Effectiveness of propolis in dental applications: A review study
DOI:
https://doi.org/10.33448/rsd-v13i8.46521Keywords:
Phytotherapy; Oral health; Antibacterials; Odontology.Abstract
Propolis, a natural resinous substance produced by bees, has received attention in dentistry for its potential therapeutic properties. The objective of this study is to review the existing literature on the efficacy of Propolis in various dental applications, highlighting its antimicrobial, anti- inflammatory, antifungal and healing properties. The search included the PubMed, Scopus, Web of Science, and Google Scholar databases using key terms such as "propolis," "dentistry," "oral health," "antimicrobial," and "anti-inflammatory." The studies included in this review were clinical trials, literature reviews, systematic reviews, and meta-analyses published in English, Spanish, or Portuguese. The results highlight the efficacy of propolis in diverse dental contexts, especially its antimicrobial action against oral pathogens such as Streptococcus mutans and Candida species. In addition, propolis has demonstrated beneficial anti-inflammatory effects for the treatment of oral mucosal conditions and gum inflammation. The diverse chemical composition of propolis, including flavonoids, phenolic acids, and terpenes, contributes to its therapeutic potential in dentistry. It is concluded that propolis has promising therapeutic applications in dentistry, showing itself as a natural or complementary alternative to conventional dental treatments. More research is needed to standardize their formulations and dosages for optimal clinical use in oral health.
References
Abbasi, A. J., Mohammadi, F., Bayat, M., Gema, S. M., Ghadirian, H., Seifi, H., et al. (2018). Applications of propolis in dentistry: a review. Ethiopian journal of health sciences, 28(4), 505-512.
Ahangari, Z., Naseri, M., & Vatandoost, F. (2018). Propolis: Chemical composition and its applications in endodontics. Iranian endodontic journal, 13(3), 285.
Alghutaimel, H., Matoug-Elwerfelli, M., Alhaji, M., Albawardi, F., Nagendrababu, V., & Dummer, P. M. H. (2024). Propolis use in dentistry: A narrative review of its preventive and therapeutic applications. International dental journal. 74(3), 365-386.
Avila‐Ortiz, G., Vegh, D., Mukaddam, K., Galindo‐Moreno, P., Pjetursson, B., & Payer, M. (2023). Treatment alternatives for the rehabilitation of the posterior edentulous maxilla. Periodontology 2000, 93(1), 183-204.
Belmehdi, O., El Menyiy, N., Bouyahya, A., El Baaboua, A., El Omari, N., Gallo, M., et al. (2023). Recent advances in the chemical composition and biological activities of propolis. Food Reviews International, 39(9), 6078-6128.
Bezerra, C. R. F., Assunção Borges, K. R., Alves, R. D. N. S., Teles, A. M., Pimentel Rodrigues, I. V., da Silva, M. A. C. N., et al. (2020). Highly efficient antibiofilm and antifungal activity of green propolis against Candida species in dentistry materials. PLoS One, 15(12), e0228828.
Biswas, S., & Premkishore, K. (2022). Propolis: A Natural Remedy to Clinical Problems in Pediatric Dentistry. Journal of Primary Care Dentistry and Oral Health, 3(3), 57-61.
Brizola, J., & Fantin, N. (2016). Revisão da literatura e revisão sistemática da literatura. Revista de Educação do Vale do Arinos-RELVA, 3(2).
Centeno, J. E. O., & Sotelo, R. N. G. (2024). Propolis in Dentistry. In Melittology-New Advances. IntechOpen.
da Silva Barboza, A., Aitken-Saavedra, J. P., Ferreira, M. L., Aranha, A. M. F., & Lund, R. G. (2021). Are propolis extracts potential pharmacological agents in human oral health?-A scoping review and technology prospecting. Journal of Ethnopharmacology, 271, 113846.
de Carvalho, C., Fernandes, W. H. C., Mouttinho, T. B. F., de Souza, D. M., Marcucci, M. C., & D’Alpino, P. H. P. (2019). Evidence-based studies and perspectives of the use of Brazilian green and red propolis in dentistry. European journal of dentistry, 13(03), 459-465.
de Groot, A. C. (2013). Propolis: a review of properties, applications, chemical composition, contact allergy, and other adverse effects. Dermatitis, 24(6), 263-282.
