Gut microbiota and depression: A scoping review exploring the interactions underlying depressive disorder
DOI:
https://doi.org/10.33448/rsd-v13i4.45507Keywords:
Gut microbiota; Depression; Gut-brain axis; Inflammation.Abstract
Introduction: Gut-brain communication plays an important role in understanding the complex etiology of depression, offering insights into new therapeutic avenues. Objective: The objective of this review is to evaluate the role of the intestinal microbiota in cases of depression. Methodology: A review of academic literature indexed in national and international databases was carried out using a scoping review methodology. Data sources used included PubMed, Lilacs and Google Scholar. The keywords "Gut Microbiota" AND "Depression" were used for the search. Results: Of the 975 articles found, 943 were excluded based on titles and abstracts, 18 articles were excluded after complete reading and 14 were included. Conclusions: These findings suggest that several taxa and their mechanisms of action may play a role in the pathophysiology of depression, involving the communication of peripheral inflammation with the brain.
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Copyright (c) 2024 Raissa Fiorese Procópio Faim; Evandro Delmondez Oliveira; Gustavo Henrique Tinen; Isabelle de Genaro Lima; Maria Clara Gonçalves Rocha ; Kamilly Lima do Vale; Luan Diego Marques Teixeira
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