Epidemiological characterization and temporal trend of Epilepsy mortality in Brazil during the years 1999 to 2019
DOI:
https://doi.org/10.33448/rsd-v13i5.45617Keywords:
Epidemiology; Health sciences; Epilepsy.Abstract
Epilepsy is a neurological disorder characterized by the permanent predisposition of the brain to generate sudden behavioral changes and recurrent epileptic seizures. It is estimated that this neurological disorder affects more than 50 million people worldwide, appearing among the most common brain conditions, with higher incidences in developing countries, as is the case in Brazil. Thus, the present study aims to characterize the epidemiological profile and analyze the temporal trend of mortality from epilepsy in Brazil between the years 1999 to 2019. For this, an epidemiological categorization was carried out according to sociodemographic variables according to the Department of Informatics of the Unified Health System -DATASUS. To analyze the temporal trend, the joinpoint regression model was applied and the annual percentage change and its respective 95%CI confidence interval were also calculated. The South and Midwest regions had the highest mortality rates, on the other hand, the Northeast and North regions had the lowest. For sociodemographic characteristics, male gender stood out 65.12%, age group ≥ 60 24.86%; white people 46.36% and people with schooling < 8 years 35.01%. The temporal trend analysis identified an annual increase of 3.1% in the mortality rate due to epilepsy, where females and the North and Northeast regions also showed the highest percentages of annual increase in the mortality rate. Psychological problems, such as depression and anxiety, social conditions, lack of information and incorrect pharmacological treatment are factors that lead to the worsening of epilepsy. Thus, the control of mortality for epilepsy can be the effectiveness of social factors and qualified health.
References
Aktürk, T., Tanık, N., Saçmacı, H., Chia, Z. J., & Lim, K. S. (2020). Validity and reliability of the Turkish version of Public Attitudes Toward Epilepsy scale. Epilepsy & Behavior, 111, 107245.
Andraus, M., Thorpe, J., Tai, X. Y., Ashby, S., Hallab, A., Ding, D., & Sen, A. (2021). Impact of the COVID-19 pandemic on people with epilepsy: findings from the Brazilian arm of the COV-E study. Epilepsy & Behavior, 123, 108261.
Antunes, JLF, & Cardoso, MRA (2015). Uso da análise de séries temporais em estudos epidemiológicos. Epidemiologia e Serviços de Saúde, 24, 565-576.
Behr, C., Goltzene, MA, Kosmalski, G., Hirsch, E., & Ryvlin, P. (2016). Epidemiologia da epilepsia. Revue neurologique,172(1), 27-36.
Bell, G. S., Neligan, A., & Sander, J. W. (2014). An unknown quantity—the worldwide prevalence of epilepsy. Epilepsia, 55(7), 958-962.
Beniczky, S., Husain, A., Ikeda, A., Alabri, H., Cross, J. H., Wilmshurst, J., & Trinka, E. (2021). Importance of access to epilepsy monitoring units during the COVID-19 pandemic: consensus statement of the International League Against Epilepsy and the International Federation of Clinical Neurophysiology. Clinical Neurophysiology, 132(9), 2248-2250.
Chakraborty, P., Sanchez, N. A., Kaddumukasa, M., Kajumba, M., Kakooza-Mwesige, A., Van Noord, M., & Koltai, D. C. (2021). Stigma reduction interventions for epilepsy: A systematized literature review. Epilepsy & Behavior, 114, 107381.
Chawla, A., Singh, G., Sharma, S., Bansal, R., Bansal, N., Chowdhury, A., & Sander, J. W. (2020). Mortality implications and factors associated with nonengagement in a public epilepsy care initiative in a transient population. Epilepsy & Behavior, 112, 107438.
Chen, S., Yoshida, S., Matsumoto, R., Ikeda, A., & Kawakami, K. (2021). Prescription patterns of antiepileptic drugs for adult patients with newly diagnosed focal epilepsy from 2006 to 2017 in Japan. Epilepsy Research, 169, 106503.
Dayapoglu, N., Ayyıldız, N. İ., & Şeker, D. (2020). Fear of negative evaluation and the concealment of their disease by epilepsy patients. Epilepsy & Behavior, 113, 107539.
Delgado-Suárez, C., García-Azorín, D., Monje, M. H. G., Molina-Sánchez, M., Iglesias, P. G., Kurtis, M. M., & Garcia-Morales, I. (2021). Identifying areas for improvement in epilepsy management in developing countries: An experience of neurocooperation in Cameroon. Neurología (English Edition), 36(1), 29-33.
