Orofacial manifestations of anemia: characteristics for a dental approach
DOI:
https://doi.org/10.33448/rsd-v9i7.4522Keywords:
Anemia; Mouth Diseases; Dentistry.Abstract
The objective of this study was to investigate in the literature which as oral and facial manifestations of anemias, addressing their etiological characteristics for better dental care in patients with this comorbidity. For this, a narrative review of the literature was carried out with articles published from 2000 to 2020 in the online databases PubMed (National Libary of Medicine) and SciELO (Scientific Electronic Library Online) using the descriptors and synonyms MeSH: "Anemias" in association with "Oral Manifestations". Of the 583 articles, 35 were used in this study. It was observed that the main anemias that presented oral signs were iron deficiency, hemolytic, megaloblastic, sickle cell and thalassemia. It was reported, mainly, the yellowish color in the oral mucosa and skin, as well as periodontitis, bone hyperplasia, osteomyelitis or even the loss of dental vitality from the infarction of local vascularization. Thus, it is extremely important for the dentist to understand the characteristics of this manifestation in order to correctly manage these patients, since some approaches may worsen the anemic picture.
References
Adeyemo, TA, Adeyemo, WL, Adediran, A, Akinbami, AJ, & Akanmu, AS. (2011). Orofacial manifestations of hematological disorders: anemia and hemostatic disorders. Indian Journal of Dental Research, 22(3): 454-461.
Akbari, M, Patel, R, Carrao, V, Hagar, W, Vichinsky, E, & Chuang, SK. (2019). Evaluation of Mandible Fractures in Patients With Sickle Cell Anemia—A Nationwide Study. Journal of Oral and Maxillofacial Surgery, 77(7), 1418–1422.
Almeida, VGV, Melo, GMS & Lima, GA. (2007). Queilite angular: sinais, sintomas e tratamento. Internacional journal of dentistry, 6(2): 55-57.
Altikat, S, Çiftçi, M, & Büyükokuroǧlu, ME. (2002). In vitro effects of some anesthetic drugs on enzymatic activity of human red blood cell glucose 6-phosphate dehydrogenase. Polish Journal of Pharmacology, 54(1), 67–70.
André, HP, Sperandio, N, Siqueira, RL, Franceschini, SDCC, & Priore SE. (2018). Food and nutrition insecurity indicators associated with iron deficiency anemia in Brazilian children: a systematic review. Ciência e Saúde Coletiva, 23(4): 1159-1167.
Ardila, AU. (2017). Deficiencia de Glucosa 6-Fosfato Deshidrogenasa en Colombia: Memorias de 22 Años de tamizaje de alto riesgo. Revista Med, 25(2), 7–21.
Bajwa, H, & Basit, H. Thalassemia. StatPearls Publishing. 2020.
Braunstein, EM. (2017). Visão geral da anemia hemolítica. Recuperado de: https://www.msdmanuals.com/pt/profissional/hematologia-e-oncologia/anemias-causadas-por-hem%C3%B3lise/vis%C3%A3o-geral-da-anemia-hemol%C3%ADtica.
Brancaleoni, E, Motta, PI & Cappellini, MD. (2016). Laboratory diagnosis of thalassemia. International Journal of Laboratory Hematology, 38: 32–40.
Carvalho, JP dos S, Catre, DLCB, Pereira, CMB, & Costa, M. (2010). Anesthesia in Patients with Positive Direct Coombs Test. Report of Three Cases. Brazilian Journal of Anesthesiology, 60(1), 75–83.
Castro, TG, Silva-Nunes, M, Conde, WL, Muniz, PT, & Cardoso, MA. (2011). Anemia and iron deficiency among schoolchildren in the Western Brazilian Amazon: prevalence and associated factors. Cad. Saúde Pública, 27(1): 131-142.
Chekroun, M, Chérifi, H, Fournier, B, Gaultier, F, Sitbon, IY, Ferré, FC, & Gogly, B. (2019). Oral manifestations of sickle cell disease. British Dental Journal, 226(1), 27–31.
Cunha, SFC, Melo, DA, Braga, CNM, Vannucchi, H, Cunha, DF. (2012). Papillary atrophy of the tongue and nutritional status of hospitalized alcoholics. Na Bras Dermatol, 87(1): 84-89.
Cutando Soriano, A, Gil Montoya, JA, López-González, JDDG. (2002). Las talasemias y sus implicaciones odontológicas. Medicina Oral, 7(1): 36–45.
Derossi, SS & Raghavendra, S. (2003). Anemia. Oral Surgery, Oral Medicine, Oral Phatology, Oral Radiology, and Endodontics, 95(2): 131-141.
Devalia, V, Hamilton, MS & Molloy, AM. (2014). British Committee for Standards in Haematology. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. British Journal of Haematology, 166(4): 496–513.
Elyassi, AR, & Rowshan, HH. (2009). Perioperative management of the glucose-6-phosphate dehydrogenase deficient patient: a review of literature. Anesthesia Progress, 56(3), 86–91.
Galanello, R, & Origa, R. (2010)BioMed Central Beta-thalassemia. Orphanet Journal of Rare Diseases, 5: 11.
