Endothelial dysfunction and thrombotic complications associated with SARS-CoV-2 in adults: a systematic review





SARS-CoV-2; Adulto; Disfunção endotelial; Complicações trombóticas.


Introduction: During the pandemic, occurrences of thromboembolic complications and endothelial dysfunctions associated with COVID-19 were observed. Thus, the pathophysiology of the mechanisms of action are not fully elucidated. Methods: Aiming at a better understanding of the associated mechanisms of endothelial function due to COVID-19, a systematic review was developeded out using index databases and a selection process in which the inclusion criteria were articles that addressed the mechanism of thrombotic events by endothelium dysfunction and publications that associate COVID-19 with thrombotic complications in adults up to 59 years of age. Conclusion: SARS-CoV-2 is associated with altered endothelial function by endothelial mechanisms induced by direct viral infection and injury, leading to changes in the angiotensin II/AT1 axis and inflammatory response.


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Pamplona M. (2022). Figure 1. PRISMA study selection and inclusion process flowchart.

Pamplona M. (2022). Figure 2. Activation of the inflammatory and thrombotic mechanism by SARS-CoV-2.

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Pamplona M. (2022). Table 1: Search Strategy.

Pamplona M. (2022). Table 2: Bibliographic search results table.

Pamplona M. (2022). Table 3. Thrombotic Complications.

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How to Cite

PAMPLONA, M. A. .; TAVEIRA, J. H. .; MATA, K. M. da .; MORAES, K. S. .; RIBEIRO, A. B. de A.; FRANÇA, M. C. M. .; FERNANDES, C. R. . Endothelial dysfunction and thrombotic complications associated with SARS-CoV-2 in adults: a systematic review. Research, Society and Development, [S. l.], v. 12, n. 4, p. e3312440859, 2023. DOI: 10.33448/rsd-v12i4.40859. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/40859. Acesso em: 9 jun. 2023.



Health Sciences