Diby, T., Khumalo, P. G., Anokyewaa-Amponsah, G., Mustapha, R., & Ampofo, A. G. (2021). Knowledge about epilepsy and factors associated with attitudes toward marrying, employing, and driving people with epilepsy: A cross-sectional survey of Asokore Mampong community dwellers in Ghana. Epilepsy & Behavior, 115, 107646.
El-Amin, R. O., El-Sadig, S. M., & Mohamed, I. N. (2021). Knowledge, attitudes, and practices of caregivers of children with epilepsy in Sudan. Epilepsy & Behavior, 123, 108283.
Espinosa-Jovel, C., Toledano, R., Aledo-Serrano, Á., García-Morales, I., & Gil-Nagel, A. (2018). Epidemiological profile of epilepsy in low income populations. Seizure, 56, 67-72.
Fadel, S. A., Boschi-Pinto, C., Yu, S., Reynales-Shigematsu, L. M., Menon, G. R., Newcombe, L., & Jha, P. (2019). Trends in cause-specific mortality among children aged 5–14 years from 2005 to 2016 in India, China, Brazil, and Mexico: an analysis of nationally representative mortality studies. The Lancet, 393(10176), 1119-1127.
Feigin, V. L., Roth, G. A., Naghavi, M., Parmar, P., Krishnamurthi, R., Chugh, S., & Stroke Experts Writing Group. (2016). Global burden of stroke and risk factors in 188 countries, during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet Neurology, 15(9), 913-924.
Guilhoto, L. M., Mosini, A. C., Susemihl, M. A., & Pinto, L. F. (2021). COVID-19 and epilepsy: How are people with epilepsy in Brazil? Epilepsy & Behavior, 122, 108115.
Gul, Z. B. (2022). Depression and sexual functions in epilepsy patients: Comparison before and during the COVID-19 pandemic. In Annales Médico-psychologiques, revue psychiatrique 180(2), 127-132.
Guzmán, C. O., Paiva, L. A., Fuentes-García, A., & Alburquenque, M. F. (2021). Translation and cross-cultural adaptation of the “Quality of Life in Epilepsy (QOLIE-31-P)” Questionnaire for Chile. Epilepsy & Behavior, 122, 108169.
Harden, J., Black, R., Pickersgill, M., Shetty, J., McLellan, A., Brand, C., & Chin, R. F. (2021). Children’s understanding of epilepsy: A qualitative study. Epilepsy & Behavior, 120, 107994.
Helmstaedter, C., Elger, C. E., & Witt, J. A. (2016). The effect of quantitative and qualitative antiepileptic drug changes on cognitive recovery after epilepsy surgery. Seizure, 36, 63-69.
Ibge. Instituto Brasileiro de Geografia e Estatística. Brasil. (2020). Disponível em: https://www.ibge.gov.br/cidades-e-estados.html. Acesso em: 18 jul.
Idris, A., Alabdaljabar, M. S., Almiro, A., Alsuraimi, A., Dawalibi, A., Abduljawad, S., & AlKhateeb, M. (2021). Prevalence, incidence, and risk factors of epilepsy in arab countries: A systematic review. Seizure, 92, 40-50.
Johnson, E. C., Atkinson, P., Muggeridge, A., Cross, J. H., & Reilly, C. (2021). Epilepsy in schools: Views on educational and therapeutic provision, understanding of epilepsy and seizure management. Epilepsy & Behavior, 122, 108179.
Kariuki, S. M., Ngugi, A. K., Kombe, M. Z., Kazungu, M., Chengo, E., Odhiambo, R., & Newton, C. R. (2021). Prevalence and mortality of epilepsies with convulsive and non-convulsive seizures in Kilifi, Kenya. Seizure, 89, 51-55.
Katyal, J., Rashid, H., Tripathi, M., & Sood, M. (2021). Prevalence of depression and suicidal ideation in persons with epilepsy during the COVID-19 pandemic: A longitudinal study from India. Epilepsy & Behavior, 124, 108342.
Khatoon, F., Prasad, K., & Kumar, V. (2022). COVID-19 associated nervous system manifestations. Sleep medicine, 91, 231-236.
Laguitton, V., Desnous, B., Lépine, A., Mcgonigal, A., Mancini, J., Daquin, G., & Villeneuve, N. (2021). Intellectual outcome from 1 to 5 year
s after epilepsy surgery in 81 children and adolescents: A longitudinal study. Seizure, 91, 384-392.
Li, Y., Zhang, S., Snyder, M. P., & Meador, K. J. (2021). Precision medicine in women with epilepsy: the challenge, systematic review, and future direction. Epilepsy & Behavior, 118, 107928.
