Dental evaluation prior to radiotherapy treatment in patients with cancer in the head and neack region

Authors

DOI:

https://doi.org/10.33448/rsd-v11i16.37923

Keywords:

Tooth extraction; Osteoradionecrosis; Head and neck neoplasms.

Abstract

Objective:  To evaluate the dental condition and describe the need to adapt the oral environment prior to radiotherapy treatment in patients with cancer in the head and neck region. Methodology: A cross-sectional study was carried out with 103 patients diagnosed with head and neck cancer with indication for treatment with radiotherapy, through an interview with the patient and clinical examination. Sociodemographic data of the patient, information on the oncological disease, indication and dental treatments performed were collected. Results: Only 19% of the sample had an indication for surgical treatment, 66% for chemotherapy and all had an indication for three-dimensional RT, with an average dose of 63.5 Gy. Regarding oral hygiene habits, 82% reported brushing their teeth at least once a day and 88% reported never having used dental floss. An average of 14 teeth present per patient was observed, 76% had extraction indicated in the treatment plan and the most frequent reason was root exposure/furcation lesion (46%). 62% of the patients completed all the indicated dental treatment and there was an average of 18 days between screening and discharge for initiation of radiotherapy. Conclusion: Most of the population performed the adequacy of the complete oral cavity and in a timely manner to start radiotherapy. Access to health services and the possibility of adhering to dental follow-up after radiotherapy should be taken into account when planning treatment.

References

Alvarenga, L. M., Ruiz, M. T., Pavarino-Bertelli, E. C., Ruback, M. J. C., Maniglia, J. V., & Goloni-Bertollo, M. (2008). Avaliação epidemiológica de pacientes com câncer de cabeça e pescoço em um hospital universitário do noroeste do estado de São Paulo. Braz J Otorhinolaryngol, 74 (1), 68-73.

Casati, M. F. M., Vasconcelos, J. A., Vergnhanini, G. S., Contreiro, P. F., Graça, T. B., Kanda, J. L., …, Matos, L. L. (2012). Epidemiologia do câncer de cabeça e pescoço no Brasil: estudo transversal de base populacional. Rev Bras Cir Cabeça Pescoço, 41(4),186-191.

Chang, D. T., Sandow, P. R., Morris, C. G., Hollander, R., Scarborough, L., Amdur, R. J., Mendenhall, W. M. (2007). Do pre-irradiation dental extractions reduce the risk of osteoradionecrosis of the mandible?. Head Neck, 29(6), 528-36.

Chronopoulos, A., Zarra, T., Ehrenfeld, M., & Otto, S. (2018). Osteoradionecrosis of the jaws: definition, epidemiology, staging and clinical and radiological findings. A concise review. Int Dent J, 68(1), 22-30.

Dedivitis, R. A., França, C. M., Mafra, A. C., Guimarães, F. T., & Guimarães, A. V. (2004). Características clínico-epidemiológicas no carcinoma espinocelular de boca e orofaringe. Rev. Bras. Otorrinolaringol, 70(1), 35-40.

Gervásio, O. L., Dutra, R. A., Tartaglia, S. M., Vasconcelos, W. A., Barbosa, A. A., & Aguiar, M. C. (2001). Oral squamous cell carcinoma: a retrospective study of 740 cases in a Brazilian population. Braz. Dent. J., 12(1), 57-61.

Gherlardi, I. R., Soares, L. A. V., Jr., Santos, P. S. S., Teixeira, S. S., Matsushita, C. M., Carrillo, C. M., …, Peres, M. P. S. M. (2008). A Necessidade da avaliação e tratamento odontológico pré-radioterapia, prática hospitalar. Prática Hospitalar, 58 (10), 149-151.

Gupta, T., Agarwal, J., Jain, S., Phurailatpam, R., Kannan, S., Ghosh-Laskar, S., …, D’Cruz, A. (2012). Three-dimensional conformal radiotherapy (3D-CRT) versus intensity modulated radiation therapy (IMRT) in squamous cell carcinoma of the head and neck: a randomized controlled trial. Radiother Oncol, 104(3), 343-8.

Hancock, P. J., Epstein, J. B., Sadler, G. R. (2003). Oral and dental management related to radiation therapy for head and neck cancer. J Can Dent Assoc, 69(9), 585-90.

Jham, B. C., & Freire A. R. S. (2006). Complicações bucais da radioterapia em cabeça e pescoço. Rev Bras Otorrinolaringol, 72(5), 704-8.

Jereczek-Fossa, B. A., Orecchia, R. (2002). Radiotherapy-induced mandibular bone complications. Cancer Treat Rev, 28(1), 65-74.

Johnson N. (2001). Tobacco use and oral cancer: a global perspective. J. Dent. Educ., 65(4), 328-39.

Kolokythas, A., Rasmussen, J. T., Reardon, J., & Feng, C. (2019). Management of osteoradionecrosis of the jaws with pentoxifylline-tocopherol: a systematic review of the literature and meta-analysis. Int J Oral Maxillofac Surg, 48(2), 173-180.

Lanzos, I., Herrera, D., Lanzos, E., & Sanz, M. (2015). A critical assessment of oral care protocols for patients under radiation therapy in the regional University Hospital Network of Madrid (Spain). J Clin Exp Dent, 7, 5, 613-21.

