Botulinum toxin and hyaluronic acid: Use and indications in the treatment of rejuvenation




Hyaluronic acid; Botulinum toxin; Rejuvenation.


The search for aesthetic procedures for facial improvements has grown considerably in recent years and the population's concern with maintaining beauty and delaying skin aging has given a great boost to advanced aesthetics. One of the most sought after procedures has been filling with Botulinum Toxin (TB) and Hyaluronic Acid (HA). The importance of studying this topic is that it has great relevance today due to the fact that the number of aesthetic procedures with of facial harmonization has increased. From this perspective, the increasingly frequent search for aesthetic procedures is emphasized, with the aim of achieving the desired results, more easily and through less invasive procedures that meet the patient's desires and needs. Therefore, the trained professional must have knowledge of risk zones for injectables for the purpose of, in-depth knowledge of the neuromuscular, arterial and venous anatomy (such as branches of the carotid artery, areas with extensive vascular anastomoses) and recognize signs and symptoms of complications, management for their prevention and treatment.


Albert, A. M., Ricanek, K. J, & Patterson, E. (2007). A review of the literature on theaging adult skull and face: implicationsfor forensic science research and applications. Forensic Sci Int. 172(1): 01-09.

Agostini, M. M. & Jalil, S. M. A. (2018). O uso do ácido hialurônico para rejuvenescimento da pele. Conexão Eletrônica – Três Lagoas, MS. 15(1), 617-623.

Bass, L.S. (2015). Injectable Filler Techniques for Facial Rejuvenation, Volumization, and Augmentation. Facial Plast Surg Clin North Am, 23(4), 479-88.

Beer K., Glogau R. G., Dover J. S., Shamban A., Handiwala L., Olin J. T. et al. (2015). A randomized, evaluator-blinded, controlledstudy of effectiveness and safety of small particle hyaluronic acid plus lidocaine for lip augmentation and perioral rhytides. Dermatol Surg. 41(1), 127-136. ed, Evaluator_Blinded, _Controlled _ Study. 3.aspx

Bernardes, I. N, et al. (2018). Preenchimento com ácido hialurônico: revisão de literatura. Revista Saúde em Foco, (10a ed.), 603-612.

Carbone, A. (2018). MDM - Harmonização Orofacial.

Coimbra, D. A., Uribe, N. C. & Oliveira, B. S. (2015). Quadralização facial no processo do envelhecimento. Surg Cosmet Dermatol, 6(1), 65-71.

Custódio, A. L. N, et al. (2020). Harmonização facial cirúrgica: área de atuação do cirurgião-dentista. Aesthetic Orofacial Science, 1(1).

Keizers, P. H. J. et al. (2018). A high crosslinking grade of hyaluronic acid found in a dermal filler causing adverse effects. Journal of Pharmaceutical and Biomedical Analysis, 159, 173-178.

Lee, B. M., et al. (2021). The effects of the molecular weights of hyaluronic acid on the immune responses. Biomaterials Research, 25(1)

Machado, A. L. R., et al. (2020). Conhecimento de graduandos em Odontologia sobre a Harmonização Orofacial. Revista da ABENO, 20(2), 16-25.

Maia, I. E. F. & Salvi, J. O. (2018). O uso do ácido hialurônico na harmonização facial: uma breve revisão. Brazilian Journal of Surgery and Clinical Research (BJSCR). 23(2), 135-139.

Mazzucco, A. (2019). Hyaluronic acid: evaluation of efficacy with different molecular weights. International Journal of Chemistry and Research, 1(1), 13-18. doi:10.18689/ijcr1000103.

Mero, A, & Campisi, M. (2014). Hyaluronic Acid Bioconjugates for the Delivery of Bioactive Molecules. Polymers, 6(2), 346–369.

Moraes B. R., et al. (2017). Ácido hialurônico dentro da área de estética e cosmética. Revista Saúde em Foco. (9a ed.), 552-562.

Papazian, M. F, et al. (2018). Principais aspectos dos preenchedores faciais. Revista Faipe. 8(1), 101-116.

Pires, Y. S., & Ribeiro, P. M. C. (2021). Harmonização Orofacial e o Uso do Ácido Hialurônico e Toxina Botulínica: O Poder de Restituir Autoestima. Revista Multidisciplinar de Psicologia. 15(56), 252-260.

Radaelli, A. & Limardo, P. (2012). Minimally invasive procedures for nasal aesthetics. J Cutan Aesthet Surg. 5(2), 115-120.

Raphael, K. G, et al. (2020). Effect of multiple injections of botulinum toxin into painful masticatory muscles on bone density in the temporomandibular complex. Journal of Oral Rehabilitation, Kansas City, 47(11), 1319-1329.

Scaglione, F. (2016). Razão de Conversão entre Botox®, Dysport®, e Xeomin® na Prática Clínica. Toxinas (Basileia). 8(3), 65. 10.3390/toxins8030065.

Schmidt, L. L. D. C. & Silva, F. C. D. (2021). A importância do conhecimento anatômico na realização de procedimentos injetáveis com propósito de harmonização facial. Aesthetic Orofacial Science, 2(2).

Serrera-Figallo, M. A, et al. (2020). Use of botulinum toxin in orofacial clinical practive. Toxins. Basel, 12(112), 1-16.



How to Cite

SOUSA, A. A. de .; SOUZA, A. A. de .; ALBUQUERQUE, G. B. de .; MORAES, L. M. B. de .; LYRA NETO, J. B. .; SILVA, L. B. . Botulinum toxin and hyaluronic acid: Use and indications in the treatment of rejuvenation. Research, Society and Development, [S. l.], v. 13, n. 3, p. e3113345210, 2024. DOI: 10.33448/rsd-v13i3.45210. Disponível em: Acesso em: 25 jun. 2024.



Health Sciences