Green, R & Datta Mitra, A. (2017). Megaloblastic Anemias: Nutritional and Other Causes. Medical Clinics of North America, 101(2): 297-317.
Green, R. (2017). Vitamin B12 deficiency from the perspective of a practicing hematologist. Blood, 129(19,): 2603–2611.
Helmi, N, Bashir M, Shireen, A, Ahmed, IM. (2017). Thalassemia review: features, dental considerations and management . Electronic physician, v9(3): 4003–4008.
Javed, F, Correa, FOB, Nooh, N, Almas, K, Romanos, GE, & Al-Hezaimi, K. (2013). Orofacial manifestations in patients with sickle cell disease. American Journal of the Medical Sciences, 345(3), 234–237.
Kawar, N, Alrayyes, S, & Aljewari, H. (2018). Sickle cell disease: An overview of orofacial and dental manifestations. Disease-a-Month, 64(6), 290–295.
Lee, SWH., Chaiyakunapruk, N, & Lai, NM. (2017). What G6PD-deficient individuals should really avoid. British Journal of Clinical Pharmacology, 83(1), 211–212.
Lopes, CMI, Cavalcanti, MC, Alves e Luna, AC, Marques, KMG, Rodrigues, MJ, & De Menezes, VA. (2018). Enamel defects and tooth eruption disturbances in children with sickle cell anemia. Brazilian Oral Research, 32, 1–8.
Lopez, A, Cacoube, P, Macdougall, IC, & Peyrin-Biroulet, L. (2015). Iron deficiency anaemia. The Lancet, 387(10021): 907–916.
Maia, U. M., Batista, D. C. de A., Pereira, W. O., & Fernandes, T. A. A. de M. (2010). Prevalência da deficiência da glicose-6-fosfato desidrogenase em doadores de sangue de Mossoró, Rio Grande do Norte. Revista Brasileira de Hematologia e Hemoterapia, 32(5), 422–423.
Muncie, HL & Campbell, JS. (2009). Alpha and beta thalassemia. American Family Physician, 80(4).
Nkhoma, ET, Poole, C, Vannappagari, V, Hall, SA, & Beutler, E. (2009). The global prevalence of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis. Blood Cells, Molecules, and Diseases, 42(3), 267–278.
Nunes, MP. (2018). Metabolismo do ferro e o impacto da anemia ferropriva à saúde humana (Trabalho de conclusão de curso). Faculdade de Ciências da Saúde da Universidade de Brasília, Brasília, Brasil.
Organização Mundial da Saúde. (2020). Anaemia. Recuperado de: https://www.who.int/health-topics/anaemia.
Piel, FB & Weatherall, DJ. (2014). The α-Thalassemias. New England Journal of Medicine, 371(20): 1908–1916.
Ramakrishna Y. (2007). Dental considerations in the management of children suffering from sickle cell disease: a case report. J Indian Soc Pedod Prev Dent, 25(3):140- 3.
Rocha, MAA. (2011). Anemias: Caracterização e implicações em medicina dentária (Dissertação de mestrado). Universidade de Lisboa, Faculdade de Medicina Dentária. Recuperado de: http://hdl.handle.net/10451/27309
Sobczynska-Malefora, A & Harrington, DJ. (2018). Laboratory assessment of folate (vitamin B9) status. Journal of Clinical Pathology, 71(11): 949–956,
Socha, DS, Souza, SI, Flagg, A, Sekeres, M, & Rogers, HJ. (2020). Severe megaloblastic anemia:vitamin deficiency and other causes. Cleveland clinic journal of medicine, 87(3): 153-164.
Stabler, SP. (2013). Clinical practice. Vitamin B12 deficiency. New England Journal of Medicine, 368(2): 149–160.
Valdés, MEA, Hernández, AB, Martínez, EE, Calderón, RG, Barrrego, EG, & Calderón, ALG. (2009). Caracterización de pacientes adultos con anemia hemolítica autoinmune atendidos en el Instituto de Hematología e Inmunolgía. Rev Cub de Hematología Inmunología y Hemoterapia, 25(3), 45–55.
Vasconcelos, PN, Santos, TMP & Vasconcelos, SML. (2013). Consumo de ferro e anemia em Mulheres Hipertensas e/ou diabéticas. Rev Bras Cardiol, 26(1): 17-25.
Vieira, RCS, & Ferreira, HS. (2010). Prevalência de anemia em crianças brasileiras, segundo diferentes cenários epidemiológicos. Rev. Nutr. 23(3): 433-444.
Wang, YP, Yu-Fong Chang, J, Wu, YC, Cheng, SJ, Chen, H, & Sun, A. (2013). Oral manifestations and blood profile inpatients with thalassemia trait. Journal of the Formosan Medical Association, 112(12), 761–765.
Yamagishi, JÁ, Alves, TP, Geron, VLMG, & Lima, RR. (2017). O Anemia ferropriva: diagnóstico e tratamento. Revista Científica da Faculdade de Educação e Meio Ambiente. 8(1): 99-110.
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.