Loffredo, L. C., Pinelli, C., Vitussi, T. R., Sundefeld, M. L. & Campos, J. A. (2006). Oral câncer mortality trends in Brazilian geographical regions from 1996-2001. Rev. Ciênc. Fram. Básica, 27(2), 133-8.

Melo, L. C., Silva, M. C., Bernardo, J. M. P., Marques, E. B., & Leite, I. C. G. (2010). Perfil epidemiológico de casos incidentes de câncer de boca e faringe. Rev. Gaúch. Odontol., 58(3), 351-5.

Miranda, M. E. P. (2015). Prevalência do câncer de cabeça e pescoço no Hospital de Especialidades “Eugenio Espejo” período 2002 - 2015, Quinto-Equador. ( Tese de doutorado). Faculdade de Odontologia, São Paulo, Brasil.

Moore, C., McLister, C., O’Neill, C., Donnelly, M., & McKenna, G. (2020). Pre-radiotherapy dental extractions in patients with head and neck cancer: a Delphi study. J Dent, 97.

Pereira, I. F., Noronha, V. R. A. S., Naves, M. D., Amaral, T. M. P. & Santos, V. R. (2016). Neoplasias malignas em região de cabeça e pescoço: perfil dos pacientes atendidos na UFMG. Rev. Cubana Estomatol., 53(4).

Podesta, O. P. G., Peres, S. V., Salaroli, L. B., Cattafesta, M., Podesta, J. R. V., Zeidler, S. L. V. V., …, Curado, M. P. (2019). Consumption of minimally processed foods as protective factors in the genesis of squamous cell carcinoma of the head and neck in Brazil. PLoS One, 14(7).

Ramli, R., Ngeow, W. C.; Rahman, R. A., & Chai, W. L. (2006). Managing complications of radiation therapy in head and neck cancer patients: Part IV. Management of osteoradionecrosis. Singapore Dent J, 28(1), 11-5.

Rocha, B. Q. C., Eneas, L., Oliveira, R. G., Junqueira, R. B., & Verner, F. S. (2017). Características epidemiológicas de pacientes portadores de neoplasias de cabeça e pescoço submetidos à radioterapia em Juiz de Fora - MG. HU Rev., 43(1), 71-75.

Rolim, A. S. H., Costa, L. J., Ramalho, L. M. P. (2011). Repercussões da radioterapia na região orofacial e seu tratamento. Radiol Bras, 44(6), 388-395.

Rosenthal, D. I., Trotti, A. (2009). Strategies for managing radiation-induced mucositis in head and neck cancer. Semin Radiat Oncol, 19(1), 29-34.

Schuurhuis, J. M., Stockman, M. A., Witjes, M. J. H., Dijkstra, P. U., Vissink, A., & Spijkervert, F. K. L. (2015). Evidence supporting pre-radiation elimination of oral foci of infection in head and neck cancer patients to prevent oral sequelae. A systematic review. Oral Oncol, 51(3), 212-20.

Silveira, A., Gonçalves, J., Sequeira, T., Ribeiro, C., Lopes, C., Monteiro, E., & Pimentel, F. L. (2012). Oncologia de cabeça e pescoço: enquadramento epidemiológico e clínico na avaliação da qualidade de vida relacionada com a saúde. Rev. Bras. Epidemiol., 15(1), 38-48.

Sousa, A. R., Koury, G. V. H., Badaranne, E. B. L., Cavalcante, H. A., & Araújo, C. N. F. (2016). Perfil clínico-epidemiológico de pacientes com câncer de cabeça e pescoço em hospital de referência. Rev. Soc. Bras. Clin. Med., 14(3), 129-32.

Souza, L. G. (2014). Visão odontológica da radioterapia de cabeça e pescoço: Protocolo clínico (Trabalho de conclusão de curso). Universidade Estadual de Londrina, Londrina, Brasil.

Sung H., Ferlay J., Siegel R. L., Laversanne, M., Soerjomataram, I., Jemal, A. & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209-249.

Teng, M. S., Futran, N. D. (2005). Osteoradionecrosis of the mandible. Curr Opin Otolaryngol Head Neck Surg, 13, 217–221.

Verás, I. D., Santos, A. F., Ferreira, S. M. S., Oliveira, C. R. R., & Costa, J. G. (2019). Alterações orais e ingestão alimentar em pacientes com câncer de cabeça e pescoço em tratamento antineoplásico. Diversitas J., 4(2), 566-79.

Vieira, S. C., Lustosa, A. M. L., Barbosa, C. N. B., Texeira, J. M. R., Brito, L. X. E., Soares, L. F. M., & Ferreira, M. A. T. (2012). Oncologia básica. Fundação Quixote.

Wahl, M. J. (2006). Osteoradionecrosis prevention myths. Int J Radiat Oncol Biol Phys, 64(3), 661-9.

Published

04/12/2022

How to Cite

BARROS, A. M. H. .; SOUSA, V. M. de .; LIMA, W. S. .; MELLO, E. L. da S. .; PENA, N. G. S.; ALBUQUERQUE, R. F. de .; RIBEIRO, L. N. .; SOUZA, V. A. de; SILVA, C. M. da; SILVA, I. H. M. Dental evaluation prior to radiotherapy treatment in patients with cancer in the head and neack region. Research, Society and Development, [S. l.], v. 11, n. 16, p. e179111637923, 2022. DOI: 10.33448/rsd-v11i16.37923. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/37923. Acesso em: 26 apr. 2024.

Issue

Section

Health Sciences