Lin, M., Chen, J., Li, S., Qin, Y., Wang, X., Liu, Y., & Li, J. (2021). Individual prediction of motor vehicle accidents for patients with epilepsy. Epilepsy & Behavior, 121, 108046.
Mei, H., Li, N., Li, J., Zhang, D., Cao, Z., Zhou, Y., & Cao, J. (2021). Depression, anxiety, and stress symptoms in pregnant women before and during the COVID-19 pandemic. Journal of psychosomatic research, 149, 110586.
Mesraoua, B., Kissani, N., Deleu, D., Elsheikh, L., Ali, M., Melikyan, G., & Asadi-Pooya, A. A. (2021). Complementary and alternative medicine (CAM) for epilepsy treatment in the Middle East and North Africa (MENA) region. Epilepsy Research, 170, 106538.
Record, E. J., Bumbut, A., Shih, S., Merwin, S., Kroner, B., & Gaillard, W. D. (2021). Risk factors, etiologies, and comorbidities in urban pediatric epilepsy. Epilepsy & Behavior, 115, 107716.
Reilly, C., Muggeridge, A., & Cross, J. H. (2021). The perceived impact of COVID-19 and associated restrictions on young people with epilepsy in the UK: Young people and caregiver survey. Seizure, 85, 111-114.
Sen, A., Jette, N., Husain, M., & Sander, JW (2020). Epilepsia em idosos. The Lancet, 395 (10225), 735-748.
Serafini, R. (2021). How much can medical management alone improve the outcome of adult drug-resistant epilepsy? An exploratory study on possibilities and limitations of combining multiple therapeutic actions. Epilepsy & Behavior, 122, 108065.
Shi, Y., Liu, S., Wang, J., Li, C., & Zhang, J. (2021). Stigma experienced by patients with epilepsy: A systematic review and meta-synthesis of qualitative studies. Epilepsy & Behavior, 118, 107926.
Subota, A., Jetté, N., Josephson, C. B., McMillan, J., Keezer, M. R., Gonzalez-Izquierdo, A., & Holroyd-Leduc, J. (2021). Risk factors for dementia development, frailty, and mortality in older adults with epilepsy–A population-based analysis. Epilepsy & Behavior,120, 108006.
Swartwood, S., Wilkes, J., Bonkowsky, J. L., & Trandafir, C. C. (2021). Celiac Disease in Children: An Association With Drug-Resistant Epilepsy. Pediatric Neurology, 120, 12-17.
Triki, C. C., Mguidich, T., Bouchaala, W., Ncir, S. B., Chaari, H., Fourati, E., & Kamoun, F. (2021). Knowledge and attitudes toward epilepsy among people in Sfax region, Tunisia. Epilepsy & Behavior, 122, 108151.
Van Marter, L. J., Pennell, P. B., Brown, C., Hartman, A. L., May, R. C., McElrath, T., & Strickland, S. (2021). Neonatal outcomes in the MONEAD study of pregnant women with epilepsy. The Journal of Pediatrics: X, 7, 100073.
Watila, M. M., Xiao, F., Keezer, M. R., Miserocchi, A., Winkler, A. S., McEvoy, A. W., & Sander, J. W. (2019). Epilepsy surgery in low-and middle-income countries: a scoping review. Epilepsy & Behavior, 92, 311-326.
Welin, K. O., Carlqvist, P., Svensson, A., Althin, R., Eklund, E., & Rask, O. (2017). Epilepsy in tuberous sclerosis patients in Sweden–Healthcare utilization, treatment, morbidity, and mortality using national register data. Seizure, 53, 4-9.
Who, World Health Organization. Epilepsy. (2019). Available in: http://www.who.int/en/news-room/fact-sheets/detail/epilepsy.
Wojewodka, G., McKinlay, A., & Ridsdale, L. (2021). Best care for older people with epilepsy: a scoping review. Seizure, 85, 70-89.
Zaccara, G., & Lattanzi, S. (2019). Comorbidity between epilepsy and cardiac arrhythmias: implication for treatment. Epilepsy & Behavior, 97, 304-312.
Zhong, R., Chen, Q., Li, M., Li, N., Zhang, X., & Lin, W. (2021). Sex differences in anxiety in patients with epilepsy: Status and risk factors analysis. Epilepsy & Behavior, 116, 107801.
Zhong, R., Chen, Q., Li, N., Zhang, X., & Lin, W. (2021). Sex-based differences in the prevalence of and risk factors for depression in adult patients with epilepsy in Northeast China. Epilepsy & Behavior, 122, 108201.
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