Dick, T. N. A., Marques, L. C., Lopes, A. D. A. L., Candreva, M. S., Santos, L. R., & Picciani, B. L. S. (2020). Phytotherapy in dentistry: A literature review based on clinical data. European Journal of Medicinal Plants, 31(10), 1-13.
Duran-Merino, D., Cruz-Ávila, J., Castañeda-Castaneira, E., Robles-Pinto, G., & Molina-Frechero, N. (2022). Properties and uses of propolis in dentistry: a review. Odontoestomatología, 24(40).
Esh, S., Chatterjee, A. N., & De, B. (2021). Propolis and its implications in dentistry: a review. International Journal of Research and Review, 8(12), 311-317.
Forma, E., & Bryś, M. (2021). Anticancer activity of propolis and its compounds. Nutrients, 13(8), 2594.
Ghosh, S., Al-Sharify, Z. T., Maleka, M. F., Onyeaka, H., Maleke, M., Maolloum, A., et al. (2022). Propolis efficacy on SARS-COV viruses: a review on antimicrobial activities and molecular simulations. Environmental Science and Pollution Research, 29(39), 58628-58647.
Gómez, P. A. M., Jon, L. Y. T. C., Torres, D. J. M., Amaranto, R. E. B., Díaz, I. E. C., Medina, C. A. M., & Choque, J. S. C. (2021). Antibacterial, antibiofilm, and cytotoxic activities and chemical compositions of Peruvian propolis in an in vitro oral biofilm. F1000Research, 10.
Gonçalves, J. R. (2019). Como escrever um artigo de revisão de literatura. Revista JRG de Estudos Acadêmicos, 2(5), 29-55.
Huang, S., Zhang, C. P., Wang, K., Li, G. Q., & Hu, F. L. (2014). Recent advances in the chemical composition of propolis. Molecules, 19(12), 19610-19632.
Jacob, A., Parolia, A., Pau, A., & Davamani Amalraj, F. (2015). The effects of Malaysian propolis and Brazilian red propolis on connective tissue fibroblasts in the wound healing process. BMC complementary and alternative medicine, 15, 1-10.
Khurshid, Z., Naseem, M., Zafar, M. S., Najeeb, S. & Zohaib, S. (2017). Propolis: A natural biomaterial for dental and oral healthcare. Journal of dental research, dental clinics, dental prospects, 11(4), 265.
Makvandi, P., Gu, J. T., Zare, E. N., Ashtari, B., Moeini, A., Tay, F. R., & Niu, L. N. (2020). Polymeric and inorganic nanoscopical antimicrobial fillers in dentistry. Acta biomaterialia, 101, 69-101.
Martin, E. G. (2022). A literature review on the benefits of propolis. Hauppauge: Nova Science Publishers, Incorporated, pp186.
Menniti‐Ippolito, F., Mazzanti, G., Santuccio, C., Angela Moro, P., Calapai, G., Firenzuoli, F., et al. (2008). Surveillance of suspected adverse reactions to natural health products in Italy. Pharmacoepidemiology and drug safety, 17(6), 626-635.
Morawiec, T., Mertas, A., Wojtyczka, R. D., Niedzielska, I., Dziedzic, A., Bubiłek-Bogacz, A., et al. 2015). The assessment of oral microflora exposed to 3% ethanolic extract of Brazilian green propolis preparation used for hygiene maintenance following minor oral surgeries. BioMed research international, 2015(1), 869575.
Necip, A., Demirtas, I., Tayhan, S. E., Işık, M., Bilgin, S., Turan, İ. F., et al. (2024). Isolation of phenolic compounds from eco‐friendly white bee propolis: Antioxidant, wound‐healing, and anti‐Alzheimer effects. Food Science & Nutrition, 12(3), 1928-1939.
Oršolić, N. (2022). Allergic inflammation: Effect of propolis and its flavonoids. Molecules, 27(19), 6694.
Pereira, Y. C. L., Issa, J. P. M., Watanabe, E., Nascimento, G. C., Iyomasa, M. M., Del Ciampo, J. O., & Ervolino, E. (2018). The therapeutic use of propolis extract in alveolar bone contaminated with bacterial endotoxin. Dentistry, 8(473), 2161-1122.
