Bibliographic survey of the causal relationship between Neurological disorders and Covid-19

Authors

DOI:

https://doi.org/10.33448/rsd-v12i4.41101

Keywords:

Neuronal Injury; SARS-CoV-2; Covid-19.

Abstract

This study aims to perform an integrative literature review to understand the causal relationship between neurological disorders and Covid-19 and to point out new updates on the subject. The world experienced the pandemic of coronavirus disease 2019, a severe acute respiratory syndrome caused by the coronavirus SARS-CoV-2, having as one of the most frequent pathological consequences neurological disorders. Damage to the central nervous system (CNS) related to infection can occur due to multiple reasons, including: Damage by direct viral invasion there are neurons; Decreased oxygen levels due to hypoxia; Formation of microthrombi with a persistent inflammatory state that induces cerebrovascular complications. Direct viral invasion leads to adverse effects on neurons in several aspects, such as cell morphology, electrophysiology, subcellular structures, and cell death. Hypoxemia has the ability to disturb the integrity of the blood brain barrier, allowing the infiltration of peripheral immune cells and protein leakage, which promotes CNS dysfunction. To date, epidemiological studies indicate that a high pathological relationship between Covid-19 and neurological diseases. Accumulated evidence indicates that patients who developed Covid-19 may present with long-term apparent neurological symptoms, such as headache, altered mental status, anosmia, and myalgia. The harmful relationship between SARS-CoV-2 infection and neurological diseases is notorious, but new searches to better understand its etiology are crucial.

References

Al-Ramadan, A., Rabab’h, O., Shah, J., & Gharaibeh, A. (2021). Acute and Post-Acute Neurological Complications of COVID-19. Neurol. Int, 13, 102-119. doi.org/10.3390/neurolint13010010

Augustine, R., S, A., Nayeem, A., Salam, S. A., Augustine, P., Dan, P., & Hasan, A. (2022). Increased complications of COVID-19 in people with cardiovascular disease: Role of the renin–angiotensin-aldosterone system (RAAS) dysregulation. Chemico-Biological Interactions, 351. doi.org/10.1016/j.cbi.2021.109738

Brann, D. H., Tsukahara, T., Weinreb, C., Lipovsek, M., Gong, B., Chance, R., Macaulay, I. C., & Datta, S. R. (2020). Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system sugests mechanisms underlying COVID-19–associated anosmia. Sci Adv, 6(31). doi.org/10.1126/sciadv.abc5801

Bridwell, R., Long, B., & Gottlieb, M. (2020, July). Neurologic complication sof COVID-19. American Journal of Emergency Medicine, 38(7), 1549e3-1549e7. doi.org/10.1016/j.ajem.2020.05.024

Dantas, H. L. de L., Costa, C. R. B., Costa, L. de M. C., Lúcio, I. M. L., & Comassetto, I. (2022). Como elaborar uma revisão integrativa: sistematização do método científico. Revista Recien - Revista Científica de Enfermagem, 12(37), 334–345. doi.org/10.24276/rrecien2022.12.37.334-345

Darif, D., Hammi, I., Kihel, A., Saik, I. E. I., Guessous, F., & Akarid, K. (2021). The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong? Microbial Pathogenesis, 153. doi.org/10.1016/j.micpath.2021.104799

Ebinger, J. E., Achamallah, N., Ji, H., Claggett, B. L., Sun, N., Botting, P., & Cheng, S. (2020). Pre-existing traits associated with Covid-19 illness severity. PLOS ONE, 15(7). doi.org/ 10.1371/journal.pone.0236240

Hingorani, K. S., Bhadola, S., & Cervantes-Arslanian, A. M. (2022). COVID-19 and the brain. Trends in Cardiovascular Medicine, 32, 323-330. doi.org/10.1016/j.tcm.2022.04.004

Hoffmann, M., Weber, H., Schroeder, S., Muller, M., Drosten, C., & Pohlmann, S. (2020). SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell, 181, 271-280. doi.org/10.1016/j.cell.2020.02.052

