Immunological aspects during the inflammatory process: a narrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v12i3.40455

Keywords:

Immune system; Inflammation; Pathophysiology.

Abstract

The immune system is made up of an intricate network of organs, cells and molecules, and its main function is to maintain the homeostasis of the human body, fighting aggression in general. It consists of two groups of immunity, innate and adaptive. Faced with inconsistencies between studies, the present proposal is characterized by a narrative review that aimed to elucidate the hypotheses in the literature regarding the paradigm of the association between the immune response and the inflammatory process. This study is a narrative review with the purpose of discussing and describing the immune response and its relationship with inflammatory processes. The database: SciElo (Scientific Electronic Library Online) and PubMed (US National Library of Medicine) were used, with scientific data from October 2, 2022, with language restriction (Portuguese) and without restriction to the year of publication. The analyzed studies mainly addressed the inflammatory response. Inflammation starts in the microcirculation. It is there that I nourish the tissues of essential micronutrients and clean out unwanted waste. Microcirculation plays a valuable role in blood pressure. It is composed of arterioles, capillaries, and postcapillary venules. They are made up of a layer of collagen-lined endothelial cells. In short, lymphocytes act in the body as an important defense structure, interacting in a complex of cells and specific molecules, recognizing invading agents and preventing their action, maintaining its integrity and balance.

References

Barros, M. P., et al (2012). Mecanismos específicos de patogenicidade de protozoários intracelulares: Tripanosoma cruzi, Leishmania spp., Toxoplasma gondii e Plasmodium spp. Revista Liberato, Novo Hamburgo, 3(20), p. 01-19.

Barshack, I., et al (2003). Relation of preexisting anti-beta 2 GPI antibodies to infarct size in a rat model. Cardiovasc Pathol; 12(4): 195-201.

Caligiuri, G., et al (2003). Autoreactive antibody repertoire is perturbed in atherosclerotic patients. Lab Invest; 83(7): 939-47.

Calixto, J. B., et al (2004). Kinin B1 receptors: key G-protein-coupled receptors and their role in inflammatory and painful processes. Br J Pharmacol. 143:803-18.

Castellano, L. R. C. (2005). Resposta imune anti-Leishmania e mecanismos de evasão. Vitae Academia Biomédica Digital, Caracas, n.25, p. 1-10.

Coelho-Castelo, A. A. M., et al (2009). Resposta imune a doenças infecciosas. Revista Medicina de Ribeirão Preto. Ribeirão Preto, 42(2), p. 42-127.

Cruvinel, W. M., et al (2010). Sistema Imunitário – Parte I Fundamentos da imunidade inata com ênfase nos mecanismos moleculares e celulares da resposta inflamatória. Revista Brasileira de Reumatologia, São Paulo, v. 50(4), p. 61 – 434.

Curtis M. A. (2003). Summary: microbiological perspective. Mol Immunol; 40(7): 477-9.

Farhat, C. K., et al (2000). Bases imunológicas e Imunizações: fundamentos e prática. (4ª. ed.): Atheneu, p. 19-36.

Jobim, M., & Jobim, L. F. J. (2008). Células natural killer e vigilância imunológica. Jornal de Pediatria, Rio de Janeiro, 84(4) (suplemento), p. S58.

Kazatchkine M. D., & Kaveri S. V (2001). Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N Engl J Med; 345: 747-55.

Kipriyanov S. M., & Le Gall F (2004). Generation and production of engineered antibodies. Mol Biotechnol; 26(1): 39-60.

Lindsley A. W., et al (2020). Eosinophil responses during COVID-19 infections and coronavirus vaccination. J Allergy Clin Immunol 146(1):1–7.

Machado, P. R. L., et al (2004). Mecanismo de resposta immune às infecções. Anais Brasileiros de Dermatologia, Rio de Janeiro79(6), p. 647- 662.

Matsumoto, Y., et al (2000). Successful TCR-based immunotherapy for autoimmune myocarditis with DNA vaccines after rapid identification of pathogenic TCR. J Immunol; 164(4): 2248-54.

Nikolich, J., et al (2004). The many important facets of T-cell repertoire diversity. Nature Reviews Immunology, 4: 123-132.

Ottino J. M. (2004). Engineering complex systems. Nature; 427(6973): 399.

Pereira A. S., et al. (2018). Metodologia da pesquisa científica. [free e-book]. Santa Maria/RS. Ed. UAB/NTE/UFSM.

Pordeus, V., et al (2003). Multiparametric Analysis of Reactivity Profiles of serum IgG of Patients with Myocarditis and Dilated Cardiomyopathy. In: Brazilian Congress on Heart Failure. São Paulo: Brazilian Society of Cardiology.

Raz, E., & Mahabaleshwar, H. (2009). Chemokine signaling in embryonic cell migration: a fisheye view. Development.136(8):1223-9. Review.

Shoenfeld, Y., et al (2002). Efficacy of IVIG affinity-purified anti-double-stranded DNA anti-idiotypic antibodies in the treatment of an experimental murine model of systemic lupus erythematosus. Int Immunol; 14(11): 1303-11.

Downloads

Published

25/02/2023

How to Cite

FRAZÃO, L. F. N. .; BATISTA, M. N. .; LIMA , S. F. S. .; LIMA, L. L. S.; SILVA, K. K. .; LOPES , J. A. de P. .; FERRAZ , B. A. .; SPAGNOLY , Y. G. L. .; BOTELHO , L. F. S. .; MENDONÇA , R. F. de .; DUARTE, A. F. .; OLIVEIRA , A. L. N. de .; MORAIS , A. C. da S. . Immunological aspects during the inflammatory process: a narrative review. Research, Society and Development, [S. l.], v. 12, n. 3, p. e7912340455, 2023. DOI: 10.33448/rsd-v12i3.40455. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/40455. Acesso em: 19 apr. 2024.

Issue

Vol. 12 No. 3

Section

Health Sciences

License

Copyright (c) 2023 Luiz Felipe Neves Frazão; Matheus Neres Batista; Sarah Flores Sotério Lima ; Leandro Luís Sotério Lima; Ketlen Kellen Silva; João Arthur de Paiva Lopes ; Bhrisa Avlis Ferraz ; Yago Gabriell Loiola Spagnoly ; Lara Fabian Silva Botelho ; Raíssa Freire de Mendonça ; André Furtado Duarte; Ana Luiza Niedermeyer de Oliveira ; Ana Caroline da Silva Morais

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.