Ravalia, M., e Wander, P. (2020). Bees and dentistry: Are the two linked?. BDJ In Practice, 33(6), 26-28.
Rivera-Yañez, C. R., Ruiz-Hurtado, P. A., Reyes-Reali, J., Mendoza-Ramos, M. I., Vargas-Díaz, M. E., Hernández-Sánchez, K. M., et al. (2022). Antifungal activity of Mexican propolis on clinical isolates of Candida species. Molecules, 27(17), 5651.
Rivera-Yanez, N., Rivera-Yanez, C. R., Pozo-Molina, G., Mendez-Catala, C. F., Reyes-Reali, J., Mendoza-Ramos, M. I., et al. (2021). Effects of propolis on infectious diseases of medical relevance. Biology, 10(5), 428.
Roberts, T., Kallon, I. I., & Schoonees, A. (2024). Efficacy and Safety of Propolis for Treating Recurrent Aphthous Stomatitis (RAS): A Systematic Review and Meta-Analysis. Dentistry Journal, 12(1), 13, 1-20.
Rojczyk, E., Klama-Baryła, A., Łabuś, W., Wilemska-Kucharzewska, K., & Kucharzewski, M. (2020). Historical and modern research on propolis and its application in wound healing and other fields of medicine and contributions by Polish studies. Journal of Ethnopharmacology, 262, 113159.
Rother, E. T. (2007). Revisión sistemática X Revisión narrativa. Acta paulista de enfermagem, 20, v-vi.
Saeed, M. A., Khabeer, A., Faridi, M. A., & Makhdoom, G. (2021). Effectiveness of propolis in maintaining oral health: a scoping review. Canadian Journal of Dental Hygiene, 55(3), 167.
Salatino, A. (2022). Perspectives for uses of propolis in therapy against infectious diseases. Molecules, 27(14), 4594.
Saputra, S. K., Sutantyo, D., Farmasyanti, C. A., & Alhasyimi, A. A. (2019). The effect of the addition of propolis to resin-modified glass ionomer cement bracket adhesive materials on the growth inhibition zone of Streptococcus mutans. F1000Research, 8.
Siheri, W., Alenezi, S., Tusiimire, J., & Watson, D. G. (2017). The chemical and biological properties of propolis. Bee products-chemical and biological properties, 137-178.
Šturm, L., e Ulrih, N. P. (2020). Advances in the propolis chemical composition between 2013 and 2018: A review. Efood, 1(1), 24-37.
Teixeira, E. W., Message, D., Negri, G., Salatino, A., & Stringheta, P. C. (2010). Seasonal variation, chemical composition and antioxidant activity of Brazilian propolis samples. Evidence‐Based Complementary and Alternative Medicine, 7(3), 307-315.
Wieczorek, P. P., Hudz, N., Yezerska, O., Horčinová-Sedláčková, V., Shanaida, M., Korytniuk, O., & Jasicka-Misiak, I. (2022). Chemical variability and pharmacological potential of propolis as a source for the development of new pharmaceutical products. Molecules, 27(5), 1600.
Zacharias, L. (2024). Propolis: Nature's aid enhancing pediatric dental care. Journal of the Indian Society of Pedodontics & Preventive Dentistry, 42. S185.
Zulhendri, F., Chandrasekaran, K., Kowacz, M., Ravalia, M., Kripal, K., Fearnley, J., & Perera, C. O. (2021). Antiviral, antibacterial, antifungal, and antiparasitic properties of propolis: A review. Foods, 10(6), 1360.
Zulhendri, F., Felitti, R., Fearnley, J., & Ravalia, M. (2021). The use of propolis in dentistry, oral health, and medicine: A review. Journal of oral biosciences, 63(1), 23-34.
Zulhendri, F., Lesmana, R., Tandean, S., Christoper, A., Chandrasekaran, K., Irsyam, I., et al. (2022). Recent update on the anti-inflammatory activities of propolis. Molecules, 27(23), 8473.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Kelle de Araujo Cordeiro; Saul Alfredo Antezana Vera
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
