Chronic myeloid leukemia in children and adolescentes: An analys of cases
DOI:
https://doi.org/10.33448/rsd-v13i1.44821Keywords:
Oncology; Chronic myeloide leukemia; Pediatrics.Abstract
Objective: to analyze the characteristics and evolution of patients diagnosed with chronic myeloid leukemia at a reference center in pediatric oncology in the western region of paraná. Method: analytical, descriptive, and retrospective study composed of medical records of pediatric oncology patients from the Cancer Hospital of Cascavel-UOPECCAN, between january 2002 and january 2022. Results: seven medical records were analyzed. Among these, 5 (71%) were male and 2 (29%) were female. The median age at diagnosis was 12 years and 1 month. The average time from symptom onset to diagnosis was 2 months and 5 days. Two (29%) patients were diagnosed in less than 30 days, 3 (43%) between 30 and 60 days, and 2 (29%) in more than 60 days. The most common clinical manifestations were weight loss (57%), splenomegaly (43%), fever (29%), and bruising (29%). Regarding clinical treatment, 2 (29%) patients showed a good therapeutic response to imatinib mesylate and remain on the medication, 3 (43%) required a switch to nilotinib, 1 (14%) patient who did not respond to both previous drugs required hematopoietic stem cell transplantation, and 1 (14%) experienced a blast crisis of acute leukemia, necessitating a distinct therapeutic approach. Out of the 7 analyzed medical records, 6 (86%) patients remain alive. Conclusion: based on this study, it is concluded that early diagnosis, recognition of the disease's clinical phase, and appropriate treatment are important factors influencing the prognosis and survival of these patients. Therefore, studies on this malignant neoplasm are of utmost importance.
References
Almeida, A., Castro I., Coutinho, J., Guerra, L., Marques, H., & Pereira, A. M. (2009). Recomendações para o diagnóstico, tratamento e monitorização da leucemia mielóide crônica. Acta Med Port, 22, 537-544. http://hdl.handle.net/10400.26/2411
Baim, B. J. Células sanguíneas: Um guia prático (4a ed.). Artmed
Barboza, L. P., Souza, J. M., Simões, F. V., Bragança, I. C., & Abdelhay, E. (2000). Análise dos transcritos da translocação t(9;22) em Leucemia Mieloide Crônica. Revista Brasileira de Hematologia e Hemoterapia, 22, 89-98. https://doi.org/10.1590/S1516-84842000000200005
Benchikh, S., Amale, B., Hamouchi, A. E., Georgina, S., Soro, C., Malki, A., & Nassereddine, S. (2002). Chronic myeloid leukemia: cytogenetics and molecular biology’s part in the comprehension and management of the pathology and treatment evolution. Egyptian Journal of Medical Human Genetics, 23(1). 10.1186/s43042-022-00248-2
Bollmann, P. W., & del Giglio, A. (2011). Leucemia mieloide crônica: passado, presente e futuro. Einstein, 9, 236-243. https://doi.org/10.1590/S1679-45082011RB2022
Bonfim, A. C. S., Anjos, B. S., França, K. F. C., Couto L. A., Santos, R. W. F., Santana, V. H.S., & Almeida, P. O. S. (2022). O papel da citogenética e da biologia molecular no diagnóstico da Leucemia Mieloide Crônica. Brazilian Journal of Health Review, 5(2), 5153-5164. 10.34119/bjhrv5n2-098
Bortolheiro, T. C., & Chiattone, C. S. (2008). Leucemia Mielóide Crônica: história natural e classificação. Revista Brasileira de Hematologia e Hemoterapia,
, 3-7. https://doi.org/10.1590/S1516-84842008000700003
Breccia, M., Efficace, F., Scalzulli, E., Ciotti, G., Maestrini, G., Colafligi, G., & Martelli, M. (2021). Measuring prognosis in chronic myeloid leukemia: what’s new?. Expert Review of Hematology, 6, 577-585. 10.1080/17474086.2021.1938534
Brioli, A., Lomaia, E., Fabisch, C., Sacha, T., Klamová, H., Morozova, E., Golos, A., Ernst, P., Olsson-Strömberg, U., Mayer, J., Nicolini, F. E., Bao, H., Castagnetti, F., Patkowska, E., Hirschbühl, K., Paczkowska, E., Parry, A., Voskanyan, A., Saussele, S., Franke, G. N., Kiani, A., Faber, E., Lewandowski, K., Krause, S. W., Dammann, E., Anhut, P., Gil, J., Südhoff, T., Heibl, S., Pfirrmann, M., Hochhaus, A., & Lauseker, M. (2022). Treatment and Disease Characteristics of Chronic Myeloid Leukemia in Blast Crisis: The European Leukemianet Blast Crisis Registry. Blood, 140, 818–820. https://doi.org/10.1182/blood-2022-162252
Chávez-González, M. A., Ayala-Sánchez, M., & Mayani, H. (2009). La leucemia mieloide crónica en el siglo XXI: biología y tratamiento. Revista de Investigación Clínica, 61, 221-232.
