-Gumuscu, S., Farber, E., ... & Gaultier, A. (2017). Microbiota alteration is associated with the development of stress-induced despair behavior. Scientific reports, 7(1), 1-10.

Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., ... & Cazaubiel, J. M. (2011). Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British Journal of Nutrition, 105(5), 755-764.

Meyer, C., & Vassar, M. (2018). The fragility of probiotic Bifidobacterium longum NCC3001 use for depression in patients with irritable bowel syndrome. Gastroenterology, 154(3), 764.

Minayo, M. D. S., Miranda, I., & Telhado, R. S. (2021). Revisão sistemática sobre os efeitos dos probióticos na depressão e ansiedade: terapêutica alternativa?. Ciência & Saúde Coletiva, 26, 4087-4099.

Mohajeri, M. H., La Fata, G., Steinert, R. E., & Weber, P. (2018). Relationship between the gut microbiome and brain function. Nutrition reviews, 76(7), 481-496.

Oliveira, E. M. B., de Moura, M. A., de Assunção, L. D. S., da Luz, A. C. R., Atan, A. K., Matos, R. L., ... & Sampaio, N. C. M. (2021). Probióticos na modulação intestinal como adjuvante no tratamento de sinais e sintomas de depressão. Research, Society and Development, 10(8), e55910816634-e55910816634.

Organização Mundial da Saúde. (2018). Depressão. Retirado de https://www.who.int/news-room/fact-sheets/detail/depression.

Pagno, M. (2020). Ministério da Saúde divulga resultados preliminares de pesquisa sobre saúde mental na pandemia. Ministério da Saúde.

Pavani, F. M., Silva, A. B. D., Olschowsky, A., Wetzel, C., Nunes, C. K., & Souza, L. B. (2021). Covid-19 e as repercussões na saúde mental: estudo de revisão narrativa de literatura. Revista Gaúcha de Enfermagem, 42.

Pellegrini, C., Antonioli, L., Colucci, R., Blandizzi, C., & Fornai, M. (2018). Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?. Acta neuropathologica, 136(3), 345-361.

Pennisi, E. (2020). Meet the psychobiome.

Pinto-Sanchez, M. I., Hall, G. B., Ghajar, K., Nardelli, A., Bolino, C., Lau, J. T., ... & Bercik, P. (2017). Probiotic Bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: a pilot study in patients with irritable bowel syndrome. Gastroenterology, 153(2), 448-459.

Reis, D. J., Ilardi, S. S., & Punt, S. E. (2018). The anxiolytic effect of probiotics: A systematic review and meta-analysis of the clinical and preclinical literature. PloS one, 13(6), e0199041.

Salleh, R. M., Kuan, G., Aziz, M. N. A., Rahim, M. R. A., Rahayu, T., Sulaiman, S., Kusuma, D. W. Y., Adikari, A. M. G. C. P., Razam, M. S. M., Radhakrishnan, A. K., & Appukutty, M. (2021). Effects of Probiotics on Anxiety, Stress, Mood and Fitness of Badminton Players. Nutrients, 13(6), 1783.

Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., ... & Mazmanian, S. K. (2016). Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease. Cell, 167(6), 1469-1480.

Sarkar, A., Lehto, S. M., Harty, S., Dinan, T. G., Cryan, J. F., & Burnet, P. W. (2016). Psychobiotics and the manipulation of bacteria–gut–brain signals. Trends in neurosciences, 39(11), 763-781.

Savignac, H. M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2014). B ifidobacteria exert strain‐specific effects on stress‐related behavior and physiology in BALB/c mice. Neurogastroenterology & Motility, 26(11), 1615-1627.

Silva, M. D. S. T., & Torres, C. R. D. O. V. (2020). Alterações neuropsicológicas do estresse: contribuições da neuropsicologia. Revista Científica Novas Configurações–Diálogos Plurais, 1(2), 67-80.

Strandwitz, P. (2018). Neurotransmitter modulation by the gut microbiota. Brain research, 1693, 128-133.

Takada, M., Nishida, K., Kataoka‐Kato, A., Gondo, Y., Ishikawa, H., Suda, K., ... & Rokutan, K. (2016). Probiotic Lactobacillus casei strain Shirota relieves stress‐associated symptoms by modulating the gut–brain interaction in human and animal models. Neurogastroenterology & Motility, 28(7), 1027-1036.

Vermeulen, E., Brouwer, I. A., Stronks, K., Bandinelli, S., Ferrucci, L., Visser, M., & Nicolaou, M. (2018). Inflammatory dietary patterns and depressive symptoms in Italian older adults. Brain, behavior, and immunity, 67, 290-298.

Wang, H., Lee, I. S., Braun, C., & Enck, P. (2016). Effect of probiotics on central nervous system functions in animals and humans: a systematic review. Journal of neurogastroenterology and motility, 22(4), 589.

Zhang, Z., Lv, J., Pan, L., & Zhang, Y. (2018). Roles and applications of probiotic Lactobacillus strains. Applied Microbiology and Biotechnology, 102(19), 8135-8143.

Published

19/11/2022

How to Cite

PEREIRA, D. C. S. .; MOURA, J. N. S. .; LANDIM, L. A. dos S. R. . Impact of psychobiotics on anxiety disorder . Research, Society and Development, [S. l.], v. 11, n. 15, p. e350111537400, 2022. DOI: 10.33448/rsd-v11i15.37400. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/37400. Acesso em: 31 jan. 2023.

Issue

Section

Review Article