Endothelial dysfunction and thrombotic complications associated with SARS-CoV-2 in adults: a systematic review
Keywords:SARS-CoV-2; Adulto; Disfunção endotelial; Complicações trombóticas.
Introduction: During the pandemic, occurrences of thromboembolic complications and endothelial dysfunctions associated with COVID-19 were observed. Thus, the pathophysiology of the mechanisms of action are not fully elucidated. Methods: Aiming at a better understanding of the associated mechanisms of endothelial function due to COVID-19, a systematic review was developeded out using index databases and a selection process in which the inclusion criteria were articles that addressed the mechanism of thrombotic events by endothelium dysfunction and publications that associate COVID-19 with thrombotic complications in adults up to 59 years of age. Conclusion: SARS-CoV-2 is associated with altered endothelial function by endothelial mechanisms induced by direct viral infection and injury, leading to changes in the angiotensin II/AT1 axis and inflammatory response.
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Pamplona M. (2022). Figure 1. PRISMA study selection and inclusion process flowchart.
Pamplona M. (2022). Figure 2. Activation of the inflammatory and thrombotic mechanism by SARS-CoV-2.
Pamplona M. (2022). Figure 3. Parameters in critically ill patients with Covid-19.
Pamplona M. (2022). Table 1: Search Strategy.
Pamplona M. (2022). Table 2: Bibliographic search results table.
Pamplona M. (2022). Table 3. Thrombotic Complications.
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Copyright (c) 2023 Mariane Arakawa Pamplona; José Hittalo Taveira; Karina Magalhães da Mata; Kleber Silva Moraes; Ana Beatriz de Assis Ribeiro; Maria Clara Mendonça França; Cleverson Rodrigues Fernandes
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