Adverse events and nursing diagnosis in patients undergoing hematopoietic stem cell transplantation

Authors

DOI:

https://doi.org/10.33448/rsd-v9i7.4618

Keywords:

Hematopoietic stem cell transplantation; Nursing; Nursing process; Nursing diagnosis.

Abstract

The aim of this study was to describe the adverse events presented by patients on the day of infusion of hematopoietic progenitor cells and to identify corresponding nursing diagnosis. Prospective cross-sectional study, whose sample consisted of 62 patients who underwent hematopoietic stem cell transplantation (allogeneic and autologous). After ethical approval, data collection took place over a period of 16 months in a public hospital in the state of São Paulo. About 53% of the transplant recipients were male, 54.8% had at least one comorbidity and 61.3% underwent allogeneic transplantation. For each type of adverse event (by organic system) presented, at least one nursing diagnosis was indicated, totaling 26 diagnosis and the most frequent ones were "risk of bleeding", "risk of allergic response", "fatigue" and "risk of impaired cardiovascular function". The highest frequency of elected nursing diagnosis belonged to the “security / protection” domain (n = 11), followed by the “activity / rest” domain (n = 5). This study found a higher frequency of nursing diagnosis belonging to the safety/protection domain and the activity/rest domain, which can be a reference for nurses in planning nursing care, with a view to the quality of care and the safety of onco-hematological patients.

Author Biographies

Juliana Bastoni da Silva, Universidade Federal do Tocantins

Professora Doutora do Curso de Graduação em Enfermagem da Universidade Federal do Tocantins

Doutora em Ciências pela Escola de Enfermagem da Universidade de São Paulo (USP)

Jessika Suellen da Costa, Hospital Centro Médico de Campinas

Enfermeira graduada pela Universidade Estadual de Campinas - SP

Andressa Gomes Melo, Hospital de Clínicas da Universidade Estadual de Campinas

Enfermeira, Mestra pela Universidade Estadual de Campinas - SP

Alessandra Martins Lother, Ambulatório de Nefrologia, Universidade Estadual de Campinas

Enfermeira, Mestra pela Universidade Estadual de Campinas - SP

References

Associação Brasileira de Transplante de Órgãos. (2019). Registro Brasileiro de Transplantes. Dimensionamento dos Transplantes no Brasil e em cada estado, 4, 1-95. Acesso em 15 maio, 2020, em http:// www.abto.org.br.

Brasil. Conselho Nacional de Saúde. (2012). Resolução n. 466, Normas Regulamentadoras de Pesquisas envolvendo seres humanos. Brasília: Ministério da Saúde.

Butcher, G.M., Bulechek H. K., Dochterman J.M., Wagner C.M. (2016). NIC Classificação das intervenções de Enfermagem. Rio de Janeiro: Gen Guanabara Koogan.

Canaani, J., Savani, B. N., Labopin, M., Huang, X. J., Ciceri, F., Arcese, W., . . . Nagler, A. (2018). Donor age determines outcome in acute leukemia patients over 40 undergoing haploidentical hematopoietic cell transplantation. Am J Hematol, 93(2), 246-253. doi:10.1002/ajh.24963

Colella, M.P., Miranda, E.C.M., Aranha, F.J.P., Vigorito, A.C. & De Souza CA. (2014).

Hematopoietic cell transplant specific comorbidity index, disease status at transplant and graft source as risk factors in patients undergoing allogeneic hematopoietic stem cell transplant. Journal of Hematology & Transfusion, 2(3), 1031-7.

Ezzone, A.S. (2009). History of hematopoietic stem cell transplantation. Seminars in Oncology Nursing, 25, 95-9.

Hening, I. & Zuckerman, T. (2014). Hematopoietic stem cell transplantation-50 years of evolution and future perpectives. Rambam Maimonides Med J, 5(4), 1-15.