Chereda, B., & Melo, J. V. (2015). Natural course and biology of CML. Ann Hematolog, 91, 107-121. 1007/s00277-015-2325-z
Corrêa, K. C., Kersting, N., Rechenmacher, C., Pecoits, R. P., Moura, S., Gouveia, R. N., Filho, N. P. C., Sousa, A. V. L., Daudt, L. E., & Michalowski, M. B. (2023). Leucemia mieloide crônica na infância: resultado inicial de registro nacional. Hematology, Transfusion and Cell Therapy, 45, 186-187. https://doi.org/10.1016/j.htct.2023.09.403
Dorfman, L. E., Floriani, M. A., Oliveira, T. M. R. D. R., Cunegatto, B., Rosa, R. F. M., & Zen, P. R. G. (2018). The role of cytogenetics and molecular biology in the diagnosis, treatment and monitoring of patients with chronic myeloid leukemia. Jornal Brasileiro de Patologia e Medicina Laboratorial, 54. https://doi.org/10.5935/1676-2444.20180015
Hijiya, N., Suttorpo, M. (2019). How I treat chronic myeloid leukemia in children and adolescents. Blood, 133(22), 2374-2384. 10.1182/blood.2018882233.
Jabbour, E., & Kantarjian, H. (2018). Chronic myeloid leukemia: 2018 update on diagnosis, therapy and monitoring. Am J Hematol., 93, 442-459. 10.1002/ajh.25011.
Merchán-Hermann, E., & Tauil, P. L. (2021). Classification proposal of the different types of descriptive epidemiological studies. Scielo Preprint. 10.1590/s1679-49742021000100026
Merck & Co. (2022). Leucemia mieloide crônica (LMC). Em Manual MSD Online. Recuperado de https://www.msdmanuals.com/pt-br/profissional/hematologia-e-oncologia/leucemia/s%C3%ADndrome-mielodispl%C3%A1sica-smd
Minciacchi, V.R., Kumar, R., & Krause, D. S. (2021). Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future. Cells, 10(1), 117. https://doi.org/10.3390/cells10010117
Naoum P. C. (2001). Avanços tecnológicos em hematologia laboratorial. Revista Brasileira de Hematologia e Hemoterapia, 2, 15-23. https://doi.org/10.1590/S1516-84842001000200010
Sossela, F. R., Zoppas, B. C. A., & Weber, L. P. (2017). Leucemia Mieloide Crônica: aspectos clínicos, diagnóstico e principais alterações observadas no hemograma. Revista Brasileira de Análises Clínicas, 49(2), 127-130. 10.21877/2448-3877.201700543
Souza, C. A., Pagnano, K. A. B., Bendit, I., Conchon, M., Freitas, C. M. M., Coelho, A. M., Moreira, V. A., & Bernardo, W. M. (2013). Leucemia Mieloide Crônica. Revista Associação Médica, 59(3), 220-232. 10.1016/j.ramb.2012.08.003
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Copyright (c) 2024 Luiza Morandini Gaspar da Silva; Carmem Maria Medonça Fiori; Ian Hirt Prata; Isabella Cristina Michelon ; Jhessica Martelli Seibert; Nathália Larissa de Matos Abe
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