Endothelial dysfunction and thrombotic complications associated with SARS-CoV-2 in adults: a systematic review
DOI:
https://doi.org/10.33448/rsd-v12i4.40859Keywords:
SARS-CoV-2; Adulto; Disfunção endotelial; Complicações trombóticas.Abstract
Introduction: During the pandemic, occurrences of thromboembolic complications and endothelial dysfunctions associated with COVID-19 were observed. Thus, the pathophysiology of the mechanisms of action are not fully elucidated. Methods: Aiming at a better understanding of the associated mechanisms of endothelial function due to COVID-19, a systematic review was developeded out using index databases and a selection process in which the inclusion criteria were articles that addressed the mechanism of thrombotic events by endothelium dysfunction and publications that associate COVID-19 with thrombotic complications in adults up to 59 years of age. Conclusion: SARS-CoV-2 is associated with altered endothelial function by endothelial mechanisms induced by direct viral infection and injury, leading to changes in the angiotensin II/AT1 axis and inflammatory response.
References
Agrati et al. (2021). Elevated P-selectin in severe Covid-19: Considerations for therapeutic options. Mediterranean Journal of Hematology and Infectious Diseases. http://dx.doi.org/10.4084/MJHID.2021.016
Almyroudi M., & Dimopoulos G. (2020). Incidence, pathogenesis and management of thromboembolic complications in severe COVID-19. Pneumon. https://www.embase.com/search/results?subaction=viewrecord&id=L2006128138&from=export
Amoah, Gunasekaran, Rahi e Buscher. (2020). A case of secondary tension pneumothorax in COVID-19 pneumonia in a patient with no prior history of lung disease. SAGE Journals Open Medical Case Reports. http://dx.doi.org/10.1177/2050313X20967504
Canzano et al. (2020). Disantangling the mechanisms behind the thrombotic complications of COVID-19 Patients: insights into platelet and endotelial activation. Research and Practice in Thrombosis and Haemostasis. http://dx.doi.org/10.1002/rth2.12413
Carmeliet P. (2021). Single vascular cell heterogeneity in health and disease: A COVID-19 update. Topics in Antiviral Medicine. https://www.embase.com/search/results?subaction=viewrecord&id=L635068396&from=export
Chen W., & Pan J. (2021). Anatomical and Pathological Observation and Analysis of SARS and COVID-19: Microthrombosis is the Main Cause of Death. BMC Biological Procedures Online. http://dx.doi.org/10.1186/s12575-021-00142-y
Della Rocca et al. (2021). Evidence of systemic endotelial injury and microthrombosis in hospitalized COVID-19 patients at different stages of the disease. Journal of Thrombosis and Thrombolysis. https://doi.org/10.1007/s11239-020-02330-1
Fei, Tang, Liu e Cao (2020). Coagulation Dysfunction: A Hallmark in COVID-19. Archives of Pathology & Laboratory Medicine. https://doi.org/10.5858/arpa.2020-0324-SA
Freda et al. (2021). SARS-CoV-2 Structural Proteins Exposure Alter Thrombotic and Inflammatory Responses in Human Endothelial Cells. Cellular and Molecular Bioengineering. http://dx.doi.org/10.1007/s12195-021-00696-7
Gencer et al. (2020). Immunoinflammatory, Thrombohaemostatic and Cardiovascular Mechanisms in COVID-19. Thrombosis and Haemostasis. http://dx.doi.org/10.1055/s-0040-1718735
Giannis et al. (2020). Thromboembolic outcomes of hospitalized COVID-19 patients in the 90-day- post-discharge period: early data from the northwell core-19 registry. Blood. https://doi.org/10.1182/blood-2020-141901
Ma, Yang, Huang e Lui (2020). Endothelial contribution to COVID-19 : an update on mechanisms and therapeutic implications. Journal of Molecular and Cellular Cardiology. 164. https://www.jmcc-online.com/article/S0022-2828(21)00225-X/fulltext#secst0055
Nagashima et al. (2020). Endothelial dysfunction and thrombosis in patients with COVID-19 – Brief report. Arteriosclerosis, Thrombosis and Vascular Biology. http://dx.doi.org/10.1161/ATVBAHA.120.314860
Pamplona M. (2022). Figure 1. PRISMA study selection and inclusion process flowchart.
Pamplona M. (2022). Figure 2. Activation of the inflammatory and thrombotic mechanism by SARS-CoV-2.
Pamplona M. (2022). Figure 3. Parameters in critically ill patients with Covid-19.
Pamplona M. (2022). Table 1: Search Strategy.
Pamplona M. (2022). Table 2: Bibliographic search results table.
Pamplona M. (2022). Table 3. Thrombotic Complications.
Róman et al. (2020). The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implemente international neurological registries. Journal of the neurological sciences. 414. https://doi.org/10.1016/j.jns.2020.116884
Shmaier et al. (2021). Tie2 activation protects Against prothrombotic endotelial dysfunction in COVID-19. JCI Insight. http://dx.doi.org/10.1172/jci.insight.151527
WHO - World Health Organization (2020).
Zhang et al. (2020). SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. Journal of Hematology & Oncology. https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-00954-7
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Copyright (c) 2023 Mariane Arakawa Pamplona; José Hittalo Taveira; Karina Magalhães da Mata; Kleber Silva Moraes; Ana Beatriz de Assis Ribeiro; Maria Clara Mendonça França; Cleverson Rodrigues Fernandes
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