Bibliographic survey of the causal relationship between Neurological disorders and Covid-19

Authors

DOI:

https://doi.org/10.33448/rsd-v12i4.41101

Keywords:

Neuronal Injury; SARS-CoV-2; Covid-19.

Abstract

This study aims to perform an integrative literature review to understand the causal relationship between neurological disorders and Covid-19 and to point out new updates on the subject. The world experienced the pandemic of coronavirus disease 2019, a severe acute respiratory syndrome caused by the coronavirus SARS-CoV-2, having as one of the most frequent pathological consequences neurological disorders. Damage to the central nervous system (CNS) related to infection can occur due to multiple reasons, including: Damage by direct viral invasion there are neurons; Decreased oxygen levels due to hypoxia; Formation of microthrombi with a persistent inflammatory state that induces cerebrovascular complications. Direct viral invasion leads to adverse effects on neurons in several aspects, such as cell morphology, electrophysiology, subcellular structures, and cell death. Hypoxemia has the ability to disturb the integrity of the blood brain barrier, allowing the infiltration of peripheral immune cells and protein leakage, which promotes CNS dysfunction. To date, epidemiological studies indicate that a high pathological relationship between Covid-19 and neurological diseases. Accumulated evidence indicates that patients who developed Covid-19 may present with long-term apparent neurological symptoms, such as headache, altered mental status, anosmia, and myalgia. The harmful relationship between SARS-CoV-2 infection and neurological diseases is notorious, but new searches to better understand its etiology are crucial.

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Published

08/04/2023

How to Cite

CARVALHO, F. dos S. .; AMARAL, J. S. P. do; DIAS, A. H. de Q. .; PORTOLEZ, C. G. . .; MARASSI, F. . . .; RODRIGUES, F. N. . . .; MACHADO, E. C. .; ZAMBRIN, G. C. . . .; BIANCHI, C. S. . . .; OLIVEIRA, C. F. . Bibliographic survey of the causal relationship between Neurological disorders and Covid-19 . Research, Society and Development, [S. l.], v. 12, n. 4, p. e17412441101, 2023. DOI: 10.33448/rsd-v12i4.41101. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/41101. Acesso em: 22 nov. 2024.

Issue

Vol. 12 No. 4

Section

Health Sciences

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Copyright (c) 2023 Felipe dos Santos Carvalho; Jonas Silva Pereira do Amaral; Afonso Henrique de Queiroz Dias; Cristiane Garcia Portolez; Fernanda Marassi; Felipe Napolitano Rodrigues; Eliza Caetano Machado; Gabrielle Coelho Zambrin; Caroline Scalabrini Bianchi; Caio Ferreira Oliveira

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