Li, Y., Zhang, Y., & Tan, B. (2021). What can cerebrospinal fluid testing and brain autopsies tell us about viral neuroinvasion of SARS‐CoV‐2. J Med Virol, 93(7), 4247-4257. https://doi.org/10.1002/jmv.26943

Mehrabani, M. M., Karvandi, M. S., Maafi, P., & Doroudian, M. (2022). Neurological complications associated with Covid‐19; molecular mechanisms and therapeutic approaches. Rev Med Virol, 2334. doi.org/10.1002/rmv.2334

Nalbandian, A., Sehgal, K., Gupta, A., Madhavan, M., McGroder, C., Stevens, J., Cook, J., & Wan, E. (2021). Post-acute COVID-19 syndrome. Nature Medicine, 27, 601-6015. doi.org/10.1038/s41591-021-01283-z

Newcombe, V., Dangayach, N., & Sonneville, R. (2021). Neurological complications of COVID 19. Intensive Care Med, 47, 1021-1023. doi.org/10.1007/s00134-021-06439-6

Ruiz, V. J. C., Montes, R. I., Puerta, J. M. P. J. M., Ruiza, C., & Rodrígueza, L. M. (2020). SARS-CoV-2 infection: The role of cytokines in COVID-19 disease. Cytokine and Growth Factor Reviews, 54, 62-75. doi.org/10.1016/j.cytogfr.2020.06.001

Sathish, T., Kapoor, N., Cao, Y., Tapp, R. J., & Zimmet, P. (2020). Proportion of newly diagnosed diabetes in COVID-19 patients: A systematic review and meta-analysis. Wiley, 23(3), 870-874. doi.org/10.1111/dom.14269

Shimohata, T. (2022). Neuro-COVID- 19. Clin Exp Neuroimmunol, 13, 17-23. doi.org/10.1111/cen3.12676

Sun, P., Qie, S., Liu, Z., Ren, J., Li, K., & Xi, J. (2020). Clinical characteristics of hospitalized patients with SARS‐CoV‐2 infection: A single arm meta‐analysis. J Med Virol, 92, 612-617. doi.org/10.1002/jmv.25735

Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8, 102-106.

Tiwari, N. R., Phatak, S., Sharma, V. R., & Agarwal, S. K. (2021). COVID-19 and thrombotic microangiopathies. Thrombosis Research, 202, 191-198. doi.org/10.1016/j.thromres.2021.04.012

Wool, G. D., & Miller, J. L. (2020). The Impact of COVID-19 Disease on Platelets and Coagulation. Pathobiology, 88(1), 15-27. doi.org/10.1159/000512007

Xu, J., & Lazartigues, E. (2022). Expression of ACE2 in Human Neurons Supports the Neuro Invasive Potential of COVID 19 Virus. Cellular and Molecular Neurobiology, 42, 305-309. doi.org/10.1007/s10571-020-00915-1

Downloads

Published

08/04/2023

How to Cite

CARVALHO, F. dos S. .; AMARAL, J. S. P. do; DIAS, A. H. de Q. .; PORTOLEZ, C. G. . .; MARASSI, F. . . .; RODRIGUES, F. N. . . .; MACHADO, E. C. .; ZAMBRIN, G. C. . . .; BIANCHI, C. S. . . .; OLIVEIRA, C. F. . Bibliographic survey of the causal relationship between Neurological disorders and Covid-19 . Research, Society and Development, [S. l.], v. 12, n. 4, p. e17412441101, 2023. DOI: 10.33448/rsd-v12i4.41101. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/41101. Acesso em: 23 nov. 2024.

Issue

Vol. 12 No. 4

Section

Health Sciences

License

Copyright (c) 2023 Felipe dos Santos Carvalho; Jonas Silva Pereira do Amaral; Afonso Henrique de Queiroz Dias; Cristiane Garcia Portolez; Fernanda Marassi; Felipe Napolitano Rodrigues; Eliza Caetano Machado; Gabrielle Coelho Zambrin; Caroline Scalabrini Bianchi; Caio Ferreira Oliveira

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.