Keller, J. W., Andreadis, C., Damon, L. E., Kaplan, L. D., Martin, T. G., Wolf, J. L., . . . Olin, R. L. (2014). Hematopoietic cell transplantation comorbidity index (HCT-CI) is predictive of adverse events and overall survival in older allogeneic transplant recipients. J Geriatr Oncol, 5(3), 238-244. doi:10.1016/j.jgo.2014.04.003

Larghero, J., Rea, D., Esperou, H., Biscay, N., Maurer, M. N., Lacassagne, M. N., . . . Marolleau, J. P. (2006). ABO-mismatched marrow processing for transplantation: results of 114 procedures and analysis of immediate adverse events and hematopoietic recovery. Transfusion, 46(3), 398-402. doi:10.1111/j.1537-2995.2006.00735.x

National Cancer Institute. (2010). Common Terminology Criteria for Adverse Events (version 4.0). Acesso em 15 maio, 2020, em https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_ 4.03/CTCAE_4.03_2010-06 14_QuickReference_8.5x11.pdf

North American Nursing Diagnosis Association – International. (2015-2017). Diagnósticos de Enfermagem da NANDA-I: definições e classificação. Porto Alegre: Artmed.

Sauer-Heilborn, A., Kadidlo, D., & McCullough, J. (2004). Patient care during infusion of hematopoietic progenitor cells. Transfusion, 44(6), 907-916. doi:10.1111/j.1537-2995.2004.03230.x

Shu, Z., Heimfeld, S., & Gao, D. (2014). Hematopoietic SCT with cryopreserved grafts: adverse reactions after transplantation and cryoprotectant removal before infusion. Bone Marrow Transplant, 49(4), 469-476. doi:10.1038/bmt.2013.152

Silva, J. B., Póvoa, V. C., Lima, M. H., Oliveira, H. C., Padilha, K. G., & Secoli, S. R. (2015). Nursing workload in hematopoietic stem cell transplantation: a cohort study. Rev Esc Enferm USP, 49 Spec No, 93-100. doi:10.1590/S0080-623420150000700014

Sorror, M. L. (2010). Comorbidities and hematopoietic cell transplantation outcomes. Hematology Am Soc Hematol Educ Program, 2010, 237-247. doi:10.1182/asheducation-2010.1.237

Sousa, R.M., Santo, F.H.E., Santana, R.F. & Lopes, M.V.O. (2015). Diagnósticos de

enfermagem identificados em pacientes onco-hematológicos: mapeamento cruzado.

Escola Anna Nery Revista de Enfermagem, 19(1), 54-65.

Timurağaoğlu, A. (2015). The role of the nurses and technicians for stem cell mobilisation and collection. Transfus Apher Sci, 53(1), 30-33. doi:10.1016/j.transci.2015.05.012

Ubaldo, I., Matos, E. & Salum, N.C. (2015). Diagnósticos de enfermagem da NANDA-I

com base nos problemas segundo teoria de Wanda Horta. Cogitare Enferm, 20(4), 687-94.

Vidula, N., Villa, M., Helenowski, I. B., Merchant, M., Jovanovic, B. D., Meagher, R., . . . Gordon, L. I. (2015). Adverse Events During Hematopoietic Stem Cell Infusion: Analysis of the Infusion Product. Clin Lymphoma Myeloma Leuk, 15(11), e157-162. doi:10.1016/j.clml.2015.08.085

Worldwide Network for Blood and Marrow Transplantation. (2013). Acesso em 15 maio, 2020, em http://www.wbmt.org.

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Published

07/06/2020

How to Cite

SILVA, J. B. da; COSTA, J. S. da; MELO, A. G.; LOTHER, A. M. Adverse events and nursing diagnosis in patients undergoing hematopoietic stem cell transplantation. Research, Society and Development, [S. l.], v. 9, n. 7, p. e728974618, 2020. DOI: 10.33448/rsd-v9i7.4618. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/4618. Acesso em: 16 nov. 2024.

Issue

Vol. 9 No. 7

Section

Health Sciences

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