Use of Pentoxifylline combined with captopril/losartan in hypertensive or diabetic patients: An integrative review of randomized clinical trials

Authors

DOI:

https://doi.org/10.33448/rsd-v12i14.44363

Keywords:

Pentoxifylline; Hypertension, malignant; Arterial pressure.

Abstract

Objective: To perform an integrative literature review to analyze the effects of the use of Pentoxifylline (PTX) combined and/or compared to captopril or losartan. Methodology: An integrative literature review was performed analyzing randomized clinical trials in Portuguese, English and Spanish in the following databases: MEDLINE via PubMed and Cochrane. The descriptors used were "Pentoxifylline", "Losartan", "Captopril", "Arterial Pressure" and "Hypertension, Malignant" according to the DeCS, with 6 randomized studies at the end. Results: Several studies point to the positive effects of PTX when associated with captopril or losartan with regard to renal function in hypertensive and/or diabetic patients. The literature is still uncertain and the data contradict each other regarding the effects on the blood pressure of patients when receiving the addition of PTX or in comparison of PTX versus losartan or captopril. Conclusion: The literature and clinical trials are still divergent regarding the effects on blood pressure, although there is a consensus regarding its positive effects on proteinuria. Randomized clinical trials analyzing the direct comparative effect between drugs are needed. Meta-analyses are necessary to make quantitative analysis of the studies already available.

References

Aminorroaya, A. et al. (2005). Comparison of the effect of pentoxifylline and captopril on proteinuria in patients with type 2 diabetes mellitus. Nephron Clinical Practice, 99(3), c73-c77.

Bhatt, D. L. et al. (2006). International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. Jama, 295(2), 180-189.

Çaliş, H., & Aslan, A. (2020). What is gray literature and how to search for it?. Acta Medica Alanya, 4(2), 111-112.

Educação, G. A. (2014). Manual Revisão Bibliográfica Sistemática Integrativa: a pesquisa baseada em evidências. Belo Horizonte: Grupo Anima Educação.

Ghorbani, A. et al. (2012). The effect of pentoxifylline on reduction of proteinuria among patients with type 2 diabetes under blockade of angiotensin system: a double blind and randomized clinical trial. Nephrology (English Edition), 32(6), 790-796.

Lewington, S. et al. (2003). Age-specific relevance of usual blood pressure to vascular mortality. The Lancet, 361(9366), 1391-1392.

Namdar, H. et al. (2020). Effects of adding pentoxifylline to captopril on primary hypertension: A pilot randomized clinical trial. The Journal of Clinical Pharmacology, 60(2), 181-187.

Pigott, T. D., & Polanin, J. R. (2020). Methodological guidance paper: High-quality meta-analysis in a systematic review. Review of Educational Research, 90(1), 24-46.

Plotnikov, M. B. et al. (2017). Pentoxifylline treatment enhances antihypertensive activity of captopril through hemorheological improvement in spontaneously hypertensive rats during development of arterial hypertension. Journal of the American Society of Hypertension, 11(11), 769-778.

Rabi, D. M. et al. (2020). Hypertension Canada’s 2020 comprehensive guidelines for the prevention, diagnosis, risk assessment, and treatment of hypertension in adults and children. Canadian Journal of Cardiology, 36(5), 596-624.

Rabizadeh, S. et al. (2018). Beneficial effects of pentoxifylline plus losartan dual therapy in type 2 diabetes with nephropathy. The American Journal of the Medical Sciences, 355 (5), 442-448.

Rapsomaniki, E. et al. (2014). Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 125 million people. The Lancet, 383(9932), 1899-1911.

Riva, J. J. et al. (2012). What is your research question? An introduction to the PICOT format for clinicians. The Journal of the Canadian Chiropractic Association, 56 (3), 167.

Roozbeh, J. et al. (2010). Captopril and combination therapy of captopril and pentoxifylline in reducing proteinuria in diabetic nephropathy. Renal failure, 32 (2), 172-178.

Sarkis-Onofre, R. et al. (2021). How to properly use the PRISMA Statement. Systematic Reviews, 10(1), 1-3.

Solerte, S. B. et al. (1987). Pentoxifylline, total urinary protein excretion rate and arterial blood pressure in long-term insulin-dependent diabetic patients with overt nephropathy. Acta diabetologia latina, 24, 229-239.

Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8, 102-106.

Thomopoulos, C., Parati, G., & Zanchetti, A. (2017). Effects of blood-pressure-lowering treatment on outcome incidence. 12. Effects in individuals with high-normal and normal blood pressure: overview and meta-analyses of randomized trials. Journal of hypertension, 35 (11), 2150-2160.

Whelton, P. K. (2018). ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines (vol 71, pg 2199, 2018). Journal of the American College of Cardiology, 71(19), 2273.

Williams, B. et al. (2018). 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. Journal of Hypertension, 36 (10), 1953-2041.

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Published

15/12/2023

How to Cite

NASCIMENTO, Y. S. .; NASCIMENTO, Y. S. .; FERREIRA, L. M. R. .; SANTOS JÚNIOR, R. F. dos . Use of Pentoxifylline combined with captopril/losartan in hypertensive or diabetic patients: An integrative review of randomized clinical trials. Research, Society and Development, [S. l.], v. 12, n. 14, p. e39121444363, 2023. DOI: 10.33448/rsd-v12i14.44363. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/44363. Acesso em: 25 dec. 2024.

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Vol. 12 No. 14

Section

Health Sciences

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Copyright (c) 2023 Yan Santiago Nascimento; Yago Santiago Nascimento; Leticia Maria Rendall Ferreira; Ricardo Ferreira dos Santos Júnior

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