Evaluation of the profile of patients with laboratory diagnosis of thrombocytopenia for regional reference outpatient clinic from 2018 to 2021

Authors

DOI:

https://doi.org/10.33448/rsd-v12i6.41872

Keywords:

Thrombocytopenia; Referral; Primary care; Hematology.

Abstract

Thrombocytopenia is defined by a platelet count of less than 150,000 000/ul and can be classified as mild, moderate, or severe. Counts below 150,000 and above 100,000/ul do not necessarily indicate disease. Platelets are cytoplasmic fragments of megakaryocytes, circulate inactivated, and are found in the form of their precursors in the bone marrow. Removed by macrophages, they have an essential function in hemostasis and maintenance of the capillary endothelium. Screening in primary care is essential because the vast majority of thrombocytopenias are present in asymptomatic patients, with isolated thrombocytopenia identified incidentally. These situations without a specific diagnosis do not require hematologic follow-up. This case study aimed to identify that a large number of patients referred to the Hematology Outpatient Clinic of the Assis Gurgacz Faculty (FAG) do not have a confirmed diagnosis of thrombocytopenia. Data will be collected by evaluating medical records of patients referred to the Hematology Outpatient Clinic of Assis Gurgacz College (FAG) in the period between 2018 and 2021 for the finding of thrombocytopenia at primary diagnosis.

References

Bain, B. (1986) Células Sanguíneas. (3a ed.), Masson do Brasil.

Berkman, N. et al. (1991). EDTA-dependent pseudothrombocytopeinia: a clinical study of 18 patients and a review of the literatures. Am J Hematol, 36, 195-201.

BVS: Atenção Primária em Saúde. Qual a abordagem diagnóstica inicial em pacientes com plaquetopenia? Disponível em: https://aps.bvs.br/aps/qual-a-abordagem-diagnostica-inicial-em-pacientes-com-plaquetopenia/.

Gernsheimer, T. B. (2012). Thrombocytopenia in pregnancy: is this immune thrombocytopenia or...? Hematology Am Soc Hematol Educ Program. 198-202.

Guerra, J. C. C. (2008) O laboratório clínico nas coagulopatias. Atualização clínico e laboratorial. Departamento de Patologia Clínica-HIAE Centro de Hematologia de São Paulo. São Paulo.

Guerra, J. C. De C., Campelo, D. H. C. (2017) Trombocitopenias e Tromobcitopatias. https://www.einstein.br/Documentos%20Compartilhados/Trombocitopenia%20e%20trombocitopatias.pdf.

Handin, R. I., Lux, S. E., Stossel, T. P. (1995) Blood: principles, practice of hemtology. J.B. Lippincott.

Kelton, J. G. (2002). Idiopathic thrombocytopenic purpura complicating pregnancy. Blood Rev. 16:43-6.

Lorenzi, T. (1992) Manual de hematologia: propedêutica e clínica. (7a ed.), Guanabara Koogan.

Lorenzi, T. (2006) Manual de Hematologia: Propedêutica e Clínica. (4a ed.), Guanabara-Koogan.

Loustau, V., Debouverie, O., Poitrine, et al. (2014). Effect of preg-nancy on the course of immune thrombocytopenia: a retrospective study of 118 pregnancies in 82 women. Br J Haematol 166:929–935.

Lourenço, D. M. In: Zago, M. A., Falcão, R. P., Pasquini, R. (2004) Hematologia fundamentos e prática. Atheneu, 764-770.

Naoum, P. C., & Naoum, F. A. (2008) Hematolgia Laboratorial: eritrócitos. (2a ed.), Edição da academia de ciência e tecnologia, p41-101

Oliveira, R. A. G. (2007) O leucograma na clínica. In: Oliveira, R.A.G. Hemograma: como fazer e interpretar. Editora Livraria Médica Paulista, 22, 312-345.

Pereira, A. S., et al. (2018). Metodologia da pesquisa científica. UFSM. https://www.ufsm.br/app/uploads/sites/358/2019/02/Metodologia-da-Pesquisa-Cientifica_final.pdf

Petersen, K. Fuentes, R. & Lacassie, H. J. (2006) Trombocitopenia y embarazo. Rev. Chil. Anestesia, 35: 165-171 (Diciembre)

Rizzatti E. G., & Franco R. F. (2001) Diagnostic investigation of bleeding disorders. Medicina, Ribeirão Preto, 34, 238-247

Rodak, B. F. (2002) Hematology: clinical priciples and applications. Philadelphia: W.B. Saunders Company,

Schrezenmeier, H. et al. (1995) Anticoagulant-induces pseudothrombopenia and pseudoleukocytosis. ThrombHaemost, 73, 506-13.

Stübner, S., Grohmann, R., Engel, R. et al. (2004) Blood dyscrasias induced by psychotropic drugs. Pharmacopsychiatry. 37(1), S70-S78.

Umbricht, D., & Kane, J. M. (1996) Medical complications of new antipsychotic drugs. Schizophr. Bull., 22(3), 475-483. <http://www.periodicos.capes.gov.br>

Yan, M., Malinowski, A. K. & Shehata, N. (2015). Thrombocytopenic syndromes in pregnancy. Obstetric Medicine 0(0) 1–6

Young, C. R., Bowers Jr, M. B., & Mazure, C. M. (1998) Management of the adverse effects of clozapine. Schizophr. Bull., 24(3), 381-390 <http://www.scholargoogle.com.br

Published

23/06/2023

How to Cite

SALDANHA, M. J. .; ZSCHORNACK, M. V. . Evaluation of the profile of patients with laboratory diagnosis of thrombocytopenia for regional reference outpatient clinic from 2018 to 2021. Research, Society and Development, [S. l.], v. 12, n. 6, p. e22312641872, 2023. DOI: 10.33448/rsd-v12i6.41872. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/41872. Acesso em: 3 may. 2024.

Issue

Section

Health Sciences