Evidence on the therapeutic use of melatonin in adults for improving sleep quality: Literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v13i3.45258

Keywords:

Melatonin; Sleep; Adults.

Abstract

Objective: This study aims to analyze the effects of therapeutic use of melatonin in adults, observing possible applications to ensure improvement in sleep quality. Methodology: It is a narrative review based on specialized literature, through consultation of books and scientific articles selected from the collection of the Central Library of the Federal University of Alfenas-MG, Alfenas campus, and databases such as Pubmed, Scielo, and Uptodate. Results and Discussion: The studies found on the use of exogenous melatonin support the hypothesis that there was an impact on sleep disorders in adults, resulting in an improvement in the sleep of the analyzed population in the raised articles, which addressed the effects and recommendations of melatonin for the treatment of various comorbidities. Conclusion: After the analysis and study of the presented articles, it is concluded that the therapeutic use of melatonin is plausible. It is effective in adults at low dosages during the night and for a short period, as there are few studies evaluating its effectiveness and side effects in long-term use. However, gaps in research on melatonin and its relationship with sleep quality were demonstrated when considering broader aspects such as age, gender, ethnicity, comorbidities, duration of use, among other factors.

References

Auld, F., Maschauer, E. L., Morrison, I., Skene, D. J., & Riha, R. L. (2017). Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. Sleep Med Rev. 10.1016/j.smrv.2016.06.005.

ANVISA; DE ALIMENTOS, Gerência-Geral. (2021, 8 de abril). Proposta de Consulta Pública inclui a melatonina como constituinte autorizado. Grupo Técnico da Rede de Alerta e Comunicação de Riscos de Alimentos – Reali - Coordenação de Inspeção e Fiscalização Sanitária de Alimentos - COALI/GIALI/GGFIS/ANVISA. Publicado em 08/04/2021 às 09h14. Atualizado em 08/04/2021.

Besag, F. M. C., Vasey, M. J., Lao, K. S. J., & Wong, I. C. K. (2019). Adverse Events Associated with Melatonin for the Treatment of Primary or Secondary Sleep Disorders: A Systematic Review. CNS Drugs, 33(12), 1167-1186. https://doi.org/10.1007/s40263-019-00680-w

Buscemi, N., Vandermeer, B., Friesen, C., Bialy, L., Tubman, M., Ospina, M., Klassen, T. P., & Witmans, M. (2005). Manifestations and management of chronic insomnia in adults. Evidence Report/Technology Assessment (Summ), (125), 1-10. https://doi.org/10.1037/e439752005-001

Buscemi, N., Vandermeer, B., Pandya, R., Hooton, N., Tjosvold, L., Hartling, L., Baker, G., Vohra, S., & Klassen, T. (2004). Melatonin for treatment of sleep disorders. Evidence Report/Technology Assessment (Summ), (108), 1-7. https://doi.org/10.1037/e439412005-001

Costello, R. B., Lentino, C. V., Boyd, C. C., O'Connell, M. L., Crawford, C. C., Sprengel, M. L., & Deuster, P. A. (2014). The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature. Nutrition Journal, 13, 106. https://doi.org/10.1186/1475-2891-13-106

da Cruz, D., Silva, R., & Ferreira, T. (2023). Eficácia e segurança no uso da melatonina para tratamento da insônia (farmácia). Repositório Institucional, 1(1).

Gandolfi, J. V., Di Bernardo, A. P. A., Chanes, D. A. V., Martin, D. F., Joles, V. B., Amendola, C. P., Sanches, L. C., Ciorlia, G. L., & Lobo, S. M. (2020). The Effects of Melatonin Supplementation on Sleep Quality and Assessment of the Serum Melatonin in ICU Patients: A Randomized Controlled Trial. Critical Care Medicine, 48(12), e1286-e1293. https://doi.org/10.1097/CCM.0000000000004690

Ibope Inteligência. (2020, março). Pesquisa "Mapa do Sono dos Brasileiros". São Paulo: Ibope Inteligência para Takeda.

Laudon, M., & Frydman-Marom, A. (2014). Therapeutic effects of melatonin receptor agonists on sleep and comorbid disorders. Int. J. Mol. Sci. https://doi.org/10.3390/ijms150915924.

Low, T. L., Choo, F. N., & Tan, S. M. (2020, fevereiro). The efficacy of melatonin and melatonin agonists in insomnia - An umbrella review. J Psychiatr Res, 121, 10-23. 10.1016/j.jpsychires.2019.10.022.

McCleery, J., & Sharpley, A. L. (2020, novembro). Farmacoterapias para distúrbios do sono na demência. Cochrane Database of Systematic Reviews, Issue 11, Art. Nº: CD009178. 10.1002/14651858.CD009178.pub4.

Ministério da Saúde, Agência Nacional de Vigilância Sanitária (ANVISA). (2021). Instrução Normativa - IN N° 102.

Palagini, L., et al. (2021, 10 de junho). International Expert Opinions and Recommendations on the Use of Melatonin in the Treatment of Insomnia and Circadian Sleep Disturbances in Adult Neuropsychiatric Disorders. Frontiers in psychiatry, 12, 688890. 10.3389/fpsyt.2021.688890.

Silverthorn, D. U. (2017). Fisiologia humana: uma abordagem integrada (7a ed.). ArtMed. https://integrada.minhabiblioteca.com.br/books/9788582714041.

Rother, E. T. (2007). Revisión sistemática X Revisión narrativa. Acta paulista de enfermagem, 20, v-vi. https://doi.org/10.1590/S0103-21002007000200001.

Sletten, T. L., Magee, M., Murray, J. M., Gordon, C. J., Lovato, N., Kennaway, D. J., & Rajaratnam, S. M. W; Delayed Sleep on Melatonin (DELSOM) Study Group. (2018, 18 de junho). Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial. PLoS Med, 15(6), e1002587. 10.1371/journal.pmed.1002587.

Sumsuzzman, D. M., Choi, J., Jin, Y., & Hong, Y. (2021, agosto). Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: A systematic review and meta-analysis of randomized controlled trials. Neurosci Biobehav Rev, 127, 459-473. 10.1016/j.neubiorev.2021.04.034.

Tan, D. X., Manchester, L. C., Hardeland, R., et al. (2003). Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. J Pineal Res, 34(1), 75–8. 10.1034/j.1600-079x.2003.02111.x.

Tordjman, S., Chokron, S., Delorme, R., Charrier, A., Bellissant, E., Jaafari, N., & Fougereou, C. (2017). Melatonin: Pharmacology, Functions and Therapeutic Benefits. Curr Neuropharmacol, 15(3), 434-443. 10.2174/1570159X14666161228122115.

Wurtman, R. Physiology and available preparations of melatonin. In: UpToDate, Editor TW Post (Ed.). UpToDate.

Published

14/03/2024

How to Cite

SILVA, A. F. P. .; YUGAWA, A. E. .; OLIVEIRA, T. C. E. de .; MINGOTI, T. de S. .; DUARTE, G. G. de M. .; BIANCO, O. A. F. M. .; MESQUITA, L. F. . Evidence on the therapeutic use of melatonin in adults for improving sleep quality: Literature review. Research, Society and Development, [S. l.], v. 13, n. 3, p. e4313345258, 2024. DOI: 10.33448/rsd-v13i3.45258. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/45258. Acesso em: 8 may. 2024.

Issue

Section

Health Sciences